Peter Walter

Radionuclides measured on three sediment cores from the Weddell Sea, Antarctica (2009)

Frank, Martin, Eisenhauer, Anton, Bonn, Wolfgang J, Walter, Peter, Grobe, Hannes, Kubik, Peter W, ...

High resolution 230Thex and 10Be and biogenic barium profiles were measured at three sediment gravity cores (length 605–850 cm) from the Weddell Sea continental margin. Applying the 230Thex dating...

Paulus : theologische Meditationen in der Fastenzeit ; Universitätskirche Freiburg 2009 (2009)

Baumann, Klaus, Schockenhoff, Eberhard, Nothelle-Wildfeuer, Ursula, Böhm, Thomas, Irsigler, Hubert, Walter, Peter, ...

Der Band dokumentiert die Theologischen Meditationen in der Fastenzeit 2009 in der Universitätskirche Freiburg im Breisgau, die aus Anlaß des "Paulus-Jahres" 2008/2009 dem Völkerapostel gewidmet...

Cortical Activation Via an Implanted Wireless Retinal Prosthesis (2008)

Peter Walter, Zoltán F. Kisvárday, Michael Görtz, Nils Alteheld, Gernot Rossler, Thomas Stieglitz, ...

PURPOSE. To demonstrate local cortical activations in the primary visual cortex of the cat as a result of retinal electrical stimulation by means of a completely wireless-controlled, implantable...

Summary (2008)

Byron C. Hann, Peter Walter

We have identified the Saccharomyces cerevisiae ho-molog of the signal recognition particle (SRP) and characterized its function in vivo. S. cerevisiae SRP is a 16s particle that includes a homolog...

Gebet : theologische Meditationen in der Fastenzeit ; Universitätskirche Freiburg 2008 (2008)

Walter, Peter, Braun, Karl-Heinz, Tzscheetzsch, Werner, Uhde, Bernhard, Striet, Magnus, Windisch, Hubert, ...

Der Band bietet die Programme und die Texte der Theologischen Meditationen in der Fastenzeit 2008 in der Freiburger Universitätskirche zum Thema "Gebet" (Bittgebet - Litanei - Klage - Beten ­...

Identification of yeast proteins necessary for cell-surface function of a potassium channel (2007)

Haass, Friederike A, Jonikas, Martin, Walter, Peter, Weissman, Jonathan S, Jan, Yuh-Nung, Jan, Lily Y, ...

Inwardly rectifying potassium (Kir) channels form gates in the cell membrane that regulate the flow of K+ ions into and out of the cell, thereby influencing the membrane potential and electrical...

Conformational changes in the GTPase modules of the signal reception particle and its receptor drive initiation of protein translocation (2007)

Shan, Shu-ou, Chandrasekar, Sowmya, Walter, Peter

During cotranslational protein targeting, two guanosine triphosphatase (GTPase) in the signal recognition particle (SRP) and its receptor (SR) form a unique complex in which hydrolyses of both...

The ABC (Analysing Biomolecular Contacts)-database (2007)

Walter, Peter, Ansari, Sam, Helms, Volkhard

As protein-protein interactions are one of the basic mechanisms in most cellular processes, it is desirable to understand the molecular details of protein-protein contacts and ultimately be able to...

Tugenden : theologische Meditationen in der Fastenzeit ; Universitätskirche Freiburg 2007 (2007)

Walter, Peter, Hoping, Helmut, Böhm, Thomas, Tzscheetzsch, Werner, Nothelle-Wildfeuer, Ursula, Schockenhoff, Eberhard

Der Band bietet die Programme und die Texte der Theologischen Meditationen in der Fastenzeit 2007 in der Freiburger Universitätskirche zum Thema "Tugenden" (Glaube - Demut - Hoffnung - Rechenschaft...

Autophagy Counterbalances Endoplasmic Reticulum Expansion during the Unfolded Protein Response (2006)

Sebastián Bernales, Kent L. McDonald, Peter Walter

The protein folding capacity of the endoplasmic reticulum (ER) is regulated by the unfolded protein response (UPR). The UPR senses unfolded proteins in the ER lumen and transmits that information to...

Visual resolution with retinal implants estimated from recordings in cat visual cortex (2006)

Eckhorn, Reinhard, Wilms, Marcus, Schanze, Thomas, Eger, Marcus, Hesse, Lutz, Eysel, Ulf T, ...

We investigated cortical responses to electrical stimulation of the retina using epi- and sub-retinal electrodes of 20-100 microm diameter. Temporal and spatial resolutions were assessed by...

