Philip Poronnik

The Ubiquitin-Protein Ligase Nedd4-2 Differentially Interacts with and Regulates Members of the Tweety Family of Chloride Ion Channels (2008)

He, Yaowu, Hryciw, Deanne H., Carroll, Melanie L., Myers, Stephen A., Whitbread, Astrid K., Kumar, Sharad, ...

The Tweety proteins comprise a family of chloride ion channels with three members identified in humans (TTYH1-3) and orthologues in fly and murine species. In humans, increased TTYH2 expression is...

The Ubiquitin-Protein Ligase Nedd4-2 Differentially Interacts with and Regulates Members of the Tweety Family of Chloride Ion Channels (2008)

He, Yaowu, Hryciw, Deanne H., Carroll, Melanie L., Myers, Stephen A., Whitbread, Astrid K., Kumar, Sharad, ...

The Tweety proteins comprise a family of chloride ion channels with three members identified in humans (TTYH1-3) and orthologues in fly and murine species. In humans, increased TTYH2 expression is...

The ubiquitin-protein ligase nedd4-2 differentially interacts with and regulates Mmembers of the tweety family of chloride ion channels (2008)

He, Yaowu, Hryciw, Deanne H., Carroll, Melanie L., Myers, Stephen A., Whitbread, Astrid K., Kumar, Sharad, ...

The Tweety proteins comprise a family of chloride ion channels with three members identified in humans (TTYH1-3) and orthologues in fly and murine species. In humans, increased TTYH2 expression is...

The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels (2008)

He, Yaowu, Hryciw, Deanne H., Carroll, Melanie L., Myers, Stephen A., Whitbread, Astrid K., Kumar, Sharad, ...

The Tweety proteins comprise a family of chloride ion channels with three members identified in humans (TTYH1-3) and orthologues in fly and murine species. In humans, increased TTYH2 expression is...

The ubiquitin-protein ligase nedd4-2 differentially interacts with and regulates Mmembers of the tweety family of chloride ion channels (2008)

He, Yaowu, Hryciw, Deanne H., Carroll, Melanie L., Myers, Stephen A., Whitbread, Astrid K., Kumar, Sharad, ...

The Tweety proteins comprise a family of chloride ion channels with three members identified in humans (TTYH1-3) and orthologues in fly and murine species. In humans, increased TTYH2 expression is...

The role of SGK-1 in angiotensin II-mediated sodium reabsorption in human proximal tubular cells (2008)

Stevens, Veronica A, Saad, Sonia, Poronnik, Philip, Fenton-Lee, Carol A, Polhill, Tania S, Pollock, Carol A

Background. The role of angiotensin II (Ang II) in mediating excessive sodium reabsorption in diabetic nephropathy is recognized. Serine-glucocorticoid kinase-1 (SGK-1) increases sodium–hydrogen...

The ubiquitin-protein ligase nedd4-2 differentially interacts with and regulates Mmembers of the tweety family of chloride ion channels (2008)

He, Yaowu, Hryciw, Deanne H., Carroll, Melanie L., Myers, Stephen A., Whitbread, Astrid K., Kumar, Sharad, ...

The Tweety proteins comprise a family of chloride ion channels with three members identified in humans (TTYH1-3) and orthologues in fly and murine species. In humans, increased TTYH2 expression is...

Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination - Novel role for Nedd4-2 (2007)

Ekberg, Jenny, Schuetz, Frederike, Boase, Natasha A., Conroy, Sarah-Jane, Manning, Jantina, Kumar, Sharad, ...

The muscarine-sensitive K+ current (M-current) stabilizes the resting membrane potential in neurons, thus limiting neuronal excitability. The M-current is mediated by heteromeric channels consisting...

Cytoskeletal anchoring of GLAST determines susceptibility to brain damage - an identified role for GFAP (2007)

Sullivan, Susan M., Lee, Aven, Bjorkman, S. Tracey, Miller, Stephanie M., Sullivan, Robert K. P., Poronnik, Philip, ...

Glial fibrillary acidic protein (GFAP) is an enigmatic protein; it currently has no unambiguously defined role. It is expressed in the cytoskeleton of astrocytes in the mammalian brain. We have used...

