England, Timothy J., Gibson, Claire L., Bath, Philip M.W.
Background Granulocyte-colony stimulating factor (G-CSF) shows promise as a treatment for stroke. This systematic review assesses G-CSF in experimental ischaemic stroke. Methods Relevant studies were...
Stem cells for enhancing recovery after stroke: a review (2009)
England, Timothy J., Martin, Paul, Bath, Philip M.W.
The potential application for stem cell therapy is vast, and development for use in ischaemic stroke is still in its infancy. Access to stem cells for research is contentious; however, stem cells are...
Good laboratory practice: preventing introduction of bias at the bench (2009)
Macleod, Malcolm R., Fisher, Marc, O'Collins, Victoria, Sena, Emily S., Dirnagl, Ulrich, Bath, Philip M.W., ...
Background and Purpose—As a research community, we have failed to demonstrate that drugs which show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human...
Sare, Gillian M., Bath, Philip M.W., Gray, Laura J., Moulin, Thierry, Woimant, France, England, Timothy, ...
Background and Purpose—High blood pressure (BP) is present in 80% of patients with acute ischemic stroke and is independently associated with poor outcome. There are few data examining the...
Systematic reviews as a tool for planning and interpreting trials (2009)
Bath, Philip M.W., Gray, Laura J.
Background Systematic reviews followed by ameta-analysis are carried out in medical research to combine the results of two or more related studies. Stroke trials have struggled to show beneficial...
Speeding stroke recovery? A systematic review of amphetamine after stroke (2009)
Sprigg, Nikola, Bath, Philip M.W.
Introduction: The use of drugs to enhance recovery (“rehabilitation pharmacology”) has been assessed. Amphetamine can improve outcome in experimental models of stroke, and several small clinical...
Bath, Philip M.W., Martin, Renée H., Palesch, Yuko, Cotton, Daniel, Yusuf, Salim, Sacco, Ralph L., ...
Background and Purpose—High blood pressure (BP) is common in acute ischemic stroke and associated independently with a poor functional outcome. However, the management of BP acutely remains unclear...
Telmisartan to prevent recurrent stroke and cardiovascular events (2008)
Yusuf, S, Diener, HC, Sacco, RL, Cotton, D, Ounpuu, S, Lawton, WA, ...
Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate...
Telmisartan to prevent recurrent stroke and cardiovascular events (2008)
Yusuf, Salim, Diener, Hans-Christoph, Sacco, Ralph L., Cotton, Daniel, Ounpuu, Stephanie, Lawton, William A., ...
Background Prolonged lowering of blood pressure after a stroke reduces the risk of recurrent stroke. In addition, inhibition of the renin–angiotensin system in high-risk patients reduces the rate...
Bath, Philip M.W., Geeganage, Chamila, Gray, Laura J., Collier, T, Pocock, S
Background and Purpose—Vascular prevention trials mostly count “yes/no” (binary) outcome events, eg, stroke/no stroke. Analysis of ordered categorical vascular events (eg, fatal stroke/nonfatal...
Bath, Philip M.W., Geeganage, Chamila, Gray, Laura J., Collier, T, Pocock, S
Background and Purpose—Vascular prevention trials mostly count “yes/no” (binary) outcome events, eg, stroke/no stroke. Analysis of ordered categorical vascular events (eg, fatal stroke/nonfatal...
Stroke outcome in clinical trial patients deriving from different countries (2008)
Ali, Myzoon, Atula, Sari, Bath, Philip M.W., Grotta, James, Hacke, Werner, Lyden, Patrick D., ...
Background and Purpose—Stroke incidence and outcome vary widely within and across geographical locations. We examined whether differences in index stroke severity, stroke risk factors, mortality,...
Crossley, Nicolas A, Sena, Emily, Goehler, Jos, Horn, Jannekke, Van Der Worp, Bart, Bath, Philip M.W., ...
Background and Purpose—At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of...