A nuclear function of Hu proteins as neuron-specific alternative RNA processing regulators. (2006)

Zhu, Hui, Hasman, Robert A., Barron, Victoria A., Luo, Guangbin, Lou, Hua, Walter, Peter

Recent advances in genome-wide analysis of alternative splicing indicate that extensive alternative RNA processing is associated with many proteins that play important roles in the nervous system....

Minireview (2005)

Shu-ou Shan, Peter Walter

The signal recognition particle (SRP) mediates the co-translational targeting of nascent proteins to the eukaryotic endoplasmic reticulum membrane, or the bacterial plasma membrane. During this...

Gene Recruitment of the Activated INO1 Locus to the Nuclear Membrane (2004)

Jason H. Brickner, Peter Walter

The spatial arrangement of chromatin within the nucleus can affect reactions that occur on the DNA and is likely to be regulated. Here we show that activation of INO1 occurs at the nuclear membrane...

Mechanism of Association and Reciprocal Activation of Two GTPases (2004)

Shu-ou Shan, Robert M. Stroud, Peter Walter

The signal recognition particle (SRP) mediates the cotranslational targeting of nascent proteins to the eukaryotic endoplasmic reticulum membrane or the bacterial plasma membrane. During this...

Mechanism of Association (2004)

And Reciprocal Activation, Shu-ou Shan, Robert M. Stroud, Peter Walter

e time. Citation: Shan S, Stroud RM, Walter P (2004) Mechanism of association and reciprocal activation of two GTPases. PLoS Biol 2(10): e320. Introduction GTPases comprise a superfamily of proteins...

Gene Recruitment of the Activated INO1 Locus (2004)

To The Nuclear, Jason H. Brickner, Peter Walter

this paper are Ire1 (NP_116622), INO1 (NP_012382), Trl1 (NP_012448), Opi1 (NP_011843), Hac1 (NP_011946), Ino2 (NP_010408), Ino4 (NP_014533), Scs2 (NP_009461), Rap1 (NP_014183), URA3 (NP_010893), SSS1...

IRE1-Independent Gain Control (2004)

Of The Unfolded, Jess H. Leber, Sebastián Bernales, Peter Walter

this paper, we show that HAC1 mRNA transcription is regulated, resulting in control of Hac1p abundance. Thus the on/off switch provided by IRE1-dependent splicing is not the only regulatory step of...

Gcn4p and Novel Upstream Activating (2004)

Sequences Regulate Targets, Christopher K. Patil, Hao Li, Peter Walter

this reporter gene under ER stress (Mori et al. 1992; Cox et al. 1993). As a positive control for UPR-dependent gene expression, we used a construct containing a triple repeat of the KAR2-derived...

2004 Niwa et Volume al. 6, Issue 1, Article R3 Open Access (2004)

Maho Niwa, Christopher K Patil, Joe Derisi, Peter Walter

Genome-scale approaches for discovering novel nonconventional splicing substrates of the Ire1 nuclease

Unfolded Proteins in the Endoplasmic Reticulum Cause (2003)

Feroz R. Papa, Chao Zhang, Kevan Shokat, Peter Walter

ough the ER stress sensor Ire1, a single-spanning ER transmembrane protein with three functional domains (4). The most amino-terminal domain, which resides in the ER lumen, senses elevated levels of...

Structural Basis for Mobility in the 1.1 A (2002)

Crystal Structure Of, Ursula D. Ramirez, George Minasov, Pamela J. Focia, Robert M. Stroud, Peter Walter, ...

and present a detailed structural analysis of the packing of the residues, including the critical a4 helix, that comprise the interface. Our data allows us to propose a structural explanation for the...

Die Gründungen des Collegium Germanicum et Hungaricum : Etappen der Kollegsgeschichte (2002)

Walter, Peter

Die Gründung des Collegium Germanicum in Rom im Jahre 1552 ist Teil eines Prozesses, der bereits vor der Reformation einsetzte, durch diese aber neue Dringlichkeit erhielt: die Reform des...

Role of SRP RNA in the GTPase Cycles of Ffh and FtsY (2001)

Paul Peluso, Shu-ou Shan, Silke Nock, Daniel Herschlag, Peter Walter

The bacterial homologues of the signal recognition particle (SRP) and its receptor, the Ffh.4.5S RNA ribonucleoprotein complex and the FtsY protein, respectively, form a unique complex in which both...

Basis for regulated RNA cleavage by functional (2001)

Analysis Of Rnase, Beihua Dong, Maho Niwa, Peter Walter, Robert H. Silverman

RNase L and Ire1p are members of a superfamily of regulated endoribonucleases that play essential roles in mediating diverse types of cellular stress responses. 29-59 oligoadenylates, produced in...