Assessing core manipulative skills in a large, first-year laboratory (2007)

Moni, Roger W., Hryciw, Deanne H., Poronnik, Philip, Lluka, LJ, Moni, Karen B.

Assessing core manipulative skills in a large, first-year laboratory. Adv Physiol Educ 31: 266-269, 2007; doi:10.1152/advan.00020.2007.- Responding to the concern from our faculty that undergraduate...

Regulation of the voltage-gated K+ channels KCNQ2/3 and KCNQ3/5 by ubiquitination - Novel role for Nedd4-2 (2007)

Ekberg, Jenny, Schuetz, Frederike, Boase, Natasha A., Conroy, Sarah-Jane, Manning, Jantina, Kumar, Sharad, ...

The muscarine-sensitive K+ current (M-current) stabilizes the resting membrane potential in neurons, thus limiting neuronal excitability. The M-current is mediated by heteromeric channels consisting...

Cytoskeletal anchoring of GLAST determines susceptibility to brain damage - an identified role for GFAP (2007)

Sullivan, Susan M., Lee, Aven, Bjorkman, S. Tracey, Miller, Stephanie M., Sullivan, Robert K. P., Poronnik, Philip, ...

Glial fibrillary acidic protein (GFAP) is an enigmatic protein; it currently has no unambiguously defined role. It is expressed in the cytoskeleton of astrocytes in the mammalian brain. We have used...

Na1-H1 Exchanger Regulatory Factor 1 is a PDZ Scaffold for the Astroglial Glutamate Transporter GLAST (2006)

Lee, Aven, Rayfield, Andrew, Hryciw, Deanne H., Ma, Theingi A., Wang, Dongsheng, Pow, David, ...

Glutamate is a key neurotransmitter and its levels in the synaptic cleft are tightly regulated by reuptake mechanisms that primarily involve transporters in astrocytes. This requires that the...

Regulation of albumin endocytosis by PSD95/Dlg/ZO-1 (PDZ) scaffolds - Interaction of Na+-H+ exchange regulatory factor-2 with ClC-5 (2006)

Hryciw, Deanne H., Ekberg, Jenny, Ferguson, Charles, Lee, Aven, Wang, Dongsheng, Parton, Robert G., ...

The constitutive reuptake of albumin from the glomerular filtrate by receptor-mediated endocytosis is a key function of the renal proximal tubules. Both the Cl- channel ClC-5 and the Na+-H+ exchanger...

Postnatal developmental expression of the PDZ scaffolds Na+-H+ exchanger regulatory factors 1 and 2 in the rat cochlea (2006)

Kanjhan, Refik, Hryciw, Deanne H., Yun, C. Chris, Bellingham, Mark C., Poronnik, Philip

Sensory transduction in the mammalian cochlea requires the maintenance of specialized fluid compartments with distinct ionic compositions. This is achieved by the concerted action of diverse ion...

Na1-H1 Exchanger Regulatory Factor 1 is a PDZ Scaffold for the Astroglial Glutamate Transporter GLAST (2006)

Lee, Aven, Rayfield, Andrew, Hryciw, Deanne H., Ma, Theingi A., Wang, Dongsheng, Pow, David, ...

Glutamate is a key neurotransmitter and its levels in the synaptic cleft are tightly regulated by reuptake mechanisms that primarily involve transporters in astrocytes. This requires that the...

The renal cortical fibroblast in renal tubulointerstitial fibrosis (2006)

Qi, Weier, Chen,Xinming, Poronnik, Philip, POLLOCK, Carol A.

Renal cortical fibroblasts have key roles in mediating intercellular communication with neighboring/infiltrating cells and extracellular matrix (ECM) and maintenance of renal tissue architecture....

A yellow fluorescent protein-based assay for high-throughput screening of glycine and GABA(A) receptor chloride channels (2005)

Kruger, Wade, Gilbert, Daniel, Hawthorne, Rebecca, Hryciw, Deanne H., Frings, Stephan, Poronnik, Philip, ...

There is a significant clinical need to identify novel ligands with high selectivity and potency for GABA(A), GABA(C) and glycine receptor Cl- channels. Two recently developed, yellow fluorescent...