Vandez, Yanet, Diehl, Gretchen E., Vallance, Bruce A., Grassl, Guntram A., Guttman, Julian A., Brown, Nathaniel Francis, ...
Host resistance against Salmonella enterica serovar Typhimurium (S. Typhimurium) is mediated by natural resistance-associated macrophage protein 1 (Nramp1/Slc11a1). Nramp1 is critical to host...
Vandez, Yanet, Diehl, Gretchen E., Vallance, Bruce A., Grassl, Guntram A., Guttman, Julian A., Brown, Nathaniel Francis, ...
Host resistance against Salmonella enterica serovar Typhimurium (S. Typhimurium) is mediated by natural resistance-associated macrophage protein 1 (Nramp1/Slc11a1). Nramp1 is critical to host...
BERTRAND, Arnaud, JOSSE, Emmanuelle, BACH, Pascal, GROS, Philippe, DAGORN, Laurent
We studied relationships between tropical tunas (albacore (Thunnus alalunga), bigeye (Thunnus obesus), and yellowfin (Thunnus albacares)) and their biotic and abiotic environments through...
GUARINI, Jean-Marc, BLANCHARD, Gerard, BACHER, Cedric, GROS, Philippe, RIERA, Pascal, RICHARD, Pierre, ...
Microphytobenthos plays an important role as primary producer in shallow embayments subject to a tidal regime. The present paper aims to characterize the spatial patterns of sedimentary chlorophyll a...
Reflecting on research prospects about management systems analysis (1992)
DE VERDELHAN, Claude, GROS, Philippe, CATANZANO, Joseph
(i) La pertinence du thème est attestée par la richesse de la littérature internationale qui lui est consacrée. 11 convient au demeurant de noter la présence de publications de l'IFREMER dans ce...
Gros, Philippe, Croop, James, Roninson, Igor, Varshavsky, Alexander, Housman, David E.
The mechanism by which mammalian cells acquire resistance to chemotherapeutic agents has been investigated by using molecular genetic techniques, LZ and C5, two independently derived...
The totality of French landings of whelk (Buccinum undatum L.) is assignable to the fisheries of the Normand-Breton Gulf, western Channel. The aim of this paper is to forecast economic rent of the...
Genetic control of resistance to intracellular parasites / (1982)
Written for the Dept. of Experimental Medicine.
Thèse (M. Sc.)--Université de Montréal.
Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice
Fortin, Anny, Cardon, Lon R., Tam, Mifong, Skamene, Emil, Stevenson, Mary M., Gros, Philippe
The genetic component of susceptibility to malaria is complex, both in humans and in the mouse model of infection. Two murine loci on chromosomes 8 (Pchr/Char2) and 9 (Char1) have previously been...
Consequence of Nramp1 Deletion to Mycobacterium tuberculosis Infection in Mice
North, Robert J., LaCourse, Ronald, Ryan, Lynn, Gros, Philippe
129sv mice functionally deleted of the antimicrobial resistance gene, Nramp1, were found to be as resistant as wild-type mice to infection with the virulent H37Rv strain of Mycobacterium...
Functional Expression of Nramp1 In Vitro in the Murine Macrophage Line RAW264.7
Govoni, Gregory, Canonne-Hergaux, François, Pfeifer, Cheryl G., Marcus, Sandra L., Mills, Scott D., Hackam, David J., ...
Mutations at the Nramp1 locus in vivo cause susceptibility to infection by unrelated intracellular microbes. Nramp1 encodes an integral membrane protein abundantly expressed in the...
Sebastiani, Giovanna, Blais, Véronique, Sancho, Vanessa, Vogel, Stefanie N., Stevenson, Mary M., Gros, Philippe, ...
Studies of mouse models of endotoxemia and sepsis with gram-negative bacteria have shown that the host response is genetically controlled. Mice infected with the gram-negative bacterium Salmonella...
Zaharik, Michelle L., Vallance, Bruce A., Puente, José L., Gros, Philippe, Finlay, B. Brett
Nramp1 (Natural resistance-associated macrophage protein-1; also known as Slc11a1) is a host resistance gene that provides protection against several intracellular pathogens, including Salmonella...
Iron chelators modulate the fusogenic properties of Salmonella-containing phagosomes
Jabado, Nada, Cuellar-Mata, Patricia, Grinstein, Sergio, Gros, Philippe
In macrophages, the divalent cations transporter Nramp1 is recruited from the lysosomal compartment to the membrane of phagosomes formed in these cells. Nramp1 mutations cause susceptibility to...
