Kraemer, Susan M, Kyes, Sue A, Aggarwal, Gautam, Springer, Amy L, Nelson, Siri O, Christodoulou, Zoe, ...
Abstract Background Var genes encode a family of virulence factors known as PfEMP1 ( Plasmodium falciparum erythrocyte membrane protein 1) which are responsible for both antigenic variation and...
Glyoxalase I from Leishmania donovani: A potential target for anti-parasite drug (2005)
Padmanabhan, Prasad K, Mukherjee, Angana, Singh, Sushma, Chattopadhyaya, Swati, Gowri, Venkataraman S, Myler, Peter J, ...
Glyoxalases are involved in a ubiquitous detoxification pathway. In pursuit of a better understanding of the biological function of the enzyme. the recombinant glyoxalase I (LdGLOI) protein has been...
Glyoxalase I from Leishmania donovani: A potential target for anti-parasite drug (2005)
Padmanabhan, Prasad K, Mukherjee, Angana, Singh, Sushma, Chattopadhyaya, Swati, Gowri, Venkataraman S, Myler, Peter J, ...
Glyoxalases are involved in a ubiquitous detoxification pathway. In pursuit of a better understanding of the biological function of the enzyme. the recombinant glyoxalase I (LdGLOI) protein has been...
Aggarwal, Gautam, Worthey, EA, McDonagh, Paul D, Myler, Peter J
Abstract Background Seattle Biomedical Research Institute (SBRI) as part of the Leishmania Genome Network (LGN) is sequencing chromosomes of the trypanosomatid protozoan species Leishmania major . At...
Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes
Myler, Peter J., Audleman, Lindsey, DeVos, Theo, Hixson, Greg, Kiser, Patti, Lemley, Craig, ...
Leishmania are evolutionarily ancient protozoans (Kinetoplastidae) and important human pathogens that cause a spectrum of diseases ranging from the asymptomatic to the lethal. The Leishmania genome...
McDonagh, Paul D., Myler, Peter J., Stuart, Kenneth
The complete chromosomal sequence for chromosome 1 from Leishmania major Friedlin predicts that this chromosome has 79 protein-coding genes. Surprisingly, the first 29 of these genes are encoded in...
Allen, Thomas E., Heidmann, Stefan, Reed, RoseMary, Myler, Peter J., Göringer, H. Ulrich, Stuart, Kenneth D.
RNA editing in Trypanosoma brucei mitochondria produces mature mRNAs by a series of enzyme-catalyzed reactions that specifically insert or delete uridylates in association with a macromolecular...
Worthey, E. A., Martinez-Calvillo, Santiago, Schnaufer, Achim, Aggarwal, Gautam, Cawthra, Jason, Fazelinia, Gholam, ...
Leishmania parasites (order Kinetoplastida, family Trypanosomatidae) cause a spectrum of human diseases ranging from asymptomatic to lethal. The ∼33.6 Mb genome is distributed among 36 chromosome...
Transcription Initiation and Termination on Leishmania major Chromosome 3
Martínez-Calvillo, Santiago, Nguyen, Dan, Stuart, Kenneth, Myler, Peter J.
Genome projects involving Leishmania and other trypanosomatids have revealed that most genes in these organisms are organized into large clusters of genes on the same DNA strand. We have previously...
The Genome of the Kinetoplastid Parasite, Leishmania major
Ivens, Alasdair C., Peacock, Christopher S., Worthey, Elizabeth A., Murphy, Lee, Aggarwal, Gautam, Berriman, Matthew, ...
Leishmania major Friedlin chromosome 1 has an unusual distribution of protein-coding genes
Myler, Peter J., Audleman, Lindsey, DeVos, Theo, Hixson, Greg, Kiser, Patti, Lemley, Craig, ...
Leishmania are evolutionarily ancient protozoans (Kinetoplastidae) and important human pathogens that cause a spectrum of diseases ranging from the asymptomatic to the lethal. The Leishmania genome...
McDonagh, Paul D., Myler, Peter J., Stuart, Kenneth
The complete chromosomal sequence for chromosome 1 from Leishmania major Friedlin predicts that this chromosome has 79 protein-coding genes. Surprisingly, the first 29 of these genes are encoded in...
Allen, Thomas E., Heidmann, Stefan, Reed, RoseMary, Myler, Peter J., Göringer, H. Ulrich, Stuart, Kenneth D.
RNA editing in Trypanosoma brucei mitochondria produces mature mRNAs by a series of enzyme-catalyzed reactions that specifically insert or delete uridylates in association with a macromolecular...
Worthey, E. A., Martinez-Calvillo, Santiago, Schnaufer, Achim, Aggarwal, Gautam, Cawthra, Jason, Fazelinia, Gholam, ...
Leishmania parasites (order Kinetoplastida, family Trypanosomatidae) cause a spectrum of human diseases ranging from asymptomatic to lethal. The ∼33.6 Mb genome is distributed among 36 chromosome...
Transcription Initiation and Termination on Leishmania major Chromosome 3
Martínez-Calvillo, Santiago, Nguyen, Dan, Stuart, Kenneth, Myler, Peter J.
Genome projects involving Leishmania and other trypanosomatids have revealed that most genes in these organisms are organized into large clusters of genes on the same DNA strand. We have previously...
Kraemer, Susan M, Kyes, Sue A, Aggarwal, Gautam, Springer, Amy L, Nelson, Siri O, Christodoulou, Zoe, ...
New Trypanosoma cruzi Repeated Element That Shows Site Specificity for Insertion▿
Souza, Renata T., Santos, Márcia R. M., Lima, Fábio M., El-Sayed, Najib M., Myler, Peter J., Ruiz, Jeronimo C., ...
A new family of site-specific repeated elements identified in Trypanosoma cruzi, which we named TcTREZO, is described here. TcTREZO appears to be a composite repeated element, since three subregions...
Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major
Arakaki, Tracy, Le Trong, Isolde, Phizicky, Eric, Quartley, Erin, DeTitta, George, Luft, Joseph, ...
The crystal structure of a conserved hypothetical protein from L. major, Pfam sequence family PF04543, structural genomics target ID Lmaj006129AAA, has been determined at a resolution of 1.6 Å.
Caruthers, Jonathan, Zucker, Frank, Worthey, Elizabeth, Myler, Peter J., Buckner, Fred, Van Voorhuis, Wes, ...
We have determined the crystal structures of three homologous proteins from the pathogenic protozoans Leishmania donovani, Leishmania major, and Trypanosoma cruzi. We propose that these proteins...