Qing Zhang

Global characterization of Artemisia annua glandular trichome transcriptome using 454 pyrosequencing (2009)

Wang, Wei, Wang, Yejun, Zhang, Qing, Qi, Yan, Guo, Dianjing

Abstract Background Glandular trichomes produce a wide variety of commercially important secondary metabolites in many plant species. The most prominent anti-malarial drug artemisinin, a...

HCV genotyping using statistical classification approach (2009)

Qiu, Ping, Cai, Xiao-Yan, Ding, Wei, Zhang, Qing, Norris, Ellie D, Greene, Jonathan R

Abstract The genotype of Hepatitis C Virus (HCV) strains is an important determinant of the severity and aggressiveness of liver infection as well as patient response to antiviral therapy. Fast and...

Towards Multidimensional Subspace Skyline Analysis (2009)

Jian Pei, Yidong Yuan, Xuemin Lin, Wen Jin, Martin Ester, Qing Liu, ...

The skyline operator is important for multicriteria decision-making applications. Although many recent studies developed efficient methods to compute skyline objects in a given space, none of them...

Application of serum proteomics to the Women's Health Initiative conjugated equine estrogens trial reveals a multitude of effects relevant to clinical findings (2009)

Katayama, Hiroyuki, Paczesny, Sophie, Prentice, Ross, Aragaki, Aaron, Faca, Vitor M, Pitteri, Sharon J, ...

Abstract Background The availability of serum collections from the Women's Health Initiative (WHI) conjugated equine estrogens (CEE) randomized controlled trial provides an opportunity to test the...

A Framework for Identifying Compromised Nodes in Wireless Sensor Networks (2009)

Qing Zhang, Ting Yu, Peng Ning

Sensor networks are often subject to physical attacks. Once a node’s cryptographic key is compromised, an attacker may completely impersonate it and introduce arbitrary false information into the...

2196 A Whole-Genome Assembly of Drosophila (2008)

Eugene W. Myers, Granger G. Sutton, Art L. Delcher, Ian M. Dew, Dan P. Fasulo, Michael J. Flanigan, ...

We report on the quality of a whole-genome assembly of Drosophila melanogaster and the nature of the computer algorithms that accomplished it. Three independent external data sources essentially...

High Charge-Carrier Mobility in an Amorphous Hexaazatrinaphthylene Derivative (2008)

Bilal R. Kaafarani, Takeshi Kondo, Junsheng Yu, Qing Zhang, Davide Dattilo, Chad Risko, ...

New electron-transport (ET) organic materials that can readily be processed from solution are required for organic electronics and optoelectronics. The 5,6,11,12,17,18-hexaazatrinaphthylene (HAT-NA)...

FEATURE GENERATION USING GENETIC PROGRAMMING BASED ON FISHER CRITERION (2008)

Hong Guo, Qing Zhang, Asoke K. N

In this paper, a novel feature extraction method is proposed; Genetic Programming (GP) is used to discover features, while the Fisher criterion is employed to provide fitness values. This produces...

Superlubricity and tribochemistry of polyhydric alcohols (2008)

Matta, C., Joly-Pottuz, L., De Barros Bouchet, M. I., Martin, J. M., Kano, M., Zhang, Qing, ...

The anomalous low friction of diamondlike carbon coated surfaces lubricated by pure glycerol was observed at 80 °C. Steel surfaces were coated with an ultrahard 1 µm thick hydrogen-free tetrahedral...

Superlubricity and tribochemistry of polyhydric alcohols (2008)

Matta, C., Joly-Pottuz, L., De Barros Bouchet, M. I., Martin, J. M., Kano, M., Zhang, Qing, ...

The anomalous low friction of diamondlike carbon coated surfaces lubricated by pure glycerol was observed at 80 °C. Steel surfaces were coated with an ultrahard 1 µm thick hydrogen-free tetrahedral...

Novel genes dramatically alter regulatory network topology in amphioxus (2008)

Zhang, Qing, Zmasek, Christian M, Dishaw, Larry J, Mueller, M Gail, Ye, Yuzhen, Litman, Gary W, ...

Abstract Background Regulation in protein networks often utilizes specialized domains that 'join' (or 'connect') the network through specific protein-protein interactions. The innate immune system,...

A mouse plasma peptide atlas as a resource for disease proteomics (2008)

Zhang, Qing, Menon, Rajasree, Deutsch, Eric W, Pitteri, Sharon J, Faca, Vitor M, Wang, Hong, ...

Abstract We present an in-depth analysis of mouse plasma leading to the development of a publicly available repository composed of 568 liquid chromatography-tandem mass spectrometry runs. A total of...

A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development (2008)

Vitor M. Faca, Kenneth S. Song, Hong Wang, Qing Zhang, Alexei L. Krasnoselsky, Lisa F. Newcomb, ...

BackgroundThe complexity and heterogeneity of the human plasma proteome have presented significant challenges in the identification of protein changes associated with tumor development. Refined...

Overexpression of an isoform of AML1 in acute leukemia and its potential role in leukemogenesis (2008)

Xiangrong Liu, Qing Zhang, Dong-er Zhang, Chunlin Zhou, Haiyan Xing, Zhen Tian, ...

AML1/RUNX1 is a critical transcription factor in hematopoietic cell differentiation and proliferation. From the _AML1_ gene, at least three isoforms, _AML1a_, _AML1b_ and _AML1c_, are produced...

Glavlit: Preventing Exfiltration at Wire Speed (2008)

Nabil Schear, Carmelo Kintana, Qing Zhang, Amin Vahdat

Protecting sensitive data is no longer a problem restricted to governments whose national security is at stake. With ubiquitous Internet connectivity, it is challenging to secure a network – not...

Towards Multidimensional Subspace Skyline Analysis (2008)

Jian Pei, Yidong Yuan, Xuemin Lin, Wen Jin, Martin Ester, Qing Liu, ...

The skyline operator is important for multicriteria decision-making applications. Although many recent studies developed efficient methods to compute skyline objects in a given space, none of them...

Building Data Synopses within a Known Maximum Error Bound (2008)

Chaoyi Pang, Qing Zhang, David Hansen, Anthony Maeder

Abstract. The constructions of Haar wavelet synopses for large data sets have proven to be useful tools for data approximation. Recently, research on constructing wavelet synopses with a guaranteed...

Error Minimization in Approximate Range Aggregates (2008)

Xuemin Lin, Qing Zhang, Yidong Yuan, Qing Liu

Histogram techniques have been used in many commercial database management systems to estimate a query result size. Recently, it has been shown that they are very effective to support approximation...

Error Minimization for Approximate Computation of Range Aggregates (2008)

Xuemin Lin, Qing Zhang

Histogram techniques are widely used in commercial database management systems for an estimation of query results. Recently, they have been also used in approximately processing database queries,...

Microdata Privacy Protection Through Permutation-Based Approaches (2008)

Zhang, Qing

Data analysts often prefer access to data in the form of original tuples(i.e., microdata), instead of pre-aggregated statistics, since the former offers advantages in information flexibility and...

2196 A Whole-Genome Assembly of Drosophila (2008)

Eugene W. Myers, Granger G. Sutton, Art L. Delcher, Ian M. Dew, Dan P. Fasulo, Michael J. Flanigan, ...

We report on the quality of a whole-genome assembly of Drosophila melanogaster and the nature of the computer algorithms that accomplished it. Three independent external data sources essentially...

Glavlit: Preventing Exfiltration at Wire Speed (2008)

Nabil Schear, Carmelo Kintana, Qing Zhang, Amin Vahdat

Protecting sensitive data is no longer a problem restricted to governments whose national security is at stake. With ubiquitous Internet connectivity, it is challenging to secure a network – not...

1,2-Bis[5-(4-cyanophenyl)-2-methyl-3-thienyl]-3,3,4,4,5,5-hexafluorocyclopent-1-ene: a photochromic diarylethene compound (2008)

Gang Liu, Qidong Tu, Qing Zhang, Congbin Fan, Tianshe Yang

The molecules of the title compound, C29H16F6N2S2, a photochromic dithienylethene with 4-cyanophenyl substituents, adopt an antiparallel arrangement that is reponsible for photoactivity. The molecule...

Dibromidobis(N,N-diethyldithiocarbamato-κ2S,S′)tetra-μ3-sulfido-dicopper(I)dimolybdenum(V) isopropanol disolvate (2008)

Qing Zhang, Min Liu

The molecule of the title compound, [Cu2Mo2Br2(C7H14NS2)2S4]·2C3H7OH, comprises one [(i-C3H7)2NCS2]2Mo2S4 unit and two CuBr units held together by six Cu—μ3-S bonds, thus forming a...

