A sequence-based survey of the complex structural organization of tumor genomes (2008)
Raphael, Benjamin J, Volik, Stanislav, Yu, Peng, Wu, Chunxiao, Huang, Guiqing, Linardopoulou, Elena V, ...
Abstract Background The genomes of many epithelial tumors exhibit extensive chromosomal rearrangements. All classes of genome rearrangements can be identified using end sequencing profiling, which...
Genomic degradation of a young Y chromosome in Drosophila miranda (2008)
Bachtrog, Doris, Hom, Emily, Wong, Karen M, Maside, Xulio, De Jong, Pieter
Abstract Background Y chromosomes are derived from ordinary autosomes and degenerate because of a lack of recombination. Well-studied Y chromosomes only have few of their original genes left and...
Babcock, Melanie, Yatsenko, Svetlana, Hopkins, Janet, Brenton, Matthew, Cao, Qing, De Jong, Pieter, ...
Segmental duplications or low-copy repeats (LCRs) constitute ∼5% of the sequenced portion of the human genome and are associated with many human congenital anomaly disorders. The low-copy repeats...
A physical map of the bovine genome (2007)
Chiu, Readman, Schein, Jacqueline, Hobbs, Matthew, Abbey, Colette, Adelson, David, ...
ABSTRACT: BACKGROUND: Cattle are important agriculturally and relevant as a model organism. Previously described genetic and radiation hybrid (RH) maps of the bovine genome have been used to identify...
A high utility integrated map of the pig genome (2007)
Humphray, Sean J, Scott, Carol E, Clark, Richard, Marron, Brandy, Bender, Clare, Camm, Nick, ...
Abstract Background The domestic pig is being increasingly exploited as a system for modeling human disease. It also has substantial economic importance for meat-based protein production. Physical...
Jonsson, Goran, Staaf, Johan, Olsson, Eleonor, Heidenblad, Markus, Vallon-Christersson, Johan, Osoegawa, Kazutoyo, ...
Abstract is not available
Using Comparative Genomics to Reorder the Human Genome Sequence into a Virtual Sheep Genome (2007)
Dalrymple, Brian, Kirkness, Ewen, Nefedov, Mikhail, McWilliam, Sean, Ratnakumar, Abhirami, Barris, Wes, ...
Background: Is it possible to construct an accurate and detailed subgene-level map of a genome using bacterial artificial chromosome (BAC) end sequences, a sparse marker map, and the sequences of...
Insights into social insects from the genome of the honeybee Apis mellifera (2006)
Robinson, Gene E, Gibbs, Richard A, Worley, Kim C, Evans, Jay D, Maleszka, Ryszard, ...
Here we report the genome sequence of the honeybee Apis mellifera, a key model for social behaviour and essential to global ecology through pollination. Compared with other sequenced insect genomes,...
Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements. (2006)
Chourrout, Daniel, Delsuc, Frédéric, Chourrout, Pascal, Edvardsen, Rolf B., Rentzsch, Fabian, Renfer, Eduard, ...
Bilaterian animals have a Hox gene cluster essential for patterning the main body axis, and a ParaHox gene cluster. Comparison of Hox and ParaHox genes has led workers to postulate that both clusters...
Minimal ProtoHox cluster inferred from bilaterian and cnidarian Hox complements. (2006)
Chourrout, Daniel, Delsuc, Frédéric, Chourrout, Pascal, Edvardsen, Rolf B., Rentzsch, Fabian, Renfer, Eduard, ...
Bilaterian animals have a Hox gene cluster essential for patterning the main body axis, and a ParaHox gene cluster. Comparison of Hox and ParaHox genes has led workers to postulate that both clusters...
A BAC-based physical map of the Drosophila buzzatii genome (2005)
Gonzalez, Josefa, Nefedov, Michael, Bosdet, Ian, Casals, Ferran, Calvete, Oriol, Delprat, Alejandra, ...
Large-insert genomic libraries facilitate cloning of large genomic regions, allow the construction of clone-based physical maps and provide useful resources for sequencing entire genomes. Drosophila...
Initial sequence of the chimpanzee genome and comparison with the human genome (2005)
Mikkelsen, Tarjei S., Hillier, LaDeana W., Eichler, Evan E., Zody, Michael C., Jaffe, David B., Yang, Shiaw-Pyng, ...
Here we present a draft genome sequence of the common chimpanzee (Pan troglodytes). Through comparison with the human genome, we have generated a largely complete catalogue of the genetic differences...
A BAC-based physical map of the Drosophila buzzatii genome (2005)
González, Josefa, Nefedov, Michael, Bosdet, Ian, Casals, Ferran, Calvete, Oriol, Delprat, Alejandra, ...
