Pradip Roy-Burman

Pten Dose Dictates Cancer Progression in the Prostate (2003)

Lloyd C. Trotman, Masaru Niki, Zohar A. Dotan, Jason A. Koutcher, Antonio Di Cristofano, Andrew Xiao, ...

Mice with progressively decreasing amounts of the tumor suppressor PTEN demonstrate that this gene affects -- in an exquisite dose-dependent fashion -- prostate tumor incidence and progression.

Pten Dose Dictates Cancer Progression in the Prostate (2003)

Lloyd C. Trotman, Masaru Niki, Zohar A. Dotan, Jason A. Koutcher, Antonio Di Cristofano, Andrew Xiao, ...

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs...

Heteroduplex Analysis of the Sequence Relationships Between the Genomes of Kirsten and Harvey Sarcoma Viruses, Their Respective Parental Murine Leukemia Viruses, and the Rat Endogenous 30S RNA (1979)

Chien, Yueh-Hsiu, Lai, Michael, Shih, Thomas Y., Verma, Inder M., Scolnick, Edward M., Roy-Burman, Pradip, ...

The sequence relations between Kirsten murine sarcoma virus (Ki-SV), Harvey murine sarcoma virus (Ha-SV), and a rat endogenous 30S RNA were studied by electron microscope heteroduplex analysis. The...

Pathogenicity Induced by Feline Leukemia Virus, Rickard Strain, Subgroup A Plasmid DNA (pFRA)

Chen, Hang, Bechtel, Marta K., Shi, Yan, Phipps, Andrew, Mathes, Lawrence E., Hayes, Kathleen A., ...

A new provirus clone of feline leukemia virus (FeLV), which we named FeLV-A (Rickard) or FRA, was characterized with respect to viral interference group, host range, complete genome sequence, and in...

A Novel Truncated env Gene Isolated from a Feline Leukemia Virus-Induced Thymic Lymphosarcoma

Shi, Yan, Roy-Burman, Pradip

We PCR amplified the exogenous feline leukemia virus (FeLV)-related env gene species from lymphosarcomas induced by intradermally administered plasmid DNA of either the prototype FeLV, subgroup A...

Differential Pathogenicity of Two Feline Leukemia Virus Subgroup A Molecular Clones, pFRA and pF6A

Phipps, Andrew J., Chen, Hang, Hayes, Kathleen A., Roy-Burman, Pradip, Mathes, Lawrence E.

F6A, a molecular clone of subgroup A feline leukemia virus (FeLV) is considered to be highly infectious but weakly pathogenic. In recent studies with a closely related subgroup A molecular clone,...

Long Terminal Repeat Regions from Exogenous but Not Endogenous Feline Leukemia Viruses Transactivate Cellular Gene Expression

Ghosh, Sajal K., Roy-Burman, Pradip, Faller, Douglas V.

We have previously reported that the long terminal repeat (LTR) region of feline leukemia viruses (FeLVs) can enhance expression of certain cellular genes such as the collagenase IV gene and MCP-1 in...

A Replication-Competent Feline Leukemia Virus, Subgroup A (FeLV-A), Tagged with Green Fluorescent Protein Reporter Exhibits In Vitro Biological Properties Similar to Those of the Parental FeLV-A

Chang, Zongli, Pan, Judong, Logg, Christopher, Kasahara, Noriyuki, Roy-Burman, Pradip

We previously established that lymphoid tumors could be induced in cats by intradermal injection of ecotropic feline leukemia virus (FeLV), subgroup A, plasmid DNA. In preparation for in vivo...

Pten Dose Dictates Cancer Progression in the Prostate

Trotman, Lloyd C, Niki, Masaru, Dotan, Zohar A, Koutcher, Jason A, Di Cristofano, Antonio, Xiao, Andrew, ...

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs...

Heteroduplex Analysis of the Sequence Relationships Between the Genomes of Kirsten and Harvey Sarcoma Viruses, Their Respective Parental Murine Leukemia Viruses, and the Rat Endogenous 30S RNA

Chien, Yueh-Hsiu, Lai, Michael, Shih, Thomas Y., Verma, Inder M., Scolnick, Edward M., Roy-Burman, Pradip, ...

The sequence relations between Kirsten murine sarcoma virus (Ki-SV), Harvey murine sarcoma virus (Ha-SV), and a rat endogenous 30S RNA were studied by electron microscope heteroduplex analysis. The...

Spontaneous Release of Endogenous Ecotropic Type C Virus from Rat Embryo Cultures

Rasheed, Suraiya, Bruszewski, Joan, Rongey, Robert W., Roy-Burman, Pradip, Charman, Howard P., Gardner, Murray B.

Type C viruses were isolated from embryo cultures of two different rat strains, Sprague-Dawley and Fischer. Both viruses (termed rat leukemia virus, RaLV) were released spontaneously from rat embryo...

