Occupational Exposure to Solvents and Risk of Non-Hodgkin Lymphoma in Connecticut Women (2009)
Wang, Rong, Zhang, Yawei, Lan, Qing, Holford, Theodore R., Leaderer, Brian, Hoar Zahm, Shelia, ...
A population-based case-control study involving 601 incident cases of non-Hodgkin lymphoma (NHL) and 717 controls was conducted in 1996–2000 among Connecticut women to examine associations with...
Lan, Qing, Zhang, Luoping, Shen, Min, Jo, William J., Vermeulen, Roel, Li, Guilan, ...
Benzene is an established human hematotoxicant and leukemogen but its mechanism of action is unclear. To investigate the role of single-nucleotide polymorphisms (SNPs) on benzene-induced...
A pooled investigation of Toll-like receptor gene variants and risk of non-Hodgkin lymphoma (2009)
Purdue, Mark P., Lan, Qing, Wang, Sophia S., Kricker, Anne, Menashe, Idan, Zheng, Tong-Zhang, ...
Toll-like receptors (TLRs) may influence the development of non-Hodgkin lymphoma (NHL) given their important roles in recognizing microbial pathogens and stimulating multiple immune pathways. We...
Zhang, Yawei, Hughes, Kathryn J., Zahm, Shelia Hoar, Zhang, Yaqun, Holford, Theodore R., Dai, Li, ...
From 1996 to 2000, the authors conducted a population-based case-control study among Connecticut women to test the hypothesis that genetic variation in xenobiotic metabolic pathway genes modifies the...
Huang, Qiang, Zhang, Quan-Bin, Dong, Jun, Wu, Yin-Yan, Shen, Yun-Tian, Zhao, Yao-Dong, ...
Abstract Background Despite the advances made during decades of research, the mechanisms by which glioma is initiated and established remain elusive. The discovery of glioma stem cells (GSCs) may...
Hematotoxicity in Workers (2008)
Exposed To Low, Qing Lan, Luoping Zhang, Guilan Li, Roel Vermeulen, Rona S. Weinberg, ...
onsideration of the risks posed by benzene as an air pollutant. Limitations in previous occupational studies evaluating hematotoxicity at low levels of benzene exposure led us to perform a large...
Chen, Hua, Huang, Qiang, Dong, Jun, Zhai, De-Zhong, Wang, Ai-Dong, Lan, Qing
Abstract Background Gliomas are the most common and aggressive primary brain tumors for which unfortunately no effective treatment modalities exist despite advances in molecular biology as the...
The Utility of t(14;18) in Understanding Risk Factors for Non-Hodgkin Lymphoma (2008)
Chiu, Brian C.-H., Lan, Qing, Dave, Bhavana J., Blair, Aaron, Zahm, Shelia Hoar, Weisenburger, Dennis D.
Characteristic chromosomal abnormalities are associated with specific histological subtypes of non-Hodgkin lymphoma (NHL). The chromosomal translocation t(14;18)(q32;q21) is one of the most common...
Chromosome Translocations in Workers Exposed to Benzene (2008)
McHale, Cliona M., Lan, Qing, Corso, Chiara, Li, Guilan, Zhang, Luoping, Vermeulen, Roel, ...
As benzene has been linked with elevated risk of both acute myeloid leukemia and lymphoma, we explored the effect of benzene exposure on levels of t(8;21), t(15;17), and t(14;18) translocations....
Hosgood, H.Dean, Menashe, Idan, Shen, Min, Yeager, Meredith, Yuenger, Jeff, Rajaraman, Preetha, ...
Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with...
Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes (2008)
Figueroa, Jonine D., Malats, Núria, García-Closas, Montserrat, Real, Francisco X., Silverman, Debra, Kogevinas, Manolis, ...
Aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs) are carcinogens present in tobacco smoke and functional polymorphisms in NAT2 and GSTM1 metabolizing genes are associated with...
Lee, Kyoung-Mu, Shen, Min, Chapman, Robert S., Yeager, Meredith, Welch, Robert, He, Xingzhou, ...
We conducted a population-based case–control study in Xuan Wei, China, where lung cancer rates are among the highest in China due to exposure to indoor coal combustion products, to evaluate the...
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma (2007)
Lan, Qing, Zheng, Tongzhang, Chanock, Stephen, Zhang, Yawei, Shen, Min, Wang, Sophia S., ...
The caspase proteins are essential for the regulation of normal B cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes, CASP3...
Purdue, Mark P., Lan, Qing, Kricker, Anne, Grulich, Andrew E., Vajdic, Claire M., Turner, Jennifer, ...
