Bellodi, Christian, Lidonnici, Maria Rosa, Hamilton, Ashley, Helgason, G. Vignir, Soliera, Angela Rachele, Ronchetti, Mattia, ...
This is the author's final draft of the paper published as Journal of Clinical Investigation, 2009, 119 (5), pp. 1109-1123. The final version is available from http://www.jci.org/articles/view/35660....
Vogler, Meike, Dinsdale, David, Sun, Xiao-Ming, Young, Kenneth W., Butterworth, Michael, Nicotera, Pierluigi, ...
This is the author's final draft of the paper published as Cell Death and Differentiation, 2008, 15, pp. 820-830. The final version is available from www.nature.com/cdd/journal. Doi:...
The dawning of a new age of toxicology (2008)
Leist, Marcel, Hartung, Thomas, Nicotera, Pierluigi
Toxicology faces enormous challenges in a world in which we are exposed to thousands of chemicals and millions of mixtures thereof. Radically new approaches to this problem need to be developed. A...
Chernova, Tatyana, Steinert, Joern R., Guerin, Christopher J., Nicotera, Pierluigi, Forsythe, Ian D., Smith, Andrew G.
Also available from http://www.jneurosci.org/cgi/content/abstract/27/32/8475. Copyright The Society for Neuroscience.
Janus a god with two faces: death and survival utilise same mechanisms conserved by evolution (2007)
Nicotera, Pierluigi, Peterson, O.H., Melino, Gerry, Verkhratsky, A.
This is the author's draft of the Editorial which was published in Cell Death and Differentiation. It is available online in it's final version at...
Berliocchi, Laura, Fava, Eugenio, Leist, Marcel, Horvat, Volker, Dinsdale, David, Read, David, ...
Clostridial neurotoxins are bacterial endopeptidases that cleave the major SNARE proteins in peripheral motorneurons. Here, we show that disruption of synaptic architecture by botulinum neurotoxin C1...
Molecular Switches Deciding the Death of Injured Neurons (2003)
The endpoints used to evaluate neurotoxicity of drugs and chemicals are multiple and reflect the complexity of the nervous system. In many instances, loss of function can result from a temporary...
Molecular Switches Deciding the Death of Injured Neurons (2003)
The endpoints used to evaluate neurotoxicity of drugs and chemicals are multiple and reflect the complexity of the nervous system. In many instances, loss of function can result from a temporary...
Molecular Switches Deciding the Death of Injured Neurons (2003)
The endpoints used to evaluate neurotoxicity of drugs and chemicals are multiple and reflect the complexity of the nervous system. In many instances, loss of function can result from a temporary...
Calpain inhibitors prevent nitric oxidetriggered excitotoxic apoptosis (2001)
Volbracht, Christiane, Fava, Eugenio, Leist, Marcel, Nicotera, Pierluigi
The pathogenesis of some neurodegenerative disorders has been linked to excitotoxicity, excess generation of nitric oxide (NO) and apoptosis. Here, we used a model of NO-triggered neuronal apoptosis...
Apoptosis in Caspase-inhibited Neurons (2001)
Volbracht, Christiane, Leist, Marcel, Kolb, Stefan A., Nicotera, Pierluigi
Background: There is growing evidence of apoptosis in neurodegenerative disease. However, it is still unclear whether the pathological manifestations observed in slow neurodegenerative diseases are...
Energy Requirement for Caspase Activation and Neuronal Cell Death (2000)
Nicotera, Pierluigi, Leist, Marcel, Fava, Eugenio, Berliocchi, Laura, Volbracht, Christiane
Recent work has shown that execution of the apoptotic program involves a relatively limited number of pathways. According to a general view, these would converge to activate the caspase family of...
ATP Controls Neuronal Apoptosis Triggered by Microtubule Breakdown or Potassium (1999)
Volbracht, Christiane, Leist, Marcel, Nicotera, Pierluigi
Background: Early loss of neurites followed by delayed damage of neuronal somata is a feature of several neurodegenerative diseases. Death by apoptosis would ensure the rapid removal of injured...
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntingtons disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Tributyltin-Induced Apoptosis Requires Glycolytic Adenosine Trisphosphate Production (1999)
Stridh, Hélène, Fava, Eugenio, Single, Barbara, Nicotera, Pierluigi, Orrenius, Sten, Leist, Marcel
The toxicity of tributyltin chloride (TBT) involves Ca2+ overload, cytoskeletal damage, and mitochondrial failure leading to cell death by apoptosis or necrosis. Here, we examined whether the...
Leist, Marcel, Volbracht, Christiane, Fava, Eugenio, Nicotera, Pierluigi
The pathogenesis of several neurodegenerative diseases may involve indirect excitotoxic mechanisms, where glutamate receptor overstimulation is a secondary consequence of initial functional defects...
Hypersensitivity to seizures in beta-amyloid precursor protein deficient mice (1998)
Steinbach, Joachim P., Müller, Ulrike, Leist, Marcel, Li, Zhi-Wei, Nicotera, Pierluigi, Aguzzi, Adriano
Secreted forms of the β-amyloid precursor protein (β-APP) have neuroprotective properties in vitro and may be involved in the containment of neuronal excitation. To test whether loss of...
