Macrophage Responses to B. Anthracis (2006)
The goal of these studies is to monitor changes occurring in host macrophages using a cell culture model of the early establishment stage of anthrax. Global changes in cultured murine macrophage...
Operon Prediction for Sequenced Bacterial Genomes without Experimental Information � † (2006)
Nicholas H. Bergman, Karla D. Passalacqua, Philip C. Hanna, Zhaohui S. Qin
Various computational approaches have been proposed for operon prediction, but most algorithms rely on experimental or functional data that are only available for a small subset of sequenced genomes....
Nicholas H. Bergman, Karla D. Passalacqua, Philip C. Hanna, Zhaohui S. Qin, Nicholas H. Bergman, Ph. D
Various computational approaches have been proposed for operon prediction, but most algorithms rely on experimental or functional data that are only available for a small subset of sequenced genomes....
Coordinate Intracellular Expression of Salmonella Genes Induced during Infection
Heithoff, Douglas M., Conner, Christopher P., Hentschel, Ute, Govantes, Fernando, Hanna, Philip C., Mahan, Michael J.
Salmonella typhimurium in vivo-induced (ivi) genes were grouped by their coordinate behavior in response to a wide variety of environmental and genetic signals, including pH, Mg2+, Fe2+, and PhoPQ....
Macrophage-Enhanced Germination of Bacillus anthracis Endospores Requires gerS
Ireland, John A. W., Hanna, Philip C.
Germination of Bacillus anthracis Sterne and plasmidless Δ-Sterne endospores was dramatically enhanced in RAW264.7 macrophage-like cells, while germination of nonpathogenic Bacillus endospores was...
Ireland, John A. W., Hanna, Philip C.
Specific combinations of amino acids or purine ribonucleosides and amino acids are required for efficient germination of endospores of Bacillus anthracis ΔSterne, a plasmidless strain, at ligand...
Weiner, Matthew A., Read, Timothy D., Hanna, Philip C.
We identified a tri-cistronic operon, gerH, in Bacillus anthracis that is important for endospore germination triggered by two distinct germination response pathways termed inosine-His and...
Macrophage-Mediated Germination of Bacillus anthracis Endospores Requires the gerH Operon
Weiner, Matthew A., Hanna, Philip C.
The gerHabc operon of Bacillus anthracis, encoding a gerA-like family member of germinant sensors, was shown to be required for endospore germination in the presence of macrophages and in...
Formation and Composition of the Bacillus anthracis Endospore†
Liu, Hongbin, Bergman, Nicholas H., Thomason, Brendan, Shallom, Shamira, Hazen, Alyson, Crossno, Joseph, ...
The endospores of Bacillus anthracis are the infectious particles of anthrax. Spores are dormant bacterial morphotypes able to withstand harsh environments for decades, which contributes to their...
Murine Macrophage Transcriptional Responses to Bacillus anthracis Infection and Intoxication
Bergman, Nicholas H., Passalacqua, Karla D., Gaspard, Renee, Shetron-Rama, Lynne M., Quackenbush, John, Hanna, Philip C.
Interactions between Bacillus anthracis and host macrophages represent critical early events in anthrax pathogenesis, but their details are not clearly understood. Here we report the first genomewide...
McConnell, Michael J., Hanna, Philip C., Imperiale, Michael J.
Adenovirus vectors are promising for use in vaccinating against potential agents of bioterrorism and emerging infections because of their proven safety in humans and their ability to elicit rapid...
Coordinate Intracellular Expression of Salmonella Genes Induced during Infection
Heithoff, Douglas M., Conner, Christopher P., Hentschel, Ute, Govantes, Fernando, Hanna, Philip C., Mahan, Michael J.
Salmonella typhimurium in vivo-induced (ivi) genes were grouped by their coordinate behavior in response to a wide variety of environmental and genetic signals, including pH, Mg2+, Fe2+, and PhoPQ....
Macrophage-Enhanced Germination of Bacillus anthracis Endospores Requires gerS
Ireland, John A. W., Hanna, Philip C.
Germination of Bacillus anthracis Sterne and plasmidless Δ-Sterne endospores was dramatically enhanced in RAW264.7 macrophage-like cells, while germination of nonpathogenic Bacillus endospores was...
Ireland, John A. W., Hanna, Philip C.
Specific combinations of amino acids or purine ribonucleosides and amino acids are required for efficient germination of endospores of Bacillus anthracis ΔSterne, a plasmidless strain, at ligand...