Konig, Inke, Ziegler, Andreas, Bluhmki, Enrich, Hacke, Werner, Bath, Philip M.W., Sacco, Ralph L, ...
Background and Purpose—An early and reliable prognosis for recovery in stroke patients is important for initiation of individual treatment and for informing patients and relatives. We recently...
Sprigg, N, Gray, Laura J., England, Timothy, Wilmot, M, Zhao, Lian, Sare, Gillian M., ...
Background: Aspirin, dipyridamole and clopidogrel are effective in secondary vascular prevention. Combination therapy with three antiplatelet agents might maximise the benefit of antiplatelet...
Crossley, Nicolas A., Sena, Emily S., Goehler, Jos, Horn, Jannekke, Van Der Worp, H. Bart, Bath, Philip M.W., ...
Background and Purpose—At least part of the failure in the transition from experimental to clinical studies in stroke has been attributed to the imprecision introduced by problems in the design of...
Konig, Inke, Ziegler, Andreas, Bluhmki, Enrich, Hacke, Werner, Bath, Philip M.W., Sacco, Ralph L., ...
Background and Purpose—An early and reliable prognosis for recovery in stroke patients is important for initiation of individual treatment and for informing patients and relatives. We recently...
Sprigg, Nikola, Gray, Laura J., England, Timothy J., Wilmot, Marc R., Zhao, Lian, Sare, Gillian M., ...
Background: Aspirin, dipyridamole and clopidogrel are effective in secondary vascular prevention. Combination therapy with three antiplatelet agents might maximise the benefit of antiplatelet...
Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke (2008)
Sacco, Ralph L., Diener, Hans-Christoph, Yusuf, Salim, Cotton, Daniel, Ounpuu, Stephanie, Lawton, William A., ...
Background Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extendedrelease...
Progesterone for the treatment of experimental brain injury; a systematic review (2008)
Gibson, Claire L., Gray, Laura J., Bath, Philip M. W., Murphy, Sean P.
Steroid sex hormones are potential neuroprotective candidates following CNS injury. All clinical trials to date have examined the effects of oestrogen alone or oestrogen-progestin combination...
Sare, Gillian M., Gray, Laura J., Bath, Philip M.W.
Aims Randomized controlled trials (RCTs) have shown that the risk of stroke and venous thromboembolism (VTE) is increased with hormone replacement therapy (HRT); the effect on coronary heart disease...
Bath, Philip M.W., Gray, Laura J., Wahlgren, Nils-Gunnar
The primary role of a trials Data Monitoring Committee (DMC) is to ensure the safety of enrolled patients. In stroke trials, safety is monitored typically by comparing death and stroke specific...
Gray, Laura J., Sprigg, Nikola, Bath, Philip M.W., Boysen, Gudrun, De Deyn, Peter Paul, Leys, Didier, ...
Introduction: Female sex is predictive of poor functional outcome in stroke, even after correction for prognostic factors. Poor quality of life (QoL) is observed in stroke survivors, with lower...
Bath, Philip M.W., Gray, Laura J., Wahlgren, Nils-Gunnar
The primary role of a trials Data Monitoring Committee (DMC) is to ensure the safety of enrolled patients. In stroke trials, safety is monitored typically by comparing death and stroke specific...
Gray, Laura J., Sprigg, Nikola, Bath, Philip M.W., Boysen, Gudrun, De Deyn, Peter Paul, Leys, Didier, ...
Introduction: Female sex is predictive of poor functional outcome in stroke, even after correction for prognostic factors. Poor quality of life (QoL) is observed in stroke survivors, with lower...
The Virtual International Stroke Trials Archive (2007)
Myzoon, Ali, Bath, Philip M.W., Curram, John, Davis, Stephen M, Diener, Hans-Christoph, Donnan, Geoffrey A, ...
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...
The Virtual International Stroke Trials Archive (2007)
Myzoon, Ali, Bath, Philip M.W., Curram, John, Davis, Stephen M., Diener, Hans-Christoph, Donnan, Geoffrey A., ...