Recent findings suggest that genetic polymorphisms in TNF and IL10 are associated with an increased risk of non-Hodgkin lymphoma (NHL), particularly for diffuse large B-cell lymphoma (DLBCL). To...
Lee, Kyoung-Mu, Shen, Min, Chapman, Robert S., Yeager, Meredith, Welch, Robert, He, Xingzhou, ...
We conducted a population-based case-control study in Xuan Wei, China, where lung cancer rates are among the highest in China due to exposure to indoor coal combustion products, to evaluate the...
Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism (2006)
Kim, Sungkyoon, Vermeulen, Roel, Waidyanatha, Suramya, Johnson, Brent A., Lan, Qing, Rothman, Nathaniel, ...
Although the toxicity of benzene has been linked to its metabolism, the dose-related production of metabolites is not well understood in humans, particularly at low levels of exposure. We...
Shen, Min, Lan, Qing, Zhang, Luoping, Chanock, Stephen, Li, Guilan, Vermeulen, Roel, ...
Benzene is a recognized hematotoxicant and carcinogen that produces genotoxic damage. DNA double-strand breaks (DSB) are one of the most severe DNA lesions caused directly and indirectly by benzene...
Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma (2006)
Wang, Sophia S., Davis, Scott, Cerhan, James R., Hartge, Patricia, Severson, Richard K., Cozen, Wendy, ...
Evidence supporting the contribution of oxidative stress to key pathways in cancer, such as inflammation and DNA damage, continues to mount. We investigated variations within genes mediating...
Shen, Min, Lan, Qing, Zhang, Luoping, Chanock, Stephen, Li, Guilan, Vermeulen, Roel, ...
Benzene is a recognized hematotoxicant and carcinogen that produces genotoxic damage. DNA double strand breaks (DSB) are one of the most severe DNA lesions caused directly and indirectly by benzene...
Genetic variants in caspase genes and susceptibility to non-Hodgkin lymphoma (2006)
Lan, Qing, Zheng, Tongzhang, Chanock, Stephen, Zhang, Yawei, Shen, Min, Wang, Sophia S., ...
The caspase proteins are essential for the regulation of normal B-cell development and regulation of apoptosis. We investigated five single nucleotide polymorphisms in four key caspase genes CASP3...
Purdue, Mark P., Lan, Qing, Kricker, Anne, Grulich, Andrew E., Vajdic, Claire M., Turner, Jennifer, ...
Recent findings suggest that genetic polymorphisms in TNF and IL10 are associated with an increased risk of non-Hodgkin lymphoma (NHL), particularly for diffuse large B-cell lymphoma (DLBCL). To...
Purdue, Mark P., Lan, Qing, Kricker, Anne, Grulich, Andrew E., Vajdic, Claire M., Turner, Jennifer, ...
Recent findings suggest that genetic polymorphisms in TNF and IL10 are associated with an increased risk of non-Hodgkin lymphoma (NHL), particularly for diffuse large B-cell lymphoma (DLBCL). To...
Polymorphisms in oxidative stress genes and risk for non-Hodgkin lymphoma (2006)
Wang, Sophia S., Davis, Scott, Cerhan, James R., Hartge, Patricia, Severson, Richard K., Cozen, Wendy, ...
Evidence supporting the contribution of oxidative stress to key pathways in cancer, such as inflammation and DNA damage, continues to mount. We investigated variations within genes mediating...
A Putative Exonic Splicing Polymorphism in the BCL6 Gene and the Risk of Non-Hodgkin Lymphoma (2005)
Zhang, Yawei, Lan, Qing, Rothman, Nathaniel, Zhu, Yong, Zahm, Shelia Hoar, Wang, Sophia S., ...
Recent studies have shown that the B-cell lymphoma 6 gene (BCL6) is an oncogene that contributes to lymphomagenesis. Exon 6 of BCL6 contains a common single nucleotide polymorphism (SNP) (−195 C>T;...
Keohavong, Phouthone, Lan, Qing, Gao, Wei-Min, Zheng, Kui-Cheng, Mady, Hussam H., Melhem, Mona F., ...
Lung cancer mortality rates in the Xuan Wei County population are among the highest in China and are associated with exposure to indoor emissions from the burning of smoky coal. Previous studies of...
Using urinary biomarkers to elucidate dose-related patterns of human benzene metabolism (2005)
Kim, Sungkyoon, Vermeulen, Roel, Waidyanatha, Suramya, Johnson, Brent A., Lan, Qing, Rothman, Nathaniel, ...
Although the toxicity of benzene has been linked to its metabolism, the dose-related production of metabolites is not well understood in humans, particularly at low levels of exposure. We...
