Regulatory Hotspots in the Malaria Parasite Genome Dictate Transcriptional Variation (2008)
Joseph M. Gonzales, Jigar J. Patel, Napawan Ponmee, Lei Jiang, Asako Tan, Steven P. Maher, ...
The determinants of transcriptional regulation in malaria parasites remain elusive. The presence of a well-characterized gene expression cascade shared by different Plasmodium falciparum strains...
Microfluidic Modeling of Cell−Cell Interactions in Malaria Pathogenesis (2007)
Meher Antia, Thurston Herricks, Pradipsinh K. Rathod
The clinical outcomes of human infections by Plasmodium falciparum remain highly unpredictable. A complete understanding of the complex interactions between host cells and the parasite will require...
Variations in frequencies of drug resistance in Plasmodium falciparum
Rathod, Pradipsinh K., McErlean, Tara, Lee, Pei-Chieh
Continual exposure of malarial parasite populations to different drugs may have selected not only for resistance to individual drugs but also for genetic traits that favor initiation of resistance to...
Jiang, Lei, Lee, Pei-Chieh, White, John, Rathod, Pradipsinh K.
Unlike mammalian cells, malarial parasites are completely dependent on the de novo pyrimidine pathway and lack the enzymes to salvage preformed pyrimidines. In the present study, first, it is shown...
Shelby, J. Patrick, White, John, Ganesan, Karthikeyan, Rathod, Pradipsinh K., Chiu, Daniel T.
Severe malaria by Plasmodium falciparum is a potentially fatal disease, frequently unresponsive to even the most aggressive treatments. Host organ failure is associated with acquired rigidity of...
Variations in frequencies of drug resistance in Plasmodium falciparum
Rathod, Pradipsinh K., McErlean, Tara, Lee, Pei-Chieh
Continual exposure of malarial parasite populations to different drugs may have selected not only for resistance to individual drugs but also for genetic traits that favor initiation of resistance to...
Jiang, Lei, Lee, Pei-Chieh, White, John, Rathod, Pradipsinh K.
Unlike mammalian cells, malarial parasites are completely dependent on the de novo pyrimidine pathway and lack the enzymes to salvage preformed pyrimidines. In the present study, first, it is shown...
Shelby, J. Patrick, White, John, Ganesan, Karthikeyan, Rathod, Pradipsinh K., Chiu, Daniel T.
Severe malaria by Plasmodium falciparum is a potentially fatal disease, frequently unresponsive to even the most aggressive treatments. Host organ failure is associated with acquired rigidity of...
Microfluidic Modeling of Cell−Cell Interactions in Malaria Pathogenesis
Antia, Meher, Herricks, Thurston, Rathod, Pradipsinh K
The clinical outcomes of human infections by Plasmodium falciparum remain highly unpredictable. A complete understanding of the complex interactions between host cells and the parasite will require...
Novel Triazine JPC-2067-B Inhibits Toxoplasma gondii In Vitro and In Vivo
Mui, Ernest J., Schiehser, Guy A., Milhous, Wilbur K., Hsu, Honghue, Roberts, Craig W., Kirisits, Michael, ...
Toxoplasmosis is a neglected tropical disease, an emerging disease as well as a significant problem in developed countries causing a substantial health burden. Better medicines with less toxicity are...
Regulatory Hotspots in the Malaria Parasite Genome Dictate Transcriptional Variation
Gonzales, Joseph M, Patel, Jigar J, Ponmee, Napawan, Jiang, Lei, Tan, Asako, Maher, Steven P, ...
The determinants of transcriptional regulation in malaria parasites remain elusive. The presence of a well-characterized gene expression cascade shared by different Plasmodium falciparum strains...
Cui, Long, Miao, Jun, Furuya, Tetsuya, Fan, Qi, Li, Xinyi, Rathod, Pradipsinh K., ...
To better understand the role of histone lysine acetylation in transcription in Plasmodium falciparum, we sought to attenuate histone acetyltransferase (HAT) activity using anacardic acid (AA). We...
Ganesan, Karthikeyan, Ponmee, Napawan, Jiang, Lei, Fowble, Joseph W., White, John, Kamchonwongpaisan, Sumalee, ...
Genome sequences of Plasmodium falciparum allow for global analysis of drug responses to antimalarial agents. It was of interest to learn how DNA microarrays may be used to study drug action in...
Novel triazine JPC-2067-B inhibits Toxoplasma gondii in vitro and in vivo
Mui, Ernest J., Schiehser, Guy A., Milhous, Wilbur K., Hsu, Honghue, Roberts, C.W., Kirisits, Michael J., ...
Toxoplasma gondii causes substantial morbidity, mortality, and costs for healthcare in the developed and developing world. Current medicines are not well tolerated and cause hypersensitivity...
Deformability limits of Plasmodium falciparum-infected red blood cells
Herricks, Thurston, Antia, Meher, Rathod, Pradipsinh K
Splenic filtration of infected red blood cells (RBCs) may contribute to innate immunity and variable outcomes of malaria infections. We show that filterability of individual RBCs is well predicted by...