Impaired Perinatal Growth and Longevity: A Life History Perspective (2009)
Deborah M. Sloboda, Alan S. Beedle, Cinda L. Cupido, Peter D. Gluckman, Mark H. Vickers
Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual...
Impaired Perinatal Growth and Longevity: A Life History Perspective (2009)
Deborah M. Sloboda, Alan S. Beedle, Cinda L. Cupido, Peter D. Gluckman, Mark H. Vickers
Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual...
Fraser, Mhoyra, Bennet, Laura, Van Zijl, Pierre L., Mocatta, Tessa J., Williams, Christopher E., Gluckman, Peter D., ...
It is widely hypothesized that accumulation of excitatory amino acids, and oxygen free radicals during or after exposure to hypoxia-ischemia play a pivotal role in preterm periventricular white...
Mohankumar, Kumarasamypet M., Perry, Jo K., Kannan, Nagarajan, Kohno, Kimitoshi, Gluckman, Peter D., Emerald, B. Starling, ...
We have previously demonstrated that the p44/42 MAPK pathway is one pathway involved in homeobox (HOX) A1-stimulated oncogenesis. However, inhibition of MAPK kinase 1 does not completely prevent...
Predictive adaptive responses in perspective (2008)
Gluckman, Peter D., Hanson, Mark A., Beedle, Alan S., Spencer, Hamish G.
Gunn, Alistair J., Wyatt, John S., Whitelaw, Andrew, Barks, John, Azzopardi, Denis, Ballard, Roberta, ...
OBJECTIVE: To evaluate whether therapeutic hypothermia alters the prognostic value of clinical grading of neonatal encephalopathy. STUDY DESIGN: This study was a secondary analysis of a multicenter...
Effect of in utero and early-life conditions on adult health and disease (2008)
Gluckman, Peter D., Hanson, Mark A., Cooper, Cyrus, Thornburg, Kent L.
A long latency period between an environmental trigger and the onset of subsequent disease is widely recognized in the etiology of certain cancers, yet this phenomenon is not generally considered in...
Evolution, developmental plasticity, and metabolic disease (2007)
Kuzawa, Christopher W., Gluckman, Peter D., Hanson, Mark A., Beedle, Alan S.
Head cooling for neonatal encephalopathy: the state of the art (2007)
Gunn, Alistair Jan, Gluckman, Peter D.
The possibility that hypothermia started during or after resuscitation at birth might reduce brain damage and cerebral palsy has tantalized clinicians for a long time. The key insight was that...
Braun, Thorsten, Li, Shaofu, Moss, Timothy J.M., Newnham, John P., Challis, John R.G., Gluckman, Peter D., ...
The placenta may mediate glucocorticoid-induced fetal growth restriction. Previous studies have examined effects of fetal cortisol in sheep, which reduces placental binucleate cell (BNC) number; the...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Determinants of outcomes after head cooling for neonatal encephalopathy (2007)
Wyatt, John S., Gluckman, Peter D., Liu, Ping Y., Azzopardi, Denis, Ballard, Roberta, Edwards, A. David, ...
OBJECTIVE: The goal of this study was to evaluate the role of factors that may determine the efficacy of treatment with delayed head cooling and mild systemic hypothermia for neonatal encephalopathy....
Migrating ovaries: early life influences on later gonadal function (2007)
Gluckman, Peter D., Beedle, Alan S.
Progress in the biomedical and clinical sciences has relied heavily on experimental animal research. However, the impact of other comparative disciplines such as evolutionary biology, and in...
Godfrey, Keith M., Lillycrop, Karen A., Burdge, Graham C., Gluckman, Peter D., Hanson, Mark A.
There is now considerable evidence that elements of the heritable or familial component of disease susceptibility are transmitted by nongenomic means, and that environmental influences acting during...
Gluckman, Peter D., Beedle, Alan S., Hanson, Mark A., Vickers, Mark H.
Events in early life are associated with changes in the risk of disease in later life. There is increasing evidence that these associations are mediated by permanent transcriptional changes in...
AlphaCP1 mediates stabilization of hTERT mRNA by autocrine human growth hormone (2007)
Emerald, B. Starling, Chen, Yong, Zhu, Tao, Zhu, Zhe, Lee, Kok-Onn, Gluckman, Peter D., ...
We herein demonstrate that autocrine human growth hormone production in human mammary carcinoma cells results in increased telomerase activity as a result of specific up-regulation of telomerase...
Evolving a definition of disease (2007)
Koch and Pasteur provided modern medicine with its primary model of disease – that it has a specific and organic cause. Treatment is generally developed from an understanding of that agent of...