Background and Purpose - Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...
The Virtual International Stroke Trials Archive (2007)
Ali, Myzoon, Bath, Philip M.W., Curram, John, Davis, Stephen M., Diener, Hans-Christoph, Donnan, Geoffrey A., ...
BACKGROUND AND PURPOSE: Stroke has global importance and it causes an increasing amount of human suffering and economic burden, but its management is far from optimal. The unsuccessful outcome of...
Background Most large acute stroke trials have been neutral. Functional outcome is usually analysed using a yes or no answer, e.g. death or dependency vs. independence. We assessed which statistical...
Background Most large acute stroke trials have been neutral. Functional outcome is usually analysed using a yes or no answer, e.g. death or dependency vs. independence. We assessed which statistical...
Sprigg, Nikola, Gray, Laura J., Bath, Philip M.W., Lindenstrom, Ewa, Boysen, Gudrun, De Deyn, Peter Paul, ...
Introduction: Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the ‘Tinzaparin in Acute...
Sprigg, Nikola, Gray, Laura J., Bath, Philip M.W., Lindenstrom, Ewa, Boysen, Gudrun, De Deyn, Peter Paul, ...
Introduction: Baseline severity and clinical stroke syndrome (Oxford Community Stroke Project, OCSP) classification are predictors of outcome in stroke. We used data from the ‘Tinzaparin in Acute...
Is there a link between aspirin therapy and stroke severity (2007)
Published by: http://npg.nature.com/
Is there a link between aspirin therapy and stroke severity (2007)
Published by: http://npg.nature.com/
Sprigg, Nikola, Gray, Laura, Bath, Philip M W, Lindenstrom, Ewa, Boysen, Gudrun, De Deyn, Peter Paul, ...
Sprigg, Nikola, Willmot, Mark, Gray, Laura J., Sunderland, Alan, Pomeroy, Val, Walker, Marion, ...
Amphetamine enhances recovery after experimental ischaemia and has shown promise in small clinical trials when combined with motor or sensory stimulation. Amphetamine, a sympathomimetic, might have...
Sprigg, Nikola, Willmot, Mark, Gray, Laura J., Sunderland, Alan, Pomeroy, Val, Walker, Marion, ...
Amphetamine enhances recovery after experimental ischaemia and has shown promise in small clinical trials when combined with motor or sensory stimulation. Amphetamine, a sympathomimetic, might have...
Sprigg, Nikola, Gray, Laura, Bath, Philip M W, Lindenstrom, Ewa, Boysen, Gudrun, De Deyn, Peter Paul, ...
Gray, Laura J., Sprigg, Nikola, Rashid, Parveen, Willmot, Mark, Bath, Philip M.W.
High blood pressure (BP), pulse pressure (PP), and rate pressure product (RPP) areeach associated independently with a poor outcome in acute ischemic stroke. Whereas nitric oxide (NO) donors, such as...
Gray, Laura J., Sprigg, Nikola, Rashid, Parveen, Willmot, Mark, Bath, Philip M.W.
High blood pressure (BP), pulse pressure (PP), and rate pressure product (RPP) areeach associated independently with a poor outcome in acute ischemic stroke. Whereas nitric oxide (NO) donors, such as...
Estrogen and experimental ischemic stroke: a systematic review (2006)
Gibson, Claire L, Gray, Laura J., Murphy, Sean, Bath, Philip M.W.
Gray, Laura J., Sprigg, Nikola, Bath, Philip M.W., Sorensen, Per, Lindenstrom, Ewa, Boysen, Gudrun, ...
Background and Purpose - Loss of motor function is common after stroke and leads to significant chronic disability. Stem cells are capable of self-renewal and of differentiating into multiple cell...
Sprigg, Nikola, Bath, Philip M.W., Zhao, Lian, Willmot, Mark, Gray, Laura J., Walker, Marion F., ...
