Prema G. Vasudev

Nucleation, Growth, and Form in Crystals of Peptide Helices (2008)

Vasudev, Prema G, Narayanaswamy, Shamala, Balaram, Padmanabhan

A model for the nucleation of crystallization in peptide helices is presented. The crystal structures of four polymorphic forms of a hydrophobic helical decapeptide...

Hybrid Peptides: Expanding the \beta Turn in Peptide Hairpins by the Insertion of \beta-, \gamma-, and \delta-Residues (2007)

Rai, Rajkishor, Vasudev, Prema G, Ananda, Kuppanna, Raghothama, Srinivasarao, Shamala, Narayanaswamy, Karle, Isabella L, ...

The \beta turn segment in designed peptide hairpins has been expanded by the insertion of \beta-, \gamma- and \delta amino acids at the i+2 position. The model octapeptides...

$C_{9}$ Helices and Ribbons in \gamma-Peptides: Crystal Structures of Gabapentin Oligomers$^{*}^{*}$ (2005)

Vasudev, Prema G, Shamala, Narayanaswamy, Ananda, Kuppanna, Balaram, Padmanabhan

The insertion of additional atoms into \alpha -polypeptide backbones by the introduction of \beta, \gamma, and higher \omega amino acid residues expands the range of polypeptide secondary...

Peptide helices with pendant cycloalkane rings. Characterization of conformations of 1-aminocyclooctane-1 carboxylic acid $(Ac_8c)$ residues in peptides (2004)

Datta, Saumen, Rathore, RNS, Vijayalakshmi, S, Vasudev, Prema G, Rao, Balaji R, Balaram, P, ...

A pentapeptide, $Boc-Leu-Ac_8c-Ala-Leu-Ac_8c-OMe 1$, an octapeptide, $Boc-Leu-Ac_8c-Ala-Leu-Ac_8c-Ala-Leu-Ac_8c-OMe 2$ and a tripeptide, $Boc-Aib-Ac_8c-Aib-OMe 3$ containing the...

Stereochemistry of gabapentin and several derivatives: Solid state conformations and solution equilibria (2003)

Ananda, K, Aravinda, S, Vasudev, Prema G, Raja, Muruga Poopathi K, Sivaramakrishnan, H, Nagarajan, K, ...

Gabapentin (1-(aminomethyl)cycloheaxaneacetic acid; Gpn) is a widely used anti-epileptic drug. The target site of action of Gpn remains controversial. Gpn can exist in two isomeric chair forms. The...