Ephrin-B1 regulates axon guidance by reverse signaling through a PDZ-dependent mechanism (2009)
Bush, Jeffrey O., Soriano, Philippe
Mutations in the ephrin-B1 gene result in craniofrontonasal syndrome (CFNS) in humans, a congenital disorder that includes a wide range of craniofacial, skeletal, and neurological malformations. In...
The PDGF signaling pathway controls multiple steroid-producing lineages (2008)
Schmahl, Jennifer, Rizzolo, Kamran, Soriano, Philippe
The platelet-derived growth factor (PDGF) signaling pathway regulates numerous lineages of mesenchymal cell origin during development and in the adult. The transcriptional targets of this pathway...
Alice Davy, Jeffrey O. Bush, Philippe Soriano
Mutations in X-linked ephrin-B1 in humans cause craniofrontonasal syndrome (CFNS), a disease that affects female patients more severely than males. Sorting of ephrin-B1–positive and –negative...
Nord, Alex S., Chang, Patricia J., Conklin, Bruce R., Cox, Antony V., Harper, Courtney A., Hicks, Geoffrey G., ...
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to...
Nord, Alex S., Chang, Patricia J., Conklin, Bruce R., Cox, Antony V., Harper, Courtney A., Hicks, Geoffrey G., ...
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to...
Aubin, Josée, Davy, Alice, Soriano, Philippe
Integration of diverse signaling pathways is essential in development and homeostasis for cells to interpret context-dependent cues. BMP and MAPK signaling converge on Smads, resulting in...
Ephrin-B1 forward and reverse signaling are required during mouse development (2004)
Davy, Alice, Aubin, Josée, Soriano, Philippe
Eph receptors and ephrin ligands are key players in many developmental processes including embryo patterning, angiogenesis, and axon guidance. Eph/ephrin interactions lead to the generation of a...
Michelle D. Tallquist, Wendy J. French, Philippe Soriano
Using both in vivo and biochemical approaches, the summation of pathways associated with the PDGFRβ signal transduction is shown to determine the expansion of a specific PDGFRβ-dependent cell type.
Michelle D. Tallquist, Wendy J. French, Philippe Soriano
The platelet-derived growth factor β receptor (PDGFRβ) is known to activate many molecules involved in signal transduction and has been a paradigm for receptor tyrosine kinase signaling for many...
Tallquist, Michelle D., Klinghoffer, Richard A., Heuchel, Rainer, Mueting-Nelsen, Peter F., Corrin, Philip D., Heldin, Carl-Henrik, ...
Davy, Alice, Gale, Nicholas W., Murray, Elizabeth W., Klinghoffer, Richard A., Soriano, Philippe, Feuerstein, Claude, ...
The genes coding for the cytoskeletal proteins actin and vimentin in warm-blooded vertebrates (1982)
Dodemont, Huub J., Soriano, Philippe, Quax, Wim J., Ramaekers, Frans, Lenstra, Johannes A.
Genes coding for vimentin and actin in mammals and birds (1982)
Quax, Wim J., Dodement, Huub J., Lenstra, Johannes A., Ramaekers, Frans C.S., Soriano, Philippe
Heuchel, Rainer, Berg, Ansgar, Tallquist, Michelle, Åhlén, Karina, Reed, Rolf K., Rubin, Kristofer, ...
Platelet-derived growth factor (PDGF) isoforms lead to mitogenic, survival, and chemotactic responses in a variety of mesenchymal cell types during development and in the adult. We have studied the...
Zambrowicz, Brian P., Imamoto, Akira, Fiering, Steve, Herzenberg, Leonard A., Kerr, William G., Soriano, Philippe
The ROSAβgeo26 (ROSA26) mouse strain was produced by random retroviral gene trapping in embryonic stem cells. Staining of ROSA26 tissues and fluorescence-activated cell sorter-Gal analysis of...
Hildebrand, Jeffrey D., Soriano, Philippe
The C-terminal binding protein (CtBP) family of proteins has been linked to multiple biological processes through their association with numerous transcription factors. We generated mice harboring...
Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development
Tallquist, Michelle D, French, Wendy J, Soriano, Philippe
The platelet-derived growth factor β receptor (PDGFRβ) is known to activate many molecules involved in signal transduction and has been a paradigm for receptor tyrosine kinase signaling for many...
Komada, Masayuki, McLean, Derek J., Griswold, Michael D., Russell, Lonnie D., Soriano, Philippe
Cell type-specific microtubules, such as the Sertoli cell microtubules and the manchette and flagellum microtubules of the spermatids, play essential roles in spermatogenesis. We identified the gene...
Komada, Masayuki, Soriano, Philippe
Hrs is an early endosomal protein homologous to Vps27p, a yeast protein required for vesicular trafficking. Hrs has a FYVE double zinc finger domain, which specifically binds...
Tallquist, Michelle D., Klinghoffer, Richard A., Heuchel, Rainer, Mueting-Nelsen, Peter F., Corrin, Philip D., Heldin, Carl-Henrik, ...
Signal transduction by the platelet-derived growth-factor receptor β (PDGFR-β) tyrosine kinase is required for proper formation of vascular smooth muscle cells (VSMC). However, the importance of...
Davy, Alice, Gale, Nicholas W., Murray, Elizabeth W., Klinghoffer, Richard A., Soriano, Philippe, Feuerstein, Claude, ...
Eph receptor tyrosine kinases and their corresponding surface-bound ligands, the ephrins, provide cues to the migration of cells and growth cones during embryonic development. Here we show that...
Ephrin-B1 forward and reverse signaling are required during mouse development
Davy, Alice, Aubin, Josée, Soriano, Philippe
Eph receptors and ephrin ligands are key players in many developmental processes including embryo patterning, angiogenesis, and axon guidance. Eph/ephrin interactions lead to the generation of a...
Aubin, Josée, Davy, Alice, Soriano, Philippe
Integration of diverse signaling pathways is essential in development and homeostasis for cells to interpret context-dependent cues. BMP and MAPK signaling converge on Smads, resulting in...
Nord, Alex S., Chang, Patricia J., Conklin, Bruce R., Cox, Antony V., Harper, Courtney A., Hicks, Geoffrey G., ...
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to...
Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms
Hamilton, T. Guy, Klinghoffer, Richard A., Corrin, Philip D., Soriano, Philippe
Receptor tyrosine kinases (RTKs) direct diverse cellular and developmental responses by stimulating a relatively small number of overlapping signaling pathways. Specificity may be determined by RTK...
Davy, Alice, Bush, Jeffrey O, Soriano, Philippe
Mutations in X-linked ephrin-B1 in humans cause craniofrontonasal syndrome (CFNS), a disease that affects female patients more severely than males. Sorting of ephrin-B1–positive and –negative...
Heuchel, Rainer, Berg, Ansgar, Tallquist, Michelle, Åhlén, Karina, Reed, Rolf K., Rubin, Kristofer, ...
Platelet-derived growth factor (PDGF) isoforms lead to mitogenic, survival, and chemotactic responses in a variety of mesenchymal cell types during development and in the adult. We have studied the...
Zambrowicz, Brian P., Imamoto, Akira, Fiering, Steve, Herzenberg, Leonard A., Kerr, William G., Soriano, Philippe
The ROSAβgeo26 (ROSA26) mouse strain was produced by random retroviral gene trapping in embryonic stem cells. Staining of ROSA26 tissues and fluorescence-activated cell sorter-Gal analysis of...
Hildebrand, Jeffrey D., Soriano, Philippe
The C-terminal binding protein (CtBP) family of proteins has been linked to multiple biological processes through their association with numerous transcription factors. We generated mice harboring...
Evolutionary Divergence of Platelet-Derived Growth Factor Alpha Receptor Signaling Mechanisms
Hamilton, T. Guy, Klinghoffer, Richard A., Corrin, Philip D., Soriano, Philippe
Receptor tyrosine kinases (RTKs) direct diverse cellular and developmental responses by stimulating a relatively small number of overlapping signaling pathways. Specificity may be determined by RTK...
