Quan Chen

Redox Regulation of Apoptosis before and after Cytochrome C Release (2008)

Chen, Quan, Crosby, Meredith, Almasan, Alex

Programmed cell death, or apoptosis, is one of the most studied areas of modern biology. Apoptosis is a genetically regulated process, which plays an essential role in the development and homeostasis...

Auto Coloring with Enhanced Character Registration (2008)

Jie Qiu, Hock Soon Seah, Feng Tian, Quan Chen, Zhongke Wu, Konstantin Melikhov

An enhanced character registration method is proposed in this paper to assist the auto coloring for 2D animation characters. After skeletons are extracted, the skeleton of the character in a target...

An analytical pipeline for genomic representations used for cytosine methylation studies (2008)

Thompson, Reid F., Reimers, Mark, Khulan, Batbayar, Gissot, Mathieu, Richmond, Todd A., Chen, Quan, ...

Motivation: Representations of the genome can be generated by the selection of a subpopulation of restriction fragments using ligation-mediated PCR. Such representations form the basis for a number...

Auto Coloring with Enhanced Character Registration (2007)

Jie Qiu, Hock Soon Seah, Feng Tian, Quan Chen, Zhongke Wu, Konstantin Melikhov

An enhanced character registration method is proposed in this paper to assist the auto coloring for 2D animation characters. After skeletons are extracted, the skeleton of the character in a target...

Identification of genes regulated by Wnt/β-catenin pathway and involved in apoptosis via microarray analysis (2006)

Huang, Moli, Wang, Yihua, Sun, Daochun, Zhu, Hongxia, Yin, Yanbing, Zhang, Wei, ...

Abstract Background Wnt/β-catenin pathway has critical roles in development and oncogenesis. Although significant progress has been made in understanding the downstream signaling cascade of this...

Comparative isoschizomer profiling of cytosine methylation: The HELP assay (2006)

Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...

The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...

Comparative isoschizomer profiling of cytosine methylation: The HELP assay (2006)

Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...

The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...

Applications of Fourier transform ion cyclotron resonance (FTICR) mass spectrometry and density functional theory to the studies of gas phase metal ion-ligand structures and reactivities (1998)

Chen, Quan

The gas-phase reactions of a number of interesting ligated metal species have been studied using Fourier transform ion cyclotron resonance mass spectrometry, together with density functional...

Regulation of the expression of NMDA Receptors and CaMkII in neurons /--Quan Chen (1995)

Chen, Quan

Ph. D. dissertation -- State University of New York, Health Science Center at Syracuse, 1995

Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G1 to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E...

Role of Apo2L/TRAIL and Bcl-2-family Proteins in Apoptosis of Multiple Myeloma*

CHEN, QUAN, RAY, SUBRATA, HUSSEIN, MOHAMAD A., SRKALOVIC, GORDAN, ALMASAN, ALEXANDRU

Apo2 Ligand or Tumour Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (Apo2L/TRAIL) is a member of the TNF gene superfamily that selectively induces apoptosis in tumor cells of diverse...

Redox Regulation of Apoptosis before and after Cytochrome C Release

Chen, Quan, Crosby, Meredith, Almasan, Alex

Programmed cell death, or apoptosis, is one of the most studied areas of modern biology. Apoptosis is a genetically regulated process, which plays an essential role in the development and homeostasis...

Apo2L/TRAIL and Bcl-2–related proteins regulate type I interferon–induced apoptosis in multiple myeloma

Chen, Quan, Gong, Bendi, Mahmoud-Ahmed, Ashraf S., Zhou, Aimin, Hsi, Eric D., Hussein, Mohamad, ...

It has been reported that interferons (IFNs) may have antitumor activity in multiple myeloma (MM). The mechanism for their effect on MM, however, remains elusive. This study shows that IFN-α and...

Proteolytic Cleavage of Cyclin E Leads to Inactivation of Associated Kinase Activity and Amplification of Apoptosis in Hematopoietic Cells

Mazumder, Suparna, Gong, Bendi, Chen, Quan, Drazba, Judith A., Buchsbaum, Jeffrey C., Almasan, Alexandru

Cyclin E/Cdk2 is a critical regulator of cell cycle progression from G1 to S in mammalian cells and has an established role in oncogenesis. Here we examined the role of deregulated cyclin E...

Comparative isoschizomer profiling of cytosine methylation: The HELP assay

Khulan, Batbayar, Thompson, Reid F., Ye, Kenny, Fazzari, Melissa J., Suzuki, Masako, Stasiek, Edyta, ...

The distribution of cytosine methylation in 6.2 Mb of the mouse genome was tested using cohybridization of genomic representations from a methylation-sensitive restriction enzyme and its...

Solution structure and backbone dynamics of the AF-6 PDZ domain/Bcr peptide complex

Chen, Quan, Niu, Xiaogang, Xu, Yingqi, Wu, Jihui, Shi, Yunyu

The human AF-6, a scaffold protein between cell membrane-associated proteins and the actin cytoskeleton, plays an important role in special cell–cell junctions and signal transduction. It can be...

Low-Level Expression of MicroRNAs let-7d and miR-205 Are Prognostic Markers of Head and Neck Squamous Cell Carcinoma

Childs, Geoffrey, Fazzari, Melissa, Kung, Gloria, Kawachi, Nicole, Brandwein-Gensler, Margaret, McLemore, Michael, ...

Small noncoding microRNAs (miRNAs) have been shown to be abnormally expressed in every tumor type examined. The importance of miRNAs as potential cancer prognostic indicators is underscored by their...

A systems biology understanding of the synergistic effects of arsenic sulfide and Imatinib in BCR/ABL-associated leukemia

Zhang, Qun-Ye, Mao, Jian-Hua, Liu, Ping, Huang, Qiu-Hua, Lu, Jing, Xie, Yin-Yin, ...

In this study, we show that combined use of Imatinib (IM) and arsenic sulfide [As4S4 (AS)] exerts more profound therapeutic effects in a BCR/ABL-positive mouse model of chronic myeloid leukemia (CML)...