Peter AC 't Hoen

CORE_TF: a user-friendly interface to identify evolutionary conserved transcription factor binding sites in sets of co-regulated genes (2008)

Hestand, Matthew S, Van Galen, Michiel, Villerius, Michel P, Den Dunnen, Johan T, 't Hoen, Peter AC

Abstract Background The identification of transcription factor binding sites is difficult since they are only a small number of nucleotides in size, resulting in large numbers of false positives and...

Mutant huntingtin activates Nrf2-responsive genes and impairs dopamine synthesis in a PC12 model of Huntington's disease (2008)

Pepers, Barry A, 't Hoen, Peter AC, Verwijmeren, Carola ACM, Den Dunnen, Johan T, Dorsman, Josephine C, ...

Abstract Background Huntington's disease is a progressive autosomal dominant neurodegenerative disorder that is caused by a CAG repeat expansion in the HD or Huntington's disease gene. Although micro...

Literature-aided meta-analysis of microarray data: a compendium study on muscle development and disease (2008)

Jelier, Rob, 't Hoen, Peter AC, Sterrenburg, Ellen, Den Dunnen, Johan T, Kors, Jan A, ...

Abstract Background Comparative analysis of expression microarray studies is difficult due to the large influence of technical factors on experimental outcome. Still, the identified differentially...

Can subtle changes in gene expression be consistently detected with different microarray platforms? (2008)

Pedotti, Paola, 't Hoen, Peter AC, Vreugdenhil, Erno, Schenk, Geert J, Vossen, Rolf HAM, Ariyurek, Yavuz, ...

Abstract Background The comparability of gene expression data generated with different microarray platforms is still a matter of concern. Here we address the performance and the overlap in the...

Exploiting the full power of temporal gene expression profiling through a new statistical test: Application to the analysis of muscular dystrophy data (2006)

Vinciotti, Veronica, Liu, Xiaohui, Turk, Rolf, De Meijer, Emile J, 't Hoen, Peter AC

Abstract Background The identification of biologically interesting genes in a temporal expression profiling dataset is challenging and complicated by high levels of experimental noise. Most...

Gene expression variation between mouse inbred strains (2004)

Turk, Rolf, 't Hoen, Peter AC, Sterrenburg, Ellen, De Menezes, Renée X, De Meijer, Emile J, Boer, Judith M, ...

Abstract Background In this study, we investigated the effect of genetic background on expression profiles. We analysed the transcriptome of mouse hindlimb muscle of five frequently used mouse inbred...