Scientific Commons: Peter L. Nagy

DNA-like class R inhibitory oligonucleotides (INH-ODNs) preferentially block autoantigen-induced B-cell and dendritic cell activation in vitroand autoantibody production in lupus-prone MRL-Faslpr/lprmice in vivo (2009)

Lenert, Petar, Yasuda, Kei, Busconi, Liliana, Nelson, Patrice, Fleenor, Courtney, Ratnabalasuriar, Radhika S, ...

Abstract Introduction B cells have many different roles in systemic lupus erythematosus (SLE), ranging from autoantigen recognition and processing to effector functions (for example, autoantibody and...

A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3

Nagy, Peter L., Griesenbeck, Joachim, Kornberg, Roger D., Cleary, Michael L.

Histone methylation has emerged as an important mechanism for regulating the transcriptional accessibility of chromatin. Several methyltransferases have been shown to target histone amino-terminal...

Male infertility, impaired spermatogenesis, and azoospermia in mice deficient for the pseudophosphatase Sbf1

Firestein, Ron, Nagy, Peter L., Daly, Megan, Huie, Phil, Conti, Marco, Cleary, Michael L.

Pseudophosphatases display extensive sequence similarities to phosphatases but harbor amino acid alterations in their active-site consensus motifs that render them catalytically inactive. A potential...

Genomewide demarcation of RNA polymerase II transcription units revealed by physical fractionation of chromatin

Nagy, Peter L., Cleary, Michael L., Brown, Patrick O., Lieb, Jason D.

Epigenetic modifications of chromatin serve an important role in regulating the expression and accessibility of genomic DNA. We report here a genomewide approach for fractionating yeast chromatin...