Per Lindblom

Pericytes limit tumor cell metastasis. (2006)

Xian, Xiaojie, Hakansson, Joakim, Stahlberg, Anders, Lindblom, Per, Betsholtz, Christer, Gerhardt, Holger, ...

Abstract is not available

Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries (2006)

Nyström, Henrik C., Lindblom, Per, Wickman, Anna, Andersson, Irene, Norlin, Jenny, Fäldt, Jenny, ...

Objective: Extracellular retention of PDGF-B has been proposed to play an important role in PDGF-B signalling. We used the PDGF-B retention motif knockout mouse (RetKO) to study the effects of...

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall (2003)

Lindblom, Per, Gerhardt, Holger, Liebner, Stefan, Abramsson, Alexandra, Enge, Maria, Hellström, Mats, ...

Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the...

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

Lindblom, Per, Gerhardt, Holger, Liebner, Stefan, Abramsson, Alexandra, Enge, Maria, Hellström, Mats, ...

Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the...

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

Abramsson, Alexandra, Lindblom, Per, Betsholtz, Christer

Tumor-infiltrating blood vessels deviate morphologically and biochemically from normal vessels, raising the prospect of selective pharmacological targeting. Current antiangiogenic approaches focus...

Pericytes limit tumor cell metastasis

Xian, Xiaojie, Håkansson, Joakim, Ståhlberg, Anders, Lindblom, Per, Betsholtz, Christer, Gerhardt, Holger, ...

Previously we observed that neural cell adhesion molecule (NCAM) deficiency in β tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient β...

Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall

Lindblom, Per, Gerhardt, Holger, Liebner, Stefan, Abramsson, Alexandra, Enge, Maria, Hellström, Mats, ...

Several platelet-derived growth factor (PDGF) and vascular endothelial growth factor (VEGF) family members display C-terminal protein motifs that confer retention of the secreted factors within the...

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

Abramsson, Alexandra, Lindblom, Per, Betsholtz, Christer

Tumor-infiltrating blood vessels deviate morphologically and biochemically from normal vessels, raising the prospect of selective pharmacological targeting. Current antiangiogenic approaches focus...

Pericytes limit tumor cell metastasis

Xian, Xiaojie, Håkansson, Joakim, Ståhlberg, Anders, Lindblom, Per, Betsholtz, Christer, Gerhardt, Holger, ...

Previously we observed that neural cell adhesion molecule (NCAM) deficiency in β tumor cells facilitates metastasis into distant organs and local lymph nodes. Here, we show that NCAM-deficient β...

Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development

Abramsson, Alexandra, Kurup, Sindhulakshmi, Busse, Marta, Yamada, Shuhei, Lindblom, Per, Schallmeiner, Edith, ...

During vascular development, endothelial platelet-derived growth factor B (PDGF-B) is critical for pericyte recruitment. Deletion of the conserved C-terminal heparin-binding motif impairs PDGF-BB...