Peter Schirmacher

Arterial calcification in patients with chronic kidney disease (2009)

Koleganova, Nadezda, Piecha, Grzegorz, Ritz, Eberhard, Schirmacher, Peter, Müller, Annett, Meyer, Hans-Peter, ...

Objective. In patients with chronic kidney disease (CKD), aortic calcification is more frequent and severe and it is also predictive of adverse cardiovascular outcome. The aim of the present study...

Cross-species comparison of biological themes and underlying genes on a global gene expression scale in a mouse model of colorectal liver metastasis and in clinical specimens (2008)

Bandapalli, Obul, Kahlert, Christoph, Hellstern, Victoria, Galindo, Luis, Schirmacher, Peter, Weitz, Jürgen, ...

Abstract Background Invasion-related genes over-expressed by tumor cells as well as by reacting host cells represent promising drug targets for anti-cancer therapy. Such candidate genes need to be...

Ampullary adenocarcinoma – differentiation matters (2008)

Schirmacher, Peter, Büchler, Markus W

Abstract The periampullary region gives rise to two main subtypes of adenocarcinoma that show either pancreatobiliary or intestinal differentiation. New data demonstrates that the histological...

DMBT1 confers mucosal protection in vivo and a deletion variant is associated with Crohn's disease (2007)

Renner, Marcus, Bergmann, Gaby, Krebs, Inge, End, Caroline, Lyer, Stefan, Hilberg, Frank, ...

BACKGROUND & AIMS: Impaired mucosal defense plays an important role in the pathogenesis of Crohn's disease (CD), one of the main subtypes of inflammatory bowel disease (IBD). Deleted in malignant...

Pancreatic metastasis from gastric carcinoma: a case report (2004)

Wente, Moritz N, Bergmann, Frank, Fröhlich, Boris E, Schirmacher, Peter, Büchler, Markus W, Friess, Helmut

Abstract Background The pancreas is a rare but occasionally favored target for metastasis. Metastatic lesions in the pancreas have been described for various primary cancers, such as carcinomas of...

Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice (2004)

Kern, Michael André, Schöneweiß, Mirja Mareike, Sahi, Dina, Bahlo, Maryam, Haugg, Anke Maria, Kasper, Hans Udo, ...

Cyclooxygenase (COX)-2 is expressed in hepatocellular carcinomas (HCCs) and HCC cell lines. COX-2 inhibition strongly suppresses growth of HCC cells in vitro by inducing apoptosis and reducing...

Cyclooxygenase-2 inhibitors suppress the growth of human hepatocellular carcinoma implants in nude mice (2004)

Kern, Michael André, Schöneweiß, Mirja Mareike, Sahi, Dina, Bahlo, Maryam, Haugg, Anke Maria, Kasper, Hans Udo, ...

Cyclooxygenase (COX)-2 is expressed in hepatocellular carcinomas (HCCs) and HCC cell lines. COX-2 inhibition strongly suppresses growth of HCC cells in vitro by inducing apoptosis and reducing...

Expression and localization of scatter factor/hepatocyte growth factor in human astrocytomas (2001)

Kunkel, Philip, Müller, Sabine, Schirmacher, Peter, Stavrou, Dimitrios, Fillbrandt, Regina, Westphal, Manfred, ...

Scatter factor/hepatocyte growth factor (SF/HGF) is a pleiotropic cytokine that has been implicated in glioma invasion and angiogenesis. The SF/HGF receptor, MET, has been found to be expressed in...

Tumor-Suppressor Function of SPARC-Like Protein 1/Hevin in Pancreatic Cancer

Esposito, Irene, Kayed, Hany, Keleg, Shereen, Giese, Thomas, Helene Sage, E., Schirmacher, Peter, ...

SPARC-like protein 1 (SPARCL1), a member of the SPARC family, is downregulated in various tumors. In the present study, the expression and localization of SPARCL1 were analyzed in a wide range of...

Hepatocellular Hyperplasia, Plasmacytoma Formation, and Extramedullary Hematopoiesis in Interleukin (IL)-6/Soluble IL-6 Receptor Double-Transgenic Mice

Schirmacher, Peter, Peters, Malte, Ciliberto, Gennaro, Blessing, Manfred, Lotz, Johannes, Meyer Zum Büschenfelde, Karl-Hermann, ...

Cytokines interact not only with membrane anchored receptors, but also with specific soluble receptors which circulate in the bloodstream. In general, soluble cytokine receptors such as soluble tumor...

Frequency and diagnostic patterns of lymphomas in liver biopsies with respect to the WHO classification

Loddenkemper, Christoph, Longerich, Thomas, Hummel, Michael, Ernestus, Karen, Anagnostopoulos, Ioannis, Dienes, Hans-Peter, ...

The recent World Health Organization (WHO) classification of hematopoietic and lymphoid tissue tumors represents the first worldwide consensus classification of these malignancies. However, the...

Extramedullary Expansion of Hematopoietic Progenitor Cells in Interleukin (IL)-6–sIL-6R Double Transgenic Mice

Peters, Malte, Schirmacher, Peter, Goldschmitt, Jutta, Odenthal, Margarete, Peschel, Christian, Fattori, Elena, ...

Soluble cytokine receptors modulate the activity of their cognate ligands. Interleukin (IL)-6 in association with the soluble IL-6 receptor (sIL-6R) can activate cells expressing the gp130 signal...

MMP19 Is Essential for T Cell Development and T Cell-Mediated Cutaneous Immune Responses

Beck, Inken M., Rückert, René, Brandt, Katja, Mueller, Markus S., Sadowski, Thorsten, Brauer, Rena, ...

Matrix metalloproteinase-19 (MMP19) affects cell proliferation, adhesion, and migration in vitro but its physiological role in vivo is poorly understood. To determine the function of MMP19, we...

Hepatic NF-κB essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis

Wunderlich, F. Thomas, Luedde, Tom, Singer, Stephan, Schmidt-Supprian, Marc, Baumgartl, Julia, Schirmacher, Peter, ...

Development of obesity-associated insulin resistance and diabetes mellitus type 2 has been linked to activation of proinflammatory pathways in the liver, leading to impaired insulin signal...

Ampullary adenocarcinoma – differentiation matters

Schirmacher, Peter, Büchler, Markus W

The periampullary region gives rise to two main subtypes of adenocarcinoma that show either pancreatobiliary or intestinal differentiation. New data demonstrates that the histological subtype –...

Reactivation of the insulin-like growth factor-II signaling pathway in human hepatocellular carcinoma

Breuhahn, Kai, Schirmacher, Peter

Constitutive activation of the insulin-like growth factor (IGF)-signaling axis is frequently observed in human hepatocellular carcinoma (HCC). Especially the overexpression of the fetal growth factor...

Chromosomal instability is more frequent in metastasized than in non-metastasized pulmonary carcinoids but is not a reliable predictor of metastatic potential

Warth, Arne, Herpel, Esther, Krysa, Sabine, Hoffmann, Hans, Schnabel, Philipp A., Schirmacher, Peter, ...

Pulmonary carcinoids are infrequent neoplasms of the lung that normally display a less aggressive biological behavior compared to small cell and non-small cell lung cancers. Approximately 15-25% of...