Large-insert genomic libraries facilitate cloning of large genomic regions, allow the construction of clone-based physical maps, and provide useful resources for sequencing entire genomes. Drosophila...
Negre, Bárbara, Casillas, Sònia, Suzanne, Magali, Sánchez-Herrero, Ernesto, Akam, Michael, Nefedov, Michael, ...
Homeotic (Hox) genes are usually clustered and arranged in the same order as they are expressed along the anteroposterior body axis of metazoans. The mechanistic explanation for this colinearity has...
Human, Mouse, and Rat Genome Large-Scale Rearrangements: Stability Versus Speciation (2004)
Zhao, Shaying, Shetty, Jyoti, Hou, Lihua, Delcher, Arthur, Zhu, Baoli, Osoegawa, Kazutoyo, ...
Using paired-end sequences from bacterial artificial chromosomes, we have constructed high-resolution synteny and rearrangement breakpoint maps among human, mouse, and rat genomes. Among the >300...
Human, Mouse, and Rat Genome Large-Scale Rearrangements: Stability Versus Speciation (2004)
Zhao, Shaying, Shetty, Jyoti, Hou, Lihua, Delcher, Arthur, Zhu, Baoli, Osoegawa, Kazutoyo, ...
Using paired-end sequences from bacterial artificial chromosomes, we have constructed high-resolution synteny and rearrangement breakpoint maps among human, mouse, and rat genomes. Among the >300...
An AscI Boundary Library for the Studies of Genetic and Epigenetic Alterations in CpG Islands (2002)
Dai, Zunyan, Weichenhan, Dieter, Wu, Yue-Zhong, Hall, Julia L, Rush, Laura J., Smith, Laura T., ...
Bellefroid, Eric J, Marine, Jean-Christophe, Ried, Thomas, Lecocq, Pierre J, Riviere, Michele, Amemiya, Chris, ...
KRAB zinc-finger proteins (KRAB-ZFPs) constitute a large subfamily of ZFPs of the Krüppel C2H2 type. KRAB (Krüppel-associated box) is an evolutionarily conserved protein domain found N-terminally...
Assembly and analysis of cosmid contigs in the CEA-gene family region of human chromosome 19 (1992)
Tynan, Katherine, Olsen, Anne, Trask, Barbara, De Jong, Pieter, Thompson, John, Zimmermann, Wolfgang, ...
The carcinoembryonic antigen (CEA)-like genes are members of a large gene family which Is part of the immunoglobulln superfamily. The CEA family is divided into two major subgroups, the CEA-subgroup...
End-sequence profiling: Sequence-based analysis of aberrant genomes
Volik, Stanislav, Zhao, Shaying, Chin, Koei, Brebner, John H., Herndon, David R., Tao, Quanzhou, ...
Genome rearrangements are important in evolution, cancer, and other diseases. Precise mapping of the rearrangements is essential for identification of the involved genes, and many techniques have...
An AscI Boundary Library for the Studies of Genetic and Epigenetic Alterations in CpG Islands
Dai, Zunyan, Weichenhan, Dieter, Wu, Yue-Zhong, Hall, Julia L, Rush, Laura J., Smith, Laura T., ...
Knudson's two-hit hypothesis postulates that genetic alterations in both alleles are required for the inactivation of tumor-suppressor genes. Genetic alterations include small or large deletions and...
Trinucleotide repeat polymorphism at the D19S190 locus
Iles, David E., Segers, Bart, De Jong, Pieter, Alleman, Jennifer, Wieringa, Bé
Dinucleotide repeat polymorphism at the D19S191 locus
Iles, David E., Segers, Bart, De Jong, Pieter, Alleman, Jennifer, Wieringa, Bé
Human, Mouse, and Rat Genome Large-Scale Rearrangements: Stability Versus Speciation
Zhao, Shaying, Shetty, Jyoti, Hou, Lihua, Delcher, Arthur, Zhu, Baoli, Osoegawa, Kazutoyo, ...
Using paired-end sequences from bacterial artificial chromosomes, we have constructed high-resolution synteny and rearrangement breakpoint maps among human, mouse, and rat genomes. Among the >300...
Negre, Bárbara, Casillas, Sònia, Suzanne, Magali, Sánchez-Herrero, Ernesto, Akam, Michael, Nefedov, Michael, ...
Homeotic (Hox) genes are usually clustered and arranged in the same order as they are expressed along the anteroposterior body axis of metazoans. The mechanistic explanation for this colinearity has...
A BAC-based physical map of the Drosophila buzzatii genome
González, Josefa, Nefedov, Michael, Bosdet, Ian, Casals, Ferran, Calvete, Oriol, Delprat, Alejandra, ...
Large-insert genomic libraries facilitate cloning of large genomic regions, allow the construction of clone-based physical maps, and provide useful resources for sequencing entire genomes. Drosophila...