In-situ synthesis of poly(dimethylsiloxane)-gold nanoparticles composite films and its application in microfluidic systems (2008)

Zhang, Qing, Xu, Jing-Juan, Liu, Yan, Chen, Hong-Yuan

We presented a simple approach for in-situ synthesis of poly(dimethylsiloxane) (PDMS)-gold nanoparticles composite film based on the special characteristics of PDMS itself. It is an environmentally...

Autocrine and Paracrine Chemokine Receptor 7 Activation in Head and Neck Cancer: Implications for Therapy (2008)

Wang, Jun, Seethala, Raja R., Zhang, Qing, Gooding, William, Van Waes, Carter, Hasegawa, Hitoshi, ...

Background The chemokine receptor 7 (CCR7) mediates survival and invasiveness of metastatic squamous cell carcinoma of the head and neck (SCCHN) to regional lymph nodes. Constitutive prosurvival...

Approaching regional left atrial function by tissue Doppler velocity and strain imaging (2008)

Zhang, Qing, Yip, Gabriel Wai-Kwok, Yu, Cheuk-Man

Atrial function is an integral part for the proper performance of the circulatory system. Assessment of its haemodynamic and mechanical characteristics by use of non-invasive echocardiography,...

Immune epitope database analysis resource (IEDB-AR) (2008)

Zhang, Qing, Wang, Peng, Kim, Yohan, Haste-Andersen, Pernille, Beaver, John, Bourne, Philip E., ...

We present a new release of the immune epitope database analysis resource (IEDB-AR, http://tools.immuneepitope.org), a repository of web-based tools for the prediction and analysis of immune...

The amphioxus genome illuminates vertebrate origins and cephalochordate biology (2008)

Holland, Linda Z., Albalat, Ricard, Azumi, Kaoru, Benito-Gutiérrez, Èlia, Blow, Matthew J., Bronner-Fraser, Marianne, ...

Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, we...

An analysis of the epitope knowledge related to Mycobacteria (2007)

Blythe, Martin J, Zhang, Qing, Vaughan, Kerrie, De Castro, Romulo, Salimi, Nima, Bui, Huynh-Hoa, ...

Abstract Background Tuberculosis, caused by the bacterium Mycobacterium tuberculosis , remains a leading cause of infectious disease morbidity and mortality, and is responsible for more than 2...

3 (2007)

Ernst L. Presman, Suresh P. Sethi, Hanqin Zhang, Qing Zhang

Abstract This paper is concerned with optimal production rates for a failure-prone machine that produces two distinct part types. We consider the problem of controlling production rates so as to...

z (2007)

Suresh P. Sethi, Qing Zhang, Xun Yu Zhou

This paper presents an asymptotic analysis of hierarchical production planning in a manufacturing system with two tandem machines that are subject to breakdown and repair. The system produces a...

and (2007)

Suresh P. Sethi, Hanqin Zhang, Qing Zhang

This paper presents an asymptotic analysis of a stochastic manufaturing system consisting of parallel machines subject to breakdown and repair and facing a constant demand, as the rates of change of...

Error Minimization for Approximate Computation of Range Aggregates (2007)

Xuemin Lin, Qing Zhang

Histogram techniques are widely used in commercial database management systems for an estimation of query results. Recently, they have been also used in approximately processing database queries,...

Surprising complexity of the ancestral apoptosis network (2007)

Zmasek, Christian M, Zhang, Qing, Ye, Yuzhen, Godzik, Adam

Abstract Background Apoptosis, one of the main types of programmed cell death, is regulated and performed by a complex protein network. Studies in model organisms, mostly in the nematode...

Automating document classification for the Immune Epitope Database (2007)

Wang, Peng, Morgan, Alexander A, Zhang, Qing, Sette, Alessandro, Peters, Bjoern

Abstract Background The Immune Epitope Database contains information on immune epitopes curated manually from the scientific literature. Like similar projects in other knowledge domains, significant...

Origin of static friction and its relationship to adhesion at the atomic scale (2007)

Zhang, Qing, Qi, Yue, Çağin, Tahir

Using atomic scale interfaces consisting of slabs of the same materials, we study the relationship between adhesion and static friction. The work of separation, which is a measure of adhesion, and...

IOP PUBLISHING NANOTECHNOLOGY (2007)

Sai Li, Ningyi Liu, Qing Zhang

Aligned single-walled carbon nanotube patterns with nanoscale width, micron-scale length and controllable pitch

Selecting Stars: the k Most Representative Skyline Operator (2007)

Xuemin Lin, Yidong Yuan, Qing Zhang, Ying Zhang

Skyline computation has many applications including multi-criteria decision making. In this paper, we study the problem of selecting k skyline points so that the number of points, which are dominated...

Aggregate query answering on anonymized tables (2007)

Qing Zhang, Nick Koudas, Divesh Srivastava, Ting Yu

Privacy is a serious concern when microdata need to be released for ad hoc analyses. The privacy goals of existing privacy protection approaches (e.g., k-anonymity and ℓ-diversity) are suitable...

Aggregate query answering on anonymized tables (2007)

Qing Zhang, Nick Koudas, Divesh Srivastava, Ting Yu

Privacy is a serious concern when microdata need to be released for ad hoc analyses. The privacy goals of existing privacy protection approaches (e.g., �-anonymity and �-diversity) are suitable...

Differing molecular pathology of pancreatic adenocarcinoma in Egyptian and United States patients (2006)

Soliman, Amr S., Bondy, Melissa, Webb, Charity Renee, Schottenfeld, David, Bonner, Joseph, El-Ghawalby, Nabih, ...

Variations in genetic mutations in pancreatic carcinoma between different populations have not been studied extensively, especially in developing countries where pancreatic cancer is rare. We studied...

Chronic systemic D-galactose exposure induces memory loss, neuro degeneration, and oxidative damage in mice: Protective effects of R-alpha-lipoic acid (2006)

Cui, Xu, Zuo, Pingping, Zhang, Qing, Li, Xuekun, Hu, Yazhuo, Long, Jiangang, ...

Chronic systemic exposure of mice, rats, and Drosophila to D-galactose causes the acceleration of senescence and has been used as an aging model. The underlying mechanism is yet unclear. To...

An empirical evaluation of the Random Forests classifier models for variable selection in a large-scale lung cancer case-control study (2006)

Zhang, Qing

Random Forests(TM) is reported to be one of the most accurate classification algorithms in complex data analysis. It shows excellent performance even when most predictors are noisy and the number of...

An empirical evaluation of the random forests classifier models for variable selection in a large-scale lung cancer case-control study / (2006)

Zhang, Qing.

Thesis (Ph. D.)--University of Texas Health Science Center at Houston, School of Public Health, 2006.

A Regime-Switching Model for European Options (2006)

David D. Yao, Qing Zhang, Xun Yu Zhou

We study the pricing of European-style options, with the rate of return and the volatility of the underlying asset depending on the market mode or regime that switches among a finite number of...

A Framework for Identifying Compromised Nodes in Sensor Networks (2006)

Qing Zhang, Ting Yu, Peng Ning

Sensor networks are often subject to physical attacks. Once a node’s cryptographic key is compromised, an attacker may completely impersonate it, and introduce arbitrary false information into the...

Decreased STAT1 Expression by Promoter Methylation in Squamous Cell Carcinogenesis (2006)

Xi, Sichuan, Dyer, Kevin F., Kimak, Mark, Zhang, Qing, Gooding, William E., Chaillet, J. Richard, ...

Background: Dysregulation of signal transducers and activators of transcription (STATs) is associated with many cancers, but no role of STAT1 in human tumor progression has been demonstrated....

Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-{beta}1 dependent and TGF-{beta}1 independent pathways (2006)

Yung, Susan, Lee, Candice Y. Y., Zhang, Qing, Lau, Shuk Kei, Tsang, Ryan C. W., Chan, Tak Mao

Background. TGF-β1 bioactivation, consequent to the interaction of latent TGF-β1 with thrombospondin-1 (TSP-1), correlates with matrix accumulation in mesangial cells. Tubulointerstitial damage...

Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-{beta}1 dependent and TGF-{beta}1 independent pathways (2006)

Yung, Susan, Lee, Candice YY, Zhang, Qing, Lau, Shuk Kei, Tsang, Ryan CW, Chan, Tak Mao

Background. TGF-β1 bioactivation, consequent to the interaction of latent TGF-β1 with thrombospondin-1 (TSP-1), correlates with matrix accumulation in mesangial cells. Tubulointerstitial damage...

Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure (2006)

Zhang, Qing, Fung, Jeffrey Wing-Hong, Auricchio, Angelo, Chan, Joseph Yat-Sun, Kum, Leo C.C., Wu, Li Wen, ...

Aims LV reverse remodelling has been shown to be a favourable response after cardiac resynchronization therapy (CRT) in many clinical trials. This study investigated whether left ventricular (LV)...

Genetic mechanisms for the synthesis of fucosyl GM1 in small cell lung cancer cell lines (2006)

Tokuda, Noriyo, Zhang, Qing, Yoshida, Shoko, Kusunoki, Susumu, Urano, Takeshi, Furukawa, Keiko, ...

Fucosyl GM1 has been reported to be specifically expressed in small cell lung cancer (SCLC) cells. However, the genetic basis for the synthesis of fucosyl GM1 has not been investigated. We analyzed...

Genetic mechanisms for the synthesis of fucosyl GM1 in small cell lung cancer cell lines (2006)

Tokuda, Noriyo, Zhang, Qing, Yoshida, Shoko, Kusunoki, Susumu, Urano, Takeshi, Furukawa, Keiko, ...

Fucosyl GM1 has been reported to be specifically expressed in small cell lung cancer (SCLC) cells. However, the genetic basis for the synthesis of fucosyl GM1 has not been investigated. We analyzed...

Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure (2006)

Zhang, Qing, Fung, Wing-Hong, Auricchio, Angelo, Chan, Joseph Yat-Sun, Kum, Leo C.C., Wu, Li Wen, ...

Aims LV reverse remodelling has been shown to be a favourable response after cardiac resynchronization therapy (CRT) in many clinical trials. This study investigated whether left ventricular (LV)...

Differential change in left ventricular mass and regional wall thickness after cardiac resynchronization therapy for heart failure (2006)

Zhang, Qing, Fung, Jeffery Wing-Hong, Auricchio, Angelo, Chan, Joseph Yat-Sun, Kum, Leo C.C., Wu, Li Wen, ...

Aims LV reverse remodelling has been shown to be a favourable response after cardiac resynchronization therapy (CRT) in many clinical trials. This study investigated whether left ventricular (LV)...

Expression Pattern Shifts Following Duplication Indicative of Subfunctionalization and Neofunctionalization in Regulatory Genes of Arabidopsis (2006)

Duarte, Jill M., Cui, Liying, Wall, P. Kerr, Zhang, Qing, Zhang, Xiaohong, Leebens-Mack, Jim, ...

Gene duplication plays an important role in the evolution of diversity and novel function and is especially prevalent in the nuclear genomes of flowering plants. Duplicate genes may be maintained...

Flexible Histone Tails in a New Mesoscopic Oligonucleosome Model (2006)

Gaurav Arya, Qing Zhang, Tamar Schlick

ABSTRACT We describe a new mesoscopic model of oligonucleosomes that incorporates flexible histone tails. The nucleosome cores are modeled using the discrete surface-charge optimization model, which...

Stereochemistry and Position-Dependent Effects of Carcinogens on TATA/TBP Binding (2006)

Qing Zhang, Tamar Schlick

ABSTRACT The TATA-box binding protein (TBP) is required by eukaryotic RNA polymerases to bind to the TATA box, an eight-basepair DNA promoter element, to initiate transcription. Carcinogen adducts...

A simple 96-well microplate method for estimation of total polyphenolic content in seaweeds (2006)

Zhang, Qing, Zhang, Junzeng, Shen, Jingkai, Silva, Angelica, Dennis, Dorothy A., Barrow, Colin J.

Seaweed polyphenols are potent antioxidants and have also been shown to have α-glucosidase inhibiting activity. In our continuous efforts to develop new marine-based nutraceuticals and...

Elevated glucose induction of thrombospondin-1 up-regulates fibronectin synthesis in proximal renal tubular epithelial cells through TGF-{beta}1 dependent and TGF-{beta}1 independent pathways (2006)

Yung, Susan, Lee, Candice YY, Zhang, Qing, Lau, Shuk Kei, Tsang, Ryan CW, Chan, Tak Mao

Background. TGF-β1 bioactivation, consequent to the interaction of latent TGF-β1 with thrombospondin-1 (TSP-1), correlates with matrix accumulation in mesangial cells. Tubulointerstitial damage...

Genetic mechanisms for the synthesis of fucosyl GM1 in small cell lung cancer cell lines (2006)

Tokuda, Noriyo, Zhang, Qing, Yoshida, Shoko, Kusunoki, Susumu, Urano, Takeshi, Furukawa, Keiko, ...

Fucosyl GM1 has been reported to be specifically expressed in small cell lung cancer (SCLC) cells. However, the genetic basis for the synthesis of fucosyl GM1 has not been investigated. We analyzed...

EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) ACTIVATION BY GASTRIN RELEASING PEPTIDE (GRP) IN HEAD AND NECK CANCER: MECHANISMS AND CLINICAL IMPLICATIONS (2005)

Zhang, Qing

Head and neck squamous cell carcinomas (HNSCC) are characterized by upregulation of the epidermal growth factor receptor (EGFR). We previously reported that a gastrin-releasing...

EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) ACTIVATION BY GASTRIN RELEASING PEPTIDE (GRP) IN HEAD AND NECK CANCER: MECHANISMS AND CLINICAL IMPLICATIONS (2005)

Zhang, Qing

Head and neck squamous cell carcinomas (HNSCC) are characterized by upregulation of the epidermal growth factor receptor (EGFR). We previously reported that a gastrin-releasing...

STIS Spectroscopy of Young Star Clusters in "The Antennae" Galaxies (NGC 4038/4039) (2005)

Whitmore, Bradley C., Gilmore, Diane, Leitherer, C., Fall, S. Michael, Chandar, Rupali, Blair, William P., ...

Long-slit spectra of several dozen young star clusters have been obtained at three positions in the Antennae galaxies with the Space Telescope Imaging Spectrograph (STIS) and its 52"x0.2" slit. Based...

Atomic simulations of kinetic friction and its velocity dependence at Al/Al and alpha-Al2O3/alpha-Al2O3 interfaces (2005)

Zhang, Qing, Qi, Yue, Çağin, Tahir

Kinetic friction during dry sliding along atomistic-scale Al(001)/Al(001) and alpha-Al2O3(0001)/alpha-Al2O3(0001) interfaces has been investigated using molecular dynamics (MD) with recently...

Molecular dynamics study of the binary Cu46Zr54 metallic glass motivated by experiments: Glass formation and atomic-level structure (2005)

Duan, Gang, Xu, Donghua, Zhang, Qing, Zhang, Guoyun, Çağin, Tahir, Johnson, William L., ...

We have identified a binary bulk metallic glass forming alloy Cu46Zr54 by analyzing the structure and thermal behaviors of copper mold cast samples using x-ray diffraction, transmission electron...

Involvement of CD147 in overexpression of MMP-2 and MMP-9 and enhancement of invasive potential of PMA-differentiated THP-1 (2005)

Zhou, Jun, Zhu, Ping, Jiang, Jian, Zhang, Qing, Wu, Zhen, Yao, Xi, ...

Abstract Background During infection and inflammation, circulating blood monocytes migrate from the intravascular compartments to the extravascular compartments, where they mature into tissue...

The Molecular Biology Toolkit (MBT): a modular platform for developing molecular visualization applications (2005)

Moreland, John L, Gramada, Apostol, Buzko, Oleksandr V, Zhang, Qing, Bourne, Philip E

Abstract Background The large amount of data that are currently produced in the biological sciences can no longer be explored and visualized efficiently with traditional, specialized software....

Mesoscopic, microscopic, and macroscopic modeling of protein/DNA complexes / (2005)

Zhang, Qing.

Thesis (Ph. D.)--New York University, Graduate School of Arts and Science, 2005.

Efficient Computation of the Skyline Cube (2005)

Yidong Yuan, Xuemin Lin, Qing Liu, Wei Wang, Jeffrey Xu Yu, Qing Zhang

Skyline has been proposed as an important operator for multi-criteria decision making, data mining and visualization, and user-preference queries. In this paper, we consider the problem of...

