R. A. Pixley

Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor (1984)

Pixley, R A, Colman, R W, Schapira, M

To define the factors responsible for the inactivation of the active fragment derived from Factor XII (Factor XIIf ) in plasma, we studied the inactivation kinetics of Factor XIIf in various purified...

The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons.

Pixley, R A, Page, J D, Kaufman, N, Wyshock, E G, Chang, A, ...

The hypotension and disseminated intravascular coagulation (DIC) in bacteremia is thought to be mediated by the combined actions of cytokines, prostaglandins, and complement. The contact system, via...

Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor.

De Agostini, A, Lijnen, H R, Pixley, R A, Colman, R W, Schapira, M

To define the factors responsible for the inactivation of the active fragment derived from Factor XII (Factor XIIf ) in plasma, we studied the inactivation kinetics of Factor XIIf in various purified...

Modulation of the human monocyte binding site for monomeric immunoglobulin G by activated Hageman factor.

Chien, P, Pixley, R A, Stumpo, L G, Colman, R W, Schreiber, A D

Macrophage Fc gamma receptors play a significant role in inflammation and host defense. One monocyte/macrophage Fc gamma receptor, Fc gamma RI, the binding site for monomeric IgG, appears to be...

Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor.

Colman, R W, Pixley, R A, Najamunnisa, S, Yan, W, Wang, J, Mazar, A, ...

The urokinase receptor (uPAR) binds urokinase-type plasminogen activator (u-PA) through specific interactions with uPAR domain 1, and vitronectin through interactions with a site within uPAR domains...

The contact system contributes to hypotension but not disseminated intravascular coagulation in lethal bacteremia. In vivo use of a monoclonal anti-factor XII antibody to block contact activation in baboons.

Pixley, R A, Page, J D, Kaufman, N, Wyshock, E G, Chang, A, ...

The hypotension and disseminated intravascular coagulation (DIC) in bacteremia is thought to be mediated by the combined actions of cytokines, prostaglandins, and complement. The contact system, via...

Inactivation of factor XII active fragment in normal plasma. Predominant role of C-1-inhibitor.

De Agostini, A, Lijnen, H R, Pixley, R A, Colman, R W, Schapira, M

To define the factors responsible for the inactivation of the active fragment derived from Factor XII (Factor XIIf ) in plasma, we studied the inactivation kinetics of Factor XIIf in various purified...

Modulation of the human monocyte binding site for monomeric immunoglobulin G by activated Hageman factor.

Chien, P, Pixley, R A, Stumpo, L G, Colman, R W, Schreiber, A D

Macrophage Fc gamma receptors play a significant role in inflammation and host defense. One monocyte/macrophage Fc gamma receptor, Fc gamma RI, the binding site for monomeric IgG, appears to be...

Binding of high molecular weight kininogen to human endothelial cells is mediated via a site within domains 2 and 3 of the urokinase receptor.

Colman, R W, Pixley, R A, Najamunnisa, S, Yan, W, Wang, J, Mazar, A, ...

The urokinase receptor (uPAR) binds urokinase-type plasminogen activator (u-PA) through specific interactions with uPAR domain 1, and vitronectin through interactions with a site within uPAR domains...

Activation of the contact system in lethal hypotensive bacteremia in a baboon model.

Pixley, R. A., DeLa Cadena, R. A., Page, J. D., Kaufman, N., Wyshock, E. G., Colman, R. W., ...

The hypotension in septicemia is believed to be mediated by the combined action of many mediators including cytokines, prostaglandins, and complement components. To evaluate the contribution of the...