Hughes, Jim R., Cheng, Jan-Fang, Ventress, Nicki, Prabhakar, Shyam, Clark, Kevin, Anguita, Eduardo, ...
An important step toward improving the annotation of the human genome is to identify cis-acting regulatory elements from primary DNA sequence. One approach is to compare sequences from multiple,...
Smeets, Hubert, Bachinski, Linda, Coerwinkel, Marga, Schepens, Jan, Hoeijmakers, Jan, Van Duin, Marcel, ...
We report on the physical ordering of genes in a relatively small area of chromosome 19, segment q13, containing the locus for myotonic dystrophy (DM), the most frequent heritable muscular dystrophy...
End-sequence profiling: Sequence-based analysis of aberrant genomes
Volik, Stanislav, Zhao, Shaying, Chin, Koei, Brebner, John H., Herndon, David R., Tao, Quanzhou, ...
Genome rearrangements are important in evolution, cancer, and other diseases. Precise mapping of the rearrangements is essential for identification of the involved genes, and many techniques have...
An AscI Boundary Library for the Studies of Genetic and Epigenetic Alterations in CpG Islands
Dai, Zunyan, Weichenhan, Dieter, Wu, Yue-Zhong, Hall, Julia L, Rush, Laura J., Smith, Laura T., ...
Knudson's two-hit hypothesis postulates that genetic alterations in both alleles are required for the inactivation of tumor-suppressor genes. Genetic alterations include small or large deletions and...
Trinucleotide repeat polymorphism at the D19S190 locus
Iles, David E., Segers, Bart, De Jong, Pieter, Alleman, Jennifer, Wieringa, Bé
Dinucleotide repeat polymorphism at the D19S191 locus
Iles, David E., Segers, Bart, De Jong, Pieter, Alleman, Jennifer, Wieringa, Bé
Human, Mouse, and Rat Genome Large-Scale Rearrangements: Stability Versus Speciation
Zhao, Shaying, Shetty, Jyoti, Hou, Lihua, Delcher, Arthur, Zhu, Baoli, Osoegawa, Kazutoyo, ...
Using paired-end sequences from bacterial artificial chromosomes, we have constructed high-resolution synteny and rearrangement breakpoint maps among human, mouse, and rat genomes. Among the >300...
Negre, Bárbara, Casillas, Sònia, Suzanne, Magali, Sánchez-Herrero, Ernesto, Akam, Michael, Nefedov, Michael, ...
Homeotic (Hox) genes are usually clustered and arranged in the same order as they are expressed along the anteroposterior body axis of metazoans. The mechanistic explanation for this colinearity has...
A BAC-based physical map of the Drosophila buzzatii genome
González, Josefa, Nefedov, Michael, Bosdet, Ian, Casals, Ferran, Calvete, Oriol, Delprat, Alejandra, ...
Large-insert genomic libraries facilitate cloning of large genomic regions, allow the construction of clone-based physical maps, and provide useful resources for sequencing entire genomes. Drosophila...
Hughes, Jim R., Cheng, Jan-Fang, Ventress, Nicki, Prabhakar, Shyam, Clark, Kevin, Anguita, Eduardo, ...
An important step toward improving the annotation of the human genome is to identify cis-acting regulatory elements from primary DNA sequence. One approach is to compare sequences from multiple,...
Smeets, Hubert, Bachinski, Linda, Coerwinkel, Marga, Schepens, Jan, Hoeijmakers, Jan, Van Duin, Marcel, ...
We report on the physical ordering of genes in a relatively small area of chromosome 19, segment q13, containing the locus for myotonic dystrophy (DM), the most frequent heritable muscular dystrophy...
A high utility integrated map of the pig genome
Humphray, Sean J, Scott, Carol E, Clark, Richard, Marron, Brandy, Bender, Clare, Camm, Nick, ...
A new physical map of the bovine genome has been constructed by integrating data from genetic and radiation hybrid maps, and a new bovine BAC map, with the bovine genome draft assembly.
Genomic degradation of a young Y chromosome in Drosophila miranda
Bachtrog, Doris, Hom, Emily, Wong, Karen M, Maside, Xulio, De Jong, Pieter
Study of the recently formed neo-Y chromosome of Drosophila miranda demonstrate that degeneration of a recently formed Y-chromosome can proceed very rapidly.
A sequence-based survey of the complex structural organization of tumor genomes
Raphael, Benjamin J, Volik, Stanislav, Yu, Peng, Wu, Chunxiao, Huang, Guiqing, Linardopoulou, Elena V, ...
Tumors and cancer cell lines were surveyed with end-sequencing profiling, yielding the largest available collection of sequence-ready tumor genome breakpoints and providing evidence that some...