Peter McPhie

Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance (2004)

Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann

Abstract Background Resistance to thyroid hormone (RTH) is caused by mutations of the thyroid hormone receptor β (TRβ) gene. To understand the transcriptional program underlying TRβ mutant-induced...

The Orphan Nuclear Receptor Ear-2 Is a Negative Coregulator for Thyroid Hormone Nuclear Receptor Function

Zhu, Xu-guang, Park, Kyung Soo, Kaneshige, Masahiro, Bhat, Manoj K., Zhu, Qihong, Mariash, Cary N., ...

Thyroid hormone (T3) nuclear receptors (TR) are ligand-dependent transcription factors which regulate growth, differentiation, and development. One emerging hypothesis suggests that TR mediate these...

Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance

Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann

Gene-expression analysis in cerebellum, heart and white adipose tissue from a knock-in mouse that harbors a human mutation and faithfully reproduces human resistance to thyroid hormone, uncovered...

Stable Secondary Structure near the Nicking Site for Adeno-Associated Virus Type 2 Rep Proteins on Human Chromosome 19

Jang, Ming Y., Yarborough, OrLando H., Conyers, Gary B., McPhie, Peter, Owens, Roland A.

Adeno-associated virus serotype 2 (AAV-2) can preferentially integrate its DNA into a 4-kb region of human chromosome 19, designated AAVS1. The nicking activity of AAV-2's Rep68 or Rep78 proteins is...

Thiol–disulphide interchange in tubulin: kinetics and the effect on polymerization

Britto, P. J., Knipling, Leslie, Mcphie, Peter, Wolff, J.

All 20 cysteine residues are accessible to disulphide reagents in the tubulin dimer, whereas only four are accessible in taxol-stabilized microtubules. Reaction rates with disulphide reagents are a...

The Orphan Nuclear Receptor Ear-2 Is a Negative Coregulator for Thyroid Hormone Nuclear Receptor Function

Zhu, Xu-guang, Park, Kyung Soo, Kaneshige, Masahiro, Bhat, Manoj K., Zhu, Qihong, Mariash, Cary N., ...

Thyroid hormone (T3) nuclear receptors (TR) are ligand-dependent transcription factors which regulate growth, differentiation, and development. One emerging hypothesis suggests that TR mediate these...

Multi-tissue gene-expression analysis in a mouse model of thyroid hormone resistance

Miller, Lance D, McPhie, Peter, Suzuki, Hideyo, Kato, Yasuhito, Liu, Edison T, Cheng, Sheue-yann

Gene-expression analysis in cerebellum, heart and white adipose tissue from a knock-in mouse that harbors a human mutation and faithfully reproduces human resistance to thyroid hormone, uncovered...

Stable Secondary Structure near the Nicking Site for Adeno-Associated Virus Type 2 Rep Proteins on Human Chromosome 19

Jang, Ming Y., Yarborough, OrLando H., Conyers, Gary B., McPhie, Peter, Owens, Roland A.

Adeno-associated virus serotype 2 (AAV-2) can preferentially integrate its DNA into a 4-kb region of human chromosome 19, designated AAVS1. The nicking activity of AAV-2's Rep68 or Rep78 proteins is...

Thiol–disulphide interchange in tubulin: kinetics and the effect on polymerization

Britto, P. J., Knipling, Leslie, Mcphie, Peter, Wolff, J.

All 20 cysteine residues are accessible to disulphide reagents in the tubulin dimer, whereas only four are accessible in taxol-stabilized microtubules. Reaction rates with disulphide reagents are a...