Peter M. Hwang

Solution structures of the cytoplasmic tail complex from platelet integrin αIIb- and β3-subunits

Weljie, Aalim M., Hwang, Peter M., Vogel, Hans J.

Integrin adhesion receptors constitute a cell-signaling system whereby interactions in the small cytoplasmic domains of the heterodimeric α- and β-subunits provoke major functional alterations in...

A ‘three-pronged’ binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

Hwang, Peter M., Li, Chengjun, Morra, Massimo, Lillywhite, Jennifer, Muhandiram, D.Ranjith, Gertler, Frank, ...

The SH2 domain protein SAP/SH2D1A, encoded by the X-linked lymphoproliferative (XLP) syndrome gene, associates with the hematopoietic cell surface receptor SLAM in a phosphorylation-independent...

Solution structure and dynamics of the outer membrane enzyme PagP by NMR

Hwang, Peter M., Choy, Wing-Yiu, Lo, Eileen I., Chen, Lu, Forman-Kay, Julie D., Raetz, Christian R. H., ...

The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic...

The integral membrane enzyme PagP alternates between two dynamically distinct states

Hwang, Peter M., Bishop, Russell E., Kay, Lewis E.

PhoPQ-activated gene P (PagP) is an integral membrane enzyme that transfers the sn-1 palmitate chain from phospholipid to lipopolysaccharide in Gram-negative bacteria. A recent x-ray crystallographic...

A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin

Ahn, Victoria E, Lo, Eileen I, Engel, Christian K, Chen, Lu, Hwang, Peter M, Kay, Lewis E, ...

The ability of enzymes to distinguish between fatty acyl groups can involve molecular measuring devices termed hydrocarbon rulers, but the molecular basis for acyl-chain recognition in any...

Quantitative NMR spectroscopy of supramolecular complexes: Dynamic side pores in ClpP are important for product release

Sprangers, Remco, Gribun, Anna, Hwang, Peter M., Houry, Walid A., Kay, Lewis E.

The highly conserved, 300-kDa cylindrical protease ClpP is an important component of the cellular protein quality machinery. It consists of 14 subunits arranged into two heptameric rings that enclose...

Solution structures of the cytoplasmic tail complex from platelet integrin αIIb- and β3-subunits

Weljie, Aalim M., Hwang, Peter M., Vogel, Hans J.

Integrin adhesion receptors constitute a cell-signaling system whereby interactions in the small cytoplasmic domains of the heterodimeric α- and β-subunits provoke major functional alterations in...

A ‘three-pronged’ binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome

Hwang, Peter M., Li, Chengjun, Morra, Massimo, Lillywhite, Jennifer, Muhandiram, D.Ranjith, Gertler, Frank, ...

The SH2 domain protein SAP/SH2D1A, encoded by the X-linked lymphoproliferative (XLP) syndrome gene, associates with the hematopoietic cell surface receptor SLAM in a phosphorylation-independent...

Solution structure and dynamics of the outer membrane enzyme PagP by NMR

Hwang, Peter M., Choy, Wing-Yiu, Lo, Eileen I., Chen, Lu, Forman-Kay, Julie D., Raetz, Christian R. H., ...

The bacterial outer membrane enzyme PagP transfers a palmitate chain from a phospholipid to lipid A. In a number of pathogenic Gram-negative bacteria, PagP confers resistance to certain cationic...

The integral membrane enzyme PagP alternates between two dynamically distinct states

Hwang, Peter M., Bishop, Russell E., Kay, Lewis E.

PhoPQ-activated gene P (PagP) is an integral membrane enzyme that transfers the sn-1 palmitate chain from phospholipid to lipopolysaccharide in Gram-negative bacteria. A recent x-ray crystallographic...

A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin

Ahn, Victoria E, Lo, Eileen I, Engel, Christian K, Chen, Lu, Hwang, Peter M, Kay, Lewis E, ...

The ability of enzymes to distinguish between fatty acyl groups can involve molecular measuring devices termed hydrocarbon rulers, but the molecular basis for acyl-chain recognition in any...

Quantitative NMR spectroscopy of supramolecular complexes: Dynamic side pores in ClpP are important for product release

Sprangers, Remco, Gribun, Anna, Hwang, Peter M., Houry, Walid A., Kay, Lewis E.

The highly conserved, 300-kDa cylindrical protease ClpP is an important component of the cellular protein quality machinery. It consists of 14 subunits arranged into two heptameric rings that enclose...