Mitsos, Loukia-Maria, Cardon, Lon R., Ryan, Lynn, LaCourse, Ronald, North, Robert J., Gros, Philippe
The mouse DBA/2 (D2) strain is very susceptible to infection with virulent Mycobacterium tuberculosis, whereas C57BL/6 (B6) is much more resistant. Infection of D2 and B6 mice with M. tuberculosis...
Forget, Adrien, Skamene, Emil, Gros, Philippe, Miailhe, Annie-Claude, Turcotte, Raymond
Intravenous infection of six inbred mouse strains with small doses of dispersed cells of Mycobacterium bovis BCG (15.5 × 103 or 15.5 × 104 colony-forming units) separated them into resistant...
Dysregulated Inflammatory Response to Candida albicans in a C5-Deficient Mouse Strain†
Mullick, Alaka, Elias, Miria, Picard, Serge, Bourget, Lucie, Jovcevski, Orce, Gauthier, Susan, ...
Experimental infection of inbred mouse strains with Candida albicans provides a good model system to identify host genetic determinants that regulate onset of, response to, and ultimate outcome of...
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages
Kwan, Tony, Liu, Jing, DuBow, Michael, Gros, Philippe, Pelletier, Jerry
Bacteriophages are the most abundant life forms in the biosphere. They play important roles in bacterial ecology, evolution, adaptation to new environments, and pathogenesis of human bacterial...
Ing, Rebecca, Gros, Philippe, Stevenson, Mary M.
Compared to C57BL/6 wild-type mice, interleukin-15−/− (IL-15−/−) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell...
Martin-Orozco, Natalia, Touret, Nicolas, Zaharik, Michael L., Park, Edwin, Kopelman, Raoul, Miller, Samuel, ...
The objective of these studies was to analyze the role of the ionic environment of phagosomal vacuoles in the control of pathogens by macrophages. Digital imaging and flow cytometry were used to...
Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages†
Kwan, Tony, Liu, Jing, DuBow, Michael, Gros, Philippe, Pelletier, Jerry
A genomic analysis of 18 P. aeruginosa phages, including nine newly sequenced DNA genomes, indicates a tremendous reservoir of proteome diversity, with 55% of open reading frames (ORFs) being novel....
Caron, Judith, Larivière, Line, Nacache, Mayss, Tam, Mifong, Stevenson, Mary M., McKerly, Colin, ...
Genetic analyses identified Ses1 as a significant quantitative trait locus influencing the carrier state of 129S6 mice following a sublethal challenge with Salmonella enterica serovar Enteritidis....
Cardiac Failure in C5-Deficient A/J Mice after Candida albicans Infection†
Mullick, Alaka, Leon, Zully, Min-Oo, Gundula, Berghout, Joanne, Lo, Rita, Daniels, Eugene, ...
The effect of a deficiency in the C5 component of complement on the pathophyisology of infection with the fungal pathogen Candida albicans was studied by using the A/J inbred mouse strain and the...
Identification of a new malaria susceptibility locus (Char4) in recombinant congenic strains of mice
Fortin, Anny, Cardon, Lon R., Tam, Mifong, Skamene, Emil, Stevenson, Mary M., Gros, Philippe
The genetic component of susceptibility to malaria is complex, both in humans and in the mouse model of infection. Two murine loci on chromosomes 8 (Pchr/Char2) and 9 (Char1) have previously been...
Consequence of Nramp1 Deletion to Mycobacterium tuberculosis Infection in Mice
North, Robert J., LaCourse, Ronald, Ryan, Lynn, Gros, Philippe
129sv mice functionally deleted of the antimicrobial resistance gene, Nramp1, were found to be as resistant as wild-type mice to infection with the virulent H37Rv strain of Mycobacterium...
Functional Expression of Nramp1 In Vitro in the Murine Macrophage Line RAW264.7
Govoni, Gregory, Canonne-Hergaux, François, Pfeifer, Cheryl G., Marcus, Sandra L., Mills, Scott D., Hackam, David J., ...
Mutations at the Nramp1 locus in vivo cause susceptibility to infection by unrelated intracellular microbes. Nramp1 encodes an integral membrane protein abundantly expressed in the...
Sebastiani, Giovanna, Blais, Véronique, Sancho, Vanessa, Vogel, Stefanie N., Stevenson, Mary M., Gros, Philippe, ...
