French Roadmap for complex Systems 2008-2009 (2009)
Chavalarias, David, Bourgine, Paul, Perrier, Edith, Amblard, Fréderic, Arlabosse, François, Auger, Pierre, ...
A “complex system” is in general any system comprised of a great number of heterogeneous entities, among which local interactions create multiple levels of collective structure and organization....
French Roadmap for complex Systems 2008-2009 (2009)
Chavalarias, David, Bourgine, Paul, Perrier, Edith, Amblard, Fréderic, Arlabosse, François, Auger, Pierre, ...
A “complex system” is in general any system comprised of a great number of heterogeneous entities, among which local interactions create multiple levels of collective structure and organization....
InteroPORC: an automated tool to predict highly conserved protein interaction networks (2008)
Michaut, Magali, Kerrien, Samuel, Montecchi-Palazzi, Luisa, Cassier-Chauvat, Corinne, Chauvat, Franck, Aude, Jean-Christophe, ...
No abstract available.
InteroPORC: automated inference of highly conserved protein interaction networks (2008)
Michaut, Magali, Kerrien, Samuel, Montecchi-Palazzi, Luisa, Chauvat, Franck, Cassier-Chauvat, Corinne, Aude, Jean-Christophe, ...
Motivation: Protein–protein interaction networks provide insights into the relationships between the proteins of an organism thereby contributing to a better understanding of cellular processes....
Houot, Laetitia, Floutier, Martin, Marteyn, Benoit, Michaut, Magali, Picciocchi, Antoine, Legrain, Pierre, ...
Abstract Background Cadmium is a persistent pollutant that threatens most biological organisms, including cyanobacteria that support a large part of the biosphere. Using a multifaceted approach, we...
Sousa, Sandra, Cabanes, Didier, Archambaud, Cristel, Colland, Frédéric, Lemichez, Emmanuel, Popoff, Michel, ...
E-cadherin mediates the formation of adherens junctions between epithelial cells. It serves as a receptor for Listeria monocytogenes, a bacterial pathogen that enters epithelial cells. The L....
Delprat, Benjamin, Michel, Vincent, Goodyear, Richard, Yamasaki, Yasuhiro, Michalski, Nicolas, El-Amraoui, Aziz, ...
Defects in myosin XVa and the PDZ domain-containing protein, whirlin, underlie deafness in humans and mice. Hair bundles of mutant mice defective for either protein have abnormally short stereocilia....
Protein interaction mapping: A Drosophila case study (2005)
Formstecher, Etienne, Aresta, Sandra, Collura, Vincent, Hamburger, Alexandre, Meil, Alain, Trehin, Alexandra, ...
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based...
Protein interaction mapping: A Drosophila case study (2005)
Formstecher, Etienne, Aresta, Sandra, Collura, Vincent, Hamburger, Alexandre, Meil, Alain, Trehin, Alexandra, ...
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based...
Delprat, Benjamin, Michel, Vincent, Goodyear, Richard, Yamasaki, Yasuhiro, Michalski, Nicolas, El-Amraoui, Aziz, ...
Defects in myosin XVa and the PDZ domain-containing protein, whirlin, underlie deafness in humans and mice. Hair bundles of mutant mice defective for either protein have abnormally short stereocilia....
Functional Proteomics Mapping of a Human Signaling Pathway (2004)
Colland, Frédéric, Jacq, Xavier, Trouplin, Virginie, Mougin, Christelle, Groizeleau, Caroline, Hamburger, Alexandre, ...
Access to the human genome facilitates extensive functional proteomics studies. Here, we present an integrated approach combining large-scale protein interaction mapping, exploration of the...
Delprat, Benjamin, Michel, Vincent, Goodyear, Richard, Yamasaki, Yasuhiro, Michalski, Nicolas, El-Amraoui, Aziz, ...
Defects in myosin XVa and the PDZ domain-containing protein, whirlin, underlie deafness in humans and mice. Hair bundles of mutant mice defective for either protein have abnormally short stereocilia....
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins (2000)
Micheline Fromont-Racine, Andrew E. Mayes, Adeline Brunet-Simon, Jean-Christophe Rain, Alan Colley, Ian Dix, ...
