Peter J. Koch

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice (2004)

Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.

Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...

Assessment of Splice Variant-Specific Functions of Desmocollin 1 in the Skin

Cheng, Xing, Mihindukulasuriya, Kusal, Den, Zhining, Kowalczyk, Andrew P., Calkins, Cathárine, Ishiko, Akira, ...

Desmocollin 1 (Dsc1) is part of a desmosomal cell adhesion receptor formed in terminally differentiating keratinocytes of stratified epithelia. The dsc1 gene encodes two proteins (Dsc1a and Dsc1b)...

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris

Mahoney, My G., Wang, Zhihong, Rothenberger, Kyle, Koch, Peter J., Amagai, Masayuki, Stanley, John R.

Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PV...

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.

Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...

Assessment of Splice Variant-Specific Functions of Desmocollin 1 in the Skin

Cheng, Xing, Mihindukulasuriya, Kusal, Den, Zhining, Kowalczyk, Andrew P., Calkins, Cathárine, Ishiko, Akira, ...

Desmocollin 1 (Dsc1) is part of a desmosomal cell adhesion receptor formed in terminally differentiating keratinocytes of stratified epithelia. The dsc1 gene encodes two proteins (Dsc1a and Dsc1b)...

Explanations for the clinical and microscopic localization of lesions in pemphigus foliaceus and vulgaris

Mahoney, My G., Wang, Zhihong, Rothenberger, Kyle, Koch, Peter J., Amagai, Masayuki, Stanley, John R.

Patients with pemphigus foliaceus (PF) have blisters on skin, but not mucous membranes, whereas patients with pemphigus vulgaris (PV) develop blisters on mucous membranes and/or skin. PF and PV...

Epidermal detachment, desmosomal dissociation, and destabilization of corneodesmosin in Spink5-/- mice

Yang, Tao, Liang, Dongcai, Koch, Peter J., Hohl, Daniel, Kheradmand, Farrah, Overbeek, Paul A.

Netherton syndrome (NS) is a human autosomal recessive skin disease caused by mutations in the SPINK5 gene, which encodes the putative proteinase inhibitor LEKTI. We have generated a transgenic mouse...

The Localization of Bullous Pemphigoid Antigen 180 (BP180) in Hemidesmosomes Is Mediated by Its Cytoplasmic Domain and Seems to be Regulated by the β4 Integrin Subunit

Borradori, Luca, Koch, Peter J., Niessen, Carien M., Erkeland, Stefan, Leusden, Manuel R. Van, Sonnenberg, Arnoud

Bullous pemphigoid antigen 180 (BP180) is a component of hemidesmosomes, i.e., cell-substrate adhesion complexes. To determine the function of specific sequences of BP180 to its incorporation in...

Targeted Disruption of the Pemphigus Vulgaris Antigen (Desmoglein 3) Gene in Mice Causes Loss of Keratinocyte Cell Adhesion with a Phenotype Similar to Pemphigus Vulgaris

Koch, Peter J., Mahoney, M G., Ishikawa, Hiroyasu, Pulkkinen, Leena, Uitto, Jouni, Shultz, Leonard, ...

In patients with pemphigus vulgaris (PV), autoantibodies against desmoglein 3 (Dsg3) cause loss of cell–cell adhesion of keratinocytes in the basal and immediate suprabasal layers of stratified...

Transgenic Mice Expressing a Mutant Form of Loricrin Reveal the Molecular Basis of the Skin Diseases, Vohwinkel Syndrome and Progressive Symmetric Erythrokeratoderma

Suga, Yasushi, Jarnik, Michal, Attar, Paul S., Longley, Mary A., Bundman, Donnie, Steven, Alasdair C., ...

Mutations in the cornified cell envelope protein loricrin have been reported recently in some patients with Vohwinkel syndrome (VS) and progressive symmetric erythrokeratoderma (PSEK). To establish a...

Lessons from Loricrin-Deficient Mice: Compensatory Mechanisms Maintaining Skin Barrier Function in the Absence of a Major Cornified Envelope Protein

Koch, Peter J., De Viragh, Pierre A., Scharer, Elisabeth, Bundman, Donnie, Longley, Mary Ann, Bickenbach, Jackie, ...

The epidermal cornified cell envelope (CE) is a complex protein–lipid composite that replaces the plasma membrane of terminally differentiated keratinocytes. This lamellar structure is essential...

Desmosomes: Just Cell Adhesion or Is There More?

Schmidt, Ansgar, Koch, Peter J

Desmosomes are cell adhesion structures (junctions) that are particularly abundant in cells derived from the ectodermal lineages. These junctions are required to maintain the integrity of organs...