Harvey, Philip D., Bellack, Alan S.
Recovery in schizophrenia is receiving increasing attention. Part of the increased focus is based on the recent working criteria for clinical remission in schizophrenia and the realization that many...
Dickinson, Dwight, Harvey, Philip D.
The schizophrenia research community, including government, industry, and academia, has made development of procognitive treatment strategies a priority. Much current research is directed at dividing...
Reichenberg, Abraham, Harvey, Philip D., Bowie, Christopher R., Mojtabai, Ramin, Rabinowitz, Jonathan, Heaton, Robert K., ...
Background: Mounting evidence suggests that compromised neurocognitive function is a central feature of schizophrenia. There are, however, schizophrenia patients with a normal neuropsychological (NP)...
Is Schizophrenia a Syndrome of Accelerated Aging? (2008)
Kirkpatrick, Brian, Messias, Erick, Harvey, Philip D., Fernandez-Egea, Emilio, Bowie, Christopher R.
Schizophrenia is associated with a number of anatomical and physiological abnormalities outside of the brain, as well as with a decrease in average life span estimated at 20% in the United States....
Implementation Considerations for Multisite Clinical Trials with Cognitive Neuroscience Tasks (2008)
Keefe, Richard S. E., Harvey, Philip D.
Multisite clinical trials aimed at cognitive enhancement across various neuropsychiatric conditions have employed standard neuropsychological tests as outcome measures. While these tests have enjoyed...
Performance-Based Measures of Functional Skills: Usefulness in Clinical Treatment Studies (2007)
Harvey, Philip D., Velligan, Dawn I., Bellack, Alan S.
Recently, attention to the assessment and treatment of functional disability has increased notably. It is widely understood that impairments in everyday living skills, including independent living...
Bellack, Alan S., Green, Michael F., Cook, Judith A., Fenton, Wayne, Harvey, Philip D., Heaton, Robert K., ...
People with schizophrenia frequently have significant problems in community functioning. Progress in developing effective interventions to ameliorate these problems has been slowed by the absence of...
Bellack, Alan S., Green, Michael F., Cook, Judith A., Fenton, Wayne, Harvey, Philip D., Heaton, Robert K., ...
People with schizophrenia frequently have significant problems in community functioning. Progress in developing effective interventions to ameliorate these problems has been slowed by the absence of...
Negative Symptoms and Cognitive Deficits: What Is the Nature of Their Relationship? (2006)
Harvey, Philip D, Koren, Danny, Reichenberg, Abraham, Bowie, Christopher R
Negative symptoms and cognitive deficits in schizophrenia share many features and are correlated in their severity on a cross-sectional basis. The question arises as to the nature of this...
Bowie, Christopher R, Serper, Mark R, Riggio, Silvana, Harvey, Philip D
Deficits in neurocognitive functioning are common to both schizophrenia and alcoholism. Recent studies suggest that neurocognitive functioning is the most significant predictor of social-adaptive...
Bowie, Christopher R., Serper, Mark R., Riggio, Silvana, Harvey, Philip D.
Deficits in neurocognitive functioning are common to both schizophrenia and alcoholism. Recent studies suggest that neurocognitive functioning is the most significant predictor of social-adaptive...
Negative Symptoms and Cognitive Deficits: What Is the Nature of Their Relationship? (2005)
Harvey, Philip D., Koren, Danny, Reichenberg, Abraham, Bowie, Christopher R.
Negative symptoms and cognitive deficits in schizophrenia share many features and are correlated in their severity on a cross-sectional basis. The question arises as to the nature of this...
Bowie, Christopher R., Serper, Mark R., Riggio, Silvana, Harvey, Philip D.
Deficits in neurocognitive functioning are common to both schizophrenia and alcoholism. Recent studies suggest that neurocognitive functioning is the most significant predictor of social-adaptive...
Negative Symptoms and Cognitive Deficits: What Is the Nature of Their Relationship? (2005)
Harvey, Philip D., Koren, Danny, Reichenberg, Abraham, Bowie, Christopher R.
Negative symptoms and cognitive deficits in schizophrenia share many features and are correlated in their severity on a cross-sectional basis. The question arises as to the nature of this...
Keefe, Richard S.E., Mohs, Richard C., Bilder, Robert M., Harvey, Philip D., Green, Michael F., Meltzer, Herbert Y., ...
Patients with schizophrenia are severely impaired in crucial aspects of neurocognitive function. This impairment is the strongest clinical correlate of poor long-term outcome and adaptive...
Gender Differences in Poor Outcome Patients With Lifelong Schizophrenia (2001)
Moriarty, Patrick J., Lieber, Dana, Bennett, Ashley, White, Leonard, Parrella, Michael, Harvey, Philip D., ...
Gender effects have been reported quite consistently in schizophrenia, with male patients having an earlier age of onset, poorer functional outcome, greater negative symptoms and cognitive...
Putnam, Katherine M., Harvey, Philip D.
Chronically institutionalized geriatric (n=174; average length of hospitalization=35.1 years) and nongeriatric (n=59; average length of hospitalization=17.3 years)...
Bergman, Andrea J., Silverman, Jeremy M., Harvey, Philip D., Smith, Christopher J., Siever, Larry J.
This study examined the nature of schizotypal symptoms in the relatives of schizophrenia patients and investigated phenomenological differences in symptomatology manifested by a familial sample and a...
Verbal Learning and Memory in Schizotypal Personality Disorder (1998)
Bergman, Andrea J., Harvey, Philip D., Roitman, Sonia Less, Mohs, Richard C., Marder, Dova, Silverman, Jeremy M., ...
The investigation of cognitive deficits in patients with schizotypal personality disorder (SPD) is important both to establish commonalities between SPD and schizophrenia and to clarify the...