The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema (2005)

Deshpande, Nita, Addess, Kenneth J., Bluhm, Wolfgang F., Merino-Ott, Jeffrey C., Townsend-Merino, Wayne, Zhang, Qing, ...

The Protein Data Bank (PDB) is the central worldwide repository for three-dimensional (3D) structure data of biological macromolecules. The Research Collaboratory for Structural Bioinformatics (RCSB)...

Expression Pattern Shifts Following Duplication Indicative of Subfunctionalization and Neofunctionalization in Regulatory Genes of Arabidopsis (2005)

Duarte, Jill M., Cui, Liying, Wall, P. Kerr, Zhang, Qing, Zhang, Xiaohong, Leebens-Mack, Jim, ...

Gene duplication plays an important role in the evolution of diversity and novel function and is especially prevalent in the nuclear genomes of flowering plants. Duplicate genes may be maintained...

Expression Pattern Shifts Following Duplication Indicative of Subfunctionalization and Neofunctionalization in Regulatory Genes of Arabidopsis (2005)

Duarte, Jill M., Cui, Liying, Wall, P. Kerr, Zhang, Qing, Zhang, Xiaohong, Leebens-Mack, Jim, ...

Gene duplication plays an important role in the evolution of diversity and novel function and is especially prevalent in the nuclear genomes of flowering plants. Duplicate genes may be maintained...

Adhesion and nonwetting-wetting transition in the Al/alpha-Al2O3 interface (2004)

Zhang, Qing, Çağin, Tahir, Van Duin, Adri, Qi, Yue

Using a reactive force field (ReaxFF), we investigated the structural, energetic, and adhesion properties, of both solid and liquid Al/alpha-Al2O3 interfaces. The ReaxFF was developed solely with ab...

The effect of elevated glucose concentration on the expression of -ACTININ-1 and F-ACTIN in human mesangial cells (2004)

Zhang, Qing

(Uncorrected OCR) Abstract of thesis entitled The effect of elevated glucose concentration on the expression of a-actinin-1 and F-actin in human mesangial cells Submitted by Zhang Qing for the degree...

The effect of elevated glucose concentration on the expression of -ACTININ-1 and F-ACTIN in human mesangial cells (2004)

Zhang, Qing

(Uncorrected OCR) Abstract of thesis entitled The effect of elevated glucose concentration on the expression of a-actinin-1 and F-actin in human mesangial cells Submitted by Zhang Qing for the degree...

Deposition of Ta-N thin films as diffusion barrier / (2004)

Zhang, Qing.

Thesis (M. Sc. (Prec. Eng.))--Nanyang Technological University, School of Mechanical and Production Engineering, 2004.

The effect of elevated glucose concentration on the expression of -ACTININ-1 and F-ACTIN in human mesangial cells (2004)

Zhang, Qing

(Uncorrected OCR) Abstract of thesis entitled The effect of elevated glucose concentration on the expression of a-actinin-1 and F-actin in human mesangial cells Submitted by Zhang Qing for the degree...

A classification scheme for trust functions in reputation-based trust management (2004)

Qing Zhang, Ting Yu, Keith Irwin

Abstract. Reputation is an important means to establish trust in decentralized environments such as the Semantic Web. In reputation-based trust management, an entity’s reputation is usually built...

A Classification Scheme for Trust Functions in (2004)

Qing Zhang, Ting Yu, Keith Irwin

Reputation is an important means to establish trust in decentralized environments such as the Semantic Web. In reputation-based trust management, an entity 's reputation is usually built on...

Discrete-time approximation of wonham filters (2004)

Qing Zhang, Senior Member, G. George Yin, Johb B. Moore, Life Fellow

Abstract—This paper is concerned with approximation of Wonham filters. A focal point is that the underlying hidden Markov chain has a large state space. To reduce computational complexity, a...

Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on the cyclooxygenase-2 of human placenta in chorioamnionitis (2004)

Temma, Kumiko, Shimoya, Koichiro, Zhang, Qing, Kimura, Tadashi, Wasada, Kenshi, Kanzaki, Toru, ...

Chorioamnionitis (CAM) is one of the causes of preterm labour. A recent study has indicated that NADPH oxidase, a reactive oxygen species (ROS)-producing enzyme, is activated in CAM. CAM is thought...

Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on the cyclooxygenase-2 of human placenta in chorioamnionitis (2004)

Temma, Kumiko, Shimoya, Koichiro, Zhang, Qing, Kimura, Tadashi, Wasada, Kenshi, Kanzaki, Toru, ...

Chorioamnionitis (CAM) is one of the causes of preterm labour. A recent study has indicated that NADPH oxidase, a reactive oxygen species (ROS)‐producing enzyme, is activated in CAM. CAM is...

10.1098/rsta.2004.1386 Deformations of promoter DNA bound to (2004)

Qing Zhang, Suse Broyde, Tamar Schlick

carcinogens help interpret effects on TATA-element structure and activity

Effects of 4-hydroxy-2-nonenal, a marker of oxidative stress, on the cyclooxygenase-2 of human placenta in chorioamnionitis (2004)

Temma, Kumiko, Shimoya, Koichiro, Zhang, Qing, Kimura, Tadashi, Wasada, Kenshi, Kanzaki, Toru, ...

Chorioamnionitis (CAM) is one of the causes of preterm labour. A recent study has indicated that NADPH oxidase, a reactive oxygen species (ROS)-producing enzyme, is activated in CAM. CAM is thought...

Genomic homogeneity between Mycobacterium aviumsubsp. aviumand Mycobacterium aviumsubsp. paratuberculosisbelies their divergent growth rates (2003)

Bannantine, John P, Zhang, Qing, Li, Ling-Ling, Kapur, Vivek

Abstract Background Mycobacterium avium subspecies avium ( M. avium ) is frequently encountered in the environment, but also causes infections in animals and immunocompromised patients. In contrast,...

Scalable concatenated differential space-time coding / (2003)

Zhang, Qing.

Thesis (M.S.E.E.)--University of Virginia, 2003.

Fractalkine (FRK) levels in amniotic fluid and its production during pregnancy (2003)

Shimoya, Koichiro, Zhang, Qing, Tenma, Kumiko, Ota, Yukinobu, Hashimoto, Kazumasa, Shizusawa, Yoshie, ...

Fractalkine is a new CX3C chemokine that has chemoattractant activity for T cells, monocytes and natural killer (NK) cells. Western blot analysis revealed that fractalkine protein was detected as a...

MGView: an alignment and visualization tool to enhance gap closure of microbial genomes (2003)

Herron-Olson, Lisa, Freeman, John, Zhang, Qing, Retzel, Ernest F., Kapur, Vivek

Gap closure is a challenging phase in microbial random shotgun genome sequencing projects, particularly since genome assemblies are often complicated by the presence of repeat elements, insertion...

LIGHT-deficiency impairs CD8+ T cell expansion, but not effector function (2003)

Liu, Jinqi, Schmidt, Clint S., Zhao, Feisha, Okragly, Angela J., Glasebrook, Andrew, Fox, Niles, ...

LIGHT, a newly identified member of the tumor necrosis factor (TNF) family, is expressed on activated T lymphocytes. To evaluate how LIGHT contributes to T cell functions, we generated...

Rule-based extraction of experimental evidence in the biomedical domain: The KDD Cup 2002 (task 1 (2002)

Yizhar Regev, Michal Finkelstein-l, Ronen Feldman, Maya Gorodetsky, Xin Zheng, Samuel Levy, ...

Below we describe the winning system that we built for the KDD Cup 2002 Task 1 competition. Our system is a Rule-based Information Extraction (IE) system. It combines pattern matching, Natural...

On Linear-Spline Based Histograms (2002)

Qing Zhang, Xuemin Lin

Abstract. Approximation is a very effective paradigm to speed up query processing in large databases. One popular approximation mechanism is data size reduction. There are three reduction techniques:...

The gene for the muted (mu) mouse, a model for Hermansky-Pudlak syndrome, defines a novel protein which regulates vesicle trafficking (2002)

Zhang, Qing, Li, Wei, Novak, Edward K., Karim, Amna, Mishra, Vishnu S., Kingsmore, Stephen F., ...

The muted (mu) mouse is a model for Hermansky–Pudlak Syndrome (HPS), an inherited disorder of humans causing hypopigmentation, hemorrhaging and early death due to lung abnormalities. The mu gene...

