Hightower, K E, De, S, Weinbaum, C, Spence, R A, Casey, P J
Protein farnesyltransferase (FTase) catalyses the formation of a thioether linkage between proteins containing a C-terminal CaaX motif and a 15-carbon isoprenoid. The involvement of substrates such...
Self-expanding stents for malignant dysphagia.
Clements, W D, Johnston, L R, McIlwrath, E, Spence, R A, McGuigan, J
Self-expanding metallic stents have been employed successfully for vascular, urethral, and biliary strictures. In a prospective study we examined the efficacy of the 16 mm Wallstent for palliation of...
Bornman, P C, Kahn, D, Terblanche, J, Worthley, C, Spence, R A, Krige, J J
During a 3-year period (June 1981-July 1984), 70 patients who presented with an endoscopically proven variceal bleed were randomized to receive either fiberoptic injection sclerotherapy (FIS, 36...
Templeton, J L, Spence, R A, Kennedy, T L, Parks, T G, Mackenzie, G, Hanna, W A
One hundred and thirty seven previously untreated out-patients with first and second degree haemorrhoids were allocated at random to treatment by infrared coagulation (n=66) or rubber band ligation...
Initial experience with indium-111 autologous leucocyte imaging in patients with acute pancreatitis.
Anderson, J R, Spence, R A, Laird, J D, Ferguson, W R, Kennedy, T L
Indium-111 labelled autologous leucocyte imaging was used to assess severity in 13 patients with acute pancreatitis. All three patients with severe disease as judged by a prognostic factor grading...
Hightower, K E, De, S, Weinbaum, C, Spence, R A, Casey, P J
Protein farnesyltransferase (FTase) catalyses the formation of a thioether linkage between proteins containing a C-terminal CaaX motif and a 15-carbon isoprenoid. The involvement of substrates such...
Self-expanding stents for malignant dysphagia.
Clements, W D, Johnston, L R, McIlwrath, E, Spence, R A, McGuigan, J
Self-expanding metallic stents have been employed successfully for vascular, urethral, and biliary strictures. In a prospective study we examined the efficacy of the 16 mm Wallstent for palliation of...
Bornman, P C, Kahn, D, Terblanche, J, Worthley, C, Spence, R A, Krige, J J
During a 3-year period (June 1981-July 1984), 70 patients who presented with an endoscopically proven variceal bleed were randomized to receive either fiberoptic injection sclerotherapy (FIS, 36...
Templeton, J L, Spence, R A, Kennedy, T L, Parks, T G, Mackenzie, G, Hanna, W A
One hundred and thirty seven previously untreated out-patients with first and second degree haemorrhoids were allocated at random to treatment by infrared coagulation (n=66) or rubber band ligation...
Initial experience with indium-111 autologous leucocyte imaging in patients with acute pancreatitis.
Anderson, J R, Spence, R A, Laird, J D, Ferguson, W R, Kennedy, T L
Indium-111 labelled autologous leucocyte imaging was used to assess severity in 13 patients with acute pancreatitis. All three patients with severe disease as judged by a prognostic factor grading...
DNA densitometry of colorectal cancer.
Deans, G T, Williamson, K, Hamilton, P, Heatley, M, Arthurs, K, Patterson, C C, ...
DNA analysis was assessed by densitometry for 281 cases of colorectal adenocarcinoma. Detection of aneuploidy in a single case rose from 65% if one, to 92.5% when three or more sections, were...
Oesophageal mucosal changes in patients with varices.
Spence, R A, Sloan, J M, Johnston, G W, Greenfield, A
Histological examination of oesophageal rings removed at transection for varices reveals dilated intraepithelial blood filled channels. These are present in all oesophageal rings removed at...
Does age influence normal gastro-oesophageal reflux?
Spence, R A, Collins, B J, Parks, T G, Love, A H
Prolonged oesophageal pH monitoring is being used increasingly to detect abnormal gastro-oesophageal reflux. To assess the influence of age on normal reflux patterns, a group of 13 young asymptomatic...
A new immunoradioactive agent: 32P-conjugated antibody
Spence, R. A., Swan, J. M., Ghose, T., Nairn, R. C., Rolland, Jennifer M., ...
A radioactive organophosphorus compound, 32P-diphenylphosphinothioic chloride (D32PT chloride) was synthesized from commercially available radioactive phosphorus pentasulphide of high specific...
Wound infection following surgery in an accident and emergency theatre.
Five hundred and six clean minor surgical procedures were carried out in an emergency theatre. One theatre was used for both clean and septic conditions; clean cases preceding the septic lesions....
Bleeding oesophageal varices with long term follow up.
Spence, R A, Johnston, G W, Odling-Smee, G W, Rodgers, H W
Complete long term follow up was obtained in 27 children who had bled from oesophageal varices. Most presented with haematemesis or melaena at an average age of 5.2 years in the portal vein...
Rectovaginal fistulae following radiation treatment for cervical carcinoma.
Anderson, J. R., Spence, R. A., Parks, T. G., Bond, E. B., Burrows, B. D.
Primary sclerosing cholangitis.
Spence, R. A., Anderson, J. R., Johnston, G. W., Fulton, T. T., Callender, M. E.
Late, solitary metastatic renal carcinoma in the pancreas.
Simpson, N. S., Mulholland, C. K., Lioe, T. F., Spence, R. A.
Hereditary breast cancer in Northern Ireland.
McKinley, A. G., Russell, S. E., Spence, R. A., Odling-Smee, W., Nevin, N. C.
The aim of this investigation was to document hereditary breast cancer in Northern Ireland. Family history details from over nine hundred women were obtained by postal survey and one hundred and...
A 3 year audit of fine needle aspirates from a symptomatic breast clinic.
Lioe, T. F., Elliott, H., Allen, D. C., Spence, R. A.
A total of 2431 fine needle aspirates of symptomatic breast lumps was performed on 2096 patients over the last three years at the weekly head, neck and breast clinic at the Belfast City Hospital...
An audit of surgery of the parotid gland.
Deans, G. T., Briggs, K., Spence, R. A.
The management of patients undergoing 50 surgical procedures to the parotid gland was reviewed. The overall accuracy of fine needle aspiration cytology was 87%, false-positive and false-negative...
Colorectal carcinoma: importance of clinical and pathological factors in survival.
Deans, G. T., Patterson, C. C., Parks, T. G., Spence, R. A., Heatley, M., Moorehead, R. J., ...
A series of clinicopathological variables was assessed on 312 patients undergoing surgical resection for primary colorectal cancer. Although the presence of venous invasion was related to mortality...
Combined barium meal and cholecystogram--an analysis of 1,444 patients.
Watt, P. C., Spence, R. A., Campbell, R. C., McGurk, J. J., Whytes, D. G.
Since many dyspeptic patients are still investigated initially by radiology, a policy was initiated whereby all such patients were directly referred for combined simultaneous double-contrast barium...
Does preoperative computed tomography scanning aid assessment of oesophageal carcinoma?
Kirk, S. J., Moorehead, R. J., McIlrath, E., Gibbons, J. P., Spence, R. A.
In this study 50 patients (36 male, 14 female) with oesophageal carcinoma have been examined preoperatively by computed tomography. Three parameters were assessed, nodal involvement, invasion of...