Additive Effects of PDGF Receptor β Signaling Pathways in Vascular Smooth Muscle Cell Development
Tallquist, Michelle D, French, Wendy J, Soriano, Philippe
The platelet-derived growth factor β receptor (PDGFRβ) is known to activate many molecules involved in signal transduction and has been a paradigm for receptor tyrosine kinase signaling for many...
Komada, Masayuki, McLean, Derek J., Griswold, Michael D., Russell, Lonnie D., Soriano, Philippe
Cell type-specific microtubules, such as the Sertoli cell microtubules and the manchette and flagellum microtubules of the spermatids, play essential roles in spermatogenesis. We identified the gene...
Komada, Masayuki, Soriano, Philippe
Hrs is an early endosomal protein homologous to Vps27p, a yeast protein required for vesicular trafficking. Hrs has a FYVE double zinc finger domain, which specifically binds...
Tallquist, Michelle D., Klinghoffer, Richard A., Heuchel, Rainer, Mueting-Nelsen, Peter F., Corrin, Philip D., Heldin, Carl-Henrik, ...
Signal transduction by the platelet-derived growth-factor receptor β (PDGFR-β) tyrosine kinase is required for proper formation of vascular smooth muscle cells (VSMC). However, the importance of...
Davy, Alice, Gale, Nicholas W., Murray, Elizabeth W., Klinghoffer, Richard A., Soriano, Philippe, Feuerstein, Claude, ...
Eph receptor tyrosine kinases and their corresponding surface-bound ligands, the ephrins, provide cues to the migration of cells and growth cones during embryonic development. Here we show that...
Ephrin-B1 forward and reverse signaling are required during mouse development
Davy, Alice, Aubin, Josée, Soriano, Philippe
Eph receptors and ephrin ligands are key players in many developmental processes including embryo patterning, angiogenesis, and axon guidance. Eph/ephrin interactions lead to the generation of a...
Aubin, Josée, Davy, Alice, Soriano, Philippe
Integration of diverse signaling pathways is essential in development and homeostasis for cells to interpret context-dependent cues. BMP and MAPK signaling converge on Smads, resulting in...
Nord, Alex S., Chang, Patricia J., Conklin, Bruce R., Cox, Antony V., Harper, Courtney A., Hicks, Geoffrey G., ...
Gene trapping is a method of generating murine embryonic stem (ES) cell lines containing insertional mutations in known and novel genes. A number of international groups have used this approach to...
Davy, Alice, Bush, Jeffrey O, Soriano, Philippe
Mutations in X-linked ephrin-B1 in humans cause craniofrontonasal syndrome (CFNS), a disease that affects female patients more severely than males. Sorting of ephrin-B1–positive and –negative...
High-Efficiency FLP and ΦC31 Site-Specific Recombination in Mammalian Cells
Raymond, Christopher S., Soriano, Philippe
DNA site-specific recombinases (SSRs) such as Cre, FLPe, and φC31, are powerful tools for analyzing gene function in vertebrates. While the availability of multiple high-efficiency SSRs would...
Komada, Masayuki, Soriano, Philippe
β-Spectrin and ankyrin are major components of the membrane cytoskeleton. We have generated mice carrying a null mutation in the βIV-spectrin gene using gene trapping in embryonic stem cells. Mice...
Regulation of neural progenitor cell state by ephrin-B
Qiu, Runxiang, Wang, Xiuyun, Davy, Alice, Wu, Chen, Murai, Kiyohito, Zhang, Heying, ...
Maintaining a balance between self-renewal and differentiation in neural progenitor cells during development is important to ensure that correct numbers of neural cells are generated. We report that...
The PDGF signaling pathway controls multiple steroid-producing lineages
Schmahl, Jennifer, Rizzolo, Kamran, Soriano, Philippe
The platelet-derived growth factor (PDGF) signaling pathway regulates numerous lineages of mesenchymal cell origin during development and in the adult. The transcriptional targets of this pathway...