Guikai Wu, Xianzhi Jiang, Wen-hwa Lee, Phang-lang Chen
Immortalized cells maintain telomere length through either a telomerase-dependent process or a telomerase-independent pathway termed alternative lengthening of telomeres (ALT). Homologous...
STAT-1 facilitates the ATM activated checkpoint pathway following DNA damage (2005)
Townsend, Paul A., Cragg, Mark S., Davidson, Sean M., McCormick, James, Barry, Sean, Lawrence, Kevin M., ...
STAT-1 plays a role in mediating stress responses to various stimuli and has also been implied to be a tumour suppressor. Here, we report that STAT-1-deficient cells have defects both in...
BRCA2 and the DNA Double-Strand Break Repair Machinery (1998)
The overall goal of my grant proposal is to test the model, BRCA2 modulates the early steps of repair mediated by the Rad5O nuclease complex, and the later stages catalyzed by the Rad51 recombinase....
Chen, Yumay, Chen, Phang-Lang, Chen, Chi-Fen, Sharp, Z. Dave, Lee, Wen-Hwa
Trip230 is a novel coactivator of the thyroid hormone receptor that is negatively regulated by the retinoblastoma tumor-suppressor protein. In an examination of its subcellular distribution, Trip230...
Chen, Phang-Lang, Chen, Chi-Fen, Chen, Yumay, Xiao, Jun, Sharp, Z. Dave, Lee, Wen-Hwa
The BRCA2 gene was identified based on its involvement in familial breast cancer. The analysis of its sequence predicts that the gene encodes a protein with 3,418 amino acids but provides very few...
A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein
Chang, Kai-Hsuan, Chen, Yumay, Chen, Tung-Ti, Chou, Wen-Hai, Chen, Phang-Lang, Ma, Yen-Ying, ...
The retinoblastoma protein (Rb) plays a critical role in cell proliferation, differentiation, and development. To decipher the mechanism of Rb function at the molecular level, we have systematically...
Retinoblastoma Protein Enhances the Fidelity of Chromosome Segregation Mediated by hsHec1p
Zheng, Lei, Chen, Yumay, Riley, Daniel J., Chen, Phang-Lang, Lee, Wen-Hwa
Retinoblastoma protein (Rb) plays important roles in cell cycle progression and cellular differentiation. It may also participate in M phase events, although heretofore only circumstantial evidence...
Chen, Phang-Lang, Liu, Feng, Cai, Suna, Lin, Xiaoqin, Li, Aihua, Chen, Yumay, ...
CtIP interacts with a group of tumor suppressor proteins including RB (retinoblastoma protein), BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through transcriptional repression as...
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells
Furuta, Saori, Jiang, Xianzhi, Gu, Bingnan, Cheng, Eric, Chen, Phang-Lang, Lee, Wen-Hwa
Cumulative evidence indicates that breast cancer-associated gene 1 (BRCA1) participates in DNA damage repair and cell-cycle checkpoint control, serving as a tumor susceptibility gene to maintain the...
Chen, Yumay, Chen, Phang-Lang, Chen, Chi-Fen, Sharp, Z. Dave, Lee, Wen-Hwa
Trip230 is a novel coactivator of the thyroid hormone receptor that is negatively regulated by the retinoblastoma tumor-suppressor protein. In an examination of its subcellular distribution, Trip230...
Chen, Phang-Lang, Chen, Chi-Fen, Chen, Yumay, Xiao, Jun, Sharp, Z. Dave, Lee, Wen-Hwa
The BRCA2 gene was identified based on its involvement in familial breast cancer. The analysis of its sequence predicts that the gene encodes a protein with 3,418 amino acids but provides very few...
A thyroid hormone receptor coactivator negatively regulated by the retinoblastoma protein
Chang, Kai-Hsuan, Chen, Yumay, Chen, Tung-Ti, Chou, Wen-Hai, Chen, Phang-Lang, Ma, Yen-Ying, ...
The retinoblastoma protein (Rb) plays a critical role in cell proliferation, differentiation, and development. To decipher the mechanism of Rb function at the molecular level, we have systematically...
Retinoblastoma Protein Enhances the Fidelity of Chromosome Segregation Mediated by hsHec1p
Zheng, Lei, Chen, Yumay, Riley, Daniel J., Chen, Phang-Lang, Lee, Wen-Hwa
Retinoblastoma protein (Rb) plays important roles in cell cycle progression and cellular differentiation. It may also participate in M phase events, although heretofore only circumstantial evidence...
Chen, Phang-Lang, Liu, Feng, Cai, Suna, Lin, Xiaoqin, Li, Aihua, Chen, Yumay, ...
CtIP interacts with a group of tumor suppressor proteins including RB (retinoblastoma protein), BRCA1, Ikaros, and CtBP, which regulate cell cycle progression through transcriptional repression as...
Depletion of BRCA1 impairs differentiation but enhances proliferation of mammary epithelial cells
Furuta, Saori, Jiang, Xianzhi, Gu, Bingnan, Cheng, Eric, Chen, Phang-Lang, Lee, Wen-Hwa
Cumulative evidence indicates that breast cancer-associated gene 1 (BRCA1) participates in DNA damage repair and cell-cycle checkpoint control, serving as a tumor susceptibility gene to maintain the...