Low birthweight and subsequent obesity in Japan (2007)
Gluckman, Peter D., Seng, Chong Y., Fukuoka, Hideoki, Beedle, Alan S., Hanson, Mark A.
The Lancet's World Report (Feb 10, p 451)1 rightly highlights the growing epidemic of obesity in Japan—a pattern that is also seen in other Asian countries and which might be of concern for future...
In vitro fertilization improves childhood growth and metabolism (2007)
Miles, Harriet L., Hofman, Paul L., Peek, John, Harris, Mark, Wilson, Dyanne, Robinson, Elizabeth M., ...
BACKGROUND: There is limited information regarding the long-term outcome of children born after in vitro fertilization (IVF), although an increase in rare imprinted gene disorders such as...
Developmental perspectives on the origins of obesity (2007)
Kuzawa, Christopher W., Gluckman, Peter D., Hanson, Mark A.
This chapter reviews the developmental pathways contributing to the origin of obesity. Evolutionary considerations are emphasized. At birth more than half of a human baby’s metabolism is devoted to...
Neural regeneration protein is a novel chemoattractive and neuronal survival-promoting factor (2006)
Gorba, Thorsten, Bradoo, Privahini, Antonic, Ana, Marvin, Keith, Liu, Dong-Xu, Lobie, Peter E., ...
Neurogenesis and neuronal migration are the prerequisites for the development of the central nervous system. We have identified a novel rodent gene encoding for a neural regeneration protein (NRP)...
Response to Wells: phenotypic responses to early environmental cues can be adaptive in adults (2006)
The developmental origins of health and disease: an overview (2006)
Gluckman, Peter D., Hanson, Mark A.
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases....
Higgins, Rosemary D., Raju, Tonse N., Perlman, Jeffrey, Azzopardi, Dennis Victor, Blackmon, Lillian R., Clark, Reese H., ...
Evolution, development and timing of puberty (2006)
Gluckman, Peter D., Hanson, Mark A.
The age of menarche has fallen as child health has improved. Although there is ample evidence of delayed puberty being associated with poorer childhood nutrition, menarche is also influenced by...
Evolution, development and timing of puberty (2006)
Gluckman, Peter D., Hanson, Mark A.
The age of menarche has fallen as child health has improved. Although there is ample evidence of delayed puberty being associated with poorer childhood nutrition, menarche is also influenced by...
Evolution, development and timing of puberty (2006)
Gluckman, Peter D., Hanson, Mark A.
The age of menarche has fallen as child health has improved. Although there is ample evidence of delayed puberty being associated with poorer childhood nutrition, menarche is also influenced by...
Zhang, Xin, Emerald, B. Starling, Mukhina, Svetlana, Mohankumar, Kumarasamypet M., Kraemer, Astrid, Yap, Alpha S., ...
Forced expression of HOXA1 is sufficient to stimulate oncogenic transformation of immortalized human mammary epithelial cells and subsequent tumor formation. We report here that the expression and...
The conceptual basis for the developmental origins of health and disease (2006)
Gluckman, Peter D., Hanson, Mark A.
This landmark publication provides the first definitive account of how and why subtle influences on the fetus and during early life can have such profound consequences for adult health and diseases....
Zhang, Xin, Emerald, B. Starling, Mukhina, Svetlana, Mohankumar, Kumarasamypet M., Kraemer, Astrid, Yap, Alpha S., ...
Forced expression of HOXA1 is sufficient to stimulate oncogenic transformation of immortalized human mammary epithelial cells and subsequent tumor formation. We report here that the expression and...
Predictive adaptive responses and human evolution (2005)
Gluckman, Peter D., Hanson, Mark A., Spencer, Hamish G.
The importance of a single genotype being able to produce different phenotypes in different environments (phenotypic plasticity) is widely recognized in evolutionary theory and its adaptive...
Gluckman, Peter D., Wyatt, John S., Azzopardi, Denis, Ballard, Roberta, Edwards, A. David, Ferriero, Donna M., ...
Background: cerebral hypothermia can improve outcome of experimental perinatal hypoxia-ischaemia. We did a multicentre randomised controlled trial to find out if delayed head cooling can improve...
Gluckman, Peter D., Hanson, Mark A., Spencer, Hamish G., Bateson, Patrick
Early experience has a particularly great effect on most organisms. Normal development may be disrupted by early environmental influences; individuals that survive have to cope with the damaging...
Life-long echoes: a critical analysis of the developmental origins of adult disease model (2005)
Gluckman, Peter D., Hanson, Mark A., Morton, Susan M., Pinal, Catherine S.