A set of seven structurally related Sm proteins forms the core of the snRNP particles containing the spliceosomal U1, U2, U4 and U5 snRNAs. A search of the genomic sequence of Saccharomyces...
Homodimerization of the human U1 snRNP-specific protein C (1995)
Van Aarssen, Yvonne, Wassenaar, Roel, Legrain, Pierre, Van Venrooij, Walther J., Nelissen, Rob L.H.
The U1 snRNP-specific protein C contains an N-terminal zinc finger-like CH motif which Is required for the binding of the U1C protein to the U1 snRNP particle. Recently a similar motif was reported...
Kramer, Angela, Legrain, Pierre, Mulhauser, Frank, Groöining, Karsten, Brosi, Reto, Bilbe, Graeme
A cDNA encoding the 60 kDa subunit of mammalian splicing factor SF3a has been isolated. The deduced protein sequence reveals a 30% Identity to the PRP9 splicing protein of the yeast S.cerevisiae. The...
Chanfreau, Guillaume, Legrain, Pierre, Dujon, Bernard, Jacquier, Alain
The splicing of group II and nuclear pre-mRNAs introns occurs via a similar splicing pathway and some of the RNA-RNA interactions involved in these splicing reactions show structural similarities....
Galisson, Frederique, Legrain, Pierre
We have raised specific antibodies against the PRP6 protein and shown that the U4, U5 and U6 snRNAs are co-precipitated with this protein. Using splicing extracts prepared from In vivo...
Septicémies au cours de l'évolution des blessures de guerre. (1918)
Paris theses 1917-18. No. 81.
Parallel analysis of genetic selections using whole genome oligonucleotide arrays
Cho, Raymond J., Fromont-Racine, Micheline, Wodicka, Lisa, Feierbach, Becket, Stearns, Timothy, Legrain, Pierre, ...
Thousands of genes have recently been sequenced in organisms ranging from Escherichia coli to human. For the majority of these genes, however, available sequence does not define a biological role....
Jensen, Torben Heick, Neville, Megan, Rain, Jean Christophe, McCarthy, Terri, Legrain, Pierre, Rosbash, Michael
Nuclear export of proteins containing leucine-rich nuclear export signals (NESs) is mediated by the NES receptor CRM1/Crm1p. We have carried out a yeast two-hybrid screen with Crm1p as a bait. The...
Functional Conservation of the Transportin Nuclear Import Pathway in Divergent Organisms
Siomi, Mikiko C., Fromont, Micheline, Rain, Jean-Christophe, Wan, Lili, Wang, Fan, Legrain, Pierre, ...
Human transportin1 (hTRN1) is the nuclear import receptor for a group of pre-mRNA/mRNA-binding proteins (heterogeneous nuclear ribonucleoproteins [hnRNP]) represented by hnRNP A1, which shuttle...
Boëda, Batiste, El-Amraoui, Aziz, Bahloul, Amel, Goodyear, Richard, Daviet, Laurent, Blanchard, Stéphane, ...
Deaf-blindness in three distinct genetic forms of Usher type I syndrome (USH1) is caused by defects in myosin VIIa, harmonin and cadherin 23. Despite being critical for hearing, the functions of...
Antiviral Drug Discovery Strategy Using Combinatorial Libraries of Structurally Constrained Peptides
Real, Eléonore, Rain, Jean-Christophe, Battaglia, Véronique, Jallet, Corinne, Perrin, Pierre, Tordo, Noël, ...
We have developed a new strategy for antiviral peptide discovery by using lyssaviruses (rabies virus and rabies-related viruses) as models. Based on the mimicry of natural bioactive peptides, two...
Functional Proteomics Mapping of a Human Signaling Pathway
Colland, Frédéric, Jacq, Xavier, Trouplin, Virginie, Mougin, Christelle, Groizeleau, Caroline, Hamburger, Alexandre, ...
Access to the human genome facilitates extensive functional proteomics studies. Here, we present an integrated approach combining large-scale protein interaction mapping, exploration of the...