The expression of secretory leukocyte protease inhibitor (SLPI) in the Fallopian tube: SLPI protects the acrosome reaction of sperm from inhibitory effects of elastase (2002)

Ota, Yukinobu, Shimoya, Koichiro, Zhang, Qing, Moriyama, Akihiro, Chin, Rika, Tenma, Kumiko, ...

BACKGROUND: Secretory leukocyte protease inhibitor (SLPI) is a protein found in various fluids, including parotid secretions, cervical mucus, seminal plasma and ascites, and is a potent inhibitor of...

Detection of fractalkine in human seminal plasma and its role in infertile patients (2002)

Zhang, Qing, Shimoya, Koichiro, Ohta, Yukinibu, Chin, Rika, Tenma, Kumiko, Isaka, Shigeyuki, ...

BACKGROUND: Fractalkine is a relatively newly discovered CX3C chemokine, which is a chemoattractant for T cells, monocytes and natural killer cells. Several reports have demonstrated the association...

Formation and Disruption of Globular Star Clusters (2001)

Fall, S. Michael, Zhang, Qing

In the first part of this article, we review observations of the mass and luminosity functions of young and old star cluster systems. We also review some of the physical processes that may determine...

Dynamical Evolution of the Mass Function of Globular Star Clusters (2001)

Fall, S. Michael, Zhang, Qing

We present a series of simple, largely analytical models to compute the effects of disruption on the mass function of star clusters. Our calculations include evaporation by two-body relaxation and...

A Multi-Wavelength Study of the Young Star Clusters and Interstellar Medium in the Antennae Galaxies (NGC 4038/9) (2001)

Zhang, Qing, Fall, S. Michael, Whitmore, Bradley C.

We report on a multi-wavelength study of the relationship between young star clusters in the Antennae galaxies (NGC 4038/9) and their interstellar environment, with the goal of understanding the...

Hydrogen-enhanced local plasticity in aluminum: an ab initio study (2001)

Lu, Gang, Zhang, Qing, Kioussis, Nicholas, Kaxiras, Efthimios

Dislocation core properties of Al with and without H impurities are studied using the Peierls-Nabarro model with parameters determined by ab initio calculations. We find that H not only facilitates...

CVSSearch: Searching through source code using CVS comments (2001)

Annie Chen, Eric Chou, Joshua Wong, Andrew Y. Yao, Qing Zhang, Shao Zhang, ...

CVSSearch is a tool that searches for fragments of source code by using CVS comments. CVS is a version control system that is widely used in the open source community [4]. Our search tool takes...

CVSSearch: Searching through source code using CVS comments (2001)

Annie Chen, Eric Chou, Joshua Wong, Andrew Y. Yao, Qing Zhang, Shao Zhang, ...

CVSSearch is a tool that searches for fragments of source code by using CVS comments. CVS is a version control system that is widely used in the open source community [4]. Our search tool takes...

Production of secretory leukocyte protease inhibitor by human amniotic membranes and regulation of its concentration in amniotic fluid (2001)

Zhang, Qing, Shimoya, Koichiro, Moriyama, Akihiro, Yamanaka, Kaoru, Nakajima, Atsuko, Nobunaga, Toshikatsu, ...

Secretory leukocyte protease inhibitor (SLPI) is a potent inhibitor of human leukocyte elastase. SLPI is a protein found in various human fluids, including parotid secretions, cervical mucus, seminal...

Management of construction international joint ventures between Australia and Asia (2000)

Zhang, Qing.

Presented to the School of Construction Management and Property, Queensland University of Technology. Includes bibliographical references.

Outcome evaluation of a multi-component violence-prevention program for middle schools: the Students for Peace project (2000)

Orpinas, Pamela, Kelder, Steve, Frankowski, Ralph, Murray, Nancy, Zhang, Qing, Mcalister, Alfred

This study evaluated the effect of Students for Peace, a multi-component violence- prevention intervention, on reducing aggressive behaviors among students of eight middle schools randomly assigned...

The Mass Function of Young Star Clusters in the "Antennae" Galaxies (1999)

Zhang, Qing, Fall, S. Michael

We determine the mass function of young star clusters in the merging galaxies the ``Antennae'' (NGC 4038/39) from deep images taken with the WFPC2 on the refurbished Hubble Space Telescope (HST)....

The Luminosity Function of Young Star Clusters In "The Antennae" Galaxies (NGC 4038/4039) (1999)

Whitmore, Bradley C., Zhang, Qing, Leitherer, Claus, Fall, S. Michael, Schweizer, Francois, Miller, Bryan W.

The WFPC2 of the HST has been used to obtain high-resolution images of NGC 4038/4039 that go roughly 3 magnitudes deeper in V than previous observations made during Cycle 2 (-14 < M_V < -6). To first...

Entrainment of a thermal with or without buoyancy reversal impinging on a stratified interface (1999)

Zhang, Qing

Laboratory experiments of a thermal with and without buoyancy reversal impinging on a stratified interface are presented. A thermal is created by releasing a small volume of buoyant fluid into a...

Entrainment of a thermal with or without buoyancy reversal impinging on a stratified interface (1999)

Zhang, Qing

Laboratory experiments of a thermal with and without buoyancy reversal impinging on a stratified interface are presented. A thermal is created by releasing a small volume of buoyant fluid into a...

Entrainment of a thermal with or without buoyancy reversal impinging on a stratified interface (1999)

Zhang, Qing

Laboratory experiments of a thermal with and without buoyancy reversal impinging on a stratified interface are presented. A thermal is created by releasing a small volume of buoyant fluid into a...

Entrainment of a thermal with or without buoyancy reversal impinging on a stratified interface (1999)

Zhang, Qing

Laboratory experiments of a thermal with and without buoyancy reversal impinging on a stratified interface are presented. A thermal is created by releasing a small volume of buoyant fluid into a...

Entrainment of a thermal with or without buoyancy reversal impinging on a stratified interface (1999)

Zhang, Qing

Laboratory experiments of a thermal with and without buoyancy reversal impinging on a stratified interface are presented. A thermal is created by releasing a small volume of buoyant fluid into a...

Entrainment of a thermal with or without buoyancy reversal impinging on a stratified interface (1999)

Zhang, Qing

Laboratory experiments of a thermal with and without buoyancy reversal impinging on a stratified interface are presented. A thermal is created by releasing a small volume of buoyant fluid into a...

A multi-frequency EM sensor /--by Qing Zhang. (1999)

Zhang, Qing.

Degree granted by Dept. of Electrical and Computer Engineering, Cullen College of Engineering.

A Roth theorem for amenable groups. (1997)

Zhang, Qing.

American Journal of Mathematics - Volume 119, Number 6, December 1997

Some width function asymptotics for weighted trees (1997)

Ossiander, Mina, Waymire, Ed, Zhang, Qing

Consider a rooted labelled tree graph $\tau_n$ having a total of n vertices. The width function counts the number of vertices as a function of the distance to the root $\phi$. In this paper we...

Genetic and biochemical analysis of the axl receptor tyrosine kinase (1997)

Zhang, Qing

Axl is the prototype of a newly identified receptor tyrosine kinase subfamily which is characterized by the combination of two immunoglobulin-like and two fibronectin type III motifs in the...

Artificial neural networks and their application to water treatment / (1996)

Zhang, Qing.

Submitted to the Faculty of Graduate Studies and Research in partial fulfilment of the requirements for the degree of Master of Science, Department of Civil and Environmental Engineering.

Functional significance of the Fas molecule in naive lymphocytes (1996)

Senju, Satoru, Negishl, Izumi, Motoyama, Noboru, Wang, Fanping, Nakayama, Kei-ichi, Nakayama, Keiko, ...

The Fas molecule mediates apoptotic signal In many ceIL types. Mouse mutations (Ipr, Ipicg gid), which impair the function of Fas, cause spontaneous autoimmune disease. We generated Fas deficient...

The Abramov-Rokhlin entropy addition formula for amenable group actions, Monatshefte fur Mathematik 114 (1992)

Thomas Ward, Qing Zhang

Abstract. In this note we show that the entropy of a skew product action of a countable amenable group satisfies the classical formula of Abramov and Rokhlin. 1.

The Long Run Demand For Broad Money in Australia Subject to Regime Shifts.

Felmingham, Bruce, Zhang, Qing

The goal is to determine if there is a stable Broad Money demand relationship for Australia. Previous studies have not reached a consensus on this important issue, partly because the time series...

