Hatfield, Robert G., Maher, Barbara A., Pates, Jacqueline M., Barker, Philip A.
Accelerated erosion and transport of fine sediment from upland temperate catchments can reflect increased erosivity and/or erodibility, due in turn to climatic and/or human forcing. Identification of...
Pispa, Johanna, Pummila, Marja, Barker, Philip A., Thesleff, Irma, Mikkola, Marja L.
The development of ectodermal organs requires signalling by ectodysplasin (Eda), a tumor necrosis factor (TNF) family member, its receptor Edar and downstream activation of the nuclear factor kappaB...
Mutations in the calcium-related gene IL1RAPL1 are associated with autism (2008)
Piton, Amélie, Michaud, Jacques L., Peng, Huashan, Aradhya, Swaroop, Gauthier, Julie, Mottron, Laurent, ...
In a systematic sequencing screen of synaptic genes on the X chromosome, we have identified an autistic female without mental retardation (MR) who carries a de novo frameshift Ile367SerfsX6 mutation...
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface (2006)
Sirerol-Piquer, Maria Salomé, Ayerdi Izquierdo, Ana, Morante Redolat, José Manuel, Herranz-Pérez, Vicente, Favell, Kristy, Barker, Philip A., ...
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Human Molecular Genetics following peer review. The definitive publisher-authenticated version Human...
A review of the oxygen isotope composition of diatom silica for palaeoclimate reconstruction. (2006)
Leng, Melanie J., Barker, Philip A.
Diatom silica (frustules) are a form of biogenic opal and contain oxygen isotopes that are being increasingly used in palaeoclimate studies. Frustules are comprised of an inner tetrahedrally bonded...
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface (2006)
Sirerol-Piquer, Ma Salomé, Ayerdi-Izquierdo, Ana, Morante-Redolat, José Manuel, Herranz-Pérez, Vicente, Favell, Kristy, Nobile, Carlo, ...
Autosomal dominant lateral temporal epilepsy (ADTLE) is a partial epilepsy caused by mutations in LGI1, a multidomain protein of unknown function. To begin to understand the biological function of...
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface (2006)
Sirerol-Piquer, Ma Salomé, Ayerdi-Izquierdo, Ana, Morante-Redolat, José Manuel, Herranz-Pérez, Vicente, Favell, Kristy, Barker, Philip A., ...
Autosomal dominant lateral temporal epilepsy (ADTLE) is a partial epilepsy caused by mutations in LGI1, a multidomain protein of unknown function. To begin to understand the biological function of...
The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface (2006)
Sirerol-Piquer, Maria Salomé, Ayerdi-Izquierdo, Ana, Morante-Redolat, José Manuel, Herranz-Pérez, Vicente, Favell, Kristy, Barker, Philip A., ...
Autosomal dominant lateral temporal epilepsy (ADTLE) is a partial epilepsy caused by mutations in LGI1, a multidomain protein of unknown function. To begin to understand the biological function of...
Late quaternary and holocene volcanic record preserved in lakes of Michoacán, central Mexico. (2005)
Newton, Anthony J., Metcalfe, Sarah E., Davies, Sarah J., Cook, Gordon, Barker, Philip A., Telford, Richard J.
This paper describes the initial stages of the development of a tephrochronology for the region of the Michoacán–Guanajuato volcanic field (MGVF) in central Mexico. There are two elements to this:...
Changing nutrient levels in Grasmere, English Lake District, during recent centuries. (2005)
Barker, Philip A., Pates, J. M., Payne, R. J, Healey, R. M.
1. Historical nutrient changes in Grasmere were investigated using a 300-year record derived from six sediment cores. One core was investigated at high resolution for diatoms, total sedimentary...
Lacustrine response to tephra deposition: examples from Mexico. (2004)
Telford, Richard J., Barker, Philip A., Metcalfe, Sarah E., Newton, Anthony
One of the major problems with palaeoclimate investigations in volcanic regions is that tephra inputs to lakes can cause changes in proxies analogous to those of climate forcing. We review the range...
A 200-year precipitation index for the Central English Lake District. (2004)
Barker, Philip A., Wilby, R. L., Borrows, J.
The geographical context and hydroclimatology of the English Lake District means that the region is an important monitor of changes to nationally significant environmental assets. Using monthly...
The potential of oxygen isotopes in diatoms as a palaeoclimate indicator in lake sediments. (2004)
Lamb, Angela L., Leng, M. J., Barker, Philip A., Morley, David W.
A 200 year precipitation index for the Central English Lake District. (2004)
Barker, Philip A., Wilby, R. L., Borrows, J.
The geographical context and hydroclimatology of the English Lake District means that the region is an important monitor of changes to nationally significant environmental assets. Using monthly...
Late quartenary climatic variability in intertropical Africa. (2004)
Barker, Philip A., Talbot, M. R., Street-Perrott, F. A., Marret, F., Scourse, J. D., Odada, E.
Climate variability in Europe and Africa during PAGES-PEPIII times stream II : a synthesis. (2004)
Partridge, T. C., Lowe, J. J., Barker, Philip A., Hoelzmann, P., Magri, D., Saarnisto, M., ...
Holocene climate variability in Europe and Africa : a PAGES-PEPIII time stream 1 sythesis. (2004)
Verschuren, D., Briffa, K., Hoelzmann, P., Barker, Philip A., Scott , L., Barber, K., ...
Barker, Philip A., Williamson, David, Gasse, Françoise, Gibert, Elisabeth
The interactions between climatic and volcanic forcing on diatom communities contained in a 50,000-year sedimentary sequence from Lake Massoko, Tanzania, were examined. At the century scale, 19...
A High Resolution Paleoclimate Record Spanning the Past 25,000 Years in Southern East Africa. (2002)
Barker, Philip A., Brown, E., Johnson, T. C., McManus, J.
High-resolution profiles of the mass accumulation rate of biogenic silica and other geochemical proxies in two piston cores from northern Lake Malawi provide a climate signal for this part of...
Makkerh, Joe P S, Ceni, Claire, Auld, Daniel S, Vaillancourt, François, Dorval, Genevieve, Barker, Philip A
Target-derived neurotrophins regulate neuronal survival and growth by interacting with cell-surface tyrosine kinase receptors. The p75 neurotrophin receptor (p75NTR) is coexpressed with Trk receptors...
Makkerh, Joe P S, Ceni, Claire, Auld, Daniel S, Vaillancourt, François, Dorval, Genevieve, Barker, Philip A
Target-derived neurotrophins regulate neuronal survival and growth by interacting with cell-surface tyrosine kinase receptors. The p75 neurotrophin receptor (p75NTR) is coexpressed with Trk receptors...
Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death
D'Souza, Sameer D., Bonetti, Bruno, Balasingam, Vijayabalan, Cashman, Neil R., Barker, Philip A., Troutt, Anthony B., ...
Fas is a cell surface receptor that transduces cell death signals when cross-linked by agonist antibodies or by fas ligand. In this study, we examined the potential of fas to contribute to...
Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation*S⃞
Boutilier, Jacqueline, Ceni, Claire, Pagdala, Promila C., Forgie, Alison, Neet, Kenneth E., Barker, Philip A.
The uncleaved, pro-form of nerve growth factor (proNGF) functions as a pro-apoptotic ligand for the p75 neurotrophin receptor (p75NTR). However, some reports have indicated that proneurotrophins bind...