Simultaneous release of adenylate kinase and cytochrome c in cell death (1998)
Single, Barbara, Leist, Marcel, Nicotera, Pierluigi
Cytochrome c (Cyt c) is located within the mitochondrial intermembrane space, and it is an essential constituent of the respiratory chain. The translocation of Cyt c from mitochondria to the cytosol...
Leist, Marcel, Kühnle, Simone, Single, Barbara, Nicotera, Pierluigi
Apoptosis and necrosis are two forms of cell death that have been defined on the basis of distinguishable morphological criteria. However, these different types of cell death may involve several...
Leist, Marcel, Single, Barbara, Castoldi, Anna F., Kühnle, Simone, Nicotera, Pierluigi
Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers...
Caspase-Mediated Apoptosis in Neuronal Excitotoxicity Triggered by Nitric Oxide (1997)
Leist, Marcel, Volbracht, Christiane, Kühnle, Simone, Fava, Eugenio, Ferrando-May, Elisa, Nicotera, Pierluigi
BACKGROUND: Excitotoxicity and excess generation of nitric oxide (NO) are believed to be fundamental mechanisms in many acute and chronic neurodegenerative disorders. Disturbance of Ca2+ homeostasis...
Leist, Marcel, Fava, Eugenio, Montecucco, Cesare, Nicotera, Pierluigi
Endogenous generation of nitric oxide and its congeners, including peroxynitrite (ONOO-), has been implicated in the mechanism of neuron loss in neurodegenerative diseases. Accordingly, nitric oxide...
Göhring, Frank, Schwab, Birgit L., Nicotera, Pierluigi, Leist, Marcel, Fackelmayer, Frank O.
The scaffold attachment factor A (SAF-A) is an abundant component of the nuclear scaffold and of chromatin, and also occurs in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes. Evidence from...
Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins (1997)
Leist, Marcel, Gantner, Florian, Naumann, Heike, Bluethmann, Horst, Vogt, Kathrin, Brigelius-Flohe, Regina, ...
BACKGROUND & AIMS: Treatment with tumor necrosis factor (TNF) induces murine hepatocyte apoptosis in vitro and in vivo when sensitizing concentrations of toxins are present. The aim of this study was...
Energy supply and the shape of death in neurons and lymphoid cells (1997)
Nicotera, Pierluigi, Leist, Marcel
Apoptosis and necrosis are considered as conceptually distinct forms of cell death. Nevertheless, there is increasing evidence that classical apoptosis and necrosis represent only the extreme ends of...
The Shape of Cell Death (1997)
Leist, Marcel, Nicotera, Pierluigi
Cell death, a scheduled event during development and tissue turnover, or the ultimate consequence of toxic or pathologic insults seems to involve a relatively limited number of execution pathways....
Cytotoxic and genotoxic effects of styrene-7,8-oxide in neuroadrenergic Pc 12 cells (1992)
Dypbukt, Jeannette M., Costa, Lucio G., Manzo, Luigi, Orrenius, Sten, Nicotera, Pierluigi
Exposure of Pc 12 cells to styrene-7,8-oxide (SO) (0.5–1 mM) caused a rapid increase in cytosolic Ca2+, depletion of intracellular glutathione and ATP, DNA damage and loss of cell viability. Lower...
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Hansson, Oskar, Petersén, Åsa, Leist, Marcel, Nicotera, Pierluigi, Castilho, Roger F., Brundin, Patrik
Huntington’s disease (HD) is a hereditary neurodegenerative disorder presenting with chorea, dementia, and extensive striatal neuronal death. The mechanism through which the widely expressed mutant...
Ca2+ signals and death programmes in neurons
Berliocchi, Laura, Bano, Daniele, Nicotera, Pierluigi
Cell death programmes are generally defined by biochemical/genetic routines that are linked to their execution and by the appearance of more or less typical morphological features. However, in...
Berliocchi, Laura, Fava, Eugenio, Leist, Marcel, Horvat, Volker, Dinsdale, David, Read, David, ...
Clostridial neurotoxins are bacterial endopeptidases that cleave the major SNARE proteins in peripheral motorneurons. Here, we show that disruption of synaptic architecture by botulinum neurotoxin C1...
Leist, Marcel, Single, Barbara, Castoldi, Anna F., Kühnle, Simone, Nicotera, Pierluigi
Apoptosis and necrosis are considered conceptually and morphologically distinct forms of cell death. Here, we report that demise of human T cells caused by two classic apoptotic triggers...
Bellodi, Cristian, Lidonnici, Maria Rosa, Hamilton, Ashley, Helgason, G. Vignir, Soliera, Angela Rachele, Ronchetti, Mattia, ...
Imatinib mesylate (IM), a potent inhibitor of the BCR/ABL tyrosine kinase, has become standard first-line therapy for patients with chronic myeloid leukemia (CML), but the frequency of resistance...