Modelling within-Host Spatiotemporal Dynamics of Invasive Bacterial Disease (2008)
Andrew J. Grant, Olivier Restif, Trevelyan J. McKinley, Mark Sheppard, Duncan J. Maskell, Pietro Mastroeni
Mechanistic determinants of bacterial growth, death, and spread within mammalian hosts cannot be fully resolved studying a single bacterial population. They are also currently poorly understood....
Intracellular Demography and the Dynamics of Salmonella enterica Infections (2006)
Sam P. Brown, Stephen J. Cornell, Mark Sheppard, Andrew J. Grant, Duncan J. Maskell, Bryan T. Grenfell, ...
An understanding of within-host dynamics of pathogen interactions with eukaryotic cells can shape the development of effective preventive measures and drug regimes. Such investigations have been...
Mastroeni, Pietro, Clare, S., Khan, S., Harrison, J. A., Hormaeche, C. E., Okamura, H., ...
Spleen and peritoneal macrophages obtained from innately resistant A/J mice released low levels of interleukin 18 (IL-18) upon infection with Salmonella typhimurium C5 RP4. Incubating the cells with...
Mastroeni, Pietro, Simmons, C., Fowler, R., Hormaeche, C. E., Dougan, G.
In the present study we evaluated the role of B cells in acquired immunity to Salmonella infection by using gene-targeted B-cell-deficient innately susceptible mice on a C57BL/6 background...
Mastroeni, Pietro, Harrison, J. A., Robinson, J. H., Clare, S., Khan, S., Maskell, D. J., ...
The attenuated S. typhimurium SL3261 (aroA) strain causes mild infections in BALB/c mice. We were able to exacerbate the disease by administering anti-interleukin-12 (IL-12) antibodies, resulting in...
Increased Susceptibility of C1q-Deficient Mice to Salmonella enterica Serovar Typhimurium Infection
Warren, Joanna, Mastroeni, Pietro, Dougan, Gordon, Noursadeghi, Mahdad, Cohen, Jonathan, Walport, Mark J., ...
The role of the complement system in host defense against Salmonella infection is poorly defined. Bacterial cell wall O-antigen polysaccharide can activate the alternative pathway in vitro. No...
Intracellular Adhesion Molecule 1 Plays a Key Role in Acquired Immunity to Salmonellosis
Clare, Simon, Goldin, Robert, Hale, Christine, Aspinall, Richard, Simmons, Cameron, Mastroeni, Pietro, ...
This study investigated the role of intracellular adhesion molecule 1 (ICAM-1) during Salmonella enterica serovar Typhimurium infection of mice. We show that ICAM-1 is expressed in and around...
Ugrinovic, Sanja, Ménager, Nathalie, Goh, Natalie, Mastroeni, Pietro
Infection of mice with Salmonella enterica serovar Typhimurium induces strong Th1 T-cell responses that are central to the control of the infection. In the present study, we examined the role of B...
Withanage, G. S. K., Kaiser, Pete, Wigley, Paul, Powers, Claire, Mastroeni, Pietro, Brooks, Heather, ...
Poultry meat and eggs contaminated with Salmonella enterica serovar Enteritidis or Salmonella enterica serovar Typhimurium are common sources of acute gastroenteritis in humans. However, the exact...
Lange, Uta G., Mastroeni, Pietro, Blackwell, Jenefer M., Stober, Carmel B.
Successful resolution of infections by intracellular pathogens requires gamma interferon (IFN-γ). DNA vaccines promote T helper 1 (Th1) responses by triggering interleukin-12 (IL-12) release by...
Withanage, G. S. K., Wigley, Paul, Kaiser, Pete, Mastroeni, Pietro, Brooks, Heather, Powers, Claire, ...
Infection of poultry with Salmonella enterica serovar Typhimurium poses a significant risk to public health through contamination of meat from infected animals. Vaccination has been proposed to...
Intracellular Demography and the Dynamics of Salmonella enterica Infections
Brown, Sam P, Cornell, Stephen J, Sheppard, Mark, Grant, Andrew J, Maskell, Duncan J, Grenfell, Bryan T, ...
An understanding of within-host dynamics of pathogen interactions with eukaryotic cells can shape the development of effective preventive measures and drug regimes. Such investigations have been...
Mastroeni, Pietro, Clare, S., Khan, S., Harrison, J. A., Hormaeche, C. E., Okamura, H., ...
Spleen and peritoneal macrophages obtained from innately resistant A/J mice released low levels of interleukin 18 (IL-18) upon infection with Salmonella typhimurium C5 RP4. Incubating the cells with...
Mastroeni, Pietro, Simmons, C., Fowler, R., Hormaeche, C. E., Dougan, G.