Molecular Biology of the Cell (2001)

Vol March Multifaceted, Sarah C. Mutka, Peter Walter, Thomas D. Fox

this article contains data set material. Online version available at www.molbiolcell.org

Ein Mainzer Theologe über das Verhältnis von Kirche und Staat in schwieriger Zeit : Peter Tischleder (1891-1947) (2001)

Walter, Peter

Der Aufsatz informiert über das Leben und das theologische Werk von Peter Tischleder, geb. 1891 in Dromersheim bei Bingen, gest. 1947. Tischleder wurde 1926 Prof., 1931 o.Prof. für Moraltheologie...

Nucleus-vacuole junctions in Saccharomyces cerevisiae are formed through the direct interaction of Vac8p with Nvj1p. (2000)

Pan, Xiaozhou, Roberts, Paul, Chen, Yan, Kvam, Erik, Shulga, Natalyia, Huang, Kristen, ...

Vac8p is a vacuolar membrane protein that is required for efficient vacuole inheritance and fusion, cytosol-to-vacuole targeting, and sporulation. By analogy to other armadillo domain proteins,...

The unfolded protein response regulates multiple aspects of secretory and membrane protein biogenesis and endoplasmic reticulum quality control (2000)

Eric D. Spear, Peter Walter

The unfolded protein response (UPR) is an intracellular signaling pathway that relays signals from the lumen of the ER to activate target genes in the nucleus.

Cell, Vol. 101, 249--258, April 28, 2000, Copyright 2000 by Cell Press (2000)

Functional And Genomic, Christopher K. Patil, Lisa Wodicka, David J. Lockhart, Jonathan S. Weissman, Peter Walter

roarrays. Rather than (Cox and Walter, 1996; Mori et al., 1996; Sidrauski et al., 1996; Sidrauski and Walter, 1997), and ultimately regulating only ER-resident chaperones and phospholipid...

Prm1p, a pheromone-regulated multispanning membrane protein, facilitates plasma membrane fusion during yeast mating (2000)

Maxwell G. Heiman, Peter Walter

Cell fusion occurs throughout development, from fertilization to organogenesis. The molecular mechanisms driving plasma membrane fusion in these processes remain unknown. While yeast mating offers an...

Molecular Biology of the Cell (1999)

Vol April Two, Wolfgang P. Barz, Peter Walter, Monitoring R, Y W. Schekman

this paper, we present evidence for two proteins that facilitate the vesicular transport of GPI proteins. In an attempt to identify the molecular function of TRAM, we identified two yeast proteins...

Cell, Vol. 99, 691--702, December 23, 1999, Copyright 1999 by Cell Press (1999)

Maho Niwa, Carmela Sidrauski, Al J. Kaufman, Peter Walter

tRNA splicing (Sidrauski et al., 1996; Gonzalez et al., by the transmembrane kinase/endoribonuclease Ire1. 1999). Both HAC1 mRNA (u 5 unspliced, uninduced) and We show that yeast HAC1 mRNA is...

Journal Of Bacteriology, (1999)

Feb Vol No, Cindy Grove Arvidson, Ted Powers, Peter Walter, Magdalene So

this report, we show that PilA does not regulate transcription of a pilE-lacZ fusion in E. coli, regardless of the conditions used. We present evidence to suggest that PilA plays a role in protein...

Structure of the Phylogenetically Most Conserved (1999)

Domain Of Srp, Uli Schmitz, Stefan Behrens, Doug M. Freymann, Robert J. Keenan, Peter Lukavsky, ...

The signal recognition particle (SRP) is a phylogenetically conserved ribonucleoprotein required for cotranslational targeting of proteins to the membrane of the endoplasmic reticulum of the...

Molecular Biology of the Cell (1999)

Vol April Regulation, Ted Powers, Peter Walter

this reporter to rapamycin. Construction of an additional control plasmid demonstrated, however, that these sequences did not confer any detectable sensitivity to rapamycin (our unpublished results)....

The EMBO Journal Vol.18 No.11 pp.3119--3132, 1999 (1999)

Tania N. Gonzalez, Carmela Sidrauski, Silke Dörfler, Peter Walter

this paper were performed under optimal ADP-stimulating conditions. A gain in affinity could result from cooperative binding of Ire1p to the two splice sites and thus lead to increased cleavage....

Research Paper (1997)

Translational Attenuation Mediated, Rowan E. Chapman, Peter Walter

slation of a mRNA can be attenuated. Background The unfolded protein response (UPR) is an intracellular signal transduction pathway that connects the endoplasmic reticulum (ER) and the nucleus...

Genetic and biochemical analysis of the fission yeast ribonucleoprotein particle containing a homolog of Srp54p (1994)

Selinger, David, Brennwald, Patrick, Althoff, Steven, Reich, Claudia, Hann, Byron, Walter, Peter, ...