Rab geranylgeranyl transferase α mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

Detter, John C., Zhang, Qing, Mules, Emilie H., Novak, Edward K., Mishra, Vishnu S., Li, Wei, ...

Few molecular events important to platelet biogenesis have been identified. Mice homozygous for the spontaneous, recessive mutation gunmetal (gm) have prolonged bleeding, thrombocytopenia, and...

Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms

Maiden, Martin C. J., Bygraves, Jane A., Feil, Edward, Morelli, Giovanna, Russell, Joanne E., Urwin, Rachel, ...

Traditional and molecular typing schemes for the characterization of pathogenic microorganisms are poorly portable because they index variation that is difficult to compare among laboratories. To...

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

Xue, Jiachun, Wu, Qingyu, Westfield, Lisa A., Tuley, Elodee A., Lu, Deshun, Zhang, Qing, ...

Deficiency of blood coagulation factor V or tissue factor causes the death of mouse embryos by 10.5 days of gestation, suggesting that part of the blood coagulation system is necessary for...

Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells

Chen, Fang, Figueroa, David J., Marmorstein, Alan D., Zhang, Qing, Petrukhin, Konstantin, Caskey, C. Thomas, ...

In an effort to identify nuclear receptors important in retinal disease, we screened a retina cDNA library for nuclear receptors. Here we describe the identification of a retina-specific nuclear...

Complete genomic sequence of Pasteurella multocida,Pm70

May, Barbara J., Zhang, Qing, Li, Ling Ling, Paustian, Michael L., Whittam, Thomas S., Kapur, Vivek

We present here the complete genome sequence of a common avian clone of Pasteurella multocida, Pm70. The genome of Pm70 is a single circular chromosome 2,257,487 base pairs in length and contains...

ARF6 Is Required for Growth Factor- and Rac-Mediated Membrane Ruffling in Macrophages at a Stage Distal to Rac Membrane Targeting

Zhang, Qing, Calafat, Jero, Janssen, Hans, Greenberg, Steven

Activation of Rac1, a member of the Rho family of GTPases, is associated with multiple cellular responses, including membrane ruffling and focal complex formation. The mechanisms by which Rac1 is...

Aerococcus urinae in Urinary Tract Infections

Zhang, Qing, Kwoh, Christopher, Attorri, Silvia, Clarridge, Jill E.

Aerococcus urinae is a rarely reported pathogen, possibly due to difficulties in the identification of the organism. A. urinae is a gram-positive coccus that grows in pairs and clusters, produces...

16S Ribosomal DNA Sequence Analysis Distinguishes Biotypes of Streptococcus bovis: Streptococcus bovis Biotype II/2 Is a Separate Genospecies and the Predominant Clinical Isolate in Adult Males

Clarridge, Jill E., Attorri, Silvia M., Zhang, Qing, Bartell, John

We characterized 22 human clinical strains of Streptococcus bovis by genotypic (16S rRNA gene sequence analysis [MicroSeq]; Applied Biosystems, Foster City, Calif.) and phenotypic (API 20 Strep and...

Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks

Smoot, James C., Barbian, Kent D., Van Gompel, Jamie J., Smoot, Laura M., Chaussee, Michael S., Sylva, Gail L., ...

Acute rheumatic fever (ARF), a sequelae of group A Streptococcus (GAS) infection, is the most common cause of preventable childhood heart disease worldwide. The molecular basis of ARF and the...

Genotypic Diversity of Clinical Actinomyces Species: Phenotype, Source, and Disease Correlation among Genospecies

Clarridge III, Jill E., Zhang, Qing

We determined the frequency distribution of Actinomyces spp. recovered in a routine clinical laboratory and investigated the clinical significance of accurate identification to the species level. We...

Pseudoepidemic Due to a Unique Strain of Mycobacterium szulgai: Genotypic, Phenotypic, and Epidemiological Analysis

Zhang, Qing, Kennon, Randa, Koza, Maureen A., Hulten, Kristina, Clarridge III, Jill E.

In mid-1999, we noted multiple isolations at the Veterans Affairs Medical Center (VAMC) Houston Tex. of an unusual nonpigmented Mycobacterium species. Since, on the basis of 16S rRNA gene sequence...

Genome Scale Comparison of Mycobacterium avium subsp. paratuberculosis with Mycobacterium avium subsp. avium Reveals Potential Diagnostic Sequences

Bannantine, John P., Baechler, Emily, Zhang, Qing, Li, LingLing, Kapur, Vivek

The genetic similarity between Mycobacterium avium subsp. paratuberculosis and other mycobacterial species has confounded the development of M. avium subsp. paratuberculosis-specific diagnostic...

MGView: an alignment and visualization tool to enhance gap closure of microbial genomes

Herron-Olson, Lisa, Freeman, John, Zhang, Qing, Retzel, Ernest F., Kapur, Vivek

Gap closure is a challenging phase in microbial random shotgun genome sequencing projects, particularly since genome assemblies are often complicated by the presence of repeat elements, insertion...

A 38-Kilobase Pathogenicity Island Specific for Mycobacterium avium subsp. paratuberculosis Encodes Cell Surface Proteins Expressed in the Host

Stratmann, Janin, Strommenger, Birgit, Goethe, Ralph, Dohmann, Karen, Gerlach, Gerald-F., Stevenson, Karen, ...

We have used representational difference analysis to identify a novel Mycobacterium avium subsp. paratuberculosis-specific ABC transporter operon (mpt), which comprises six open reading frames...

Multilocus Short Sequence Repeat Sequencing Approach for Differentiating among Mycobacterium avium subsp. paratuberculosis Strains

Amonsin, Alongkorn, Li, Ling Ling, Zhang, Qing, Bannantine, John P., Motiwala, Alifiya S., Sreevatsan, Srinand, ...

We describe a multilocus short sequence repeat (MLSSR) sequencing approach for the genotyping of Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) strains. Preliminary analysis...

The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema

Deshpande, Nita, Addess, Kenneth J., Bluhm, Wolfgang F., Merino-Ott, Jeffrey C., Townsend-Merino, Wayne, Zhang, Qing, ...

The Protein Data Bank (PDB) is the central worldwide repository for three-dimensional (3D) structure data of biological macromolecules. The Research Collaboratory for Structural Bioinformatics (RCSB)...

Electrostatic mechanism of nucleosomal array folding revealed by computer simulation

Sun, Jian, Zhang, Qing, Schlick, Tamar

Although numerous experiments indicate that the chromatin fiber displays salt-dependent conformations, the associated molecular mechanism remains unclear. Here, we apply an irregular Discrete Surface...

Trypanosomal TBP Functions with the Multisubunit Transcription Factor tSNAP To Direct Spliced-Leader RNA Gene Expression

Das, Anish, Zhang, Qing, Palenchar, Jennifer B., Chatterjee, Bithi, Cross, George A. M., Bellofatto, Vivian

Protein-coding genes of trypanosomes are mainly transcribed polycistronically and cleaved into functional mRNAs in a process that requires trans splicing of a capped 39-nucleotide RNA derived from a...

The complete genome sequence of Mycobacterium avium subspecies paratuberculosis

Li, Lingling, Bannantine, John P., Zhang, Qing, Amonsin, Alongkorn, May, Barbara J., Alt, David, ...

We describe here the complete genome sequence of a common clone of Mycobacterium avium subspecies paratuberculosis (Map) strain K-10, the causative agent of Johne's disease in cattle and other...

Effect of DNA Superhelicity and Bound Proteins on Mechanistic Aspects of the Hin-Mediated and Fis-Enhanced Inversion

Huang, Jing, Zhang, Qing, Schlick, Tamar

Using a recently developed inhomogeneous, macroscopic model for long DNA bound to proteins, we examine topological and geometric aspects of DNA/protein structures and dynamics on various stages of...

Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt

Kriegel, Alison M., Soliman, Amr S., Zhang, Qing, El-Ghawalby, Nabih, Ezzat, Farouk, Soultan, Ahmed, ...

The northeast Nile Delta region exhibits a high incidence of early-onset pancreatic cancer. It is well documented that this region has one of the highest levels of pollution in Egypt. Epidemiologic...

The intra cellular domain of CD44 promotes the fusion of macrophages

Cui, Weiguo, Zhang Ke, Juan, Zhang, Qing, Ke, Hua-Zhu, Chalouni, Cècile, Vignery, Agnès

Macrophages seed all tissues in which they have the ability, in specific and rare instances, to fuse with themselves and to differentiate into osteoclasts in bone, or into giant cells in chronic...

