L1210 leukaemia cells were preloaded with [3H methotrexate] (MTX) to saturate high-affinity intracellular sites, and were then incubated with [3H]MTX to determine the steady-state intracellular MTX...
In vitro correlates of clinical response to methotrexate in actue leukaemia and Burkitt's lymphoma.
Bender, R. A., Bleyer, W. A., Drake, J. C., Ziegler, J. L.
The response of drug-resistant patients with acute leukaemia and Burkitt's lymphoma to treatment with a 24 h infusion of methotrexate (MTX) followed, in some cases,by cytosine arabinoside was...