Mammalian signal recognition particle (SRP), a complex of six polypeptides and one 7SL RNA molecule, is required for targeting nascent presecretory proteins to the endoplasmic reticulum (ER). Earlier...

GTPase domain of the 54-kD subunit of the mammalian signal recognition particle is required for protein translocation but not for signal sequence binding (1993)

Dieter Zopf, Harris D. Bernstein, Peter Walter

Abstract. The 54-kD subunit of the signal recognition particle (SRP54) binds to signal sequences of nascent secretory and transmembrane proteins. SRP54 consists of two separable domains, a 33-kD...

Sequence and structure of Tetrahymena SRP RNA (1991)

Patrick J. Brennwald, Vivian Siegel, Peter Walter, Jo Ann Wise

Signal recognition particle (SRP) is a ribonucleoprotein required for targeting ofpresecretory proteins to the endoplasmic reticulum (reviewed in 1). The well-studied canine particle is composed of...

The Membranes of a Eukaryotic Cell (1989)

WALTER, PETER

The evolution of internal membrane systems has introduced many additional control steps into pathways that, although basically similar in prokaryotic cells, are less sophisticated and leave many...

Signal recognition protein is required for the integration of acetylcholine receptor delta subunit, a transmembrane glycoprotein, into the endoplasmic reticulum membrane (1982)

Anderson, David J., Walter, Peter, Blobel, Günter

Purified Signal Recognition Protein (SRP) has previously been shown to be required for the translocation of secretory proteins across the microsomal membrane (Walter and Blobel, 1980. Proc. Natl....

Betriebswirtschaftliche Kapitalerhaltung und Preissteigerungsrücklage in der deutschen und französischen Ertragsteuerbilanz. (1958)

Walter, Peter.

Univ. d. Saarlandes, Rechts- u. wirtschaftswiss. F., Diss. v. 27. Aug. 1958 (Nur in beschr. Anz. f. d. Aust.).

Recht und Gerechtigkeit in der spanischen Spätscholastik. (1953)

Walter, Peter.

Behandelt vornehmlich Francisco de Vitoria und Franz Suarez

Identification of yeast proteins necessary for cell-surface function of a potassium channel

Haass, Friederike A., Jonikas, Martin, Walter, Peter, Weissman, Jonathan S., Jan, Yuh-Nung, Jan, Lily Y., ...

Inwardly rectifying potassium (Kir) channels form gates in the cell membrane that regulate the flow of K+ ions into and out of the cell, thereby influencing the membrane potential and electrical...

Structures of SRP54 and SRP19, the Two Proteins that Organize the Ribonucleic Core of the Signal Recognition Particle from Pyrococcus furiosus

Egea, Pascal F., Napetschnig, Johanna, Walter, Peter, Stroud, Robert M.

In all organisms the Signal Recognition Particle (SRP), binds to signal sequences of proteins destined for secretion or membrane insertion as they emerge from translating ribosomes. In Archaea and...

Structures of the Signal Recognition Particle Receptor from the Archaeon Pyrococcus furiosus: Implications for the Targeting Step at the Membrane

Egea, Pascal F., Tsuruta, Hiro, De Leon, Gladys P., Napetschnig, Johanna, Walter, Peter, Stroud, Robert M.

In all organisms, a ribonucleoprotein called the signal recognition particle (SRP) and its receptor (SR) target nascent proteins from the ribosome to the translocon for secretion or membrane...

Pkh-kinases control eisosome assembly and organization

Walther, Tobias C, Aguilar, Pablo S, Fröhlich, Florian, Chu, Feixia, Moreira, Karen, Burlingame, Alma L, ...

Eisosomes help sequester a subgroup of plasma membrane proteins into discrete membrane domains that colocalize with sites of endocytosis. Here we show that the major eisosome component Pil1 in vivo...

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

Lin, Jonathan H., Li, Han, Zhang, Yuhong, Ron, David, Walter, Peter

Protein misfolding in the endoplasmic reticulum (ER) activates a set of intracellular signaling pathways, collectively termed the Unfolded Protein Response (UPR). UPR signaling promotes cell survival...

Pil1 Controls Eisosome Biogenesis

Moreira, Karen E., Walther, Tobias C., Aguilar, Pablo S., Walter, Peter

The molecular composition of plasma membranes is constantly remodeled by endocytosis and exocytosis. Eisosomes are large cytoplasmic protein assemblies that localize to specialized domains on the...

Membrane lysis during biological membrane fusion: collateral damage by misregulated fusion machines

Engel, Alex, Walter, Peter

In the canonical model of membrane fusion, the integrity of the fusing membranes is never compromised, preserving the identity of fusing compartments. However, recent molecular simulations provided...