Qihua Tan, Mads Thomassen, Kirsten M. Jochumsen, Ole Mogensen, Kaare Christensen, Torben A. Kruse
Different from significant gene expression analysis which looks for genes that are differentially regulated, feature selection in the microarray-based prognostic gene expression analysis aims at...
Qihua Tan, Mads Thomassen, Kirsten M. Jochumsen, Ole Mogensen, Kaare Christensen, Torben A. Kruse
Different from significant gene expression analysis which looks for genes that are differentially regulated, feature selection in the microarray-based prognostic gene expression analysis aims at...
Thomassen, Mads, Tan, Qihua, Kruse, Torben A
Abstract Background Metastasis is believed to progress in several steps including different pathways but the determination and understanding of these mechanisms is still fragmentary. Microarray...
Qihua Tan, Mads Thomassen, Torben A. Kruse
Abstract: Among the major issues in gene expression profi le classifi cation, feature selection is an important and necessary step in achieving and creating good classifi cation rules given the high...
Tan, Qihua, Thomassen, Mads, Christensen, Kaare, Kruse, Torben A.
Different from significant gene expression analysis which looks for all genes that are differentially regulated, feature selection in prognostic gene expression analysis aims at finding a subset of...
Tan, Qihua, Thomassen, Mads, Christensen, Kaare, Kruse, Torben A.
Different from significant gene expression analysis which looks for all genes that are differentially regulated, feature selection in prognostic gene expression analysis aims at finding a subset of...
Mining gene networks with application to GAW15 Problem 1 (2007)
Zhao, Jing, Luan, Jian'an, Baksh, M Fazil, Tan, Qihua
Abstract The Genetic Analysis Workshop 15 (GAW15) Problem 1 contained baseline expression levels of 8793 genes in immortalized B cells from 194 individuals in 14 Centre d'Etude du Polymorphisme...
© 2001 Kluwer Academic Publishers. Printed in the Netherlands. Research article (2007)
Qihua Tan, G. De Benedictis, A. I. Yashin, M. Bonafe, M. Deluca, S. Valensin, ...
Measuring the genetic influence in modulating the human life span: gene–environment interaction and the sex-specific genetic effect
*Address for correspondence (2007)
Karen Andersen-ranberg, Qihua Tan, Qihua Tan, Anatoli I. Yashin, Anatoli I. Yashin, Else M. Bladbjerg, ...
© Copyright is held by the authors.
Tan, Qihua, Christiansen, Lene, Brasch-Andersen, Charlotte, Zhao, Jing, Li, Shuxia, Kruse, Torben A, ...
Abstract Background The etiology of multifactorial human diseases involves complex interactions between numerous environmental factors and alleles of many genes. Efficient statistical tools are...
Qihua Tan, Mads Thomassen, Torben A. Kruse
Among the major issues in gene expression profile classification, feature selection is an important and necessary step in achieving and creating good classification rules given the high...
Qihua Tan, Mads Thomassen, Torben A. Kruse
Among the major issues in gene expression profile classification, feature selection is an important and necessary step in achieving and creating good classification rules given the high...
Mining gene networks with application to GAW15 Problem 1 (2007)
Jing Hua Zhao, M Fazil Baksh, Qihua Tan, Biomed Central, Fazil Baksh, Qihua Tan
BMC Proceedings Proceedings
Tan, Qihua, Dahlgaard, Jesper, Vach, Werner, Abdallah, Basem M, Kassem, Moustapha, Kruse, Torben A
Abstract We introduce a non-parametric approach using bootstrap-assisted correspondence analysis to identify and validate genes that are differentially expressed in factorial microarray experiments....
Estimating haplotype relative risks on human survival in population-based association studies (2005)
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Zhao, Jing H., Yashin, Anatoli I., Vaupel, James W., ...
Association-based linkage disequilibrium (LD) mapping is an increasingly important tool for localizing genes that show potential influence on human aging and longevity. As haplotypes contain more LD...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Zhao, Jing H., Vach, Werner, Vaupel, James W., ...
Haplotype based linkage disequilibrium (LD) mapping exhibits higher power than the single locus approach because it makes use of the LD information contained in the flanking markers. New statistical...
Bathum, Lise, Christiansen, Lene, Tan, Qihua, Vaupel, James W., Jeune, Bernard, Christensen, Kaare
Previous studies have reported two SNPs and a haplotype marker within the Microsomal Transfer Protein gene associated with extreme longevity. Here, we test this finding in a longitudinal study of...
Tan, Qihua, Zhao, Jing H., Iachine, Ivan A., Hjelmborg, Jacob, Vach, Werner, Vaupel, James W., ...
This report investigates the power issue in applying the non-parametric linkage analysis of affected sib-pairs (ASP) [Kruglyak and Lander, 1995: Am J Hum Genet 57:439-454] to localize genes that...
Multidisciplinary approaches in genetic studies of human aging and longevity (2004)
Tan, Qihua, Yashin, Anatoli I., Christensen, Kaare, Jeune, Bernard, De Benedictis, Giovanna, Kruse, Torben A., ...
The amount of research on human aging and longevity has been growing rapidly in recent years. Multidisciplinary approaches, which integrate classic population genetics methods with the principles of...
