Modeling Developmental Transitions in Adaptive Resonance Theory: Maartje Raijmakers and (2008)
Matthew Schlesinger, Domenico Parisi, Hebbian Learning, Development Yuko Munakata, Jason Pfaffly, Peter Molenaar
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
The low-affinity site of the β1-adrenoceptor and its relevance to cardiovascular pharmacology (2008)
Kaumann, Alberto J., Molenaar, Peter
β-Adrenoceptor blocking agents (β-blockers) that at low concentrations antagonize cardiostimulant effects of catecholamines, but at high concentrations also cause cardiostimulation, have been...
Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart (2006)
Molenaar, Peter, Christ, Torsten, Ravens, Ursula, Kaumann, Alberto
Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart and beta(2)-adrenoceptors. Methods: The positive inotropic...
Molenaar, Peter, Chen, Lu, Parsonage, William A.
There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that...
Carvedilol blocks beta(2)- more than beta(1)-adrenoceptors in human heart (2006)
Molenaar, Peter, Christ, Torsten, Ravens, Ursula, Kaumann, Alberto
Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart and beta(2)-adrenoceptors. Methods: The positive inotropic...
Molenaar, Peter, Chen, Lu, Parsonage, William A.
There are proposals for the implementation of beta(2)-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that...
Carvedilol blocks {beta}2- more than {beta}1-adrenoceptors in human heart (2006)
Molenaar, Peter, Christ, Torsten, Ravens, Ursula, Kaumann, Alberto
Objective: To understand the basis of the effectiveness of carvedilol in heart failure by determining its specific properties at human heart β1- and β2-adrenoceptors. Methods: The positive...
Russell, Fraser D, Molenaar, Peter
Objective: This study investigated signaling pathways that may contribute to the potent positive inotropic effect of human urotensin-II (hU-II) in human isolated right atrial trabeculae obtained from...
Sarsero, Doreen, Russell, Fraser D., Lynham, James A., Rabnott, Glenn, Yang, Ian, Fong, Kwun M., ...
Two forms of the activated beta(1)-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists...
Sarsero, Doreen, Russell, Fraser D., Lynham, James A., Rabnott, Glenn, Yang, Ian, Fong, Kwun M., ...
Two forms of the activated beta(1)-adrenoceptor exist, one that is stabilized by (-)-noradrenaline and is sensitive to blockade by (-)-propranolol and another which is stabilized by partial agonists...
Typescript (photocopy) Errata leaf inserted. Bibliography: leaves 134-156.
Studies on the affinity and efficacy of compounds acting at β-Adrenoceptor sites (1985)
Addendum end lining page. Bibliography: leaves 222-245.
Martínez-Martínez, Pilar, Losen, Mario, Duimel, Hans, Frederik, Peter, Spaans, Frank, Molenaar, Peter, ...
The primary autoantigen in myasthenia gravis, the acetylcholine receptor (AChR), is clustered and anchored in the postsynaptic membrane of the neuromuscular junction by rapsyn. Previously, we found...
Molenaar, Peter, Sarsero, Doreen, Arch, Jonathan R S, Kelly, John, Henson, Sian M, Kaumann, Alberto J
Chronic treatment of patients with β-blockers causes atrial inotropic hyperresponsiveness through β2-adrenoceptors, 5-HT4 receptors and H2-receptors but apparently not through β1-adrenoceptors...
Validity of (−)-[3H]-CGP 12177A as a radioligand for the ‘putative β4-adrenoceptor' in rat atrium
Sarsero, Doreen, Molenaar, Peter, Kaumann, Alberto J
We have recently suggested the existence in the heart of a ‘putative β4-adrenoceptor' based on the cardiostimulant effects of non-conventional partial agonists, compounds that cause...
Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists
Sarsero, Doreen, Fujiwara, Toshimasa, Molenaar, Peter, Angus, James A
Voltage-operated calcium channel (VOCC) antagonists are effective antihypertensive and antianginal agents but they also depress myocardial contractility.We compared four L-type calcium channel...
Sarsero, Doreen, Molenaar, Peter, Kaumann, Alberto J, Freestone, Nicholas S
We identified putative β4-adrenoceptors by radioligand binding, measured increases in ventricular contractile force by (−)-CGP 12177 and (±)-cyanopindolol and demonstrated increased Ca2+...
Oostendorp, Jaap, Preitner, Frédéric, Moffatt, James, Jimenez, Maria, Giacobino, Jean Paul, Molenaar, Peter, ...
The smooth muscle relaxant responses to the mixed β3-, putative β4-adrenoceptor agonist, (−)-CGP 12177 in rat colon are partially resistant to blockade by the β3-adrenoceptor antagonist SR59230A...
Cardiostimulant effects of urotensin-II in human heart in vitro
Russell, Fraser D, Molenaar, Peter, O'Brien, Donalee M
The effects of the recently identified human peptide urotensin-II (hU-II) were investigated on human cardiac muscle contractility and coronary artery tone. In right atrial trabeculae from non-failing...
Heubach, Jürgen F, Graf, Eva M, Molenaar, Peter, Jäger, Andreas, Schröder, Frank, Herzig, Stefan, ...
The functional coupling of β2-adrenoceptors (β2-ARs) to murine L-type Ca2+ current (ICa(L)) was investigated with two different approaches. The β2-AR signalling cascade was activated either with...
Li, Joan, Wang, Jianchun, Russell, Fraser D, Molenaar, Peter
The calcineurin (CaN) enzyme–transcriptional pathway is critically involved in hypertrophy of heart muscle in some animal models. Currently there is no information concerning the regulation of CaN...
Cardiac implications for the use of β2-adrenoceptor agonists for the management of muscle wasting
Molenaar, Peter, Chen, Lu, Parsonage, William A
There are proposals for the implementation of β2-adrenoceptor agonists for the management of muscle wasting diseases. The idea has been initiated by studies in animal models which show that...
Comment on fitting MA time series by structural equation models
lagged variables, moving-averages, stationarity, invertibility, polynomial factorization, dynamic factor analysis,
Optimal measurement conditions for spatiotemporal eeg/meg source analysis
Hilde Huizenga, Dirk Heslenfeld, Peter Molenaar
spatiotemporal EEG/MEG source analysis, multiresponse nonlinear regression, optimal design, Fedorov exchange,
Dynamic factor analysis of nonstationary multivariate time series
Peter Molenaar, Jan Gooijer, Bernhard Schmitz
AIC, dynamic factor analysis, Kalman filter, Markovian state-space model, nonstationarity, SBIC,
Rotation in the dynamic factor modeling of multivariate stationary time series
Peter Molenaar, John Nesselroade
dynamic factor model, identifiability, polynomial division, moving-average, rotation criteria,
Martinez-Martinez, Pilar, Phemambucq, Marko, Steinbusch, Laura, Schaeffer, Laurent, Berrih-Aknin, Sonia, Duimel, Hans, ...
The receptor-associated protein of the synapse (rapsyn) is required for anchoring and stabilizing the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane of the neuromuscular...
Martinez-Martinez, Pilar, Phemambucq, Marko, Steinbusch, Laura, Schaeffer, Laurent, Berrih-Aknin, Sonia, Duimel, Hans, ...
The receptor-associated protein of the synapse (rapsyn) is required for anchoring and stabilizing the nicotinic acetylcholine receptor (AChR) in the postsynaptic membrane of the neuromuscular...