Martin, Robert CG, Hughes, Kalista, Doll, Mark A, Lan, Qing, Martini, Benjamin D, Lissowska, Jolanta, ...
Abstract Background Manganese superoxide dismutase (MnSOD) plays a critical role in the detoxification of mitochondrial reactive oxygen species constituting a major cellular defense mechanism against...
VERMEULEN, ROEL, LI, GUILAN, LAN, QING, DOSEMECI, MUSTAFA, RAPPAPORT, STEPHEN M., BOHONG, XU, ...
Objectives: We carried out a detailed exposure assessment of benzene and toluene in two shoe factories in Tianjin, China. Our goal was to identify workers with a broad range of benzene exposures, for...
Lan, Qing, Mumford, Judy L., Shen, Min, DeMarini, David M., Bonner, Matthew R., He, Xingzhou, ...
Lung cancer rates among men and particularly among women, almost all of whom are nonsmokers, in Xuan Wei County, China are among the highest in China and have been causally associated with exposure...
Keohavong, Phouthone, Lan, Qing, Gao, Wei-Min, Zheng, Kui-Cheng, Mady, Hussam H., Melhem, Mona F., ...
Lung cancer mortality rates in the Xuan Wei County population are among the highest in China and are associated with exposure to indoor emissions from the burning of smoky coal. Previous studies of...
The Centre for Modeling Human Disease Gene Trap resource (2004)
To, Christine, Epp, Trevor, Reid, Tammy, Lan, Qing, Yu, Mei, Li, Carol Y. J., ...
Gene trap mutagenesis of mouse embryonic stem cells generates random loss‐of‐function mutations, which can be identified by a sequence tag and can often report the endogenous expression of...
Lan, Qing, Mumford, Judy L., Shen, Min, DeMarini, David M., Bonner, Matthew R., He, Xingzhou, ...
Lung cancer rates among men and particularly among women, almost all of whom are non-smokers, in Xuan Wei County, China are among the highest in China and have been causally associated with exposure...
Household Stove Improvement and Risk of Lung Cancer in Xuanwei, China (2002)
Lan, Qing, Chapman, Robert S., Schreinemachers, Dina M., Tian, Linwei, He, Xingzhou
Background: Lung cancer rates in rural Xuanwei County, Yunnan Province, are among the highest in China. Residents traditionally burned “smoky” coal in unvented indoor firepits that generated very...
Engel, Lawrence S., Taioli, Emanuela, Pfeiffer, Ruth, Garcia-Closas, Montserrat, Marcus, Pamela M., Lan, Qing, ...
Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in...
Printout.
Thesis (M.S.)--Thayer School of Engineering, 1992.
The Centre for Modeling Human Disease Gene Trap resource
To, Christine, Epp, Trevor, Reid, Tammy, Lan, Qing, Yu, Mei, Li, Carol Y. J., ...
Gene trap mutagenesis of mouse embryonic stem cells generates random loss-of-function mutations, which can be identified by a sequence tag and can often report the endogenous expression of the...
Martin, Robert CG, Hughes, Kalista, Doll, Mark A, Lan, Qing, Martini, Benjamin D, Lissowska, Jolanta, ...
Hematotoxicity in Workers Exposed to Low Levels of Benzene
Lan, Qing, Zhang, Luoping, Li, Guilan, Vermeulen, Roel, Weinberg, Rona S., Dosemeci, Mustafa, ...
Benzene is known to have toxic effects on the blood and bone marrow, but its impact at levels below the U.S. occupational standard of 1 part per million (ppm) remains uncertain. In a study of 250...
Forrest, Matthew S., Lan, Qing, Hubbard, Alan E., Zhang, Luoping, Vermeulen, Roel, Zhao, Xin, ...
Benzene is an industrial chemical and component of gasoline that is an established cause of leukemia. To better understand the risk benzene poses, we examined the effect of benzene exposure on...
Chapman, Robert S, He, Xingzhou, Blair, Aaron E, Lan, Qing
Objective To test whether improvement in household coal stoves affected the incidence of chronic obstructive pulmonary disease (COPD) in Xuanwei County, China.
Vermeulen, Roel, Lan, Qing, Zhang, Luoping, Gunn, Laura, McCarthy, Diane, Woodbury, Ronald L., ...
Benzene is an important industrial chemical and environmental contaminant that causes leukemia. To obtain mechanistic insight into benzene's mechanism of action, we examined the impact of benzene on...
Liu, Yang, Lan, Qing, Siegfried, Jill M, Luketich, James D, Keohavong, Phouthone
Aberrant methylation in gene promoter regions leads to transcriptional inactivation of cancer-related genes and plays an integral role in tumorigenesis. This alteration has been investigated in lung...
