Peter D. Walzer

In Vitro and In Vivo Effects of Quinupristin-Dalfopristin against Pneumocystis carinii

Walzer, Peter D., Ashbaugh, Alan, Collins, Margaret, Cushion, Melanie T.

Quinupristin-dalfopristin (Q-D), which is active against bacteria and Toxoplasma gondii, was examined for its activity against Pneumocystis carinii. After 72 h of incubation with rat P. carinii in an...

Identification of a Putative Precursor to the Major Surface Glycoprotein of Pneumocystis carinii

Sunkin, Susan M., Linke, Michael J., McCormack, Francis X., Walzer, Peter D., Stringer, James R.

The major surface glycoprotein (MSG) of Pneumocystis carinii f. sp. carinii is a family of proteins encoded by a family of heterogeneous genes. Messenger RNAs encoding different MSGs each begin with...

Expression, Structure, and Location of Epitopes of the Major Surface Glycoprotein of Pneumocystis carinii f. sp. carinii

Linke, Michael J., Sunkin, Susan M., Andrews, Ryan P., Stringer, James R., Walzer, Peter D.

The major surface glycoprotein (MSG) of Pneumocystis carinii f. sp. carinii consists of a heterogeneous family of proteins that are encoded by approximately 100 unique genes. A genomic expression...

Use of Terbinafine in Mouse and Rat Models of Pneumocystis carinii Pneumonia

Walzer, Peter D., Ashbaugh, Alan

Terbinafine, an allylamine used to treat onychomycosis, has been reported to be active against rat Pneumocystis carinii in vitro and in vivo. By contrast, our in vitro data showed that the 50%...

New Rat Model of Pneumocystis Pneumonia Induced by Anti-CD4+ T-Lymphocyte Antibodies

Thullen, Timothy D., Ashbaugh, Alan D., Daly, Kieran R., Linke, Michael J., Steele, Paul E., Walzer, Peter D.

The CD4+ T lymphocyte plays a central role in host defense against Pneumocystis pneumonia but has received only limited attention in rats. CD4+ T-cell-depleting (OX-38) and nondepleting (W3/25)...

Attachment of Pneumocystis carinii to Type I Alveolar Cells Studied by Freeze-Fracture Electron Microscopy

Yoneda, Kokichi, Walzer, Peter D.

Pneumocystis carinii was tightly attached to host alveolar type I cells, as judged by freeze-fracture electron microscopy. In contrast to other organisms studied by this technique, no changes in the...

Sensitized Splenocytes Result in Deleterious Cytokine Cascade and Hyperinflammatory Response in Rats with Pneumocystis Pneumonia despite the Presence of Corticosteroids

Thullen, Timothy D., Ashbaugh, Alan D., Daly, Kieran R., Linke, Michael J., Steele, Paul E., Walzer, Peter D.

The immune response to the opportunistic pulmonary pathogen Pneumocystis can have beneficial and harmful effects on the host despite the presence of corticosteroids. We hypothesized that this...

Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds

Cushion, Melanie T., Walzer, Peter D., Collins, Margaret S., Rebholz, Sandra, Vanden Eynde, Jean Jacques, Mayence, Annie, ...

Trimethoprim-sulfamethoxazole and pentamidine isethionate have been used extensively for the prophylaxis and therapy of pneumonia caused by Pneumocystis jirovecii. Problems associated with toxicity...

Interaction of Pneumocystis carinii with Host Lungs: an Ultrastructural Study

Yoneda, Kokichi, Walzer, Peter D.

Pneumocystis carinii pneumonia was produced in rats by the administration of corticosteroids, low (8%) protein diet, and tetracycline in the drinking water. The rats were sacrificed at weekly...

In Vitro Selection and In Vivo Efficacy of Piperazine- and Alkanediamide-Linked Bisbenzamidines against Pneumocystis Pneumonia in Mice

Cushion, Melanie T., Walzer, Peter D., Ashbaugh, Alan, Rebholz, Sandra, Brubaker, Ronald, Vanden Eynde, Jean Jacques, ...

Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential...

In Vitro and In Vivo Effects of Quinupristin-Dalfopristin against Pneumocystis carinii

Walzer, Peter D., Ashbaugh, Alan, Collins, Margaret, Cushion, Melanie T.