Studies of mouse models of endotoxemia and sepsis with gram-negative bacteria have shown that the host response is genetically controlled. Mice infected with the gram-negative bacterium Salmonella...
Zaharik, Michelle L., Vallance, Bruce A., Puente, José L., Gros, Philippe, Finlay, B. Brett
Nramp1 (Natural resistance-associated macrophage protein-1; also known as Slc11a1) is a host resistance gene that provides protection against several intracellular pathogens, including Salmonella...
Iron chelators modulate the fusogenic properties of Salmonella-containing phagosomes
Jabado, Nada, Cuellar-Mata, Patricia, Grinstein, Sergio, Gros, Philippe
In macrophages, the divalent cations transporter Nramp1 is recruited from the lysosomal compartment to the membrane of phagosomes formed in these cells. Nramp1 mutations cause susceptibility to...
Mitsos, Loukia-Maria, Cardon, Lon R., Ryan, Lynn, LaCourse, Ronald, North, Robert J., Gros, Philippe
The mouse DBA/2 (D2) strain is very susceptible to infection with virulent Mycobacterium tuberculosis, whereas C57BL/6 (B6) is much more resistant. Infection of D2 and B6 mice with M. tuberculosis...
Forget, Adrien, Skamene, Emil, Gros, Philippe, Miailhe, Annie-Claude, Turcotte, Raymond
Intravenous infection of six inbred mouse strains with small doses of dispersed cells of Mycobacterium bovis BCG (15.5 × 103 or 15.5 × 104 colony-forming units) separated them into resistant...
Dysregulated Inflammatory Response to Candida albicans in a C5-Deficient Mouse Strain†
Mullick, Alaka, Elias, Miria, Picard, Serge, Bourget, Lucie, Jovcevski, Orce, Gauthier, Susan, ...
Experimental infection of inbred mouse strains with Candida albicans provides a good model system to identify host genetic determinants that regulate onset of, response to, and ultimate outcome of...
The complete genomes and proteomes of 27 Staphylococcus aureus bacteriophages
Kwan, Tony, Liu, Jing, DuBow, Michael, Gros, Philippe, Pelletier, Jerry
Bacteriophages are the most abundant life forms in the biosphere. They play important roles in bacterial ecology, evolution, adaptation to new environments, and pathogenesis of human bacterial...
Ing, Rebecca, Gros, Philippe, Stevenson, Mary M.
Compared to C57BL/6 wild-type mice, interleukin-15−/− (IL-15−/−) mice showed delayed clearance of Plasmodium chabaudi AS infection, lower type 1 cytokine production, impaired dendritic cell...
Martin-Orozco, Natalia, Touret, Nicolas, Zaharik, Michael L., Park, Edwin, Kopelman, Raoul, Miller, Samuel, ...
The objective of these studies was to analyze the role of the ionic environment of phagosomal vacuoles in the control of pathogens by macrophages. Digital imaging and flow cytometry were used to...
Comparative Genomic Analysis of 18 Pseudomonas aeruginosa Bacteriophages†
Kwan, Tony, Liu, Jing, DuBow, Michael, Gros, Philippe, Pelletier, Jerry
A genomic analysis of 18 P. aeruginosa phages, including nine newly sequenced DNA genomes, indicates a tremendous reservoir of proteome diversity, with 55% of open reading frames (ORFs) being novel....
Caron, Judith, Larivière, Line, Nacache, Mayss, Tam, Mifong, Stevenson, Mary M., McKerly, Colin, ...
Genetic analyses identified Ses1 as a significant quantitative trait locus influencing the carrier state of 129S6 mice following a sublethal challenge with Salmonella enterica serovar Enteritidis....
Cardiac Failure in C5-Deficient A/J Mice after Candida albicans Infection†
Mullick, Alaka, Leon, Zully, Min-Oo, Gundula, Berghout, Joanne, Lo, Rita, Daniels, Eugene, ...
The effect of a deficiency in the C5 component of complement on the pathophyisology of infection with the fungal pathogen Candida albicans was studied by using the A/J inbred mouse strain and the...
Liu, Jing, Fujiwara, T. Mary, Buu, Natalie T., Sánchez, Fabio O., Cellier, Mathieu, Paradis, Ann Josée, ...
The most common mycobacterial disease in humans is tuberculosis, and there is evidence for genetic factors in susceptibility to tuberculosis. In the mouse, the Bcg gene controls macrophage priming...
