Peter Schu

Binding partners for the COOH-Terminal appendage domains of the GGAs and gamma-adaptin (2003)

Lui, Winnie W. Y., Collins, Brett M., Hirst, Jennifer, Motley, Alison, Millar, Caroline, Schu, Peter, ...

The adaptor appendage domains are believed to act as binding platforms for coated vesicle accessory proteins. Using glutathione S-transferase pulldowns from pig brain cytosol, we find three proteins...

Binding partners for the COOH-Terminal appendage domains of the GGAs and gamma-adaptin (2003)

Lui, Winnie W. Y., Collins, Brett M., Hirst, Jennifer, Motley, Alison, Millar, Caroline, Schu, Peter, ...

The adaptor appendage domains are believed to act as binding platforms for coated vesicle accessory proteins. Using glutathione S-transferase pulldowns from pig brain cytosol, we find three proteins...

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Saftig, Paul, Hunziker, Ernst, Wehmeyer, Olaf, Jones, Sheila, Boyde, Alan, Rommerskirch, Winfried, ...

Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a vital role in the resorption and remodeling of bone. Pycnodysostosis...

Rabaptin-5α/rabaptin-4 serves as a linker between rab4 and γ1-adaptin in membrane recycling from endosomes

Deneka, Magdalena, Neeft, Maaike, Popa, Ioana, Van Oort, Masja, Sprong, Hein, Oorschot, Viola, ...

Rab4 regulates recycling from early endosomes. We investigated the role of the rab4 effector rabaptin-5α and its putative partner γ1-adaptin in membrane recycling. We found that rabaptin-5α forms...

Binding Partners for the COOH-Terminal Appendage Domains of the GGAs and γ-Adaptin

Lui, Winnie W.Y., Collins, Brett M., Hirst, Jennifer, Motley, Alison, Millar, Caroline, Schu, Peter, ...

The adaptor appendage domains are believed to act as binding platforms for coated vesicle accessory proteins. Using glutathione S-transferase pulldowns from pig brain cytosol, we find three proteins...

µ1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors

Meyer, Christoph, Zizioli, Daniela, Lausmann, Susanne, Eskelinen, Eeva-Liisa, Hamann, Jens, Saftig, Paul, ...

The heterotetrameric AP-1 complex is involved in the formation of clathrin-coated vesicles at the trans-Golgi network (TGN) and interacts with sorting signals in the cytoplasmic tails of cargo...

γ-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking

Neubrand, Veronika E, Will, Rainer D, Möbius, Wiebke, Poustka, Annemarie, Wiemann, Stefan, Schu, Peter, ...

A novel peripheral membrane protein (2c18) that interacts directly with the gamma ‘ear' domain of the adaptor protein complex 1 (AP-1) in vitro and in vivo is described. Ultrastructural analysis...

The polarized epithelia-specific µ1B-adaptin complements µ1A-deficiency in fibroblasts

Eskelinen, Eeva-Liisa, Meyer, Christoph, Ohno, Hiroshi, Von Figura, Kurt, Schu, Peter

The heterotetrameric AP-1A adaptor complex of clathrin-coated vesicles is ubiquitously expressed. The µ1-adaptin subunit of the complex exists as the ubiquitous µ1A and the polarized...

Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice

Saftig, Paul, Hunziker, Ernst, Wehmeyer, Olaf, Jones, Sheila, Boyde, Alan, Rommerskirch, Winfried, ...

Cathepsin K is a recently identified lysosomal cysteine proteinase. It is abundant in osteoclasts, where it is believed to play a vital role in the resorption and remodeling of bone. Pycnodysostosis...

Rabaptin-5α/rabaptin-4 serves as a linker between rab4 and γ1-adaptin in membrane recycling from endosomes

Deneka, Magdalena, Neeft, Maaike, Popa, Ioana, Van Oort, Masja, Sprong, Hein, Oorschot, Viola, ...

Rab4 regulates recycling from early endosomes. We investigated the role of the rab4 effector rabaptin-5α and its putative partner γ1-adaptin in membrane recycling. We found that rabaptin-5α forms...

Binding Partners for the COOH-Terminal Appendage Domains of the GGAs and γ-Adaptin

Lui, Winnie W.Y., Collins, Brett M., Hirst, Jennifer, Motley, Alison, Millar, Caroline, Schu, Peter, ...

The adaptor appendage domains are believed to act as binding platforms for coated vesicle accessory proteins. Using glutathione S-transferase pulldowns from pig brain cytosol, we find three proteins...

µ1A-adaptin-deficient mice: lethality, loss of AP-1 binding and rerouting of mannose 6-phosphate receptors

Meyer, Christoph, Zizioli, Daniela, Lausmann, Susanne, Eskelinen, Eeva-Liisa, Hamann, Jens, Saftig, Paul, ...

The heterotetrameric AP-1 complex is involved in the formation of clathrin-coated vesicles at the trans-Golgi network (TGN) and interacts with sorting signals in the cytoplasmic tails of cargo...

γ-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking

Neubrand, Veronika E, Will, Rainer D, Möbius, Wiebke, Poustka, Annemarie, Wiemann, Stefan, Schu, Peter, ...

A novel peripheral membrane protein (2c18) that interacts directly with the gamma ‘ear' domain of the adaptor protein complex 1 (AP-1) in vitro and in vivo is described. Ultrastructural analysis...

The polarized epithelia-specific µ1B-adaptin complements µ1A-deficiency in fibroblasts

Eskelinen, Eeva-Liisa, Meyer, Christoph, Ohno, Hiroshi, Von Figura, Kurt, Schu, Peter

The heterotetrameric AP-1A adaptor complex of clathrin-coated vesicles is ubiquitously expressed. The µ1-adaptin subunit of the complex exists as the ubiquitous µ1A and the polarized...

The Clathrin Adaptor Complex AP-1 Binds HIV-1 and MLV Gag and Facilitates Their Budding

Camus, Grégory, Segura-Morales, Carolina, Molle, Dorothee, Lopez-Vergès, Sandra, Begon-Pescia, Christina, Cazevieille, Chantal, ...

Retroviral assembly is driven by Gag, and nascent viral particles escape cells by recruiting the machinery that forms intralumenal vesicles of multivesicular bodies. In this study, we show that the...

Sorting by the Cytoplasmic Domain of the Amyloid Precursor Protein Binding Receptor SorLA▿ †

Nielsen, Morten S., Gustafsen, Camilla, Madsen, Peder, Nyengaard, Jens R., Hermey, Guido, Bakke, Oddmund, ...

SorLA/LR11 (250 kDa) is the largest and most composite member of the Vps10p-domain receptors, a family of type 1 proteins preferentially expressed in neuronal tissue. SorLA binds several ligands,...

Distribution and Function of Ap-1 Clathrin Adaptor Complexes in Polarized Epithelial Cells

Fölsch, Heike, Pypaert, Marc, Schu, Peter, Mellman, Ira

Expression of the epithelial cell–specific heterotetrameric adaptor complex AP-1B is required for the polarized distribution of many membrane proteins to the basolateral surface of LLC-PK1 kidney...