CD45 regulates apoptosis in peripheral T lymphocytes (2006)
Liu, Zhe, Dawes, Ritu, Petrova, Svetla, Beverley, Peter C. L., Tchilian, Elma Z.
Programmed cell death (apoptosis) is a key mechanism for regulating lymphocyte numbers. Murine lymph node lymphocytes cultured in vitro without added stimuli show significant levels of apoptosis over...
Disease associations and altered immune function in CD45 138G variant carriers (2004)
Boxall, Sally, Stanton, Tara, Hirai, Kouzo, Ward, Victoria, Yasui, Tomoyo, Tahara, Hideki, ...
The CD45 antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor mediated signalling in lymphocytes. Expression of different patterns of alternatively spliced CD45...
Disease associations and altered immune function in CD45 138G variant carriers (2004)
Boxall, Sally, Stanton, Tara, Hirai, Kouzo, Ward, Victoria, Yasui, Tomoyo, Tahara, Hideki, ...
The CD45 antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor mediated signalling in lymphocytes. Expression of different patterns of alternatively spliced CD45...
Altered CD45 isoform expression affects lymphocyte function in CD45 Tg mice (2004)
Tchilian, Elma Z., Dawes, Ritu, Hyland, Lisa, Montoya, Maria, Le Bon, Agnes, Borrow, Persephone, ...
Transgenic mice have been constructed expressing high (CD45RABC) and low (CD45R0) molecular weight CD45 isoforms on a CD45−/− background. Phenotypic analysis and in vivo challenge of these mice...
Disease associations and altered immune function in CD45 138G variant carriers (2004)
Boxall, Sally, Stanton, Tara, Hirai, Kouzo, Ward, Victoria, Yasui, Tomoyo, Tahara, Hideki, ...
The CD45 antigen is a haemopoietic cell specific tyrosine phosphatase essential for antigen receptor mediated signalling in lymphocytes. Expression of different patterns of alternatively spliced CD45...
Wedderburn, Lucy R., Maini, Mala K., Patel, Alka, Beverley, Peter C. L., Woo, Patricia
We have demonstrated a stable expansion of CD8+ T cells in the peripheral blood of a child with chronic arthritis. The expanded TCRBV family (TCRBV14) was enriched for CD57hiCD28– T cells....
Vyakarnam, Annapurna, Matear, Patricia M., Cranenburg, Charmaine, Michie, Colin, Beverley, Peter C. L., Wahren, Britta, ...
We demonstrate that peptides (16 amino acids long) covering the sequence of the HIV-1 core protein p24 induce significant proliferation in peripheral blood mononuclear cells (PBMC) of several...
Merkenschlager, Matthias, Beverley, Peter C. L., MacDonald, Robson
On the basis of differential CD45 expression, human T cells can be separated into approximately reciprocal populations. The mAb UCHL1 detects a 180 kd molecular mass isoform, CD45R0. The CD45RA...
Stanton, Tara, Boxall, Sally, Hirai, Kouzo, Dawes, Ritu, Tonks, Susan, Yasui, Tomoyo, ...
CD45 (leukocyte common) antigen is a hemopoietic cell-specific tyrosine phosphatase essential for antigen receptor-mediated signaling in lymphocytes. The molecule undergoes complex alternative...
Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...
While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+CD45RO+CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium...
Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...
Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...
Stanton, Tara, Boxall, Sally, Hirai, Kouzo, Dawes, Ritu, Tonks, Susan, Yasui, Tomoyo, ...
CD45 (leukocyte common) antigen is a hemopoietic cell-specific tyrosine phosphatase essential for antigen receptor-mediated signaling in lymphocytes. The molecule undergoes complex alternative...
Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...
While memory T cells are maintained by continuous turnover, it is not clear how human regulatory CD4+CD45RO+CD25hi Foxp3+ T lymphocyte populations persist throughout life. We therefore used deuterium...
Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...
Vukmanovic-Stejic, Milica, Zhang, Yan, Cook, Joanne E., Fletcher, Jean M., McQuaid, Arthur, Masters, Joanne E., ...
CD45 negatively regulates tumour necrosis factor and interleukin-6 production in dendritic cells
Piercy, Jenny, Petrova, Svetla, Tchilian, Elma Z, Beverley, Peter C L
CD45 is known to regulate signalling through many different surface receptors in diverse haemopoietic cell types. Here we report for the first time that CD45−/− bone marrow dendritic cells (BMDC)...
Wallace, Diana L, Bérard, Marion, Soares, Maria V D, Oldham, Janine, Cook, Joanne E, Akbar, Arne N, ...
Interleukin (IL)-7 and IL-15 are cytokines implicated in homeostatic control of the peripheral CD8 T-cell pool. We compared the effects of IL-7 and IL-15 on survival and proliferation of purified...
Reed, John R., Vukmanovic-Stejic, Milica, Fletcher, Jean M., Soares, Maria Vieira D., Cook, Joanne E., Orteu, Catherine H., ...
The extent of human memory T cell proliferation, differentiation, and telomere erosion that occurs after a single episode of immune challenge in vivo is unclear. To investigate this, we injected...
Rapid Turnover of Effector–Memory CD4+ T Cells in Healthy Humans
Macallan, Derek C., Wallace, Diana, Zhang, Yan, De Lara, Catherine, Worth, Andrew T., Ghattas, Hala, ...
Memory T cells can be divided into central–memory (TCM) and effector–memory (TEM) cells, which differ in their functional properties. Although both subpopulations can persist long term, it is not...
Clutterbuck, Elizabeth A., Oh, Sarah, Hamaluba, Mainga, Westcar, Sharon, Beverley, Peter C. L., Pollard, Andrew J.
Glycoconjugate vaccines have dramatically reduced the incidence of encapsulated bacterial diseases in toddlers under 2 years of age, but vaccine-induced antibody levels in this age group wane...
Zhang, Yan, Wallace, Diana L, De Lara, Catherine M, Ghattas, Hala, Asquith, Becca, Worth, Andrew, ...
Human natural killer (NK) cells form a circulating population in a state of dynamic homeostasis. We investigated NK cell homeostasis by labelling dividing cells in vivo using deuterium-enriched...
Bayry, Jagadeesh, Tchilian, Elma Z., Davies, Matthew N., Forbes, Emily K., Draper, Simon J., Kaveri, Srini V., ...
Adjuvants are substances that enhance immune responses and thus improve the efficacy of vaccination. Few adjuvants are available for use in humans, and the one that is most commonly used (alum) often...
Juleff, Nicholas, Windsor, Miriam, Lefevre, Eric A., Gubbins, Simon, Hamblin, Pip, Reid, Elizabeth, ...
The role of T-lymphocyte subsets in recovery from foot-and-mouth disease virus (FMDV) infection in calves was investigated by administering subset-specific monoclonal antibodies. The depletion of...