Abstract Background Self-renewal of the epithelium of the small intestine is a highly regulated process involving cell proliferation and differentiation of stem cells or progenitor cells located at...
Function of Cell Cycle Control Proteins in Breast Cancer. (1998)
Loss of the retinoblastoma tumor suppressor protein (pRb) can contribute to breast tumor formation. However, many breast tumors retain expression of normal pRb, indicating that other genetic events...
Kinase Independent Functions of Cyclin D1 Which Contribute to its Oncogenic Potential In Vivo (1998)
Landis, Mark W., Hinds, Philip W.
Cyclin D1, an important cell cycle regulator, is a potent oncogene in several tumor types, including breast cancer. The most well understood function of cyclin D1 is to bind and activate cdks 4 and...
Kinase Independent Functions of Cyclin D1 Which Contribute to its Oncogenic Potential In Vivo (1998)
Landis, Mark W., Hinds, Philip W.
Cyclin D1, an important cell cycle regulator, is a potent oncogene in several tumor types, including breast cancer. The most well understood function of cyclin D1 is to bind and activate cdks 4 and...
Kinase Independent Functions of Cyclin D1 Which Contribute to its Oncogenic Potential In Vivo (1998)
Landis, Mark W., Hinds, Philip W.
Cyclin D1, an important cell cycle regulator, is a potent oncogene in several tumor types, including breast cancer. The most well understood function of cyclin D1 is to bind and activate cdks 4 and...
Function of Cell Cycle Control Proteins in Breast Cancer. (1997)
Loss of the retinoblastoma tumor suppressor protein (pRb) can contribute to breast tumor formation. However, many breast tumors retain expression of normal pRb, indicating that other genetic events...
Biological consequences of mutation of the p53 proto-oncogene /--Philip W. Hinds. (1989)
Thesis (Ph. D.)--Princeton University, 1989.
Includes vita.
Statistical and biological analyses of tuplet frequencies in DNA sequences / (1983)
Thesis (Honors)--University of Maine, 1983.
Requirement for p27KIP1 in Retinoblastoma Protein-Mediated Senescence
Alexander, Kamilah, Hinds, Philip W.
In vivo and in vitro evidence indicate that cells do not divide indefinitely but instead stop growing and undergo a process termed cellular proliferative senescence. Very little is known about how...
Cellular Senescence Requires CDK5 Repression of Rac1 Activity
Alexander, Kamilah, Yang, Hai-Su, Hinds, Philip W.
Cellular senescence is a tumor-suppressive process characterized by an irreversible cell cycle exit, a unique morphology, and expression of senescence-associated β-galactosidase (SA-β-Gal). We...
Essential role of retinoblastoma protein in mammalian hair cell development and hearing
Sage, Cyrille, Huang, Mingqian, Vollrath, Melissa A., Brown, M. Christian, Hinds, Philip W., Corey, David P., ...
The retinoblastoma protein pRb is required for cell-cycle exit of embryonic mammalian hair cells but not for their early differentiation. However, its role in postnatal hair cells is unknown. To...
Requirement for p27KIP1 in Retinoblastoma Protein-Mediated Senescence
Alexander, Kamilah, Hinds, Philip W.
In vivo and in vitro evidence indicate that cells do not divide indefinitely but instead stop growing and undergo a process termed cellular proliferative senescence. Very little is known about how...
Cellular Senescence Requires CDK5 Repression of Rac1 Activity
Alexander, Kamilah, Yang, Hai-Su, Hinds, Philip W.
Cellular senescence is a tumor-suppressive process characterized by an irreversible cell cycle exit, a unique morphology, and expression of senescence-associated β-galactosidase (SA-β-Gal). We...
Essential role of retinoblastoma protein in mammalian hair cell development and hearing
Sage, Cyrille, Huang, Mingqian, Vollrath, Melissa A., Brown, M. Christian, Hinds, Philip W., Corey, David P., ...
The retinoblastoma protein pRb is required for cell-cycle exit of embryonic mammalian hair cells but not for their early differentiation. However, its role in postnatal hair cells is unknown. To...
Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma
Thomas, David M., Johnson, Sandra A., Sims, Natalie A., Trivett, Melanie K., Slavin, John L., Rubin, Brian P., ...
The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt...
Impaired bone development and increased mesenchymal progenitor cells in calvaria of RB1−/− mice
Gutierrez, Gabriel M., Kong, Elizabeth, Sabbagh, Yves, Brown, Nelson E., Lee, Jong-Seo, Demay, Marie B., ...
We have previously shown that the retinoblastoma protein (pRb) can activate expression of Runx2-dependent, bone-specific genes in cultured cells. We now show that pRb also plays a role early in...
Zhang, Xin, Neganova, Irina, Przyborski, Stefan, Yang, Chunbo, Cooke, Michael, Atkinson, Stuart P., ...
In this study, we show that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components....