Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis (2009)
Kümpers, Philipp, Van Meurs, Matijs, David, Sascha, Molema, Grietje, Bijzet, Johan, Lukasz, Alexander, ...
Abstract Introduction Endothelial activation leading to vascular barrier breakdown denotes a devastating event in sepsis. Angiopoietin (Ang)-2, a circulating antagonistic ligand of the endothelial...
Bench-to-bedside review: Angiopoietin signalling in critical illness – a future target? (2009)
Van Meurs, Matijs, Kümpers, Philipp, Ligtenberg, Jack JM, Meertens, John HJM, Molema, Grietje, Zijlstra, Jan G
Abstract Multiple organ dysfunction syndrome (MODS) occurs in response to major insults such as sepsis, severe haemorrhage, trauma, major surgery and pancreatitis. The mortality rate is high despite...
Lovric, Svjetlana, Erdbruegger, Uta, Kümpers, Philipp, Woywodt, Alexander, Koenecke, Christian, Wedemeyer, Heiner, ...
Background. B-cell depletion with rituximab, a chimeric anti-CD20 antibody, is a novel treatment for refractory and relapsing ANCA-associated small-vessel vasculitis. Data are limited and most...
Kümpers, Philipp, Hellpap, Julian, David, Sascha, Horn, Rüdiger, Leitolf, Holger, Haller, Hermann, ...
Background. The endothelial-specific angiopoietin (Ang)-Tie ligand–receptor system has been identified as a non-redundant regulator of endothelial cell detachment in vitro. Binding of circulating...
David, Sascha, Kümpers, Philipp, Eisenbach, Georg M., Haller, Hermann, Kielstein, Jan T.
Introduction. Under physiological conditions kidneys work continuously, 168 h/week. In contrast, patients with end-stage renal disease are usually dialyzed only 12–15 h/ week. This unphysiological...
Schiffer, Lena, Kümpers, Philipp, Davalos-Misslitz, Ana. M., Haubitz, Marion, Haller, Hermann, Anders, Hans-Joachim, ...
Objectives. The chemokine CXCL13, also known as BCA-1 (B-cell-attracting chemokine-1) or BLC (B-lymphocyte chemoattractant), is a major regulator of B-cell trafficking. We have recently shown that...
Kümpers, Philipp, Lukasz, Alexander, David, Sascha, Horn, Rüdiger, Hafer, Carsten, Faulhaber-Walter, Robert, ...
Abstract Introduction The endothelial specific angiopoietin (Ang)-Tie2 ligand-receptor system has been identified as a non-redundant mediator of endothelial activation in experimental sepsis. Binding...
Lukasz, Alexander, Hellpap, Julian, Horn, Rüdiger, Kielstein, Jan T, David, Sascha, Haller, Hermann, ...
Abstract Introduction In critically ill patients, the massive release of angiopoietin-2 (Ang-2) from endothelial Weibel–Palade bodies interferes with constitutive angiopoietin-1 (Ang-1)/Tie2...
David, Sascha, Kümpers, Philipp, Seidler, Vega, Biertz, Frank, Haller, Hermann, Fliser, Danilo
Background. Natriuretic peptides such as N-terminal pro-B-type natriuretic peptide (NT-proBNP) have become increasingly important in diagnosing left ventricular dysfunction (LVD), however, in...
Everolimus-associated interstitial pneumonitis in a patient with a heart transplant (2007)
David, Sascha, Kümpers, Philipp, Shin, Hoen, Haller, Hermann, Fliser, Danilo
Immobilisation nach elektrothermischem Shrinkage kollagenhaltigen Gewebes (2005)
In dieser Studie wurden die Ligg. patellae von Kaninchen mittels Radiofrequenz (RF)-Energie verkürzt und postoperativ immobilisiert. Ziel war es, die Auswirkungen einer postoperativen Immobilisation...
Lukasz, Alexander, Hellpap, Julian, Horn, Rüdiger, Kielstein, Jan T, David, Sascha, Haller, Hermann, ...