Chugani, Diane C., Chugani, Harry T., Muzik, Otto, Shah, Jagdish R., Shah, Aashit K., Canady, Alexa, ...
Several reports have indicated that cortical resection is effective in alleviating intractable epilepsy in children with tuberous sclerosis complex (TSC). Because of the multitude of cortical...
Human brain serotonin synthesis capacity measured in vivo with α-[C-11]methyl- L -tryptophan (1998)
Chugani, Diane C., Muzik, Otto, Chakraborty, Pulak K., Mangner, Thomas J., Chugani, Harry T.
Local cerebral serotonin synthesis capacity was measured with α-[C-11]methyl-L-tryptophan ([C-11]AMT) in normal adult human brain ( n = 10; five males, five females; age range, 18–38 years, mean...
Altered serotonin synthesis in the dentatothalamocortical pathway in autistic boys (1997)
Chugani, Diane C., Muzik, Otto, Rothermel, Robert, Behen, Michael E., Chakraborty, Pulak K., Mangner, Thomas J., ...
Based on reports of increased platelet serotonin in 30 to 50% of autistic subjects, abnormal serotonergic neurotransmission may be important in the pathogenesis of autism. However, serotonin...
Chakraborty, Pulak K., Gildersleeve, David L., Jewett, Douglas M., Toorongian, Steven A., Kilbourn, Michael R., Schwaiger, Markus, ...
R-(-)-[11C]Epinephrine ([11C]EPI) has been synthesized from R-(-)-norepinephrine by direct methylation with [11C]methyl iodide or [11C]methyl triflate. The total synthesis time including HPLC...
Hooberman, Barry H., Chakraborty, Pulak K., Sinsheimer, Joseph E.
A quantitative structure-activity relationship approach was used to investigate the mutagenicity of a series of seventeen-monosubstituted propylene oxides in Salmonella typhimurium strains TA100 and...
Van Dort, Marcian E., Kilbourn, Michael R., Chakraborty, Pulak K., Richfield, Eric K., Gildersleeve, David L., Wieland, Donald M.
A series of fluorine-18 and iodine-125 labeled aryl-1,4-dialkylpiperazine analogs, derivatives of GBR 12935, were synthesized as radiotracers for positron emission tomography or single photon...
Chakraborty, Pulak K., Kilbourn, Michael R.
The synthesis of 4-[18F]fluoroguaiacol (4-[18F]fluoro-2-methoxyphenol) has been achieved in no-carrier-added form starting from 2-methoxy-4-nitrobenzaldehyde, using nucleophilic aromatic substitution...
[18F]fluorination/decarbonylation: New route to aryl [18F]fluorides (1991)
Chakraborty, Pulak K., Kilbourn, Michael R.
A new route to aryl [18F]fluorides without electron withdrawing ring substituents has been developed. [18F]Fluorobenzaldehydes, prepared from no-carrier-added (NCA) [18F]fluoride using nucleophilic...
DNA strand breaks in liver for four aliphatic epoxides in mice (1990)
Giri, A. K., Messerly, E. A., Chakraborty, Pulak K., Hooberman, Barry H., Sinsheimer, Joseph E.
Four aliphatic epoxides, 1-naphthyl glycidyl ether (NGE), 1-naphthylpropylene oxide (NPO), 4-nitrophenyl glycidyl ether (NPGE), 3,3,3-trichloropropylene oxide (TCPO) and two of their precursors,...
Mutagenicity of oxaspiro compounds with Salmonella (1989)
Sinsheimer, Joseph E., Chakraborty, Pulak K., Messerly, E. A., Gaddamidi, V.
The spiro attachment of an epoxide group to a tetrahydropyran ring in the trichothecene mycotoxins has prompted this study of the mutagenicity and alkylation rates of the trichothecene, anguidine,...
Mutagenicity of aromatic glycidyl ethers with Salmonella (1988)
Rosman, L. B., Chakraborty, Pulak K., Messerly, E. A., Sinsheimer, Joseph E.
6 aromatic glycidyl ethers containing naphthyl, biphenyl or benzylphenyl substituents were synthesized. These epoxides together with the commercially available compounds 2-biphenylyl glycidyl ether...