Postmortem Studies in Schizophrenia (1998)
Powchik, Peter, Davidson, Michael, Haroutunian, Vahram, Gabriel, Stephen M., Purohit, Dushyant P., Perl, Daniel P., ...
The past decade has seen renewed interest in the neuropathology of schizophrenia. The advent of new postmortem techniques and functional imaging, along with a greater understanding of the...
Harvey, Philip D., Davidson, Michael, Mueser, Kim T., Parrella, Michael, White, Leonard, Powchik, Peter
Geriatric chronic psychiatric inpatients often remain in a chronic psychiatric hospital because of serious deficits in adaptive life functions. Because the additional complications and adaptive...
The Factor Structure of Schizotypal Symptoms in a Clinical Population (1996)
Bergman, Andrea J., Harvey, Philip D., Mitropoulou, Vivian, Aronson, Andrew, Marder, Dova, Silverman, Jeremy, ...
There is some support for the hypothesis that the factor structure of schizophrenia symptoms is similar to the factor structure of schizotypal symptoms in nonschizophrenia populations. However, no...
The Need to Integrate Neuropsychological and Experimental Schizophrenia Research (1994)
Serper, Mark R., Harvey, Philip D.
Although the experimental and the neuropsychological approaches to the study of schizophrenic cognition have coexisted for many years, they remain detached, with virtually independent methods and...
Leukotomy and Aging in Chronic Schizophrenia: A Followup Study 40 Years After Psychosurgery (1993)
Harvey, Philip D., Mohs, Richard C., Davidson, Michael
Many followup studies have found that frontal leukotomy does not lead to marked changes in behavioral or cognitive functions in patients with chronic schizophrenia. However, these studies left open...
Cognitive Deficits and Thought Disorder: II. An 8-month Followup Study (1990)
Harvey, Philip D., Docherty, Nancy M., Serper, Mark R., Rasmussen, Myrna
Schizophrenic (n=21) and manic (n=19) patients were followed up an average of 8 months after an index assessment during an acute admission. These patients were tested at both assessments with...
Cognitive Deficits and Thought Disorder: A Retest Study (1988)
Harvey, Philip D., Earle-Boyer, Elizabeth A., Levinson, Joyce C.
Manic (n = 26), schizophrenic (n = 26), and normal (n = 25) subjects were examined with a digit span distraction task and with a reality monitoring task. All subjects were tested twice at a 4-day...
Dichotic Listening and Recall in Schizophrenia and Mania (1988)
Wielgus, Mark S., Harvey, Philip D.
Schizophrenic (n = 20), manic, (n = 16), and normal (n = 16) subjects were examined for their ability to shadow information dichotically and recall it. Text passages were varied in their level of...
Encoding, Memory, and Thought Disorder in Schizophrenia and Mania (1986)
Harvey, Philip D., Earle-Boyer, Elizabeth A., Wielgus, Mark S., Levinson, Joyce C.
Schizophrenic (n = 24) and manic (n = 20) inpatients were compared with a normal comparison sample (n = 10) on memory and encoding performance for both self- and other-generated speech. It was found...
The Need to Relate Cognitive Deficits to Specific Behavioral Referents of Schizophrenia (1985)
Neale, John M., Oltmanns, Thomas F., Harvey, Philip D.
The implicit rationale for many cognitive studies of schizophrenia hinges on the recognition that verbal communication generated by patients with this disorder is often elusive or difficult to...
Bellack, Alan S., Green, Michael F., Cook, Judith A., Fenton, Wayne, Harvey, Philip D., Heaton, Robert K., ...
People with schizophrenia frequently have significant problems in community functioning. Progress in developing effective interventions to ameliorate these problems has been slowed by the absence of...
Negative Symptoms and Cognitive Deficits: What Is the Nature of Their Relationship?
Harvey, Philip D, Koren, Danny, Reichenberg, Abraham, Bowie, Christopher R
Negative symptoms and cognitive deficits in schizophrenia share many features and are correlated in their severity on a cross-sectional basis. The question arises as to the nature of this...
Performance-Based Measures of Functional Skills: Usefulness in Clinical Treatment Studies
Harvey, Philip D., Velligan, Dawn I., Bellack, Alan S.
Recently, attention to the assessment and treatment of functional disability has increased notably. It is widely understood that impairments in everyday living skills, including independent living...
Leung, Winnie W, McClure, Margaret M, Siever, Larry J, Barch, Deanna M, Harvey, Philip D
A functional polymorphism of the gene coding for Catechol-O-methyltrasferase (COMT), an enzyme responsible for the degradation of the catecholamine dopamine (DA), epinephrine, and norepinephrine, is...
Cognitive deficits and functional outcome in schizophrenia
Bowie, Christopher R, Harvey, Philip D
Cognitive dysfunction is a core feature of schizophrenia. Deficits are moderate to severe across several domains, including attention, working memory, verbal learning and memory, and executive...
Implementation Considerations for Multisite Clinical Trials with Cognitive Neuroscience Tasks
Keefe, Richard S. E., Harvey, Philip D.
Multisite clinical trials aimed at cognitive enhancement across various neuropsychiatric conditions have employed standard neuropsychological tests as outcome measures. While these tests have enjoyed...
When Does Cognitive Decline Occur in the Period Prior to the First Episode of Schizophrenia?
Cognitive impairment is common in people with schizophrenia. These impairments are detectable prior to any signs of illness in people who are destined to develop the disease and they are as severe at...
Is Schizophrenia a Syndrome of Accelerated Aging?
Kirkpatrick, Brian, Messias, Erick, Harvey, Philip D., Fernandez-Egea, Emilio, Bowie, Christopher R.
Schizophrenia is associated with a number of anatomical and physiological abnormalities outside of the brain, as well as with a decrease in average life span estimated at 20% in the United States....