Biogenesis of eukaryotic 20S proteasomes: the complex maturation pathway of a complex enzyme (2008)
Marion Schmidt, Peter-m. Kloetzel
ABSTRACT Eukaryotic 20S proteasomes harbor a remarkably complex architecture and unique proteolytic properties. Its catalytic mechanism places this enzyme in a new kind of protease family. The...
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope (2003)
Seifert,Ulrike, Maranon,Concepcion, Shmueli,Ayelet, Desoutter,Jean-Francois, Wesoloski,Lisa, Janek,Katharina, ...
Most of the peptides presented by major histocompatibility complex (MHC) class I molecules require processing by proteasomes. Tripeptidyl peptidase II (TPPII), an aminopeptidase with endoproteolytic...
MAPPP: MHC class I antigenic peptide processing prediction (2003)
Hakenberg,Jorg, Nussbaum,Alexander K., Schild,Hansjorg, Rammensee,Hans-Georg, Kuttler,Christina, Holzhutter,Hermann-Georg, ...
MAPPP is a bioinformatics tool for the prediction of potential antigenic epitopes presented on the cell surface by major histocompatibility complex class I (MHC I) molecules to CD8 positive T...
An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope (2003)
Seifert, Ulrike, Maranon, Concepcion, Shmueli, Ayelet, Desoutter, Jean-Francois, Wesoloski, Lisa, Janek, Katharina, ...
MAPPP: MHC class I antigenic peptide processing prediction (2003)
Hakenberg, Jorg, Nussbaum, Alexander K., Schild, Hansjorg, Rammensee, Hans-Georg, Kuttler, Christina, Holzhutter, Hermann-Georg, ...
MAPPP is a bioinformatics tool for the prediction of potential antigenic epitopes presented on the cell surface by major histocompatibility complex class I (MHC I) molecules to CD8 positive T...
Boes, Bettina, Hengel, Hartmut, Ruppert, Thomas, Multhaupt, Gerd, Koszinowski, Ulrich H., Kloetzel, Peter-M.
The proteasome is a 700-kD multisubunit enzyme complex with several proteolytically active sites. The enzyme complex is involved in both ubiquitin-dependent and -independent protein degradation and...
Kloetzel, Peter-M., Whitfeld, William, Sommerville, John
Previtellogenic oocytes of Triturus cristatus accumulate a free cyto-plasmic RNP which sediments at 40S and contains 5S RNA and tRNA in associ-ation with two proteins of MW 45,000 and 59,0C0 daltons...
PI31 is a modulator of proteasome formation and antigen processing
Zaiss, Dietmar M. W., Standera, Sybille, Kloetzel, Peter-M.
Regulation of the proteasome system, which is responsible for the generation of most MHC class I-bound peptides, occurs through the interaction of the 20S proteasome with several regulatory proteins....
Hepatitis C virus mutation affects proteasomal epitope processing
Seifert, Ulrike, Liermann, Heike, Racanelli, Vito, Halenius, Anne, Wiese, Manfred, Wedemeyer, Heiner, ...
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation...
Heat-shock proteins are associated with hnRNA in Drosophila melanogaster tissue culture cells
Kloetzel, Peter-M., Bautz, Ekkehard K.F.
Ribonucleoprotein complexes of Drosophila melanogaster Kc tissue culture cells grown at 24°C or heat-shocked at 37°C were cross-linked in vivo by u.v. irradiation. Cross-linked heterogeneous...
IFN-γ-induced immune adaptation of the proteasome system is an accelerated and transient response
Heink, Sylvia, Ludwig, Daniela, Kloetzel, Peter-M., Krüger, Elke
Peptide generation by the proteasome is rate-limiting in MHC class I-restricted antigen presentation in response to IFN-γ. IFN-γ-induced de novo formation of immunoproteasomes, therefore,...
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
Shin, Eui-Cheol, Seifert, Ulrike, Kato, Takanobu, Rice, Charles M., Feinstone, Stephen M., Kloetzel, Peter-M., ...
IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits,...
PI31 is a modulator of proteasome formation and antigen processing
Zaiss, Dietmar M. W., Standera, Sybille, Kloetzel, Peter-M.
Regulation of the proteasome system, which is responsible for the generation of most MHC class I-bound peptides, occurs through the interaction of the 20S proteasome with several regulatory proteins....
Hepatitis C virus mutation affects proteasomal epitope processing
Seifert, Ulrike, Liermann, Heike, Racanelli, Vito, Halenius, Anne, Wiese, Manfred, Wedemeyer, Heiner, ...
The high incidence of hepatitis C virus (HCV) persistence raises the question of how HCV interferes with host immune responses. Studying a single-source HCV outbreak, we identified an HCV mutation...
Heat-shock proteins are associated with hnRNA in Drosophila melanogaster tissue culture cells
Kloetzel, Peter-M., Bautz, Ekkehard K.F.
Ribonucleoprotein complexes of Drosophila melanogaster Kc tissue culture cells grown at 24°C or heat-shocked at 37°C were cross-linked in vivo by u.v. irradiation. Cross-linked heterogeneous...
IFN-γ-induced immune adaptation of the proteasome system is an accelerated and transient response
Heink, Sylvia, Ludwig, Daniela, Kloetzel, Peter-M., Krüger, Elke
Peptide generation by the proteasome is rate-limiting in MHC class I-restricted antigen presentation in response to IFN-γ. IFN-γ-induced de novo formation of immunoproteasomes, therefore,...
Virus-induced type I IFN stimulates generation of immunoproteasomes at the site of infection
Shin, Eui-Cheol, Seifert, Ulrike, Kato, Takanobu, Rice, Charles M., Feinstone, Stephen M., Kloetzel, Peter-M., ...
IFN-γ is known as the initial and primary inducer of immunoproteasomes during viral infections. We now report that type I IFN induced the transcription and translation of immunoproteasome subunits,...
Van Hall, Thorbald, Sijts, Alice, Camps, Marcel, Offringa, Rienk, Melief, Cornelis, Kloetzel, Peter-M., ...
The proteasome is the principal provider of major histocompatibility complex (MHC) class I–presented peptides. Interferon (IFN)-γ induces expression of three catalytically active proteasome...
Kuckelkorn, Ulrike, Ruppert, Thomas, Strehl, Britta, Jungblut, Peter R., Zimny-Arndt, Ursula, Lamer, Stephanie, ...
Adoptive transfer of cross-reactive HSP60-specific CD8+ T cells into immunodeficient mice causes autoimmune intestinal pathology restricted to the small intestine. We wondered whether local...
Ruppert, Thomas, Rehermann, Barbara, Schmidt, Marion, Koszinowski, Ulrich, Kloetzel, Peter-M.
Interferon (IFN)-γ–induced cells express the proteasome subunits low molecular weight protein (LMP)2, LMP7, and MECL-1 (multicatalytic endopeptidase complex–like 1), leading to the formation of...
Schmidtke, Gunter, Eggers, Maren, Ruppert, Thomas, Groettrup, Marcus, Koszinowski, Ulrich H., Kloetzel, Peter-M.
Proteasomes generate peptides bound by major histocompatibility complex (MHC) class I molecules. Avoiding proteasome inhibitors, which in most cases do not distinguish between individual active sites...
Theobald, Matthias, Ruppert, Thomas, Kuckelkorn, Ulrike, Hernandez, Javier, Häussler, Annett, Ferreira, Edite Antunes, ...
A high proportion of tumors arise due to mutation of the p53 tumor suppressor protein. A p53 hotspot mutation at amino acid position 273 from R to H, flanking a peptide epitope that spans residues...