Rapid serological detection of autoantibodies associated with Sjögren's syndrome (2009)
Burbelo, Peter D, Ching, Kathryn H, Issa, Alexandra T, Loftus, Caroline M, Li, Yi, Satoh, Minoru, ...
Abstract Background Sjögren's syndrome (SjS) is a relatively common autoimmune disease characterized by oral and ocular dryness. There is an increasing need for simple, sensitive and rapid...
Highly quantitative serological detection of anti-cytomegalovirus (CMV) antibodies (2009)
Burbelo, Peter D, Issa, Alexandra T, Ching, Kathryn H, Exner, Maurice, Drew, W Lawrence, Alter, Harvey J, ...
Abstract Background Human cytomegalovirus infection is associated with a variety of pathological conditions including retinitis, pneumonia, hepatitis and encephalitis that may be transmitted...
Burbelo, Peter D, Meoli, Elise, Leahy, Hannah P, Graham, Jhanelle, Yao, Karen, Oh, Unsong, ...
Abstract Background HTLV-I is the causal agent of adult T cell leukemia (ATLL) and HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Biomarkers are needed to diagnose and/or...
Burbelo, Peter D, Goldman, Radoslav, Mattson, Thomas L
Abstract Background Assays detecting human antigen-specific antibodies are medically useful. However, the usefulness of existing simple immunoassay formats is limited by technical considerations such...
Our research goals involve identifying and characterizing proteins/peptide targeting sequences that could be used in the specific delivery of chemotherapeutic agents to breast cancer cells. In order...
MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts
Burbelo, Peter D., Snow, Dianne M., Bahou, Wadie, Spiegel, Sarah
Cdc42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization, kinase-signaling activation, and cell polarization. MSE55 is a nonkinase CRIB...
Structure and function of human Vps20 and Snf7 proteins.
Peck, Jeremy W, Bowden, Emma T, Burbelo, Peter D
Snf7p (sucrose non-fermenting) and Vps20p (vacuolar protein-sorting) are small coil-coiled proteins involved in yeast MVB (multivesicular body) structure, formation and function. In the present...
MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts
Burbelo, Peter D., Snow, Dianne M., Bahou, Wadie, Spiegel, Sarah
Cdc42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization, kinase-signaling activation, and cell polarization. MSE55 is a nonkinase CRIB...
Structure and function of human Vps20 and Snf7 proteins.
Peck, Jeremy W, Bowden, Emma T, Burbelo, Peter D
Snf7p (sucrose non-fermenting) and Vps20p (vacuolar protein-sorting) are small coil-coiled proteins involved in yeast MVB (multivesicular body) structure, formation and function. In the present...
Rapid, Novel, Specific, High-Throughput Assay for Diagnosis of Loa loa Infection▿
Burbelo, Peter D., Ramanathan, Roshan, Klion, Amy D., Iadarola, Michael J., Nutman, Thomas B.
The ability to diagnose Loa loa infection readily and accurately remains a demanding task. Among the available diagnostic methods, many are impractical for point-of-care field testing. To investigate...
Highly quantitative serological detection of anti-cytomegalovirus (CMV) antibodies
Burbelo, Peter D, Issa, Alexandra T, Ching, Kathryn H, Exner, Maurice, Drew, W Lawrence, Alter, Harvey J, ...
A Four-Antigen Mixture for Rapid Assessment of Onchocerca volvulus Infection
Burbelo, Peter D., Leahy, Hannah P., Iadarola, Michael J., Nutman, Thomas B.
Caused by the filarial parasite Onchocerca volvulus, onchocerciasis is a neglected tropical disease associated with blindness and severe dermatitis. Available diagnostic methods are either invasive,...
Burbelo, Peter D., Hirai, Hiroki, Leahy, Hannah, Lernmark, Ake, Ivarsson, Sten A., Iadarola, Michael J., ...
OBJECTIVE—Insulinoma-associated protein 2 (IA-2) is a major autoantigen in type 1 diabetes, and IA-2 autoantibodies are routinely detected by a liquid-phase radioimmunoprecipitation assay. The...
Burbelo, Peter D., Hoshino, Yo, Leahy, Hannah, Krogmann, Tammy, Hornung, Ronald L., Iadarola, Michael J., ...
Highly quantitative and high-throughput serological tests for evaluation of humoral responses to herpes simplex virus 1 (HSV-1) and HSV-2 are not available. The efficacy of luciferase...
Rapid serological detection of autoantibodies associated with Sjögren's syndrome
Burbelo, Peter D, Ching, Kathryn H, Issa, Alexandra T, Loftus, Caroline M, Li, Yi, Satoh, Minoru, ...
Four-Antigen Mixture Containing V-Cyclin for Serological Screening of Human Herpesvirus 8 Infection▿
Burbelo, Peter D., Leahy, Hannah P., Groot, Sandra, Bishop, Lisa R., Miley, Wendell, Iadarola, Michael J., ...
Improved diagnostic reagents and testing are currently needed for the serological detection of human herpesvirus 8 (HHV-8) infections. We evaluated the luciferase immunoprecipitation systems (LIPS)...