Assessing genetic association with human survival at multi-allelic loci (2004)
Tan, Qihua, De Benedictis, Giovanna, Yashin, Anatoli I., Bathum, Lise, Christiansen, Lene, Dahlgaard, Jesper, ...
Genetic variation plays an important role in natural selection and population evolution. However, it also presents geneticists interested in aging research with problems in data analysis because of...
Tan, Qihua, Bathum, Lise, Christiansen, Lene, De Benedictis, Giovanna, Dahlgaard, Jesper, Frizner, N, ...
In this paper, we apply logistic regression models to measure genetic association with human survival for highly polymorphic and pleiotropic genes. By modelling genotype frequency as a function of...
Tan,Qihua, Bellizzi,Dina, Rose,Guiseppina, Garasto,S., Franceschi,Claudio, Kruse,Torben, ...
A new method based on the recently developed relative risk approach is introduced, and applied to data from Italian centenarian study (965 subjects aged from 13 to 109 years old) for investigating...
A centenarian-only approach for assessing gene-gene interaction in human longevity (2002)
Tan,Qihua, De Benedictis,Giovanna, Ukraintseva,Svetlana V., Franceschi,Claudio, Vaupel,James W., Yashin,Anatoli I.
A case-only approach for assessing gene by sex interaction in human longevity (2002)
Tan,Qihua, Yashin,Anatoli I., Bladbjerg,Else M., De Maat,Moniek, Andersen-Ranberg,Karen, Jeune,Bernard, ...
As one aspect of the complex feature of longevity, gene by sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing...
A case-only approach for assessing gene by sex interaction in human longevity (2002)
Tan, Qihua, Yashin, Anatoli I., Bladbjerg, Else M., De Maat, Moniek, Andersen-Ranberg, Karen, Jeune, Bernard, ...
As one aspect of the complex feature of longevity, gene by sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing...
A centenarian-only approach for assessing gene-gene interaction in human longevity (2002)
Tan, Qihua, De Benedictis, Giovanna, Ukraintseva, Svetlana V., Franceschi, Claudio, Vaupel, James W., Yashin, Anatoli I.
Tan, Qihua, Bellizzi, Dina, Rose, Guiseppina, Garasto, S., Franceschi, Claudio, Kruse, Torben, ...
A new method based on the recently developed relative risk approach is introduced, and applied to data from Italian centenarian study (965 subjects aged from 13 to 109 years old) for investigating...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Li, Shuxia, Kruse, Torben A., Christensen, Kaare
Although the case-control or the cross-sectional design has been popular in genetic association studies of human longevity, such a design is prone to false positive results due to sampling bias and a...
Tan, Qihua, Christiansen, Lene, Bathum, Lise, Li, Shuxia, Kruse, Torben A., Christensen, Kaare
Although the case-control or the cross-sectional design has been popular in genetic association studies of human longevity, such a design is prone to false positive results due to sampling bias and a...
Singh, Ripudaman, Kølvraa, Steen, Bross, Peter, Jensen, Uffe Birk, Gregersen, Niels, Tan, Qihua, ...
Age-dependent changes in heat shock response (HSR) were studied in mononuclear cells (monocytes and lymphocytes) collected from young (mean age = 22.6 ± 1.7 years) and middle-aged (mean age = 56.3...
Tan, Qihua, Christiansen, Lene, Brasch-Andersen, Charlotte, Zhao, Jing Hua, Li, Shuxia, Kruse, Torben A, ...
A case-only approach for assessing gene-sex interaction in human longevity
Qihua Tan, Anatoli I. Yashin, Else M. Bladbjerg, Moniek De Maat, Karen Andersen-Ranberg, Bernard Jeune, ...
As one aspect of the complex feature of longevity, gene-sex interaction plays an important role in influencing human life span. With advances in molecular genetics, more studies aimed at assessing...
Mining gene networks with application to GAW15 Problem 1
Zhao, Jing Hua, Luan, Jian'an, Baksh, M Fazil, Tan, Qihua
The Genetic Analysis Workshop 15 (GAW15) Problem 1 contained baseline expression levels of 8793 genes in immortalized B cells from 194 individuals in 14 Centre d'Etude du Polymorphisme Humain (CEPH)...
Skov, Vibe, Glintborg, Dorte, Knudsen, Steen, Tan, Qihua, Jensen, Thomas, Kruse, Torben A., ...
Insulin resistance is a common metabolic abnormality in women with PCOS and leads to an elevated risk of type 2 diabetes. Studies have shown that thiazolidinediones (TZDs) improve metabolic...
Feature Selection for Predicting Tumor Metastases in Microarray Experiments using Paired Design
Tan, Qihua, Thomassen, Mads, Kruse, Torben A.
Among the major issues in gene expression profile classification, feature selection is an important and necessary step in achieving and creating good classification rules given the high...
Power for Genetic Association Study of Human Longevity Using the Case-Control Design
Tan, Qihua, Zhao, Jing Hua, Zhang, Dongfeng, Kruse, Torben A., Christensen, Kaare
The efficiency of the popular case-control design in gene-longevity association studies needs to be verified because, different from a binary trait, longevity represents only the extreme end of the...