The Centre for Modeling Human Disease Gene Trap resource
To, Christine, Epp, Trevor, Reid, Tammy, Lan, Qing, Yu, Mei, Li, Carol Y. J., ...
Gene trap mutagenesis of mouse embryonic stem cells generates random loss-of-function mutations, which can be identified by a sequence tag and can often report the endogenous expression of the...
Martin, Robert CG, Hughes, Kalista, Doll, Mark A, Lan, Qing, Martini, Benjamin D, Lissowska, Jolanta, ...
Forrest, Matthew S., Lan, Qing, Hubbard, Alan E., Zhang, Luoping, Vermeulen, Roel, Zhao, Xin, ...
Benzene is an industrial chemical and component of gasoline that is an established cause of leukemia. To better understand the risk benzene poses, we examined the effect of benzene exposure on...
Chapman, Robert S, He, Xingzhou, Blair, Aaron E, Lan, Qing
Objective To test whether improvement in household coal stoves affected the incidence of chronic obstructive pulmonary disease (COPD) in Xuanwei County, China.
Vermeulen, Roel, Lan, Qing, Zhang, Luoping, Gunn, Laura, McCarthy, Diane, Woodbury, Ronald L., ...
Benzene is an important industrial chemical and environmental contaminant that causes leukemia. To obtain mechanistic insight into benzene's mechanism of action, we examined the impact of benzene on...
Liu, Yang, Lan, Qing, Siegfried, Jill M, Luketich, James D, Keohavong, Phouthone
Aberrant methylation in gene promoter regions leads to transcriptional inactivation of cancer-related genes and plays an integral role in tumorigenesis. This alteration has been investigated in lung...
Albumin Adducts of Electrophilic Benzene Metabolites in Benzene-Exposed and Control Workers
Lin, Yu-Sheng, Vermeulen, Roel, Tsai, Chin H., Waidyanatha, Suramya, Lan, Qing, Rothman, Nathaniel, ...
Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma
Lan, Qing, Zheng, Tongzhang, Rothman, Nathaniel, Zhang, Yawei, Wang, Sophia S., Shen, Min, ...
Studies have demonstrated that common polymorphisms in Th1 and Th2 cytokine genes can alter gene expression, modulate the balance between Th1/Th2 responsiveness, and influence susceptibility for...
Exogenous and Endogenous Determinants of Blood Trihalomethane Levels after Showering
Backer, Lorraine C., Lan, Qing, Blount, Benjamin C., Nuckols, J.R., Branch, Robert, Lyu, Christopher W., ...
Lim, Unhee, Wang, Sophia S., Hartge, Patricia, Cozen, Wendy, Kelemen, Linda E., Chanock, Stephen, ...
We previously reported a lower risk of non-Hodgkin lymphoma (NHL) associated with high consumption of vitamin B6 and methionine, dietary determinants of one-carbon metabolism. Evidence has linked...
Shen, Min, Chapman, Robert S., Vermeulen, Roel, Tian, Linwei, Zheng, Tongzhang, Chen, Bingshu E., ...
Wang, Sophia S., Purdue, Mark P., Cerhan, James R., Zheng, Tongzhang, Menashe, Idan, Armstrong, Bruce K., ...
Evidence That Humans Metabolize Benzene via Two Pathways
Rappaport, Stephen M., Kim, Sungkyoon, Lan, Qing, Vermeulen, Roel, Waidyanatha, Suramya, Zhang, Luoping, ...
Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes
Figueroa, Jonine D., Malats, Núria, García-Closas, Montserrat, Real, Francisco X., Silverman, Debra, Kogevinas, Manolis, ...
Aromatic amines (AAs) and polycyclic aromatic hydrocarbons (PAHs) are carcinogens present in tobacco smoke and functional polymorphisms in NAT2 and GSTM1 metabolizing genes are associated with...
Hosgood, H.Dean, Menashe, Idan, Shen, Min, Yeager, Meredith, Yuenger, Jeff, Rajaraman, Preetha, ...
Common genetic variation may play an important role in altering lung cancer risk. We conducted a pathway-based candidate gene evaluation to identify genetic variations that may be associated with...
A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma
Lan, Qing, Lim, Unhee, Liu, Chin-San, Weinstein, Stephanie J., Chanock, Stephen, Bonner, Matthew R., ...
Mitochondrial DNA (mtDNA) copy number is increased in patients with chronic lymphocytic leukemia (CLL), in Burkitt lymphoma and Epstein-Barr virus–transformed lymphoblastoid cell lines, and in T...