Pathogenicity Induced by Feline Leukemia Virus, Rickard Strain, Subgroup A Plasmid DNA (pFRA)

Chen, Hang, Bechtel, Marta K., Shi, Yan, Phipps, Andrew, Mathes, Lawrence E., Hayes, Kathleen A., ...

A new provirus clone of feline leukemia virus (FeLV), which we named FeLV-A (Rickard) or FRA, was characterized with respect to viral interference group, host range, complete genome sequence, and in...

A Novel Truncated env Gene Isolated from a Feline Leukemia Virus-Induced Thymic Lymphosarcoma

Shi, Yan, Roy-Burman, Pradip

We PCR amplified the exogenous feline leukemia virus (FeLV)-related env gene species from lymphosarcomas induced by intradermally administered plasmid DNA of either the prototype FeLV, subgroup A...

Differential Pathogenicity of Two Feline Leukemia Virus Subgroup A Molecular Clones, pFRA and pF6A

Phipps, Andrew J., Chen, Hang, Hayes, Kathleen A., Roy-Burman, Pradip, Mathes, Lawrence E.

F6A, a molecular clone of subgroup A feline leukemia virus (FeLV) is considered to be highly infectious but weakly pathogenic. In recent studies with a closely related subgroup A molecular clone,...

Long Terminal Repeat Regions from Exogenous but Not Endogenous Feline Leukemia Viruses Transactivate Cellular Gene Expression

Ghosh, Sajal K., Roy-Burman, Pradip, Faller, Douglas V.

We have previously reported that the long terminal repeat (LTR) region of feline leukemia viruses (FeLVs) can enhance expression of certain cellular genes such as the collagenase IV gene and MCP-1 in...

A Replication-Competent Feline Leukemia Virus, Subgroup A (FeLV-A), Tagged with Green Fluorescent Protein Reporter Exhibits In Vitro Biological Properties Similar to Those of the Parental FeLV-A

Chang, Zongli, Pan, Judong, Logg, Christopher, Kasahara, Noriyuki, Roy-Burman, Pradip

We previously established that lymphoid tumors could be induced in cats by intradermal injection of ecotropic feline leukemia virus (FeLV), subgroup A, plasmid DNA. In preparation for in vivo...

Pten Dose Dictates Cancer Progression in the Prostate

Trotman, Lloyd C, Niki, Masaru, Dotan, Zohar A, Koutcher, Jason A, Di Cristofano, Antonio, Xiao, Andrew, ...

Complete inactivation of the PTEN tumor suppressor gene is extremely common in advanced cancer, including prostate cancer (CaP). However, one PTEN allele is already lost in the vast majority of CaPs...

Heteroduplex Analysis of the Sequence Relationships Between the Genomes of Kirsten and Harvey Sarcoma Viruses, Their Respective Parental Murine Leukemia Viruses, and the Rat Endogenous 30S RNA

Chien, Yueh-Hsiu, Lai, Michael, Shih, Thomas Y., Verma, Inder M., Scolnick, Edward M., Roy-Burman, Pradip, ...

The sequence relations between Kirsten murine sarcoma virus (Ki-SV), Harvey murine sarcoma virus (Ha-SV), and a rat endogenous 30S RNA were studied by electron microscope heteroduplex analysis. The...

Spontaneous Release of Endogenous Ecotropic Type C Virus from Rat Embryo Cultures

Rasheed, Suraiya, Bruszewski, Joan, Rongey, Robert W., Roy-Burman, Pradip, Charman, Howard P., Gardner, Murray B.

Type C viruses were isolated from embryo cultures of two different rat strains, Sprague-Dawley and Fischer. Both viruses (termed rat leukemia virus, RaLV) were released spontaneously from rat embryo...

A Novel Association between the Human Heat Shock Transcription Factor 1 (HSF1) and Prostate Adenocarcinoma

Hoang, Arthur T., Huang, Jiapeng, Rudra-Ganguly, Nandini, Zheng, Jianping, Powell, William C., Rabindran, Sridhar K., ...

A search for differentially expressed genes in a pair of nonmetastatic (PC-3) versus metastatic variant (PC-3M) human prostate carcinoma cell lines led to identification of the human heat shock...

Suppression of Prostate Carcinoma Cell Invasion by Expression of Antisense L-Plastin Gene

Zheng, Jianping, Rudra-Ganguly, Nandini, Powell, William C., Roy-Burman, Pradip

Based on the finding that gene expression for the actin-bundling protein L-plastin is inducible by androgen and that L-plastin is overexpressed in malignant epithelium of the prostate, we examined...

Pten null prostate tumorigenesis and AKT activation are blocked by targeted knockout of ER chaperone GRP78/BiP in prostate epithelium

Fu, Yong, Wey, Shiuan, Wang, Miao, Ye, Risheng, Liao, Chun-Peng, Roy-Burman, Pradip, ...

GRP78/BiP has recently emerged as a novel biomarker for aggressive prostate cancer. Here, we report that homozygous deletion of Grp78 specifically in mouse prostate epithelium suppresses prostate...