Pierre Savagner

Transforming growth factor-beta1-mediated Slug and Snail transcription factor up-regulation reduces the density of Langerhans cells in epithelial metaplasia by affecting E-cadherin expression (2008)

Herfs, Michael, Hubert, Pascale, Kholod, Natalia, Caberg, Jean-Hubert, Gilles, Christine, Berx, Geert, ...

Epithelial metaplasia (EpM) is an acquired tissue abnormality resulting from the transformation of epithelium into another tissue with a different structure and function. This adaptative process is...

Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. (2005)

Savagner, Pierre, Kusewitt, Donna, Carver, Ethan, Magnino, Fabrice, Choi, Chagsun, Gridley, Thomas, ...

During re-epithelialization of cutaneous wounds, keratinocytes recapitulate several aspects of the embryonic process of epithelial-mesenchymal transition (EMT), including migratory activity and...

Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. (2005)

Savagner, Pierre, Kusewitt, Donna, Carver, Ethan, Magnino, Fabrice, Choi, Chagsun, Gridley, Thomas, ...

During re-epithelialization of cutaneous wounds, keratinocytes recapitulate several aspects of the embryonic process of epithelial-mesenchymal transition (EMT), including migratory activity and...

Developmental transcription factor slug is required for effective re-epithelialization by adult keratinocytes. (2005)

Savagner, Pierre, Kusewitt, Donna, Carver, Ethan, Magnino, Fabrice, Choi, Chagsun, Gridley, Thomas, ...

During re-epithelialization of cutaneous wounds, keratinocytes recapitulate several aspects of the embryonic process of epithelial-mesenchymal transition (EMT), including migratory activity and...

Rise and Fall of Epithelial Phenotype: Concepts of Epithelial-Mesenchymal Transition (2005)

Savagner, Pierre.

Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression. (2004)

Côme, Christophe, Arnoux, Valérie, Bibeau, Frédéric, Savagner, Pierre

The zinc-finger transcription factors Snail and Slug are involved in different processes controlling cell differentiation and apoptosis. They also appear to be involved in tumor progression. Their...

Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression. (2004)

Côme, Christophe, Arnoux, Valérie, Bibeau, Frédéric, Savagner, Pierre

The zinc-finger transcription factors Snail and Slug are involved in different processes controlling cell differentiation and apoptosis. They also appear to be involved in tumor progression. Their...

Roles of the transcription factors snail and slug during mammary morphogenesis and breast carcinoma progression. (2004)

Côme, Christophe, Arnoux, Valérie, Bibeau, Frédéric, Savagner, Pierre

The zinc-finger transcription factors Snail and Slug are involved in different processes controlling cell differentiation and apoptosis. They also appear to be involved in tumor progression. Their...

Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. (2003)

Seki, Kenji, Fujimori, Toshihiko, Savagner, Pierre, Hata, Akiko, Aikawa, Tomonao, Ogata, Naoshi, ...

Snail family genes are conserved among species during evolution and encode transcription factors expressed at different stages of development in different tissues. These genes are involved in a broad...

Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. (2003)

Conacci-Sorrell, Maralice, Simcha, Inbal, Ben-Yedidia, Tamar, Blechman, Janna, Savagner, Pierre, Ben-Ze'Ev, Avri

Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert...

Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. (2003)

Seki, Kenji, Fujimori, Toshihiko, Savagner, Pierre, Hata, Akiko, Aikawa, Tomonao, Ogata, Naoshi, ...

Snail family genes are conserved among species during evolution and encode transcription factors expressed at different stages of development in different tissues. These genes are involved in a broad...

Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. (2003)

Conacci-Sorrell, Maralice, Simcha, Inbal, Ben-Yedidia, Tamar, Blechman, Janna, Savagner, Pierre, Ben-Ze'Ev, Avri

Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert...

Mouse Snail family transcription repressors regulate chondrocyte, extracellular matrix, type II collagen, and aggrecan. (2003)

Seki, Kenji, Fujimori, Toshihiko, Savagner, Pierre, Hata, Akiko, Aikawa, Tomonao, Ogata, Naoshi, ...

Snail family genes are conserved among species during evolution and encode transcription factors expressed at different stages of development in different tissues. These genes are involved in a broad...

Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. (2003)

Conacci-Sorrell, Maralice, Simcha, Inbal, Ben-Yedidia, Tamar, Blechman, Janna, Savagner, Pierre, Ben-Ze'Ev, Avri

Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert...

Characterization of the promoter for the rat and human link protein gene (1991)

Rhodes, Craig, Savagner, Pierre, Line, Sergio, Sasaki, Makoto, Chirigos, Mike, Doege, Kurt, ...

We have isolated the 5′-end of the gene for the rat and human link protein by screening genomic libraries with oligonucleotides corresponding to the 5′-cDNA sequence. Several overlapping clones...

The Zinc-Finger Protein Slug Causes Desmosome Dissociation, an Initial and Necessary Step for Growth Factor–induced Epithelial–Mesenchymal Transition

Savagner, Pierre, Yamada, Kenneth M., Thiery, Jean Paul

Epithelial–mesenchymal transition (EMT) is an essential morphogenetic process during embryonic development. It can be induced in vitro by hepatocyte growth factor/scatter factor (HGF/SF), or by...

Autoregulation of E-cadherin expression by cadherin–cadherin interactions: the roles of β-catenin signaling, Slug, and MAPK

Conacci-Sorrell, Maralice, Simcha, Inbal, Ben-Yedidia, Tamar, Blechman, Janna, Savagner, Pierre, Ben-Ze'ev, Avri

Transcriptional repression of E-cadherin, characteristic of epithelial to mesenchymal transition, is often found also during tumor cell invasion. At metastases, migratory fibroblasts sometimes revert...

Transforming Growth Factor-β1-Mediated Slug and Snail Transcription Factor Up-Regulation Reduces the Density of Langerhans Cells in Epithelial Metaplasia by Affecting E-Cadherin Expression

Herfs, Michael, Hubert, Pascale, Kholod, Natalia, Hubert Caberg, Jean, Gilles, Christine, Berx, Geert, ...

Epithelial metaplasia (EpM) is an acquired tissue abnormality resulting from the transformation of epithelium into another tissue with a different structure and function. This adaptative process is...

Erk5 Controls Slug Expression and Keratinocyte Activation during Wound Healing

Arnoux, Valerie, Nassour, Mayssaa, L'Helgoualc'h, Annie, Hipskind, Robert A., Savagner, Pierre

Reepithelialization during cutaneous wound healing involves numerous signals that result in basal keratinocyte activation, spreading, and migration, all linked to a loosening of cell–cell adhesion...

Epithelial-Mesenchymal Transition : A Cancer Researcher’s Conceptual Friend and Foe

Klymkowsky, Michael W., Savagner, Pierre

Epithelial-mesenchymal transition (EMT) describes a series of rapid changes in cellular phenotype. During EMT, epithelial cells down-modulate cell-cell adhesion structures, alter their polarity,...