Kim, Dong Wook, Lenzen, Gerlinde, Page, Anne-Laure, Legrain, Pierre, Sansonetti, Philippe J., Parsot, Claude
Bacteria of Shigella spp. are responsible for shigellosis in humans. They use a type III secretion system to inject effector proteins into host cells and induce their entry into epithelial cells or...
Protein interaction mapping: A Drosophila case study
Formstecher, Etienne, Aresta, Sandra, Collura, Vincent, Hamburger, Alexandre, Meil, Alain, Trehin, Alexandra, ...
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based...
Parallel analysis of genetic selections using whole genome oligonucleotide arrays
Cho, Raymond J., Fromont-Racine, Micheline, Wodicka, Lisa, Feierbach, Becket, Stearns, Timothy, Legrain, Pierre, ...
Thousands of genes have recently been sequenced in organisms ranging from Escherichia coli to human. For the majority of these genes, however, available sequence does not define a biological role....
Jensen, Torben Heick, Neville, Megan, Rain, Jean Christophe, McCarthy, Terri, Legrain, Pierre, Rosbash, Michael
Nuclear export of proteins containing leucine-rich nuclear export signals (NESs) is mediated by the NES receptor CRM1/Crm1p. We have carried out a yeast two-hybrid screen with Crm1p as a bait. The...
Functional Conservation of the Transportin Nuclear Import Pathway in Divergent Organisms
Siomi, Mikiko C., Fromont, Micheline, Rain, Jean-Christophe, Wan, Lili, Wang, Fan, Legrain, Pierre, ...
Human transportin1 (hTRN1) is the nuclear import receptor for a group of pre-mRNA/mRNA-binding proteins (heterogeneous nuclear ribonucleoproteins [hnRNP]) represented by hnRNP A1, which shuttle...
Boëda, Batiste, El-Amraoui, Aziz, Bahloul, Amel, Goodyear, Richard, Daviet, Laurent, Blanchard, Stéphane, ...
Deaf-blindness in three distinct genetic forms of Usher type I syndrome (USH1) is caused by defects in myosin VIIa, harmonin and cadherin 23. Despite being critical for hearing, the functions of...
Antiviral Drug Discovery Strategy Using Combinatorial Libraries of Structurally Constrained Peptides
Real, Eléonore, Rain, Jean-Christophe, Battaglia, Véronique, Jallet, Corinne, Perrin, Pierre, Tordo, Noël, ...
We have developed a new strategy for antiviral peptide discovery by using lyssaviruses (rabies virus and rabies-related viruses) as models. Based on the mimicry of natural bioactive peptides, two...
Functional Proteomics Mapping of a Human Signaling Pathway
Colland, Frédéric, Jacq, Xavier, Trouplin, Virginie, Mougin, Christelle, Groizeleau, Caroline, Hamburger, Alexandre, ...
Access to the human genome facilitates extensive functional proteomics studies. Here, we present an integrated approach combining large-scale protein interaction mapping, exploration of the...
Protein interaction mapping: A Drosophila case study
Formstecher, Etienne, Aresta, Sandra, Collura, Vincent, Hamburger, Alexandre, Meil, Alain, Trehin, Alexandra, ...
The Drosophila (fruit fly) model system has been instrumental in our current understanding of human biology, development, and diseases. Here, we used a high-throughput yeast two-hybrid (Y2H)-based...
Kim, Dong Wook, Lenzen, Gerlinde, Page, Anne-Laure, Legrain, Pierre, Sansonetti, Philippe J., Parsot, Claude
Bacteria of Shigella spp. are responsible for shigellosis in humans. They use a type III secretion system to inject effector proteins into host cells and induce their entry into epithelial cells or...
Houot, Laetitia, Floutier, Martin, Marteyn, Benoit, Michaut, Magali, Picciocchi, Antoine, Legrain, Pierre, ...
Genome-Wide Protein Interaction Screens Reveal Functional Networks Involving Sm-Like Proteins
Fromont-Racine, Micheline, Mayes, Andrew E., Brunet-Simon, Adeline, Rain, Jean-Christophe, Colley, Alan, Dix, Ian, ...
A set of seven structurally related Sm proteins forms the core of the snRNP particles containing the spliceosomal U1, U2, U4 and U5 snRNAs. A search of the genomic sequence of Saccharomyces...