In the present study we evaluated the role of B cells in acquired immunity to Salmonella infection by using gene-targeted B-cell-deficient innately susceptible mice on a C57BL/6 background...
Mastroeni, Pietro, Harrison, J. A., Robinson, J. H., Clare, S., Khan, S., Maskell, D. J., ...
The attenuated S. typhimurium SL3261 (aroA) strain causes mild infections in BALB/c mice. We were able to exacerbate the disease by administering anti-interleukin-12 (IL-12) antibodies, resulting in...
Increased Susceptibility of C1q-Deficient Mice to Salmonella enterica Serovar Typhimurium Infection
Warren, Joanna, Mastroeni, Pietro, Dougan, Gordon, Noursadeghi, Mahdad, Cohen, Jonathan, Walport, Mark J., ...
The role of the complement system in host defense against Salmonella infection is poorly defined. Bacterial cell wall O-antigen polysaccharide can activate the alternative pathway in vitro. No...
Intracellular Adhesion Molecule 1 Plays a Key Role in Acquired Immunity to Salmonellosis
Clare, Simon, Goldin, Robert, Hale, Christine, Aspinall, Richard, Simmons, Cameron, Mastroeni, Pietro, ...
This study investigated the role of intracellular adhesion molecule 1 (ICAM-1) during Salmonella enterica serovar Typhimurium infection of mice. We show that ICAM-1 is expressed in and around...
Ugrinovic, Sanja, Ménager, Nathalie, Goh, Natalie, Mastroeni, Pietro
Infection of mice with Salmonella enterica serovar Typhimurium induces strong Th1 T-cell responses that are central to the control of the infection. In the present study, we examined the role of B...
Withanage, G. S. K., Kaiser, Pete, Wigley, Paul, Powers, Claire, Mastroeni, Pietro, Brooks, Heather, ...
Poultry meat and eggs contaminated with Salmonella enterica serovar Enteritidis or Salmonella enterica serovar Typhimurium are common sources of acute gastroenteritis in humans. However, the exact...
Lange, Uta G., Mastroeni, Pietro, Blackwell, Jenefer M., Stober, Carmel B.
Successful resolution of infections by intracellular pathogens requires gamma interferon (IFN-γ). DNA vaccines promote T helper 1 (Th1) responses by triggering interleukin-12 (IL-12) release by...
Withanage, G. S. K., Wigley, Paul, Kaiser, Pete, Mastroeni, Pietro, Brooks, Heather, Powers, Claire, ...
Infection of poultry with Salmonella enterica serovar Typhimurium poses a significant risk to public health through contamination of meat from infected animals. Vaccination has been proposed to...
Intracellular Demography and the Dynamics of Salmonella enterica Infections
Brown, Sam P, Cornell, Stephen J, Sheppard, Mark, Grant, Andrew J, Maskell, Duncan J, Grenfell, Bryan T, ...
An understanding of within-host dynamics of pathogen interactions with eukaryotic cells can shape the development of effective preventive measures and drug regimes. Such investigations have been...
Kalupahana, Ruwani Sagarika, Mastroeni, Pietro, Maskell, Duncan, Blacklaws, Barbara Ann
Macrophages and dendritic cells (DCs) are antigen-presenting cells (APCs), and the direct involvement of both cell types in the immune response to Salmonella has been identified. In this study we...
Uppington, Hazel, Menager, Nathalie, Boross, Peter, Wood, James, Sheppard, Mark, Verbeek, Sjef, ...
Immune serum has a protective role against Salmonella infections in mice, domestic animals and humans. In this study, the effect of antibody on the interaction between murine macrophages and S....
Menager, Nathalie, Foster, Gemma, Ugrinovic, Sanja, Uppington, Hazel, Verbeek, Sjef, Mastroeni, Pietro
Antibodies play an important role in immunity to Salmonella enterica. Here we evaluated the requirement for Fcγ receptors in host resistance to S. enterica using an in vivo model of systemic...
Mastroeni, Pietro, Vazquez-Torres, Andrés, Fang, Ferric C., Xu, Yisheng, Khan, Shahid, Hormaeche, Carlos E., ...
The roles of the NADPH phagocyte oxidase (phox) and inducible nitric oxide synthase (iNOS) in host resistance to virulent Salmonella typhimurium were investigated in gp91phox−/−, iNOS−/−, and...
Vazquez-Torres, Andrés, Jones-Carson, Jessica, Mastroeni, Pietro, Ischiropoulos, Harry, Fang, Ferric C.
The contribution of the NADPH phagocyte oxidase (phox) and inducible nitric oxide (NO) synthase (iNOS) to the antimicrobial activity of macrophages for Salmonella typhimurium was studied by using...