Quinupristin-dalfopristin (Q-D), which is active against bacteria and Toxoplasma gondii, was examined for its activity against Pneumocystis carinii. After 72 h of incubation with rat P. carinii in an...

Identification of a Putative Precursor to the Major Surface Glycoprotein of Pneumocystis carinii

Sunkin, Susan M., Linke, Michael J., McCormack, Francis X., Walzer, Peter D., Stringer, James R.

The major surface glycoprotein (MSG) of Pneumocystis carinii f. sp. carinii is a family of proteins encoded by a family of heterogeneous genes. Messenger RNAs encoding different MSGs each begin with...

Expression, Structure, and Location of Epitopes of the Major Surface Glycoprotein of Pneumocystis carinii f. sp. carinii

Linke, Michael J., Sunkin, Susan M., Andrews, Ryan P., Stringer, James R., Walzer, Peter D.

The major surface glycoprotein (MSG) of Pneumocystis carinii f. sp. carinii consists of a heterogeneous family of proteins that are encoded by approximately 100 unique genes. A genomic expression...

Use of Terbinafine in Mouse and Rat Models of Pneumocystis carinii Pneumonia

Walzer, Peter D., Ashbaugh, Alan

Terbinafine, an allylamine used to treat onychomycosis, has been reported to be active against rat Pneumocystis carinii in vitro and in vivo. By contrast, our in vitro data showed that the 50%...

New Rat Model of Pneumocystis Pneumonia Induced by Anti-CD4+ T-Lymphocyte Antibodies

Thullen, Timothy D., Ashbaugh, Alan D., Daly, Kieran R., Linke, Michael J., Steele, Paul E., Walzer, Peter D.

The CD4+ T lymphocyte plays a central role in host defense against Pneumocystis pneumonia but has received only limited attention in rats. CD4+ T-cell-depleting (OX-38) and nondepleting (W3/25)...

Attachment of Pneumocystis carinii to Type I Alveolar Cells Studied by Freeze-Fracture Electron Microscopy

Yoneda, Kokichi, Walzer, Peter D.

Pneumocystis carinii was tightly attached to host alveolar type I cells, as judged by freeze-fracture electron microscopy. In contrast to other organisms studied by this technique, no changes in the...

Sensitized Splenocytes Result in Deleterious Cytokine Cascade and Hyperinflammatory Response in Rats with Pneumocystis Pneumonia despite the Presence of Corticosteroids

Thullen, Timothy D., Ashbaugh, Alan D., Daly, Kieran R., Linke, Michael J., Steele, Paul E., Walzer, Peter D.

The immune response to the opportunistic pulmonary pathogen Pneumocystis can have beneficial and harmful effects on the host despite the presence of corticosteroids. We hypothesized that this...

Highly Active Anti-Pneumocystis carinii Compounds in a Library of Novel Piperazine-Linked Bisbenzamidines and Related Compounds

Cushion, Melanie T., Walzer, Peter D., Collins, Margaret S., Rebholz, Sandra, Vanden Eynde, Jean Jacques, Mayence, Annie, ...

Trimethoprim-sulfamethoxazole and pentamidine isethionate have been used extensively for the prophylaxis and therapy of pneumonia caused by Pneumocystis jirovecii. Problems associated with toxicity...

Interaction of Pneumocystis carinii with Host Lungs: an Ultrastructural Study

Yoneda, Kokichi, Walzer, Peter D.

Pneumocystis carinii pneumonia was produced in rats by the administration of corticosteroids, low (8%) protein diet, and tetracycline in the drinking water. The rats were sacrificed at weekly...

In Vitro Selection and In Vivo Efficacy of Piperazine- and Alkanediamide-Linked Bisbenzamidines against Pneumocystis Pneumonia in Mice

Cushion, Melanie T., Walzer, Peter D., Ashbaugh, Alan, Rebholz, Sandra, Brubaker, Ronald, Vanden Eynde, Jean Jacques, ...

Bisbenzamidines, such as pentamidine isethionate, are aromatic dicationic compounds that are active against Pneumocystis and other microbes but are oftentimes toxic to the host. To identify potential...