Lysosomal Catabolism of a Protein Toxin: Staphylococcal Enterotoxin B (2007)
Lysosomal proteases of rabbit liver, kidney and polymorphonuclear cells were tested for their ability to hydrolyze staphylococcal enterotoxin B, a protein exotoxin of Staphylococcus aureus. All...
Canonico,Peter G., Rill,Wayne, Ayala,Eleanor
The activity of hepatic peroxisomal enzymes, catalase, urate oxidase, D-amino acid oxidase, hydroxy acid oxidase, and carnitine acetyltransferase were serially measured following a turpentine-induced...
Canonico,Peter G., Ayala,E., Rill,W. L.
The gluconeogenic capacity of single cell suspension of hepatocytes isolated from control and S. pneumoniae infected rats was determined. It is shown that (1) gluconeogenesis from pyruvate and...
Little,James S., Kishimoto,Richard A., Canonico,Peter G.
The inactivation of Coxiella burnetii in suspension or in cultures of guinea pig peritoneal macrophages by ultraviolet (UV) light was studied. The effect of UV treatment on the activity of macrophage...
Glucose and Alanine Metabolism During Bacterial Infections in Rats and Rhesus Monkeys, (2002)
Beall,Franics A., Canonico,Peter G., Dinterman,Richard E., Hadick,Clayton L.
Supersedes report dated 24 Jul 78, AD-A059 371.
Effect of Ribavirin on Protein and RNA Synthesis in VEE Virus-Infected Cells. (2002)
Canonico,Peter G., Little,James S., Jahrling,Peter B., Stephen,Edward L.
Ribavirin is a nucleoside analogue with antiviral activity against the etiologic agents of such militarily important diseases as Lassa fever, Bolivian and Argentinian hemorrhagic fevers, Rift Valley...
Mechanism of Action of Ribavirin: An Antiviral Drug of Military Importance, (2002)
Canonico,Peter G., Little,James S., Jahrling,Peter B., Stephen,Edward L.
Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a nucleoside analogue having broad spectrum antiviral activity against both DNA and RNA viruses (18). A variety of specific effects...
Intracellular Fate of Phase I Coxiella burnetii in Guinea Pig Peritoneal Macrophages. (2002)
Little,James S., Kishimoto,Richard A., Canonico,Peter G.
Guinea pig peritoneal macrophages were infected with phase I Coxiella burnetii to assess the intracellular distribution of ingested rickettsiae. Localization of organisms was determined by...
Little,Stephen F., Canonico,Peter G.
The Washington and Philadephia L-1 strains of Legionella pneumophila were mechanically disrupted and cell wall and ribosomal subunits isolated by differential centrifugation. Complete protection of...
Kenyon,Richard H., Canonico,Peter G., Green,David E., Peters,Clarence J.
Junin virus causes Argentine hemorrhagic fever, an acute, severe disease with a mortality rate in untreated humans of 15 to 30%. The only effective therapy for the disease, other than supportive...
Kende, Meir, Lupton, Harold W., Rill, Wayne L., Canonico, Peter G., Levy, Hilton B.
The therapeutic efficacy of polyriboinosinic-polyribocytidylic acid stabilized with poly-L-lysine and carboxymethyl cellulose POLY(ICLC) given alone or in combination with ribavirin was evaluated in...
In-vivo activity of antivirals against exotic RNA viral infections (1984)
Canonico, Peter G., Kende, Meir, Luscri, Bruno J., Huggins, John W.
Infection of humans by viruses belonging to the families of Toga-, Bunya-, and Arenaviridae constitutes a major health problem worldwide and certain of the viruses have the potential to cause...
Inhibition of RNA Viruses In Vitro and in Rift Valley Fever-Infected Mice by Didemnins A and B
Canonico, Peter G., Pannier, Wallace L., Huggins, John W., Rienehart, Kenneth L.
Didemnins, a new class of depsipeptides isolated from a Caribbean tunicate, have been shown to have potent antiviral activity against a broad range of RNA viruses in vitro. Didemnins A and B both...
Canonico, Peter G., Van Zwieten, Matthew J., Christmas, William A.
The purification of large quantities of inactivated, phase II Coxiella burnetii by isopycnic zonal centrifugation for use as diagnostic antigen and as a vaccine is described. The fractionation of egg...
Kaplan, Joseph, Canonico, Peter G., Caspary, William J.
Lipid-soluble spin labels were incorporated into human lymphocytes and mouse L-cells and the resulting electron spin resonance spectra were compared with spectra obtained from similarly labeled human...
Inhibition of RNA Viruses In Vitro and in Rift Valley Fever-Infected Mice by Didemnins A and B
Canonico, Peter G., Pannier, Wallace L., Huggins, John W., Rienehart, Kenneth L.
Didemnins, a new class of depsipeptides isolated from a Caribbean tunicate, have been shown to have potent antiviral activity against a broad range of RNA viruses in vitro. Didemnins A and B both...
Canonico, Peter G., Van Zwieten, Matthew J., Christmas, William A.
The purification of large quantities of inactivated, phase II Coxiella burnetii by isopycnic zonal centrifugation for use as diagnostic antigen and as a vaccine is described. The fractionation of egg...
Kaplan, Joseph, Canonico, Peter G., Caspary, William J.
Lipid-soluble spin labels were incorporated into human lymphocytes and mouse L-cells and the resulting electron spin resonance spectra were compared with spectra obtained from similarly labeled human...
LYSOSOMES IN SKELETAL MUSCLE TISSUE : Zonal Centrifugation Evidence for Multiple Cellular Sources
Canonico, Peter G., Bird, John W. C.
Postnuclear supernates from homogenates of skeletal muscle from rats subjected to starvation, injections of Triton WR-1339, dextran-500, and dextran + corticosterone were fractionated by means of...