Peter Lauer

Short-term genome evolution of Listeria monocytogenesin a non-controlled environment (2008)

Orsi, Renato H, Borowsky, Mark L, Lauer, Peter, Young, Sarah K, Nusbaum, Chad, Galagan, James E, ...

Abstract Background While increasing data on bacterial evolution in controlled environments are available, our understanding of bacterial genome evolution in natural environments is limited. We thus...

Short-term genome evolution of Listeria monocytogenes in a non-controlled environment (2008)

Orsi, Renato H., Borowsky, Mark L., Lauer, Peter, Young, Sarah K., Nusbaum, Chad, Galagan, James E., ...

Background: While increasing data on bacterial evolution in controlled environments are available, our understanding of bacterial genome evolution in natural environments is limited. We thus...

Experimental studies on particle emissions from cruising ship, their characteristic properties, transformation and atmospheric lifetime in the marine boundary layer (2008)

Petzold, Andreas, Hasselbach, Jan, Lauer, Peter, Baumann, Robert, Franke, Klaus, Gurk, Christian, ...

Particle emissions from ship engines and their atmospheric transformation in the marine boundary layer (MBL) were investigated in engine test bed studies and in airborne measurements of expanding...

Particle Emissions from Ship Engines: Emission Properties and Transformation in the Marine Boundary Layer (2007)

Petzold, Andreas, Weinzierl, Bernadett, Fiebig, Markus, Lichtenstern, Michael, Lauer, Peter, Gurk, Christian, ...

In the framework of a combined effort ship emission studies were conducted in 2004. Detailed aerosol microphysics and chemistry was measured in the raw exhaust gas of a single-cylinder test bed...

Particle Emissions from Ship Engines: Emission Properties and Transformation in the Marine Boundary Layer (2006)

Petzold, Andreas, Weinzierl, Bernadett, Feibig, Markus, Lichtenstern, Michael, Lauer, Peter, Gurk, Christian, ...

In the framework of a combined effort ship emission studies were conducted in 2004 as part of the European Integrated Project HERCULES . Detailed aerosol microphysics and chemistry was measured in...

Construction and validation of yeast artificial chromosome contig maps by RecA-assisted restriction endonuclease cleavage

Lauer, Peter, Schneider, Sandra S., Gnirke, Andreas

RecA-assisted restriction endonuclease (RARE) cleavage is an “Achilles’ heel” approach to restriction mapping whereby a RecA-protein–oligodeoxynucleotide complex protects an individual...

Construction, Characterization, and Use of Two Listeria monocytogenes Site-Specific Phage Integration Vectors

Lauer, Peter, Chow, Man Yin Nora, Loessner, Martin J., Portnoy, Daniel A., Calendar, Richard

Two site-specific shuttle integration vectors were developed with two different chromosomal bacteriophage integration sites to facilitate strain construction in Listeria monocytogenes. The first...

Construction and validation of yeast artificial chromosome contig maps by RecA-assisted restriction endonuclease cleavage

Lauer, Peter, Schneider, Sandra S., Gnirke, Andreas

RecA-assisted restriction endonuclease (RARE) cleavage is an “Achilles’ heel” approach to restriction mapping whereby a RecA-protein–oligodeoxynucleotide complex protects an individual...

Construction, Characterization, and Use of Two Listeria monocytogenes Site-Specific Phage Integration Vectors

Lauer, Peter, Chow, Man Yin Nora, Loessner, Martin J., Portnoy, Daniel A., Calendar, Richard

Two site-specific shuttle integration vectors were developed with two different chromosomal bacteriophage integration sites to facilitate strain construction in Listeria monocytogenes. The first...

Constitutive Activation of the PrfA Regulon Enhances the Potency of Vaccines Based on Live-Attenuated and Killed but Metabolically Active Listeria monocytogenes Strains▿

Lauer, Peter, Hanson, Bill, Lemmens, Edward E., Liu, Weiqun, Luckett, William S., Leong, Meredith L., ...

Recombinant vaccines derived from the facultative intracellular bacterium Listeria monocytogenes are presently undergoing early-stage clinical evaluation in oncology treatment settings. This effort...

KBMA Listeria monocytogenes is an effective vector for DC-mediated induction of antitumor immunity

Skoberne, Mojca, Yewdall, Alice, Bahjat, Keith S., Godefroy, Emmanuelle, Lauer, Peter, Lemmens, Edward, ...

Vaccine strategies that utilize human DCs to enhance antitumor immunity have yet to realize their full potential. Approaches that optimally target a spectrum of antigens to DCs are urgently needed....

Listeria monocytogenes multidrug resistance transporters activate a cytosolic surveillance pathway of innate immunity

Crimmins, Gregory T., Herskovits, Anat A., Rehder, Kai, Sivick, Kelsey E., Lauer, Peter, Dubensky, Thomas W., ...

To gain insight into the interaction of intracellular pathogens with host innate immune pathways, we performed an unbiased genetic screen of Listeria monocytogenes mutants that induced an enhanced or...

Memory CD8 T cell responses exceeding a large but definable threshold provide long-term immunity to malaria

Schmidt, Nathan W., Podyminogin, Rebecca L., Butler, Noah S., Badovinac, Vladimir P., Tucker, Brad J., Bahjat, Keith S., ...

Infection of mice with sporozoites of Plasmodium berghei or Plasmodium yoelii has been used extensively to evaluate liver-stage protection by candidate preerythrocytic malaria vaccines....