Complex genetic control of susceptibility to malaria: positional cloning of the Char9 locus
Min-Oo, Gundula, Fortin, Anny, Pitari, Giuseppina, Tam, Mifong, Stevenson, Mary M., Gros, Philippe
Mouse strains AcB55 and AcB61 are resistant to malaria by virtue of a mutation in erythrocyte pyruvate kinase (PklrI90N). Linkage analysis in [AcB55 × A/J] F2 mice detected a second locus (Char9;...
Turcotte, Karine, Gauthier, Susan, Tuite, Ashleigh, Mullick, Alaka, Malo, Danielle, Gros, Philippe
BXH-2 mice develop a fatal myeloid leukemia by a two-step mutagenic process. First, a BXH-2–specific recessive mutation causes a myeloproliferative syndrome. Second, retroviral insertions alter...
Lee, Seung-Hwan, Zafer, Ahmed, De Repentigny, Yves, Kothary, Rashmi, Tremblay, Michel L., Gros, Philippe, ...
Natural resistance to infection with mouse cytomegalovirus (MCMV) is controlled by a dominant locus, Cmv1. Cmv1 is linked to the Ly49 family of natural killer receptors on distal chromosome 6. While...
Endotoxin-tolerant Mice Have Mutations in Toll-like Receptor 4 (Tlr4)
Qureshi, Salman T., Larivière, Line, Leveque, Gary, Clermont, Sophie, Moore, Karen J., Gros, Philippe, ...
Bacterial lipopolysaccharide (LPS) provokes a vigorous, generalized proinflammatory state in the infected host. Genetic regulation of this response has been localized to the Lps locus on mouse...
Gruenheid, Samantha, Canonne-Hergaux, François, Gauthier, Susan, Hackam, David J., Grinstein, Sergio, Gros, Philippe
The natural resistance associated macrophage protein (Nramp) gene family is composed of two members in mammals, Nramp1 and Nramp2. Nramp1 is expressed primarily in macrophages and mutations at this...
Jabado, Nada, Jankowski, Andrzej, Dougaparsad, Samuel, Picard, Virginie, Grinstein, Sergio, Gros, Philippe
Mutations at the natural resistance–associated macrophage protein 1 (Nramp1) locus cause susceptibility to infection with antigenically unrelated intracellular pathogens. Nramp1 codes for an...
Gruenheid, Samantha, Pinner, Elhanan, Desjardins, Michel, Gros, Philippe
The Nramp1 (natural-resistance-associated macrophage protein 1) locus (Bcg, Ity, Lsh) controls the innate resistance or susceptibility of mice to infection with a group of unrelated intracellular...
Hackam, David J., Rotstein, Ori D., Zhang, Wei-jian, Gruenheid, Samantha, Gros, Philippe, Grinstein, Sergio
The mechanisms underlying the survival of intracellular parasites such as mycobacteria in host macrophages remain poorly understood. In mice, mutations at the Nramp1 gene (for natural...
Marquis, Jean-François, Nantel, André, LaCourse, Ronald, Ryan, Lynn, North, Robert J., Gros, Philippe
The differential susceptibility of inbred mouse strains DBA/2J (susceptible) and C57BL/6J (resistant) to pulmonary tuberculosis following aerosol infection is under complex genetic control. In this...
Pyruvate kinase deficiency confers susceptibility to Salmonella typhimurium infection in mice
Roy, Marie-France, Riendeau, Noémie, Bédard, Christian, Hélie, Pierre, Min-Oo, Gundula, Turcotte, Karine, ...
The mouse response to acute Salmonella typhimurium infection is complex, and it is under the influence of several genes, as well as environmental factors. In a previous study, we identified two novel...
Genetic interaction between members of the Vangl family causes neural tube defects in mice
Torban, Elena, Patenaude, Anne-Marie, Leclerc, Severine, Rakowiecki, Staci, Gauthier, Susan, Andelfinger, Gregor, ...
Neural tube defects (NTDs) are very frequent congenital abnormalities in humans. Recently, we have documented independent association of Vangl1 and Vangl2 gene mutations with NTDs. In the Looptail...
C5 deficiency and C5a or C5aR blockade protects against cerebral malaria
Patel, Samir N., Berghout, Joanne, Lovegrove, Fiona E., Ayi, Kodjo, Conroy, Andrea, Serghides, Lena, ...
Experimental infection of mice with Plasmodium berghei ANKA (PbA) provides a powerful model to define genetic determinants that regulate the development of cerebral malaria (CM). Based on the...