Qing-Dong Wang

Pharmacological possibilities for protection against myocardial reperfusion injury (2002)

Wang, Qing-Dong, Pernow, John, Sjöquist, Per-Ove, Rydén, Lars

Reperfusion through thrombolysis or percutananeous coronary angioplasty is standard treatment in impending acute myocardial infarction. Although restoration of blood flow to the jeopardised...

The endothelin A receptor antagonist LU 135252 protects the myocardium from neutrophil injury during ischaemia/reperfusion (1998)

Gonon, Adrian T, Wang, Qing-Dong, Pernow, John

Objective: Endothelin-1 (ET-1) is not only a potent vasoconstrictor but also a stimulator of polymorphonuclear leukocyte (PMN) aggregation and adhesion. The aim of this study was to investigate...

Endothelin in myocardial ischaemia and reperfusion (1997)

Pernow, John, Wang, Qing-Dong

Endothelin-1 (ET-1) is an extremely potent vasoconstrictor peptide derived from vascular endothelial cells. ET-1 can also be produced by other cell types such as smooth muscle cells and...

Coronary venous drug infusion in the ischaemic-reperfused isolated rat heart (1996)

Uriuda, Yozo, Wang, Qing-Dong, Li, Xing-San, Sjöquist, Per-Ove, Nordlander, Rolf, Rydén, Lars

Objectives: Coronary venous retroinfusion (CVR) has been used experimentally in large animals for selective drug delivery into ischaemic myocardium. It would be an advantage if CVR could also be used...

Antithrombotic activity of inogatran, a new low-molecular-weight inhibitor of thrombin, in a closed-chest porcine model of coronary artery thrombosis (1996)

Uriuda, Yozo, Wang, Qing-Dong, Grip, Lars, Rydén, Lars, Sjöquist, Per-Ove, Mattsson, Christer

Objective: To characterize the antithrombotic activitiy of inogatran per se in a porcine model of copper-coil-induced coronary artery thrombosis and to compare its effect with that of heparin and...

Protective effects of non-peptide endothelin receptor antagonist bosentan on myocardial ischaemic and reperfusion injury in the pig (1995)

Wang, Qing-Dong, Li, Xing-San, Lundberg, Jan M, Pernow, John

Objective: The aim was to investigate the effects of the non-peptide endothelin receptor antagonist bosentan (Ro 47-0203) on haemodynamic variables, infarct size, myocardial overflow, and tissue...

Local overflow and enhanced tissue content of endothelin following myocardial ischaemia and reperfusion in the pig: modulation by L-arginine (1995)

Wang, Qing-Dong, Hemsén, Anette, Li, Xing-San, Lundberg, Jan M, Uriuda, Yozo, Pernow, John

Objective: The local myocardial overflow and tissue content of endothelin-like immunoreactivity (ET-LI) during ischaemia and reperfusion as well as the coronary vascular effects of endothelin were...