Bladder Cancer Predisposition: A Multigenic Approach to DNA-Repair and Cell-Cycle–Control Genes

Wu, Xifeng, Gu, Jian, Grossman, H. Barton, Amos, Christopher I., Etzel, Carol, Huang, Maosheng, ...

The candidate-gene approach in association studies of polygenic diseases has often yielded conflicting results. In this hospital-based case-control study with 696 white patients newly diagnosed with...

Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation

Zhang, Qing, Thomas, Sufi M., Lui, Vivian Wai Yan, Xi, Sichuan, Siegfried, Jill M., Fan, Huizhou, ...

G protein-coupled receptors induce EGF receptor (EGFR) signaling, leading to the proliferation and invasion of cancer cells. Elucidation of the mechanism of EGFR activation by G protein-coupled...

Rab geranylgeranyl transferase α mutation in the gunmetal mouse reduces Rab prenylation and platelet synthesis

Detter, John C., Zhang, Qing, Mules, Emilie H., Novak, Edward K., Mishra, Vishnu S., Li, Wei, ...

Few molecular events important to platelet biogenesis have been identified. Mice homozygous for the spontaneous, recessive mutation gunmetal (gm) have prolonged bleeding, thrombocytopenia, and...

Multilocus sequence typing: A portable approach to the identification of clones within populations of pathogenic microorganisms

Maiden, Martin C. J., Bygraves, Jane A., Feil, Edward, Morelli, Giovanna, Russell, Joanne E., Urwin, Rachel, ...

Traditional and molecular typing schemes for the characterization of pathogenic microorganisms are poorly portable because they index variation that is difficult to compare among laboratories. To...

Incomplete embryonic lethality and fatal neonatal hemorrhage caused by prothrombin deficiency in mice

Xue, Jiachun, Wu, Qingyu, Westfield, Lisa A., Tuley, Elodee A., Lu, Deshun, Zhang, Qing, ...

Deficiency of blood coagulation factor V or tissue factor causes the death of mouse embryos by 10.5 days of gestation, suggesting that part of the blood coagulation system is necessary for...

Retina-specific nuclear receptor: A potential regulator of cellular retinaldehyde-binding protein expressed in retinal pigment epithelium and Müller glial cells

Chen, Fang, Figueroa, David J., Marmorstein, Alan D., Zhang, Qing, Petrukhin, Konstantin, Caskey, C. Thomas, ...

In an effort to identify nuclear receptors important in retinal disease, we screened a retina cDNA library for nuclear receptors. Here we describe the identification of a retina-specific nuclear...

Complete genomic sequence of Pasteurella multocida,Pm70

May, Barbara J., Zhang, Qing, Li, Ling Ling, Paustian, Michael L., Whittam, Thomas S., Kapur, Vivek

We present here the complete genome sequence of a common avian clone of Pasteurella multocida, Pm70. The genome of Pm70 is a single circular chromosome 2,257,487 base pairs in length and contains...

ARF6 Is Required for Growth Factor- and Rac-Mediated Membrane Ruffling in Macrophages at a Stage Distal to Rac Membrane Targeting

Zhang, Qing, Calafat, Jero, Janssen, Hans, Greenberg, Steven

Activation of Rac1, a member of the Rho family of GTPases, is associated with multiple cellular responses, including membrane ruffling and focal complex formation. The mechanisms by which Rac1 is...

Aerococcus urinae in Urinary Tract Infections

Zhang, Qing, Kwoh, Christopher, Attorri, Silvia, Clarridge, Jill E.

Aerococcus urinae is a rarely reported pathogen, possibly due to difficulties in the identification of the organism. A. urinae is a gram-positive coccus that grows in pairs and clusters, produces...

16S Ribosomal DNA Sequence Analysis Distinguishes Biotypes of Streptococcus bovis: Streptococcus bovis Biotype II/2 Is a Separate Genospecies and the Predominant Clinical Isolate in Adult Males

Clarridge, Jill E., Attorri, Silvia M., Zhang, Qing, Bartell, John

We characterized 22 human clinical strains of Streptococcus bovis by genotypic (16S rRNA gene sequence analysis [MicroSeq]; Applied Biosystems, Foster City, Calif.) and phenotypic (API 20 Strep and...

Genome sequence and comparative microarray analysis of serotype M18 group A Streptococcus strains associated with acute rheumatic fever outbreaks

Smoot, James C., Barbian, Kent D., Van Gompel, Jamie J., Smoot, Laura M., Chaussee, Michael S., Sylva, Gail L., ...

Acute rheumatic fever (ARF), a sequelae of group A Streptococcus (GAS) infection, is the most common cause of preventable childhood heart disease worldwide. The molecular basis of ARF and the...

Genotypic Diversity of Clinical Actinomyces Species: Phenotype, Source, and Disease Correlation among Genospecies

Clarridge III, Jill E., Zhang, Qing

We determined the frequency distribution of Actinomyces spp. recovered in a routine clinical laboratory and investigated the clinical significance of accurate identification to the species level. We...

Pseudoepidemic Due to a Unique Strain of Mycobacterium szulgai: Genotypic, Phenotypic, and Epidemiological Analysis

Zhang, Qing, Kennon, Randa, Koza, Maureen A., Hulten, Kristina, Clarridge III, Jill E.

In mid-1999, we noted multiple isolations at the Veterans Affairs Medical Center (VAMC) Houston Tex. of an unusual nonpigmented Mycobacterium species. Since, on the basis of 16S rRNA gene sequence...

Genome Scale Comparison of Mycobacterium avium subsp. paratuberculosis with Mycobacterium avium subsp. avium Reveals Potential Diagnostic Sequences

Bannantine, John P., Baechler, Emily, Zhang, Qing, Li, LingLing, Kapur, Vivek

The genetic similarity between Mycobacterium avium subsp. paratuberculosis and other mycobacterial species has confounded the development of M. avium subsp. paratuberculosis-specific diagnostic...

MGView: an alignment and visualization tool to enhance gap closure of microbial genomes

Herron-Olson, Lisa, Freeman, John, Zhang, Qing, Retzel, Ernest F., Kapur, Vivek

Gap closure is a challenging phase in microbial random shotgun genome sequencing projects, particularly since genome assemblies are often complicated by the presence of repeat elements, insertion...

A 38-Kilobase Pathogenicity Island Specific for Mycobacterium avium subsp. paratuberculosis Encodes Cell Surface Proteins Expressed in the Host

Stratmann, Janin, Strommenger, Birgit, Goethe, Ralph, Dohmann, Karen, Gerlach, Gerald-F., Stevenson, Karen, ...

We have used representational difference analysis to identify a novel Mycobacterium avium subsp. paratuberculosis-specific ABC transporter operon (mpt), which comprises six open reading frames...

Multilocus Short Sequence Repeat Sequencing Approach for Differentiating among Mycobacterium avium subsp. paratuberculosis Strains

Amonsin, Alongkorn, Li, Ling Ling, Zhang, Qing, Bannantine, John P., Motiwala, Alifiya S., Sreevatsan, Srinand, ...

We describe a multilocus short sequence repeat (MLSSR) sequencing approach for the genotyping of Mycobacterium avium subsp. paratuberculosis (M. paratuberculosis) strains. Preliminary analysis...

The RCSB Protein Data Bank: a redesigned query system and relational database based on the mmCIF schema

Deshpande, Nita, Addess, Kenneth J., Bluhm, Wolfgang F., Merino-Ott, Jeffrey C., Townsend-Merino, Wayne, Zhang, Qing, ...

The Protein Data Bank (PDB) is the central worldwide repository for three-dimensional (3D) structure data of biological macromolecules. The Research Collaboratory for Structural Bioinformatics (RCSB)...

Electrostatic mechanism of nucleosomal array folding revealed by computer simulation

Sun, Jian, Zhang, Qing, Schlick, Tamar

Although numerous experiments indicate that the chromatin fiber displays salt-dependent conformations, the associated molecular mechanism remains unclear. Here, we apply an irregular Discrete Surface...

Trypanosomal TBP Functions with the Multisubunit Transcription Factor tSNAP To Direct Spliced-Leader RNA Gene Expression

Das, Anish, Zhang, Qing, Palenchar, Jennifer B., Chatterjee, Bithi, Cross, George A. M., Bellofatto, Vivian

Protein-coding genes of trypanosomes are mainly transcribed polycistronically and cleaved into functional mRNAs in a process that requires trans splicing of a capped 39-nucleotide RNA derived from a...

