Peter Olson

Geomagnetic dipole moment collapse by convective mixing in the core (2009)

Liu, Lijun, Olson, Peter

Convective mixing in the fluid outer core can induce rapid transient decrease of the geomagnetic dipole. Here we determine rates of dipole moment decrease as a function of magnetic Reynolds number...

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer (2009)

Olson, Peter, Lu, Jun, Zhang, Hao, Shai, Anny, Chun, Matthew G., Wang, Yucheng, ...

While altered expression of microRNAs (miRs) in tumors has been well documented, it remains unclear how the miR transcriptome intersects neoplastic progression. By profiling the miR transcriptome we...

Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer (2006)

Bardeesy, Nabeel, Cheng, Kuang-hung, Berger, Justin H., Chu, Gerald C., Pahler, Jessica, Olson, Peter, ...

SMAD4 is inactivated in the majority of pancreatic ductal adenocarcinomas (PDAC) with concurrent mutational inactivation of the INK4A/ARF tumor suppressor locus and activation of the KRAS oncogene....

PPAR{gamma} signaling exacerbates mammary gland tumor development (2004)

Saez, Enrique, Rosenfeld, John, Livolsi, Antonia, Olson, Peter, Lombardo, Eleuterio, Nelson, Michael, ...

Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor γ (PPARγ) can be prompted to undergo growth arrest and differentiation when treated with synthetic...

A cytosine analog that confers enhanced potency to antisense oligonucleotides

Flanagan, W. Michael, Wolf, John J., Olson, Peter, Grant, Debbie, Lin, Kuei-Ying, Wagner, Richard W., ...

Antisense technology is based on the ability to design potent, sequence-specific inhibitors. The G-clamp heterocycle modification, a cytosine analog that clamps on to guanine by forming an additional...

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

He, Weimin, Barak, Yaacov, Hevener, Andrea, Olson, Peter, Liao, Debbie, Le, Jamie, ...

Syndrome X, typified by obesity, insulin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic thiazolidinediones (TZDs). Peroxisome proliferator-activated...

PPARγ signaling exacerbates mammary gland tumor development

Saez, Enrique, Rosenfeld, John, Livolsi, Antonia, Olson, Peter, Lombardo, Eleuterio, Nelson, Michael, ...

Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor γ (PPARγ) can be prompted to undergo growth arrest and differentiation when treated with synthetic...

PPARδ regulates glucose metabolism and insulin sensitivity

Lee, Chih-Hao, Olson, Peter, Hevener, Andrea, Mehl, Isaac, Chong, Ling-Wa, Olefsky, Jerrold M., ...

The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in response to fatty acids and, as such, are...

A cytosine analog that confers enhanced potency to antisense oligonucleotides

Flanagan, W. Michael, Wolf, John J., Olson, Peter, Grant, Debbie, Lin, Kuei-Ying, Wagner, Richard W., ...

Antisense technology is based on the ability to design potent, sequence-specific inhibitors. The G-clamp heterocycle modification, a cytosine analog that clamps on to guanine by forming an additional...

Adipose-specific peroxisome proliferator-activated receptor γ knockout causes insulin resistance in fat and liver but not in muscle

He, Weimin, Barak, Yaacov, Hevener, Andrea, Olson, Peter, Liao, Debbie, Le, Jamie, ...

Syndrome X, typified by obesity, insulin resistance (IR), dyslipidemia, and other metabolic abnormalities, is responsive to antidiabetic thiazolidinediones (TZDs). Peroxisome proliferator-activated...

PPARγ signaling exacerbates mammary gland tumor development

Saez, Enrique, Rosenfeld, John, Livolsi, Antonia, Olson, Peter, Lombardo, Eleuterio, Nelson, Michael, ...

Breast cancer cell lines that express the nuclear peroxisome proliferator-activated receptor γ (PPARγ) can be prompted to undergo growth arrest and differentiation when treated with synthetic...

PPARδ regulates glucose metabolism and insulin sensitivity

Lee, Chih-Hao, Olson, Peter, Hevener, Andrea, Mehl, Isaac, Chong, Ling-Wa, Olefsky, Jerrold M., ...

The metabolic syndrome is a collection of obesity-related disorders. The peroxisome proliferator-activated receptors (PPARs) regulate transcription in response to fatty acids and, as such, are...

PPARδ regulates multiple proinflammatory pathways to suppress atherosclerosis

Barish, Grant D., Atkins, Annette R., Downes, Michael, Olson, Peter, Chong, Ling-Wa, Nelson, Mike, ...

Lipid homeostasis and inflammation are key determinants in atherogenesis, exemplified by the requirement of lipid-laden, foam cell macrophages for atherosclerotic lesion formation. Although the...

MicroRNA dynamics in the stages of tumorigenesis correlate with hallmark capabilities of cancer

Olson, Peter, Lu, Jun, Zhang, Hao, Shai, Anny, Chun, Matthew G., Wang, Yucheng, ...

While altered expression of microRNAs (miRs) in tumors has been well documented, it remains unclear how the miR transcriptome intersects neoplastic progression. By profiling the miR transcriptome we...