The hypothesis that there is a developmental component to subsequent adult disease initially arose from epidemiological findings relating birth size to either indices of disease risk or actual...
The developmental origins of adult disease (2005)
Gluckman, Peter D., Hanson, Mark A., Pinal, Catherine
Epidemiological and clinical observations have led to the hypothesis that the risk of developing some chronic diseases in adulthood is influenced not only by genetic and adult lifestyle factors, but...
The fetal, neonatal, and infant environments: the long-term consequences for disease risk (2005)
Gluckman, Peter D., Cutfield, Wayne, Hofman, Paul, Hanson, Mark A.
The developmental origins of health and disease can be understood by reference to the fundamentals of developmental plasticity. It is essential to distinguish between those environmental effects...
Developmental processes and the induction of cardiovascular function: conceptual aspects (2005)
Hanson, Mark A., Gluckman, Peter D.
The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider...
Developmental origins of disease paradigm: a mechanistic and evolutionary perspective (2004)
Gluckman, Peter D., Hanson, Mark A.
Fetal growth is determined by the interaction between the environment and the fetal genome. The fetal environment, in turn, is determined by the maternal environment and by maternal and placental...
Living with the past: evolution, development, and patterns of disease (2004)
Gluckman, Peter D., Hanson, Mark A.
Epidemiological observations have led to the hypothesis that the risk of developing some chronic noncommunicable diseases in adulthood is influenced not only by genetic and adult life-style factors...
Maternal constraint of fetal growth and its consequences (2004)
Gluckman, Peter D., Hanson, Mark A.
The major non-genetic factor determining the size of the fetus at term is maternal constraint. This term refers to a set of poorly defined processes by which maternal and uteroplacental factors act...
The developmental origins of the metabolic syndrome (2004)
Gluckman, Peter D., Hanson, Mark A.
Both epidemiological and clinical evidence suggest relationships between the antenatal environment and the risk of developing insulin resistance and associated cardiovascular disease (part of the...
Developmental plasticity and human health (2004)
Bateson, Patrick, Barker, David, Clutton-Brock, Timothy, Deb, Debal, D'Udine, Bruno, Foley, Robert A., ...
Many plants and animals are capable of developing in a variety of ways, forming characteristics that are well adapted to the environments in which they are likely to live. In adverse circumstances,...
Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone
Mukhina, Svetlana, Mertani, Hichem C., Guo, Ke, Lee, Kok-Onn, Gluckman, Peter D., Lobie, Peter E.
We report here that autocrine production of human growth hormone (hGH) results in a phenotypic conversion of mammary carcinoma cells such that they exhibit the morphological and molecular...
Developmental processes and the induction of cardiovascular function: conceptual aspects
Hanson, Mark A, Gluckman, Peter D
The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider...
Phenotypic conversion of human mammary carcinoma cells by autocrine human growth hormone
Mukhina, Svetlana, Mertani, Hichem C., Guo, Ke, Lee, Kok-Onn, Gluckman, Peter D., Lobie, Peter E.
We report here that autocrine production of human growth hormone (hGH) results in a phenotypic conversion of mammary carcinoma cells such that they exhibit the morphological and molecular...
Developmental processes and the induction of cardiovascular function: conceptual aspects
Hanson, Mark A, Gluckman, Peter D
The epidemiological basis of the developmental origins of disease concept is now widely accepted. The current impetus in research concerns establishing the underlying mechanisms. We discuss the wider...
Migrating Ovaries: Early Life Influences on Later Gonadal Function
Gluckman, Peter D, Beedle, Alan S
The authors discuss a new study of Bangladeshi migrants to the UK, which found that adult women who had migrated before the age of 8 years had greater luteal phase progesterone secretion than those...
Gluckman, Peter D, Hanson, Mark A, Spencer, Hamish G, Bateson, Patrick
Early experience has a particularly great effect on most organisms. Normal development may be disrupted by early environmental influences; individuals that survive have to cope with the damaging...
Gluckman, Peter D., Lillycrop, Karen A., Vickers, Mark H., Pleasants, Anthony B., Phillips, Emma S., Beedle, Alan S., ...
Developmental plasticity in response to environmental cues can take the form of polyphenism, as for the discrete morphs of some insects, or of an apparently continuous spectrum of phenotype, as for...
Impaired Perinatal Growth and Longevity: A Life History Perspective
Sloboda, Deborah M., Beedle, Alan S., Cupido, Cinda L., Gluckman, Peter D., Vickers, Mark H.
Life history theory proposes that early-life cues induce highly integrated responses in traits associated with energy partitioning, maturation, reproduction, and aging such that the individual...