Background and Purpose - Loss of motor function is common after stroke and leads to significant chronic disability. Stem cells are capable of self-renewal and of differentiating into multiple cell...
Estrogen and experimental ischemic stroke: a systematic review (2006)
Gibson, Claire L, Gray, Laura J., Murphy, Sean, Bath, Philip M.W.
Gray, Laura J., Sprigg, Nikola, Bath, Philip M.W., Sorensen, Per, Lindenstrom, Ewa, Boysen, Gudrun, ...
Sprigg, Nikola, Gray, Laura, Bath, Philip M W, Boysen, Gudrun, De Deyn, Peter Paul, Leys, Didier, ...
Willmot, Mark, Gray, Laura J., Gibson, Claire, Murphy, Sean, Bath, Philip M.W.
Background: Nitric oxide (NO) is a candidate treatment for acute ischaemic stroke, however published studies in experimental stroke have given conflicting results. Methods: We performed a systematic...
Sprigg, Nikola, Gray, Laura J., Bath, Philip M.W., Boysen, Gudrun, De Deyn, Peter Paul, Leys, Didier, ...
Background: Venous thromboembolism (VTE) is a well recognised and preventable complication of acute stroke. While graduated compression stockings reduce the risk of VTE in surgical patients their...
Sprigg, Nikola, Gray, Laura, Bath, Philip M W, Boysen, Gudrun, De Deyn, Peter Paul, Leys, Didier, ...
Willmot, Mark, Gray, Laura J., Gibson, Claire L., Murphy, Sean, Bath, Philip M.W.
Background: Nitric oxide (NO) is a candidate treatment for acute ischaemic stroke, however published studies in experimental stroke have given conflicting results. Methods: We performed a systematic...
Sprigg, Nikola, Gray, Laura J., Bath, Philip M.W., Boysen, Gudrun, De Deyn, Peter Paul, Leys, Didier, ...
Background: Venous thromboembolism (VTE) is a well recognised and preventable complication of acute stroke. While graduated compression stockings reduce the risk of VTE in surgical patients their...
Current status of stroke prevention in patients with atrial fibrillation (2005)
Bath, Philip M.W., Zhao, Lian, Heptinstall, Stan
Atrial fibrillation (AF) is a common dysrhythmia and increases the risk of stroke. Data from primary and secondary trials have shown that anticoagulation with vitamin K antagonists such as warfarin,...
Emmerich, Joseph, Le Heuzey, Jean-Yves, Bath, Philip M.W., Connolly, Stuart J.
Cardioembolic stroke secondary to atrial fibrillation (AF) is an urgent public-health problem. On the basis of the data from several randomized controlled clinical trials and pooled analyses, several...
Lees, Kennedy R., Bath, Philip M. W., Naylor, A. Ross
No abstract available.
A trial of blood pressure reduction in acute stroke (2000)
Bath, Philip M. W., Weaver, Chris, Iddenden, Robert, Bath, Fiona J.
There is a wealth of experimental and clinical information showing that hypertension, hyperglycaemia, hyperthermia and intracranial hypertension are each independent indicators of a poor prognosis...
Megakaryocyte DNA content is increased in patients with coronary artery atherosclerosis (1994)
Bath, Philip M W, Gladwin, Ann-Marie, Carden, Natalie, Martin, John F
Objective: Increased megakaryocyte size and megakaryocyte ploidy have been observed in man following myocardial infarction and sudden cardiac death. The aim of this study was to compare megakaryocyte...
Aspirin and Extended-Release Dipyridamole versus Clopidogrel for Recurrent Stroke
Sacco, RL, Diener, Hans-Christoph, Yusuf, S, Cotton, D, Ounpuu, S, Lawton, WA, ...
Background Recurrent stroke is a frequent, disabling event after ischemic stroke. This study compared the efficacy and safety of two antiplatelet regimens — aspirin plus extendedrelease...