Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons (2007)
Wang, Qian-fei, Prabhakar, Shyam, Chanan, Sumita, Cheng, Jan-Fang, Rubin, Edward M, Boffelli, Dario
Abstract Background Genomic comparisons between human and distant, non-primate mammals are commonly used to identify cis -regulatory elements based on constrained sequence evolution. However, these...
Primate-specific evolution of an LDLR enhancer (2006)
Wang, Qian-fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M, Chanan, Sumita, Brown, Myles, ...
Background Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. Results In this...
Primate-Specific Evolution of an LDLR Enhancer (2006)
Wang, Qian-fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M., Chanan, Sumita, Brown, Myles, ...
Sequence changes in regulatory regions have often been invoked to explain phenotypic divergence among species, but molecular examples of this have been difficult to obtain. In this study, we...
Detection of Weakly Conserved Ancestral Mammalian Regulatory Sequences by Primate Comparisons (2006)
Wang, Qian-fei, Prabhakar, Shyam, Chanan, Sumita, Cheng, Jan-Fang, Rubin, Edward M., Boffelli, Dario
Genomic comparisons between human and distant, non-primate mammals are commonly used to identify cis-regulatory elements based on constrained sequence evolution. However, these methods fail to detect...
Primate-specific evolution of an LDLR enhancer (2005)
Wang, Qian-Fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M., Chanan, Sumita, Brown, Myles, ...
Haplotypes in the APOA1-C3-A4-A5 Gene Cluster affect Plasma Lipids in both Humans and Baboons (2004)
Qian-fei Wang, Xin Liu, Ze Peng, Ronald M. Krauss, David L, John L. V, ...
Copyright © 2004 Oxford University Press Genetic studies in non-human primates serve as a potential strategy for identifying genomic intervals where polymorphisms impact upon human disease-related...
Haplotypes in the APOA1-C3-A4-A5 Gene Cluster affect Plasma Lipids in both Humans and Baboons (2004)
Wang, Qian-fei, Liu, Xin, O'Connell, Jeff, Peng, Ze, Krauss, Ronald M., Rainwater, David L., ...
Genetic studies in non-human primates serve as a potential strategy for identifying genomic intervals where polymorphisms impact upon human disease-related phenotypes. It remains unclear, however,...
Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons (2004)
Wang, Qian-fei, Liu, Xin, O'Connell, Jeff, Peng, Ze, Krauss, Ronald M., Rainwater, David L., ...
Genetic studies in non-human primates serve as a potential strategy for identifying genomic intervals where polymorphisms impact upon human disease-related phenotypes. It remains unclear, however,...
Haplotypes in the APOA1-C3-A4-A5 Gene Cluster affect Plasma Lipids in both Humans and Baboons (2004)
Wang, Qian-fei, Liu, Xin, O'Connell, Jeff, Peng, Ze, Krauss, Ronald M., Rainwater, David L., ...
Genetic studies in non-human primates serve as a potential strategy for identifying genomic intervals where polymorphisms impact upon human disease-related phenotypes. It remains unclear, however,...
Haplotypes in the APOA1-C3-A4-A5 gene cluster affect plasma lipids in both humans and baboons (2003)
Wang, Qian-fei, Liu, Xin, O'Connell, Jeff, Peng, Ze, Krauss, Ronald M., Rainwater, David L., ...
Genetic studies in non-human primates serve as a potential strategy for identifying genomic intervals where polymorphisms impact upon human disease-related phenotypes. It remains unclear, however,...
Wang, Qian-Fei, Lauring, Josh, Schlissel, Mark S.
The RAG-2 gene encodes a component of the V(D)J recombinase which is essential for the assembly of antigen receptor genes in B and T lymphocytes. Previously, we reported that the transcription factor...
Wang, Qian-Fei, Lauring, Josh, Schlissel, Mark S.
The RAG-2 gene encodes a component of the V(D)J recombinase which is essential for the assembly of antigen receptor genes in B and T lymphocytes. Previously, we reported that the transcription factor...
Primate-specific evolution of an LDLR enhancer
Wang, Qian-fei, Prabhakar, Shyam, Wang, Qianben, Moses, Alan M, Chanan, Sumita, Brown, Myles, ...
Analysis of primate-specific evolution of the LDL receptor enhancer demonstrates a molecular mechanism by which ancestral mammalian regulatory elements can evolve to perform new functions.
Detection of weakly conserved ancestral mammalian regulatory sequences by primate comparisons
Wang, Qian-fei, Prabhakar, Shyam, Chanan, Sumita, Cheng, Jan-Fang, Rubin, Edward M, Boffelli, Dario
Intra-primate genome comparisons identify functional modules that are undetected by comparisons with non-mammalian genomes.