Weiner, Matthew A., Read, Timothy D., Hanna, Philip C.
We identified a tri-cistronic operon, gerH, in Bacillus anthracis that is important for endospore germination triggered by two distinct germination response pathways termed inosine-His and...
Macrophage-Mediated Germination of Bacillus anthracis Endospores Requires the gerH Operon
Weiner, Matthew A., Hanna, Philip C.
The gerHabc operon of Bacillus anthracis, encoding a gerA-like family member of germinant sensors, was shown to be required for endospore germination in the presence of macrophages and in...
Formation and Composition of the Bacillus anthracis Endospore†
Liu, Hongbin, Bergman, Nicholas H., Thomason, Brendan, Shallom, Shamira, Hazen, Alyson, Crossno, Joseph, ...
The endospores of Bacillus anthracis are the infectious particles of anthrax. Spores are dormant bacterial morphotypes able to withstand harsh environments for decades, which contributes to their...
Murine Macrophage Transcriptional Responses to Bacillus anthracis Infection and Intoxication
Bergman, Nicholas H., Passalacqua, Karla D., Gaspard, Renee, Shetron-Rama, Lynne M., Quackenbush, John, Hanna, Philip C.
Interactions between Bacillus anthracis and host macrophages represent critical early events in anthrax pathogenesis, but their details are not clearly understood. Here we report the first genomewide...
McConnell, Michael J., Hanna, Philip C., Imperiale, Michael J.
Adenovirus vectors are promising for use in vaccinating against potential agents of bioterrorism and emerging infections because of their proven safety in humans and their ability to elicit rapid...
Bergman, Nicholas H., Anderson, Erica C., Swenson, Ellen E., Niemeyer, Matthew M., Miyoshi, Amy D., Hanna, Philip C.
The life cycle of Bacillus anthracis includes both vegetative and endospore morphologies which alternate based on nutrient availability, and there is considerable evidence indicating that the ability...
Operon Prediction for Sequenced Bacterial Genomes without Experimental Information▿ †
Bergman, Nicholas H., Passalacqua, Karla D., Hanna, Philip C., Qin, Zhaohui S.
Various computational approaches have been proposed for operon prediction, but most algorithms rely on experimental or functional data that are only available for a small subset of sequenced genomes....
Biosynthetic Analysis of the Petrobactin Siderophore Pathway from Bacillus anthracis▿
Lee, Jung Yeop, Janes, Brian K., Passalacqua, Karla D., Pfleger, Brian F., Bergman, Nicholas H., Liu, Haichuan, ...
The asbABCDEF gene cluster from Bacillus anthracis is responsible for biosynthesis of petrobactin, a catecholate siderophore that functions in both iron acquisition and virulence in a murine model of...
Passalacqua, Karla D., Bergman, Nicholas H., Lee, Jung Yeop, Sherman, David H., Hanna, Philip C.
Microarray analyses were conducted to evaluate the paraquat-induced global transcriptional response of Bacillus anthracis Sterne (34F2) to varying levels of endogenous superoxide stress. Data...
Transcriptional Profiling of Bacillus anthracis during Infection of Host Macrophages▿ †
Bergman, Nicholas H., Anderson, Erica C., Swenson, Ellen E., Janes, Brian K., Fisher, Nathan, Niemeyer, Matthew M., ...
The interaction between Bacillus anthracis and the mammalian phagocyte is one of the central stages in the progression of inhalational anthrax, and it is commonly believed that the host cell plays a...
The Type III Pantothenate Kinase Encoded by coaX Is Essential for Growth of Bacillus anthracis▿
Paige, Carleitta, Reid, Sean D., Hanna, Philip C., Claiborne, Al
In Bacillus anthracis, the novel type III pantothenate kinase (PanKBa; encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth...
Pfleger, Brian F., Kim, Youngchang, Nusca, Tyler D., Maltseva, Natalia, Lee, Jung Yeop, Rath, Christopher M., ...
Petrobactin, a virulence-associated siderophore produced by Bacillus anthracis, chelates ferric iron through the rare 3,4-isomer of dihydroxybenzoic acid (3,4-DHBA). Most catechol siderophores,...
Transcriptional Profiling of Bacillus anthracis Sterne (34F2) during Iron Starvation
Carlson, Paul E., Carr, Katherine A., Janes, Brian K., Anderson, Erica C., Hanna, Philip C.
Lack of available iron is one of many environmental challenges that a bacterium encounters during infection and adaptation to iron starvation is important for the pathogen to efficiently replicate...