Protein evolution on a human signaling network (2009)
Cui, Qinghua, Purisima, Enrico O, Wang, Edwin
Abstract Background The architectural structure of cellular networks provides a framework for innovations as well as constraints for protein evolution. This issue has previously been studied...
Guomin Shi, Qinghua Cui, Youyi Zhang
As the prime criminal among all the cardio-vascular diseases, chronic heart failure (CHF) is still far from being fully understood after decades of study by researchers. The booming bioinformatics...
Miao, Jing, Fan, Qingfeng, Cui, Qinghua, Zhang, Han, Chen, Lihong, Wang, Suxia, ...
Background. Proteinuria, one of the main manifestations of nephrotic syndrome, is an important risk factor for the progression of renal diseases. Podocyte foot processes (FPs) injury induces...
SNP analysis reveals an evolutionary acceleration of the human-specific microRNAs (2008)
Qipeng Zhang, Ming Lu, Qinghua Cui
MicroRNAs are one class of important gene regulators at the post-transcriptional level by binding to the 3’UTRs of target mRNAs. It has been reported that human microRNAs are evolutionary...
MicroRNAs preferentially target the genes with high transcriptional regulation complexity (2006)
Cui, Qinghua, Yu, Zhenbao, Pan, Youlian, Purisima, Enrico, Wang, Edwin
Over the past few years, microRNAs (miRNAs) have emerged as a new prominent class of gene regulatory factors that negatively regulate expression of approximately one-third of the genes in animal...
Principles of microRNA regulation of a human cellular signaling network (2006)
Cui, Qinghua, Yu, Zhenbao, Purisima, Enrico O., Wang, Edwin
MicroRNAs (miRNAs) are endogenous 22-nucleotide RNAs, which suppress gene expression by selectively binding to the 3-noncoding region of specific message RNAs through base-pairing. Given the...
Cui, Qinghua, Liu, Bing, Jiang, Tianzi, Ma, Songde
Motivation: One popular method for analyzing functional connectivity between genes is to cluster genes with similar expression profiles. The most popular metrics measuring the similarity (or...
Liu, Bing, Cui, Qinghua, Jiang, Tianzi, Ma, Songde
Abstract Background Microarray experiments are becoming a powerful tool for clinical diagnosis, as they have the potential to discover gene expression patterns that are characteristic for a...
Esub8: A novel tool to predict protein subcellular localizations in eukaryotic organisms (2004)
Cui, Qinghua, Jiang, Tianzi, Liu, Bing, Ma, Songde
Abstract Background Subcellular localization of a new protein sequence is very important and fruitful for understanding its function. As the number of new genomes has dramatically increased over...
BioMed Central Open Access (2004)
Bmc Bioinformatics, Bing Liu, Qinghua Cui, Tianzi Jiang, Songde Ma
Research article A combinational feature selection and ensemble neural network method for classification of gene expression data
Cui, Qinghua, Liu, Bing, Jiang, Tianzi, Ma, Songde
Motivation: one popular method for analyzing functional connectivity between genes is to cluster genes with similar expression profiles. The most popular metrics measuring the similarity (or...
Cui, Qinghua, Liu, Bing, Jiang, Tianzi, Ma, Songde
Motivation: one popular method for analyzing functional connectivity between genes is to cluster genes with similar expression profiles. The most popular metrics measuring the similarity (or...
Das Spektrum der Vaskulitiden und Möglichkeiten ihrer Früherkennung. (1990)
Münster (Westfalen), Univ., Diss., 1990.
Das Spektrum der Vaskulitiden und Möglichkeiten ihrer Früherkennung [microform] / (1990)
Thesis (doctoral)--Westfälische Wilhelms-Universität Münster, 1990.
Principles of microRNA regulation of a human cellular signaling network
Cui, Qinghua, Yu, Zhenbao, Purisima, Enrico O, Wang, Edwin
MicroRNAs (miRNAs) are endogenous ∼22-nucleotide RNAs, which suppress gene expression by selectively binding to the 3′-noncoding region of specific messenger RNAs through base-pairing. Given the...
A map of human cancer signaling
Cui, Qinghua, Ma, Yun, Jaramillo, Maria, Bari, Hamza, Awan, Arif, Yang, Song, ...
We conducted a comprehensive analysis of a manually curated human signaling network containing 1634 nodes and 5089 signaling regulatory relations by integrating cancer-associated genetically and...
An Analysis of Human MicroRNA and Disease Associations
Lu, Ming, Zhang, Qipeng, Deng, Min, Miao, Jing, Guo, Yanhong, Gao, Wei, ...
It has been reported that increasingly microRNAs are associated with diseases. However, the patterns among the microRNA-disease associations remain largely unclear. In this study, in order to dissect...
Cepred: Predicting the Co-Expression Patterns of the Human Intronic microRNAs with Their Host Genes
Wang, Dong, Lu, Ming, Miao, Jing, Li, Tingting, Wang, Edwin, Cui, Qinghua
Identifying the tissues in which a microRNA is expressed could enhance the understanding of the functions, the biological processes, and the diseases associated with that microRNA. However, the...
PP2A Regulates the Pro-apoptotic Activity of FOXO1*
Yan, Ling, Lavin, Viviana A., Moser, Leta R., Cui, Qinghua, Kanies, Cindy, Yang, Elizabeth
FOXO1, a member of the evolutionarily conserved forkhead family of transcription factors, regulates expression of a number of genes that play critical roles in cell cycle and apoptosis. A pivotal...