Philippe Souque

Effect of Chlamydia trachomatis Infection and Subsequent Tumor Necrosis Factor Alpha Secretion on Apoptosis in the Murine Genital Tract

Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...

The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...

Effect of Chlamydia trachomatis Infection and Subsequent Tumor Necrosis Factor Alpha Secretion on Apoptosis in the Murine Genital Tract

Perfettini, Jean-Luc, Darville, Toni, Gachelin, Gabriel, Souque, Philippe, Huerre, Michel, Dautry-Varsat, Alice, ...

The pathology observed during Chlamydia infection is due initially to localized tissue damage caused by the infection itself, followed by deleterious host inflammatory responses that lead to...

Nuclear Import Defect of Human Immunodeficiency Virus Type 1 DNA Flap Mutants Is Not Dependent on the Viral Strain or Target Cell Type

Arhel, Nathalie, Munier, Sandie, Souque, Philippe, Mollier, Karine, Charneau, Pierre

We have previously established, using human immunodeficiency virus type 1 (HIV-1) strain LAI, that the HIV-1 central DNA Flap acts as a cis determinant of viral genome nuclear import. Although the...

HIV-1 DNA Flap formation promotes uncoating of the pre-integration complex at the nuclear pore

Arhel, Nathalie J, Souquere-Besse, Sylvie, Munier, Sandie, Souque, Philippe, Guadagnini, Stéphanie, Rutherford, Sandra, ...

The HIV-1 central DNA Flap acts as a cis-acting determinant of HIV-1 genome nuclear import. Indeed, DNA-Flap re-insertion within lentiviral-derived gene transfer vectors strongly stimulates gene...