The complete genome sequence of Mycobacterium avium subspecies paratuberculosis

Li, Lingling, Bannantine, John P., Zhang, Qing, Amonsin, Alongkorn, May, Barbara J., Alt, David, ...

We describe here the complete genome sequence of a common clone of Mycobacterium avium subspecies paratuberculosis (Map) strain K-10, the causative agent of Johne's disease in cattle and other...

Effect of DNA Superhelicity and Bound Proteins on Mechanistic Aspects of the Hin-Mediated and Fis-Enhanced Inversion

Huang, Jing, Zhang, Qing, Schlick, Tamar

Using a recently developed inhomogeneous, macroscopic model for long DNA bound to proteins, we examine topological and geometric aspects of DNA/protein structures and dynamics on various stages of...

Serum Cadmium Levels in Pancreatic Cancer Patients from the East Nile Delta Region of Egypt

Kriegel, Alison M., Soliman, Amr S., Zhang, Qing, El-Ghawalby, Nabih, Ezzat, Farouk, Soultan, Ahmed, ...

The northeast Nile Delta region exhibits a high incidence of early-onset pancreatic cancer. It is well documented that this region has one of the highest levels of pollution in Egypt. Epidemiologic...

Bladder Cancer Predisposition: A Multigenic Approach to DNA-Repair and Cell-Cycle–Control Genes

Wu, Xifeng, Gu, Jian, Grossman, H. Barton, Amos, Christopher I., Etzel, Carol, Huang, Maosheng, ...

The candidate-gene approach in association studies of polygenic diseases has often yielded conflicting results. In this hospital-based case-control study with 696 white patients newly diagnosed with...

Phosphorylation of TNF-α converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation

Zhang, Qing, Thomas, Sufi M., Lui, Vivian Wai Yan, Xi, Sichuan, Siegfried, Jill M., Fan, Huizhou, ...

G protein-coupled receptors induce EGF receptor (EGFR) signaling, leading to the proliferation and invasion of cancer cells. Elucidation of the mechanism of EGFR activation by G protein-coupled...

Stereochemistry and Position-Dependent Effects of Carcinogens on TATA/TBP Binding

Zhang, Qing, Schlick, Tamar

The TATA-box binding protein (TBP) is required by eukaryotic RNA polymerases to bind to the TATA box, an eight-basepair DNA promoter element, to initiate transcription. Carcinogen adducts that bind...

The intracellular domain of CD44 promotes the fusion of macrophages

Cui, Weiguo, Ke, Juan Zhang, Zhang, Qing, Ke, Hua-Zhu, Chalouni, Cécile, Vignery, Agnès

Macrophages seed all tissues in which they have the ability, in specific and rare instances, to fuse with themselves and to differentiate into osteoclasts in bone or into giant cells in chronic...

Flexible Histone Tails in a New Mesoscopic Oligonucleosome Model

Arya, Gaurav, Zhang, Qing, Schlick, Tamar

We describe a new mesoscopic model of oligonucleosomes that incorporates flexible histone tails. The nucleosome cores are modeled using the discrete surface-charge optimization model, which treats...

Novel Human Rotavirus of Genotype G5P[6] Identified in a Stool Specimen from a Chinese Girl with Diarrhea▿

Duan, Zhao-Jun, Li, Dan-Di, Zhang, Qing, Liu, Na, Huang, Can-Ping, Jiang, Xi, ...

During a rotavirus surveillance conducted in Lulong County, Hebei Province, China, a total of 331 stool specimens collected in 2003 from children under 5 years old with diarrhea were screened. We...

Surprising complexity of the ancestral apoptosis network

Zmasek, Christian M, Zhang, Qing, Ye, Yuzhen, Godzik, Adam

A comparative genomics approach revealed that the genes for several components of the apoptosis network with single copies in vertebrates have multiple paralogs in cnidarian-bilaterian ancestors,...

CD200 and its receptor, CD200R, modulate bone mass via the differentiation of osteoclasts

Cui, Weiguo, Cuartas, Esteban, Ke, Juan, Zhang, Qing, Einarsson, Halldor B., Sedgwick, Jonathon D., ...

Fusion of macrophages is an essential step in the differentiation of osteoclasts, which play a central role in the development and remodeling of bone. Osteoclasts are important mediators of bone...

Requirements for Both Rac1 and Cdc42 in Membrane Ruffling and Phagocytosis in Leukocytes

Cox, Dianne, Chang, Peter, Zhang, Qing, Reddy, P. Gopal, Bokoch, Gary M., Greenberg, Steven

Specific pathways linking heterotrimeric G proteins and Fcγ receptors to the actin-based cytoskeleton are poorly understood. To test a requirement for Rho family members in cytoskeletal events...

The role of FDI, exports and spillover effects in the regional development of China

Qing Zhang, Bruce Felmingham

The objective of this analysis is to assess the impacts of export expansion, inward FDI, domestic investment and labour on the growth of China's Eastern, Central and Western regions using panel data...

Immune epitope database analysis resource (IEDB-AR)

Zhang, Qing, Wang, Peng, Kim, Yohan, Haste-Andersen, Pernille, Beaver, John, Bourne, Philip E., ...

We present a new release of the immune epitope database analysis resource (IEDB-AR, http://tools.immuneepitope.org), a repository of web-based tools for the prediction and analysis of immune...

A mouse plasma peptide atlas as a resource for disease proteomics

Zhang, Qing, Menon, Rajasree, Deutsch, Eric W, Pitteri, Sharon J, Faca, Vitor M, Wang, Hong, ...

A publicly available repository for high-quality peptide and protein data, identified by LC-MS/MS analysis.

A Mouse to Human Search for Plasma Proteome Changes Associated with Pancreatic Tumor Development

Faca, Vitor M, Song, Kenneth S, Wang, Hong, Zhang, Qing, Krasnoselsky, Alexei L, Newcomb, Lisa F, ...

Samir Hanash and colleagues identify proteins that are increased at an early stage of pancreatic tumor development in a mouse model and may be a useful tool in detecting early tumors in humans.

Identification of a Novel Prophage-Like Gene Cluster Actively Expressed in Both Virulent and Avirulent Strains of Leptospira interrogans Serovar Lai ▿

Qin, Jin-Hong, Zhang, Qing, Zhang, Zhi-Ming, Zhong, Yi, Yang, Yang, Hu, Bao-Yu, ...

DNA microarray analysis was used to compare the differential gene expression profiles between Leptospira interrogans serovar Lai type strain 56601 and its corresponding attenuated strain IPAV. A...

Novel genes dramatically alter regulatory network topology in amphioxus

Zhang, Qing, Zmasek, Christian M, Dishaw, Larry J, Mueller, M Gail, Ye, Yuzhen, Litman, Gary W, ...

Domain rearrangements in the innate immune network of amphioxus suggests that domain shuffling has shaped the evolution of immune systems.

Licensing Procedures in Developing Countries: Should They Be Part of the Set-up Process?

Zhang, Qing, Ogus, Anthony

Surveys have shown that, in general, developing countries tend to regulate the set-up processes for firms more intensively than developed countries. In particular, while many developing countries...

The amphioxus genome illuminates vertebrate origins and cephalochordate biology

Holland, Linda Z., Albalat, Ricard, Azumi, Kaoru, Benito-Gutiérrez, Èlia, Blow, Matthew J., Bronner-Fraser, Marianne, ...

Cephalochordates, urochordates, and vertebrates evolved from a common ancestor over 520 million years ago. To improve our understanding of chordate evolution and the origin of vertebrates, we...

Immunomic Analysis of the Repertoire of T-Cell Specificities for Influenza A Virus in Humans ▿ † ‡

Assarsson, Erika, Bui, Huynh-Hoa, Sidney, John, Zhang, Qing, Glenn, Jean, Oseroff, Carla, ...

Continuing antigenic drift allows influenza viruses to escape antibody-mediated recognition, and as a consequence, the vaccine currently in use needs to be altered annually. Highly conserved epitopes...

HCV genotyping using statistical classification approach

Qiu, Ping, Cai, Xiao-Yan, Ding, Wei, Zhang, Qing, Norris, Ellie D, Greene, Jonathan R

The genotype of Hepatitis C Virus (HCV) strains is an important determinant of the severity and aggressiveness of liver infection as well as patient response to antiviral therapy. Fast and accurate...