Peter J. Jenks

Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice (2003)

Loughlin, Michael F., Ala’Aldeen, Dlawer A., Jenks, Peter J.

Objective: To determine the ability of mastic monotherapy to eradicate Helicobacter pylori infection from mice. Materials and methods: The susceptibility of H. pylori SS1 to mastic was assessed by...

Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice (2003)

Loughlin, Michael F., Ala'Aldeen, Dlawer A., Jenks, Peter J.

Objective: To determine the ability of mastic monotherapy to eradicate Helicobacter pylori infection from mice. Materials and methods: The susceptibility of H. pylori SS1 to mastic was assessed by...

Monotherapy with mastic does not eradicate Helicobacter pylori infection from mice (2003)

Loughlin, Michael F., Ala'Aldeen, Dlawer A., Jenks, Peter J.

Objective: To determine the ability of mastic monotherapy to eradicate Helicobacter pylori infection from mice. Materials and methods: The susceptibility of H. pylori SS1 to mastic was assessed by...

Production of the RdxA protein in metronidazole-susceptible and -resistant isolates of Helicobacter pylori cultured from treated mice (2002)

Latham, Stephanie R., Labigne, Agnès, Jenks, Peter J.

The objective of this study was to use immunoblotting with RdxA antisera to examine the production of the RdxA protein in mouse-derived metronidazole-susceptible and -resistant isolates of...

Short-term infection with Helicobacter pylori and 1 week exposure to metronidazole does not enhance gastric mutation frequency in transgenic mice (2000)

Touati, Eliette, Hofnung, Maurice, Thiberge, Jean-Michel, Michel, Valérie, Labigne, Agnès, Jenks, Peter J.

The aim of this study was to determine whether exposure of Helicobacter pylori-infected mice to metronidazole resulted in the delivery of mutagenic compounds to the gastric epithelium via the...

Differentiation of Metronidazole-Sensitive and -Resistant Clinical Isolates of Helicobacter pylori by Immunoblotting with Antisera to the RdxA Protein

Latham, Stephanie R., Owen, Robert J., Elviss, Nicola C., Labigne, Agnès, Jenks, Peter J.

Antimicrobial resistance in Helicobacter pylori is a serious and increasing problem, and the development of rapid, reliable methods for detecting resistance would greatly improve the selection of...

Exposure to Metronidazole In Vivo Readily Induces Resistance in Helicobacter pylori and Reduces the Efficacy of Eradication Therapy in Mice

Jenks, Peter J., Labigne, Agnes, Ferrero, Richard L.

The Helicobacter pylori SS1 mouse model was used to characterize the development of resistance in H. pylori after treatment with metronidazole monotherapy and to examine the effect of prior exposure...

Frequent Association between Alteration of the rdxA Gene and Metronidazole Resistance in French and North African Isolates of Helicobacter pylori

Tankovic, Jacques, Lamarque, Dominique, Delchier, Jean-Charles, Soussy, Claude-James, Labigne, Agnes, Jenks, Peter J.

Mutations in the rdxA gene have been associated with the acquisition of resistance to metronidazole in Helicobacter pylori. This gene encodes an NADPH nitroreductase whose expression is necessary for...

Evaluation of Nitrofurantoin Combination Therapy of Metronidazole-Sensitive and -Resistant Helicobacter pylori Infections in Mice

Jenks, Peter J., Ferrero, Richard L., Tankovic, Jacques, Thiberge, Jean-Michel, Labigne, Agnès

The main objectives of this study were to determine whether the nitroreductase enzyme encoded by the rdxA gene of Helicobacter pylori was responsible for reductive activation of nitrofurantoin and...

Helicobacter pylori Mutants Defective in RuvC Holliday Junction Resolvase Display Reduced Macrophage Survival and Spontaneous Clearance from the Murine Gastric Mucosa

Loughlin, Michael F., Barnard, Faye M., Jenkins, David, Sharples, Gary J., Jenks, Peter J.

Homologous recombination contributes to the extraordinary genetic diversity of Helicobacter pylori and may be critical for surface antigen expression and adaptation to environmental challenges within...

Microbial genome sequencing—beyond the double helix

Jenks, Peter J

Causes of failure of eradication of Helicobacter pylori : Antibiotic resistance is the major cause, and susceptibility testing may help

Jenks, Peter J

Differentiation of Metronidazole-Sensitive and -Resistant Clinical Isolates of Helicobacter pylori by Immunoblotting with Antisera to the RdxA Protein

Latham, Stephanie R., Owen, Robert J., Elviss, Nicola C., Labigne, Agnès, Jenks, Peter J.

Antimicrobial resistance in Helicobacter pylori is a serious and increasing problem, and the development of rapid, reliable methods for detecting resistance would greatly improve the selection of...

Exposure to Metronidazole In Vivo Readily Induces Resistance in Helicobacter pylori and Reduces the Efficacy of Eradication Therapy in Mice

Jenks, Peter J., Labigne, Agnes, Ferrero, Richard L.

The Helicobacter pylori SS1 mouse model was used to characterize the development of resistance in H. pylori after treatment with metronidazole monotherapy and to examine the effect of prior exposure...

Frequent Association between Alteration of the rdxA Gene and Metronidazole Resistance in French and North African Isolates of Helicobacter pylori

Tankovic, Jacques, Lamarque, Dominique, Delchier, Jean-Charles, Soussy, Claude-James, Labigne, Agnes, Jenks, Peter J.

Mutations in the rdxA gene have been associated with the acquisition of resistance to metronidazole in Helicobacter pylori. This gene encodes an NADPH nitroreductase whose expression is necessary for...

Evaluation of Nitrofurantoin Combination Therapy of Metronidazole-Sensitive and -Resistant Helicobacter pylori Infections in Mice

Jenks, Peter J., Ferrero, Richard L., Tankovic, Jacques, Thiberge, Jean-Michel, Labigne, Agnès

The main objectives of this study were to determine whether the nitroreductase enzyme encoded by the rdxA gene of Helicobacter pylori was responsible for reductive activation of nitrofurantoin and...

Helicobacter pylori Mutants Defective in RuvC Holliday Junction Resolvase Display Reduced Macrophage Survival and Spontaneous Clearance from the Murine Gastric Mucosa

Loughlin, Michael F., Barnard, Faye M., Jenkins, David, Sharples, Gary J., Jenks, Peter J.

Homologous recombination contributes to the extraordinary genetic diversity of Helicobacter pylori and may be critical for surface antigen expression and adaptation to environmental challenges within...

Microbial genome sequencing—beyond the double helix

Jenks, Peter J

Causes of failure of eradication of Helicobacter pylori : Antibiotic resistance is the major cause, and susceptibility testing may help

Jenks, Peter J